MX391908B - Vacunas de fmdv vectorizadas con adenovirus recombinantes y usos de las mismas. - Google Patents

Vacunas de fmdv vectorizadas con adenovirus recombinantes y usos de las mismas.

Info

Publication number
MX391908B
MX391908B MX2018009244A MX2018009244A MX391908B MX 391908 B MX391908 B MX 391908B MX 2018009244 A MX2018009244 A MX 2018009244A MX 2018009244 A MX2018009244 A MX 2018009244A MX 391908 B MX391908 B MX 391908B
Authority
MX
Mexico
Prior art keywords
vectorized
fmdv
recombinant adenovirus
fmdv vaccines
vaccines
Prior art date
Application number
MX2018009244A
Other languages
English (en)
Other versions
MX2018009244A (es
Inventor
Damodar Ettyreddy
Douglas Brough
Duncan McVEY
Jason Gall
Justin Widener
Leonardo Siger
Leszlie Woodyward
Tom Burrage
Original Assignee
Boehringer Ingelheim Animal Health Usa Inc
Genvec Inc
The Government Of The Us Secretary Of Homeland Security
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Animal Health Usa Inc, Genvec Inc, The Government Of The Us Secretary Of Homeland Security filed Critical Boehringer Ingelheim Animal Health Usa Inc
Publication of MX2018009244A publication Critical patent/MX2018009244A/es
Publication of MX391908B publication Critical patent/MX391908B/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/125—Picornaviridae, e.g. calicivirus
    • A61K39/135—Foot- and mouth-disease virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5256—Virus expressing foreign proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/55—Medicinal preparations containing antigens or antibodies characterised by the host/recipient, e.g. newborn with maternal antibodies
    • A61K2039/552—Veterinary vaccine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/10011—Adenoviridae
    • C12N2710/10034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/32011—Picornaviridae
    • C12N2770/32111—Aphthovirus, e.g. footandmouth disease virus
    • C12N2770/32134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2800/00—Nucleic acids vectors
    • C12N2800/10—Plasmid DNA
    • C12N2800/106—Plasmid DNA for vertebrates
    • C12N2800/107—Plasmid DNA for vertebrates for mammalian
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A40/00—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production
    • Y02A40/70—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production in livestock or poultry

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)

Abstract

La presente invención se refiere a vacunas o composiciones de FMDV. Se describen vectores recombinantes que codifican y que expresan antígenos, epitopes o inmunógenos de FMDV que se pueden usar para proteger animales, en particular ovinos, bovinos, caprinos, o porcinos, contra el FMDV.
MX2018009244A 2016-01-29 2017-01-30 Vacunas de fmdv vectorizadas con adenovirus recombinantes y usos de las mismas. MX391908B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662288540P 2016-01-29 2016-01-29
PCT/US2017/015622 WO2017132666A1 (en) 2016-01-29 2017-01-30 Recombinant adenovirus vectored fmdv vaccines and uses thereof

Publications (2)

Publication Number Publication Date
MX2018009244A MX2018009244A (es) 2019-07-10
MX391908B true MX391908B (es) 2025-03-21

Family

ID=58191570

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2018009244A MX391908B (es) 2016-01-29 2017-01-30 Vacunas de fmdv vectorizadas con adenovirus recombinantes y usos de las mismas.

Country Status (22)

