MX428647B - Anticuerpos injertados con péptido natriurético auricular. - Google Patents

Anticuerpos injertados con péptido natriurético auricular.

Info

Publication number
MX428647B
MX428647B MX2020010684A MX2020010684A MX428647B MX 428647 B MX428647 B MX 428647B MX 2020010684 A MX2020010684 A MX 2020010684A MX 2020010684 A MX2020010684 A MX 2020010684A MX 428647 B MX428647 B MX 428647B
Authority
MX
Mexico
Prior art keywords
antibody
fragment
natriuretic peptide
atrial natriuretic
amino acid
Prior art date
Application number
MX2020010684A
Other languages
English (en)
Other versions
MX2020010684A (es
Inventor
Andreas Wilmen
Anke Mayer-Bartschmid
Christoph Mahlert
Claudia Noack
Damian Brockschnieder
Ernst Weber
Frank Wunder
Hannah Jörissen
Ilka Mathar
Jan Tebbe
Lucas Hudson Hofmeister
Marcel Geertz
Simone Greven
Stuart Walsh
Thomas Mondritzki
Tobias Marquardt
Original Assignee
Bayer Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag filed Critical Bayer Ag
Publication of MX2020010684A publication Critical patent/MX2020010684A/es
Publication of MX428647B publication Critical patent/MX428647B/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/58—Atrial natriuretic factor complex; Atriopeptin; Atrial natriuretic peptide [ANP]; Cardionatrin; Cardiodilatin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/2242—Atrial natriuretic factor complex: Atriopeptins, atrial natriuretic protein [ANP]; Cardionatrin, Cardiodilatin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/53—Hinge
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/567—Framework region [FR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2318/00—Antibody mimetics or scaffolds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2318/00—Antibody mimetics or scaffolds
    • C07K2318/10—Immunoglobulin or domain(s) thereof as scaffolds for inserted non-Ig peptide sequences, e.g. for vaccination purposes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/31—Fusion polypeptide fusions, other than Fc, for prolonged plasma life, e.g. albumin

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cardiology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Endocrinology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Epidemiology (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Un anticuerpo, o un fragmento del mismo, que comprende por lo menos una secuencia de aminoácidos heteróloga incorporada en por lo menos una región CDR de dicho anticuerpo o fragmento del mismo, en donde dicha por lo menos una secuencia de aminoácidos heteróloga comprende una secuencia conectora N-terminal (Ntls), un péptido natriurético auricular (ANP) y una secuencia conectora C-terminal (Ctls). Opcionalmente, por lo menos una porción de dicha por lo menos una región CDR se reemplaza por dicha por lo menos una secuencia de aminoácidos heteróloga incorporada en la misma. La presente invención se relaciona además con dicho anticuerpo o fragmento del mismo para usar en un método de tratamiento, una composición que comprende dicho anticuerpo o fragmento del mismo, un ácido nucleico o una mezcla de ácidos nucleicos que codifica dicho anticuerpo o fragmento del mismo, una célula huésped que comprende dicho ácido nucleico o dicha mezcla de ácidos nucleicos y con un proceso para producir dicho anticuerpo o fragmento del mismo.
MX2020010684A 2018-04-12 2019-04-10 Anticuerpos injertados con péptido natriurético auricular. MX428647B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP18167102.5A EP3553081A1 (en) 2018-04-12 2018-04-12 Atrial natriuretic peptide engrafted antibodies
PCT/EP2019/059093 WO2019197470A1 (en) 2018-04-12 2019-04-10 Atrial natriuretic peptide engrafted antibodies

Publications (2)

Publication Number Publication Date
MX2020010684A MX2020010684A (es) 2020-11-06
MX428647B true MX428647B (es) 2025-11-13

Family

ID=62044486

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2020010684A MX428647B (es) 2018-04-12 2019-04-10 Anticuerpos injertados con péptido natriurético auricular.

Country Status (15)

Country Link
US (2) US12331094B2 (es)
EP (2) EP3553081A1 (es)
JP (2) JP2021520801A (es)
KR (2) KR20260041908A (es)
CN (2) CN112236196B (es)
AR (1) AR114481A1 (es)
AU (1) AU2019250363B2 (es)
BR (1) BR112020020037A2 (es)
CA (1) CA3096750A1 (es)
IL (1) IL277868B2 (es)
MX (1) MX428647B (es)
PE (1) PE20210020A1 (es)
SA (1) SA520420339B1 (es)
SG (1) SG11202009413WA (es)
WO (1) WO2019197470A1 (es)

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Also Published As

Publication number Publication date
IL277868A (en) 2020-11-30
EP3773901A1 (en) 2021-02-17
CA3096750A1 (en) 2019-10-17
AR114481A1 (es) 2020-09-09
BR112020020037A2 (pt) 2021-01-05
CN112236196A (zh) 2021-01-15
US12331094B2 (en) 2025-06-17
IL277868B1 (en) 2024-12-01
US20250361282A1 (en) 2025-11-27
TW201943734A (zh) 2019-11-16
AU2019250363A1 (en) 2020-11-12
CN112236196B (zh) 2025-06-24
WO2019197470A1 (en) 2019-10-17
PE20210020A1 (es) 2021-01-07
MX2020010684A (es) 2020-11-06
AU2019250363B2 (en) 2026-02-05
SG11202009413WA (en) 2020-10-29
CN120737211A (zh) 2025-10-03
JP2021520801A (ja) 2021-08-26
IL277868B2 (en) 2025-04-01
KR20260041908A (ko) 2026-03-27
SA520420339B1 (ar) 2024-02-26
US20210139555A1 (en) 2021-05-13
KR20210003787A (ko) 2021-01-12
JP2024050750A (ja) 2024-04-10
EP3553081A1 (en) 2019-10-16