MX394452B - Inhibicion de la actividad de olig2. - Google Patents
Inhibicion de la actividad de olig2.Info
- Publication number
- MX394452B MX394452B MX2017011018A MX2017011018A MX394452B MX 394452 B MX394452 B MX 394452B MX 2017011018 A MX2017011018 A MX 2017011018A MX 2017011018 A MX2017011018 A MX 2017011018A MX 394452 B MX394452 B MX 394452B
- Authority
- MX
- Mexico
- Prior art keywords
- olig2
- inhibition
- compounds
- activity
- olig2 activity
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/48—Two nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/17—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Oncology (AREA)
- Hospice & Palliative Care (AREA)
- Hematology (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562126382P | 2015-02-27 | 2015-02-27 | |
| PCT/US2016/019932 WO2016138479A1 (en) | 2015-02-27 | 2016-02-26 | Inhibition of olig2 activity |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX2017011018A MX2017011018A (es) | 2018-01-18 |
| MX394452B true MX394452B (es) | 2025-03-21 |
Family
ID=56789909
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2017011018A MX394452B (es) | 2015-02-27 | 2016-02-26 | Inhibicion de la actividad de olig2. |
Country Status (15)
| Country | Link |
|---|---|
| US (4) | US20180244631A1 (OSRAM) |
| EP (1) | EP3261631B1 (OSRAM) |
| JP (2) | JP2018510138A (OSRAM) |
| KR (1) | KR102629269B1 (OSRAM) |
| CN (1) | CN107530304A (OSRAM) |
| AU (1) | AU2016225000B2 (OSRAM) |
| BR (1) | BR112017018198A2 (OSRAM) |
| CA (1) | CA2977521C (OSRAM) |
| EA (1) | EA039121B1 (OSRAM) |
| HK (1) | HK1248139A1 (OSRAM) |
| IL (1) | IL254007B2 (OSRAM) |
| MX (1) | MX394452B (OSRAM) |
| SG (1) | SG11201706989SA (OSRAM) |
| WO (1) | WO2016138479A1 (OSRAM) |
| ZA (1) | ZA201705708B (OSRAM) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10227333B2 (en) | 2015-02-11 | 2019-03-12 | Curtana Pharmaceuticals, Inc. | Inhibition of OLIG2 activity |
| BR112017018198A2 (pt) | 2015-02-27 | 2018-04-10 | Curtana Pharmaceuticals Inc | inibição da atividade de olig2 |
| SG11201901679XA (en) | 2016-08-26 | 2019-03-28 | Curtana Pharmaceuticals Inc | Inhibition of olig2 activity |
| WO2019169112A1 (en) * | 2018-02-28 | 2019-09-06 | Curtana Pharmaceuticals, Inc. | Inhibition of olig2 activity |
| CN110283130B (zh) * | 2019-07-05 | 2023-12-19 | 温州医科大学 | 一种1-(2,5-二甲氧基苯基)-3-取代脲类结肠癌抑制剂及其制备和应用 |
| US20220306640A1 (en) * | 2019-09-06 | 2022-09-29 | Ono Pharmaceutical Co., Ltd. | Hydantoin derivative |
| WO2022046650A1 (en) * | 2020-08-24 | 2022-03-03 | Curtana Pharmaceuticals, Inc. | Combination therapies with olig2 inhibitors |
| KR102710867B1 (ko) * | 2020-12-18 | 2024-09-27 | (주)인비보텍 | Oligodendrocyte transcription factor 2 억제제를 유효성분으로 포함하는 흑색종 치료 효과 증진용 약학적 조성물 |
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| DK2470173T3 (en) | 2009-08-25 | 2016-06-06 | Abraxis Bioscience Llc | Combination therapy of nanoparticle composition of the taxane and the hedgehog inhibitors |
| WO2011031974A1 (en) | 2009-09-10 | 2011-03-17 | Southern Research Institute | Acridine analogs in the treatment of gliomas |
| AR088291A1 (es) | 2011-10-11 | 2014-05-21 | Univ Nac Quilmes | Derivados de fenil-guanidina |