Country Link
US (2) US10188721B2 (es)
EP (1) EP3408398B1 (es)
JP (1) JP6878464B2 (es)
KR (1) KR102283303B1 (es)
CN (1) CN108779474B (es)
AR (1) AR110458A1 (es)
AU (1) AU2017212813B2 (es)
CA (1) CA3012802A1 (es)
CY (1) CY1124218T1 (es)
DK (1) DK3408398T3 (es)
ES (1) ES2787902T3 (es)
JO (1) JOP20170022B1 (es)
MA (1) MA43195B1 (es)
MX (1) MX391908B (es)
NZ (1) NZ744786A (es)
PT (1) PT3408398T (es)
PY (1) PY1702922A (es)
RU (1) RU2725495C9 (es)
TW (1) TWI760322B (es)
UY (1) UY37100A (es)
WO (1) WO2017132666A1 (es)
ZA (1) ZA201804965B (es)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI760322B (zh) * 2016-01-29 2022-04-11 美商百靈佳殷格翰動物保健美國有限公司 重組腺病毒載體裝載之fmdv疫苗及其用途
EP3824906A1 (en) 2016-12-21 2021-05-26 Amgen Inc. Anti-tnf alpha antibody formulations
CN108997493B (zh) * 2018-08-15 2019-07-09 中国农业科学院兰州兽医研究所 一种全牛源o型口蹄疫病毒广谱中和抗体的制备方法
US11582956B2 (en) * 2018-09-27 2023-02-21 The United States Of America, As Represented By The Secretary Of Agriculture Recombinant adenovirus-based interferon biotherapeutics in swine
CN113817068B (zh) * 2020-12-24 2024-01-30 北京微佰生物科技有限公司 一种以人复制缺陷型重组腺病毒为载体的o型口蹄疫疫苗
CN114957480B (zh) * 2021-02-23 2024-01-30 北京微佰生物科技有限公司 一种以人复制缺陷型重组腺病毒为载体的a型口蹄疫疫苗
CN112852760A (zh) * 2021-03-04 2021-05-28 温氏食品集团股份有限公司 重组鸭肠炎病毒及其应用
US12453767B2 (en) 2021-08-18 2025-10-28 The United States Of America, As Represented By The Secretary Of Agriculture Development of mosaic vaccines against foot and mouth disease virus serotype O
WO2023090771A1 (ko) * 2021-11-17 2023-05-25 대한민국(농림축산식품부 농림축산검역본부장) 강력한 적응성 면역반응 유도 및 모체이행항체의 간섭을 극복하는 재조합 구제역 o형 바이러스 및 이를 포함하는 구제역 백신 조성물
KR102770876B1 (ko) * 2022-02-14 2025-02-26 대한민국 구제역바이러스 구조단백질 vp0 부위에 특이적으로 결합하는 항체 또는 이의 항원 결합 단편, 및 이들의 용도
KR102937376B1 (ko) 2022-09-07 2026-03-11 주식회사 바이오노트 구제역 바이러스 Asia 1형과 특이적으로 결합하는 항체 및 이의 용도
KR20240098951A (ko) 2022-12-21 2024-06-28 대한민국(농림축산식품부 농림축산검역본부장) 초기 방어가 가능한 피내접종용 구제역 백신 조성물
KR20240098948A (ko) 2022-12-21 2024-06-28 대한민국(농림축산식품부 농림축산검역본부장) 장기 면역 유도가 가능한 피내접종용 구제역 백신 조성물
KR20240098952A (ko) 2022-12-21 2024-06-28 대한민국(농림축산식품부 농림축산검역본부장) 구제역백신의 무침 피내 접종방법
US20250134984A1 (en) * 2023-10-26 2025-05-01 The United States Of America, As Represented By The Secretary Of Agriculture Development of mosaic vaccines against foot and mouth disease virus serotype asia
CN119899854B (zh) * 2024-12-30 2025-12-09 中国兽医药品监察所 一种猪口蹄疫o型和a型二价病毒样颗粒的制备方法和应用
CN119979483A (zh) * 2025-02-10 2025-05-13 华中农业大学 一种自发产生病毒样颗粒的重组腺病毒制备方法及应用

