MX9203775A - Compuestos arilicos biciclicos substituidos, que exhiben actividad antagonista al leucotrieno b4 selectiva. - Google Patents
Compuestos arilicos biciclicos substituidos, que exhiben actividad antagonista al leucotrieno b4 selectiva.Info
- Publication number
- MX9203775A MX9203775A MX9203775A MX9203775A MX9203775A MX 9203775 A MX9203775 A MX 9203775A MX 9203775 A MX9203775 A MX 9203775A MX 9203775 A MX9203775 A MX 9203775A MX 9203775 A MX9203775 A MX 9203775A
- Authority
- MX
- Mexico
- Prior art keywords
- compounds
- pct
- selective
- leucotrene
- aril
- Prior art date
Links
- 239000005557 antagonist Substances 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 title abstract 2
- 230000000694 effects Effects 0.000 title abstract 2
- 230000001747 exhibiting effect Effects 0.000 title 1
- VNYSSYRCGWBHLG-AMOLWHMGSA-N leukotriene B4 Chemical compound CCCCC\C=C/C[C@@H](O)\C=C\C=C\C=C/[C@@H](O)CCCC(O)=O VNYSSYRCGWBHLG-AMOLWHMGSA-N 0.000 abstract 2
- 125000001424 substituent group Chemical group 0.000 abstract 2
- 150000001735 carboxylic acids Chemical group 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/32—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
- C07C235/34—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/12—Radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D209/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an alkyl or cycloalkyl radical attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Rheumatology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Indole Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US58024390A | 1990-09-10 | 1990-09-10 |
Publications (1)
Publication Number | Publication Date |
---|---|
MX9203775A true MX9203775A (es) | 1992-07-01 |
Family
ID=24320298
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX9203775A MX9203775A (es) | 1990-09-10 | 1992-06-29 | Compuestos arilicos biciclicos substituidos, que exhiben actividad antagonista al leucotrieno b4 selectiva. |
Country Status (9)
Country | Link |
---|---|
US (1) | US5468898A (es) |
EP (1) | EP0548250B1 (es) |
JP (1) | JP3334087B2 (es) |
AT (1) | ATE136026T1 (es) |
AU (1) | AU8641991A (es) |
CA (1) | CA2091257A1 (es) |
DE (1) | DE69118388T2 (es) |
MX (1) | MX9203775A (es) |
WO (1) | WO1992004321A1 (es) |
Families Citing this family (30)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2088011T3 (es) * | 1990-07-16 | 1996-08-01 | Merrell Pharma Inc | Antagonistas de aminoacidos excitadores. |
US5076271A (en) * | 1990-07-19 | 1991-12-31 | Siemens-Pacesetter, Inc. | Rate-responsive pacing method and system employing minimum blood oxygen saturation as a control parameter and as a physical activity indicator |
GB9609641D0 (en) | 1996-05-09 | 1996-07-10 | Pfizer Ltd | Compounds useful in therapy |
US6416733B1 (en) | 1996-10-07 | 2002-07-09 | Bristol-Myers Squibb Pharma Company | Radiopharmaceuticals for imaging infection and inflammation |
ES2384551T3 (es) * | 1997-03-05 | 2012-07-06 | Sugen, Inc. | Formulaciones para agentes farmacéuticos hidrófobos |
JPH10287647A (ja) * | 1997-04-11 | 1998-10-27 | Higeta Shoyu Co Ltd | 新規インドールアルカロイド系化合物 0089−d |
US7064114B2 (en) * | 1999-03-19 | 2006-06-20 | Parker Hughes Institute | Gel-microemulsion formulations |
WO2001032621A1 (fr) * | 1999-10-29 | 2001-05-10 | Wakunaga Pharmaceutical Co., Ltd. | Nouveaux derives d'indole, et medicaments contenant lesdits derives comme principe actif |
CA2424222A1 (en) * | 2000-10-02 | 2002-04-11 | Merck & Co., Inc. | Inhibitors of prenyl-protein transferase |
EP1347784A2 (en) | 2000-11-03 | 2003-10-01 | Bristol-Myers Squibb Pharma Company | Simultaneous dual isotope imaging of cardiac perfusion and cardiac inflammation |
TWI317634B (en) * | 2001-12-13 | 2009-12-01 | Nat Health Research Institutes | Aroyl indoles compounds |
US7632955B2 (en) * | 2001-12-13 | 2009-12-15 | National Health Research Institutes | Indole compounds |
US7528165B2 (en) * | 2001-12-13 | 2009-05-05 | National Health Research Institutes | Indole compounds |
AU2003239972B2 (en) * | 2002-06-14 | 2008-02-28 | Merck & Co., Inc. | Ophthalmic compositions for treating ocular hypertension |
JP2005008631A (ja) * | 2003-05-29 | 2005-01-13 | New Industry Research Organization | ベンゾフラン化合物、およびそれを含有してなる医薬組成物 |
WO2004108714A1 (en) * | 2003-06-05 | 2004-12-16 | Warner-Lambert Company Llc | Cycloalkylsulfanyl substituted benzo[b]thiophenes as therapeutic agents |
CA2527934A1 (en) * | 2003-06-05 | 2004-12-16 | Warner-Lambert Company Llc | Tetrazol benzofurancarboxamides with p13k activity as therapeutic agents |