| CN106905297A (zh) | 2012-06-15 | 2017-06-30 | 加利福尼亚大学董事会 | 用于脑癌的新颖治疗剂 |
| WO2016081732A1 (en) | 2014-11-19 | 2016-05-26 | Memorial Sloan-Kettering Cancer Center | Thienopyrimidines and uses thereof |
| US10227333B2 (en) | 2015-02-11 | 2019-03-12 | Curtana Pharmaceuticals, Inc. | Inhibition of OLIG2 activity |
| BR112017018198A2 (pt) | 2015-02-27 | 2018-04-10 | Curtana Pharmaceuticals Inc | inibição da atividade de olig2 |
-
2016
- 2016-02-26 BR BR112017018198A patent/BR112017018198A2/pt not_active Application Discontinuation
- 2016-02-26 EP EP16756516.7A patent/EP3261631B1/en active Active
- 2016-02-26 JP JP2017544033A patent/JP2018510138A/ja active Pending
- 2016-02-26 IL IL254007A patent/IL254007B2/en unknown
- 2016-02-26 US US15/553,478 patent/US20180244631A1/en not_active Abandoned
- 2016-02-26 HK HK18107810.3A patent/HK1248139A1/zh unknown
- 2016-02-26 EA EA201791933A patent/EA039121B1/ru unknown
- 2016-02-26 AU AU2016225000A patent/AU2016225000B2/en active Active
- 2016-02-26 CA CA2977521A patent/CA2977521C/en active Active
- 2016-02-26 MX MX2017011018A patent/MX394452B/es unknown
- 2016-02-26 WO PCT/US2016/019932 patent/WO2016138479A1/en not_active Ceased
- 2016-02-26 SG SG11201706989SA patent/SG11201706989SA/en unknown
- 2016-02-26 CN CN201680024824.XA patent/CN107530304A/zh active Pending
- 2016-02-26 KR KR1020177027034A patent/KR102629269B1/ko active Active
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2017
- 2017-08-22 ZA ZA2017/05708A patent/ZA201705708B/en unknown
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2020
- 2020-11-06 JP JP2020186198A patent/JP7295833B2/ja active Active
- 2020-11-20 US US17/100,658 patent/US20210114991A1/en not_active Abandoned
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2021
- 2021-07-02 US US17/367,099 patent/US11691951B2/en active Active
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2023
- 2023-05-10 US US18/315,285 patent/US20230271926A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| KR20170129785A (ko) | 2017-11-27 |
| US20180244631A1 (en) | 2018-08-30 |
| US20210347739A1 (en) | 2021-11-11 |
| EA201791933A1 (ru) | 2017-12-29 |
| BR112017018198A2 (pt) | 2018-04-10 |
| US20230271926A1 (en) | 2023-08-31 |
| IL254007A0 (en) | 2017-10-31 |
| CA2977521A1 (en) | 2016-09-01 |
| HK1248139A1 (zh) | 2018-10-12 |
| JP2018510138A (ja) | 2018-04-12 |
| MX2017011018A (es) | 2018-01-18 |
| EA039121B1 (ru) | 2021-12-07 |
| EP3261631A4 (en) | 2019-03-06 |
| EP3261631C0 (en) | 2025-09-10 |
| AU2016225000A1 (en) | 2017-09-07 |
| IL254007B1 (en) | 2024-04-01 |
| CA2977521C (en) | 2024-03-19 |
| CN107530304A (zh) | 2018-01-02 |
| SG11201706989SA (en) | 2017-09-28 |
| EP3261631B1 (en) | 2025-09-10 |
| JP2021046404A (ja) | 2021-03-25 |
| US20210114991A1 (en) | 2021-04-22 |
| WO2016138479A1 (en) | 2016-09-01 |
| ZA201705708B (en) | 2023-05-31 |
| KR102629269B1 (ko) | 2024-01-24 |
| EP3261631A1 (en) | 2018-01-03 |
| AU2016225000B2 (en) | 2021-04-01 |
| IL254007B2 (en) | 2024-08-01 |
| US11691951B2 (en) | 2023-07-04 |
| JP7295833B2 (ja) | 2023-06-21 |
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