SG11202009413WA - Atrial natriuretic peptide engrafted antibodies - Google Patents
Atrial natriuretic peptide engrafted antibodiesInfo
- Publication number
- SG11202009413WA SG11202009413WA SG11202009413WA SG11202009413WA SG11202009413WA SG 11202009413W A SG11202009413W A SG 11202009413WA SG 11202009413W A SG11202009413W A SG 11202009413WA SG 11202009413W A SG11202009413W A SG 11202009413WA SG 11202009413W A SG11202009413W A SG 11202009413WA
- Authority
- SG
- Singapore
- Prior art keywords
- natriuretic peptide
- atrial natriuretic
- peptide engrafted
- engrafted antibodies
- antibodies
- Prior art date
Links
- 102000002723 Atrial Natriuretic Factor Human genes 0.000 title 1
- 101800001288 Atrial natriuretic factor Proteins 0.000 title 1
- 101800001890 Atrial natriuretic peptide Proteins 0.000 title 1
- NSQLIUXCMFBZME-MPVJKSABSA-N carperitide Chemical compound C([C@H]1C(=O)NCC(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](C(NCC(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CSSC[C@@H](C(=O)N1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(O)=O)=O)[C@@H](C)CC)C1=CC=CC=C1 NSQLIUXCMFBZME-MPVJKSABSA-N 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/58—Atrial natriuretic factor complex; Atriopeptin; Atrial natriuretic peptide [ANP]; Cardionatrin; Cardiodilatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/2242—Atrial natriuretic factor complex: Atriopeptins, atrial natriuretic protein [ANP]; Cardionatrin, Cardiodilatin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/53—Hinge
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/567—Framework region [FR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2318/00—Antibody mimetics or scaffolds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2318/00—Antibody mimetics or scaffolds
- C07K2318/10—Immunoglobulin or domain(s) thereof as scaffolds for inserted non-Ig peptide sequences, e.g. for vaccination purposes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/31—Fusion polypeptide fusions, other than Fc, for prolonged plasma life, e.g. albumin
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Cardiology (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Endocrinology (AREA)
- Pharmacology & Pharmacy (AREA)
- Zoology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Heart & Thoracic Surgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Hospice & Palliative Care (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP18167102.5A EP3553081A1 (en) | 2018-04-12 | 2018-04-12 | Atrial natriuretic peptide engrafted antibodies |
PCT/EP2019/059093 WO2019197470A1 (en) | 2018-04-12 | 2019-04-10 | Atrial natriuretic peptide engrafted antibodies |
Publications (1)
Publication Number | Publication Date |
---|---|
SG11202009413WA true SG11202009413WA (en) | 2020-10-29 |
Family
ID=62044486
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11202009413WA SG11202009413WA (en) | 2018-04-12 | 2019-04-10 | Atrial natriuretic peptide engrafted antibodies |
Country Status (16)
Country | Link |
---|---|
US (1) | US20210139555A1 (en) |
EP (2) | EP3553081A1 (en) |
JP (2) | JP2021520801A (en) |
KR (1) | KR20210003787A (en) |
CN (1) | CN112236196A (en) |
AR (1) | AR114481A1 (en) |
AU (1) | AU2019250363A1 (en) |
BR (1) | BR112020020037A2 (en) |
CA (1) | CA3096750A1 (en) |
IL (1) | IL277868A (en) |
MX (1) | MX2020010684A (en) |
PE (1) | PE20210020A1 (en) |
SA (1) | SA520420339B1 (en) |
SG (1) | SG11202009413WA (en) |
TW (1) | TW201943734A (en) |
WO (1) | WO2019197470A1 (en) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN113332423A (en) * | 2021-05-26 | 2021-09-03 | 华中科技大学同济医学院附属协和医院 | Application of PCSK9 inhibitor in anti-rejection reaction after heart transplantation |