CA2527779A1 (en) * | 2003-06-05 | 2004-12-16 | Warner-Lambert Company Llc | 3-substituted indoles and derivatives thereof as therapeutic agents |
MXPA05012953A (es) * | 2003-06-05 | 2006-02-13 | Warner Lambert Co | Benzo[b]tiofenos 3-arilsulfanil y 3-heteroarilsulfanil sustituidos como agentes terapeuticos. |
WO2004108713A1 (en) * | 2003-06-05 | 2004-12-16 | Warner-Lambert Company Llc | Cycloalkyl and heterocycloalkyl substituted benzothiophenes as therapeutic agents |
US20040259926A1 (en) * | 2003-06-05 | 2004-12-23 | Bruendl Michelle M. | 3-Aryloxy and 3-heteroaryloxy substituted benzo[b]thiophenes as therapeutic agents |
ITRM20030355A1 (it) * | 2003-07-18 | 2005-01-19 | Sigma Tau Ind Farmaceuti | Composti ad attivita' citotossica derivati della combretastatina. |
WO2005021518A1 (ja) * | 2003-09-01 | 2005-03-10 | Ono Pharmaceutical Co., Ltd. | 縮環化合物およびその用途 |
RU2007115522A (ru) * | 2004-10-12 | 2008-10-27 | Декод Дженетикс Ехф (Is) | Пери-замещенные бициклические карбоновые кислоты для лечения окклюзионного заболевания артерий |
US7456289B2 (en) * | 2004-12-31 | 2008-11-25 | National Health Research Institutes | Anti-tumor compounds |
CA2722102C (en) | 2008-04-28 | 2013-06-11 | Asahi Kasei Pharma Corporation | Phenylpropionic acid derivative and use thereof |
FR2961812A1 (fr) * | 2010-06-29 | 2011-12-30 | Centre Nat Rech Scient | Procede de synthese d'alcaloides du type ergoline par double cyclisation a partir de bicycles indoliques, produits obtenus et produits intermediaires |
KR101432078B1 (ko) * | 2013-04-22 | 2014-08-21 | 영남대학교 산학협력단 | 항병원성 활성을 갖는 7-벤질옥시인돌 화합물의 신규한 용도 |
CR20170594A (es) | 2015-06-09 | 2018-04-27 | Abbvie Inc | Moduladores de receptor nuclear |
CN112321479B (zh) * | 2020-11-04 | 2022-02-08 | 吉林大学 | 一种桑寄生中具有抑菌活性的吲哚-4-甲醛化合物、制备方法及其应用 |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2692882A (en) * | 1952-04-01 | 1954-10-26 | Upjohn Co | (5-benzyloxy-3-indole)-alkanoylamides and preparation thereof |
NL271818A (es) * | 1960-11-25 | |||
US3868405A (en) * | 1967-05-17 | 1975-02-25 | Beecham Group Ltd | Naphthylene derivatives |
FR2230349A1 (en) * | 1973-05-23 | 1974-12-20 | Delalande Sa | 1-Phenyl-2-methyl-5-methoxy indoles - with e.g. sedative, cardiac analeptic, vasodilator, antihypertensive, analgesic, and antiinflammatory activities |
US4814463A (en) * | 1985-12-31 | 1989-03-21 | Biomeasure, Inc. | CCK antagonists |
CA1320490C (en) * | 1987-01-12 | 1993-07-20 | Darrel M. Gapinski | Anti-inflammatory agents |
CA1315279C (en) * | 1987-01-12 | 1993-03-30 | Nancy Grace Bollinger | Anti-inflammatory agents |
US4889871A (en) * | 1987-05-29 | 1989-12-26 | G. D. Searle & Co. | Alkoxy-substituted dihydrobenzopyran-2-carboxylate derivatives |
DE3840338A1 (de) * | 1988-11-30 | 1990-05-31 | Bayer Ag | Neue 2-halogensubstituierte n-indolylethyl-sulfonsaeureamide, verfahren zu ihrer herstellung und ihre verwendung in arzneimitteln |
US5232948A (en) * | 1990-09-10 | 1993-08-03 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | Substituted monocyclic aryl compounds exhibiting selective leukotriene b4 antagonist activity |
US5210208A (en) * | 1990-09-24 | 1993-05-11 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | Disubstituted aryl compounds exhibiting selective leukotriene b4 antagonist activity |
-
1991
- 1991-09-06 JP JP51616191A patent/JP3334087B2/ja not_active Expired - Lifetime
- 1991-09-06 AT AT91917468T patent/ATE136026T1/de not_active IP Right Cessation
- 1991-09-06 WO PCT/US1991/006447 patent/WO1992004321A1/en active IP Right Grant
- 1991-09-06 EP EP91917468A patent/EP0548250B1/en not_active Expired - Lifetime
- 1991-09-06 DE DE69118388T patent/DE69118388T2/de not_active Expired - Lifetime
- 1991-09-06 CA CA002091257A patent/CA2091257A1/en not_active Abandoned
- 1991-09-06 AU AU86419/91A patent/AU8641991A/en not_active Abandoned
- 1991-09-06 US US07/777,246 patent/US5468898A/en not_active Expired - Lifetime
-
1992
- 1992-06-29 MX MX9203775A patent/MX9203775A/es unknown
Also Published As
Publication number | Publication date |
---|---|
US5468898A (en) | 1995-11-21 |
DE69118388T2 (de) | 1996-11-14 |
EP0548250A4 (en) | 1993-10-27 |
CA2091257A1 (en) | 1992-03-11 |
EP0548250A1 (en) | 1993-06-30 |
WO1992004321A1 (en) | 1992-03-19 |
AU8641991A (en) | 1992-03-30 |
JPH06504520A (ja) | 1994-05-26 |
DE69118388D1 (de) | 1996-05-02 |
JP3334087B2 (ja) | 2002-10-15 |
ATE136026T1 (de) | 1996-04-15 |
EP0548250B1 (en) | 1996-03-27 |
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