US11896719B2 (en) | 2022-01-24 | 2024-02-13 | Calliditas Therapeutics Ab | Pharmaceutical compositions |
Family Cites Families (45)
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US5179017A (en) | 1980-02-25 | 1993-01-12 | The Trustees Of Columbia University In The City Of New York | Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials |
US4634665A (en) | 1980-02-25 | 1987-01-06 | The Trustees Of Columbia University In The City Of New York | Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials |
US4399216A (en) | 1980-02-25 | 1983-08-16 | The Trustees Of Columbia University | Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials |
US4510245A (en) | 1982-11-18 | 1985-04-09 | Chiron Corporation | Adenovirus promoter system |
GB8308235D0 (en) | 1983-03-25 | 1983-05-05 | Celltech Ltd | Polypeptides |
US5168062A (en) | 1985-01-30 | 1992-12-01 | University Of Iowa Research Foundation | Transfer vectors and microorganisms containing human cytomegalovirus immediate-early promoter-regulatory DNA sequence |
US4968615A (en) | 1985-12-18 | 1990-11-06 | Ciba-Geigy Corporation | Deoxyribonucleic acid segment from a virus |
US5288931A (en) * | 1991-12-06 | 1994-02-22 | Genentech, Inc. | Method for refolding insoluble, misfolded insulin-like growth factor-I into an active conformation |
DE19834044A1 (en) | 1998-07-29 | 2000-02-03 | Bayer Ag | New substituted pyrazole derivatives |
DE19834047A1 (en) | 1998-07-29 | 2000-02-03 | Bayer Ag | Substituted pyrazole derivatives |
GB9912350D0 (en) * | 1999-05-26 | 1999-07-28 | European Molecular Biology Lab Embl | Modified cytokine |
DE19943634A1 (en) | 1999-09-13 | 2001-04-12 | Bayer Ag | Novel dicarboxylic acid derivatives with pharmaceutical properties |
DE19943635A1 (en) | 1999-09-13 | 2001-03-15 | Bayer Ag | Novel aminodicarboxylic acid derivatives with pharmaceutical properties |
DE19943636A1 (en) | 1999-09-13 | 2001-03-15 | Bayer Ag | Novel dicarboxylic acid derivatives with pharmaceutical properties |
DE19943639A1 (en) | 1999-09-13 | 2001-03-15 | Bayer Ag | Dicarboxylic acid derivatives with novel pharmaceutical properties |
AR031176A1 (en) | 2000-11-22 | 2003-09-10 | Bayer Ag | NEW DERIVATIVES OF PIRAZOLPIRIDINA SUBSTITUTED WITH PIRIDINE |
US20040253242A1 (en) | 2000-12-05 | 2004-12-16 | Bowdish Katherine S. | Rationally designed antibodies |
DE10110750A1 (en) | 2001-03-07 | 2002-09-12 | Bayer Ag | Novel aminodicarboxylic acid derivatives with pharmaceutical properties |
DE10110749A1 (en) | 2001-03-07 | 2002-09-12 | Bayer Ag | Substituted aminodicarboxylic acid derivatives |
WO2002078612A2 (en) * | 2001-04-02 | 2002-10-10 | Euro-Celtique S.A. | Thrombopoietin (tpo) synthebody for stimulation of platelet production |
FI117667B (en) * | 2001-07-05 | 2007-01-15 | Univ Zuerich | A pharmaceutical composition suitable for use in orthopedics and dentistry |
DE10220570A1 (en) | 2002-05-08 | 2003-11-20 | Bayer Ag | Carbamate-substituted pyrazolopyridines |
CA2513213C (en) | 2003-01-22 | 2013-07-30 | Human Genome Sciences, Inc. | Albumin fusion proteins |
WO2005082004A2 (en) | 2004-02-24 | 2005-09-09 | Alexion Pharmaceuticals, Inc. | Rationally designed antibodies having a domain-exchanged scaffold |
KR100754667B1 (en) | 2005-04-08 | 2007-09-03 | 한미약품 주식회사 | Immunoglobulin Fc fragment modified by non-peptide polymer and pharmaceutical composition comprising the same |
US20090035287A1 (en) * | 2005-09-26 | 2009-02-05 | Zurit Levine | Atrial natriuretic peptide (anp) splice variants and methods of using same |
US20080181903A1 (en) | 2006-12-21 | 2008-07-31 | Pdl Biopharma, Inc. | Conjugate of natriuretic peptide and antibody constant region |
KR20080098216A (en) | 2007-05-04 | 2008-11-07 | 한미약품 주식회사 | Natriuretic peptide conjugate using carrier substance |
CA2689492A1 (en) | 2007-06-06 | 2008-12-18 | Boehringer Ingelheim International Gmbh | Natriuretic fusion proteins |
WO2009033094A2 (en) * | 2007-09-07 | 2009-03-12 | Agensys, Inc. | Antibodies and related molecules that bind to 24p4c12 proteins |
JP5882058B2 (en) * | 2008-11-07 | 2016-03-09 | ファブラス エルエルシー | Combination antibody library and use thereof |
DE102010001064A1 (en) | 2009-03-18 | 2010-09-23 | Bayer Schering Pharma Aktiengesellschaft | Substituted 2-acetamido-5-aryl-1,2,4-triazolones and their use |
CA2754408A1 (en) | 2009-03-30 | 2010-10-14 | Boehringer Ingelheim International Gmbh | Fusion proteins comprising canine fc portions |
HUE057174T2 (en) | 2009-05-20 | 2022-04-28 | Biomarin Pharm Inc | Variants of c-type natriuretic peptide |
US20120108514A1 (en) * | 2009-07-09 | 2012-05-03 | University Of Iowa Research Foundation | Long acting atrial natriuretic peptide (la-anp) and methods for use thereof |
BR112012021498B8 (en) | 2010-02-27 | 2020-04-14 | Bayer Ip Gmbh | Bisaryl-linked aryltriazolones and their use |
DE102010021637A1 (en) | 2010-05-26 | 2011-12-01 | Bayer Schering Pharma Aktiengesellschaft | Substituted 5-fluoro-1H-pyrazolopyridines and their use |
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DE102010040233A1 (en) | 2010-09-03 | 2012-03-08 | Bayer Schering Pharma Aktiengesellschaft | Bicyclic aza heterocycles and their use |
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CN103906761B (en) * | 2011-08-30 | 2016-12-21 | 梅约医学教育与研究基金会 | Profit sodium polypeptide |
CN105085659B (en) * | 2014-05-20 | 2021-02-19 | 深圳大学 | Recombinant natriuretic peptide and preparation method thereof |
PE20170945A1 (en) | 2014-11-03 | 2017-07-13 | Bayer Pharma AG | HYDROXYALKYL SUBSTITUTED PHENYLTRIAZOLE DERIVATIVES AND THEIR USES |
-
2018
- 2018-04-12 EP EP18167102.5A patent/EP3553081A1/en active Pending
-
2019
- 2019-04-10 BR BR112020020037-9A patent/BR112020020037A2/en unknown
- 2019-04-10 WO PCT/EP2019/059093 patent/WO2019197470A1/en active Application Filing
- 2019-04-10 US US17/046,509 patent/US20210139555A1/en active Pending
- 2019-04-10 PE PE2020001581A patent/PE20210020A1/en unknown
- 2019-04-10 CN CN201980038627.7A patent/CN112236196A/en active Pending
- 2019-04-10 EP EP19716169.8A patent/EP3773901A1/en active Pending
- 2019-04-10 KR KR1020207032277A patent/KR20210003787A/en not_active Application Discontinuation
- 2019-04-10 AR ARP190100945A patent/AR114481A1/en unknown
- 2019-04-10 MX MX2020010684A patent/MX2020010684A/en unknown
- 2019-04-10 JP JP2020555230A patent/JP2021520801A/en active Pending
- 2019-04-10 CA CA3096750A patent/CA3096750A1/en active Pending
- 2019-04-10 SG SG11202009413WA patent/SG11202009413WA/en unknown
- 2019-04-10 TW TW108112514A patent/TW201943734A/en unknown
- 2019-04-10 AU AU2019250363A patent/AU2019250363A1/en active Pending
-
2020
- 2020-10-07 IL IL277868A patent/IL277868A/en unknown
- 2020-10-12 SA SA520420339A patent/SA520420339B1/en unknown
-
2024
- 2024-02-01 JP JP2024014201A patent/JP2024050750A/en active Pending
Also Published As
Publication number | Publication date |
---|---|
TW201943734A (en) | 2019-11-16 |
JP2024050750A (en) | 2024-04-10 |
EP3773901A1 (en) | 2021-02-17 |
CN112236196A (en) | 2021-01-15 |
EP3553081A1 (en) | 2019-10-16 |
JP2021520801A (en) | 2021-08-26 |
AR114481A1 (en) | 2020-09-09 |
SA520420339B1 (en) | 2024-02-26 |
IL277868A (en) | 2020-11-30 |
BR112020020037A2 (en) | 2021-01-05 |
PE20210020A1 (en) | 2021-01-07 |
CA3096750A1 (en) | 2019-10-17 |
KR20210003787A (en) | 2021-01-12 |
AU2019250363A1 (en) | 2020-11-12 |
MX2020010684A (en) | 2020-11-06 |
WO2019197470A1 (en) | 2019-10-17 |
US20210139555A1 (en) | 2021-05-13 |
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