Family Cites Families (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2909462A (en) 1955-12-08 1959-10-20 Bristol Myers Co Acrylic acid polymer laxative compositions
US5505941A (en) 1981-12-24 1996-04-09 Health Research, Inc. Recombinant avipox virus and method to induce an immune response
US4708871A (en) 1983-03-08 1987-11-24 Commonwealth Serum Laboratories Commission Antigenically active amino acid sequences
DE3584341D1 (de) 1984-08-24 1991-11-14 Upjohn Co Rekombinante dna-verbindungen und expression von polypeptiden wie tpa.
US5168062A (en) 1985-01-30 1992-12-01 University Of Iowa Research Foundation Transfer vectors and microorganisms containing human cytomegalovirus immediate-early promoter-regulatory DNA sequence
US4968615A (en) 1985-12-18 1990-11-06 Ciba-Geigy Corporation Deoxyribonucleic acid segment from a virus
US4963481A (en) 1985-12-18 1990-10-16 Genetics Institute Inc Promoter system
NZ221790A (en) 1986-09-12 1990-07-26 Genentech Inc Method for the continuous production of a heterologous protein in a eukaryotic host cell
GB8717430D0 (en) 1987-07-23 1987-08-26 Celltech Ltd Recombinant dna product
DE3743138A1 (de) 1987-12-18 1989-09-14 Mayr Christian Gmbh & Co Kg Schleifringlose, elektromagnetische ueberlastkupplung
ZA915593B (en) 1990-07-24 1993-03-31 Novagene Inc Herpesvirus-based viral vector which expresses a foot and mounth disease virus epitope on the surface of virus-infected cells and on the surface of virus particles,and vaccine against foot and mounth disease containing the same
JP3602530B2 (ja) 1991-03-07 2004-12-15 ヴァイロジェネティクス コーポレイション 遺伝子操作したワクチン菌株
EP0826063A1 (en) 1995-04-25 1998-03-04 Vical Incorporated Single-vial formulations of dna/lipid complexes
US5846946A (en) 1996-06-14 1998-12-08 Pasteur Merieux Serums Et Vaccins Compositions and methods for administering Borrelia DNA
FR2751225B1 (fr) 1996-07-19 1998-11-27 Rhone Merieux Formule de vaccin polynucleotidique aviaire
FR2751224B1 (fr) 1996-07-19 1998-11-20 Rhone Merieux Formule de vaccin polynucleotidique contre les pathologies respiratoires et de reproduction des porcs
FR2751226B1 (fr) 1996-07-19 1998-11-27 Rhone Merieux Formule de vaccin polynucleotidique contre les pathologies du cheval
FR2751229B1 (fr) 1996-07-19 1998-11-27 Rhone Merieux Formule de vaccin polynucleotidique notamment contre la pathologie respiratoire des bovins
FR2751228B1 (fr) 1996-07-19 1998-11-20 Rhone Merieux Vaccin polynucleotidique bovin pour voie intradermique
FR2751227B1 (fr) 1996-07-19 1998-11-27 Rhone Merieux Formule de vaccin polynucleotidique contre les pathologies canines, notamment les pathologies respiratoires et digestives
EP0930893B1 (en) 1996-10-11 2005-04-13 The Regents of The University of California Immunostimulatory polynucleotide/immunomodulatory molecule conjugates
HUP0004589A3 (en) 1997-06-30 2003-08-28 Centre Nat Rech Scient Improved method for transferring nucleic acid into the striped muscle and combination therefor
FR2778858B1 (fr) 1998-05-20 2000-06-16 Oreal Emulsion e/h/e stable et son utilisation comme composition cosmetique et/ou dermatologique
US6107021A (en) * 1998-06-20 2000-08-22 United Biomedical, Inc. Synthetic peptide vaccines for foot-and-mouth disease
FR2801607B1 (fr) 1999-11-26 2001-12-28 Merial Sas Pneumovirus du canard et vaccins correspondants
US6852705B2 (en) 2000-01-21 2005-02-08 Merial DNA vaccines for farm animals, in particular bovines and porcines
FR2810888B1 (fr) 2000-06-29 2004-07-30 Merial Sas Vaccin contre la fievre aphteuse
RU2294211C2 (ru) * 2001-01-19 2007-02-27 Цитос Байотекнолоджи Аг Композиция и способ для иммунизации, способ продуцирования неприродного, упорядоченного и повторяющегося массива антигенов
HRP20080235T3 (hr) 2003-07-24 2008-07-31 Merial Limited Formulacija vakcine koja sadrži emulziju ulje-u-vodi
ES2424847T3 (es) * 2004-06-25 2013-10-09 Merial Ltd. Genes del virus de la fiebre aftosa que expresan avipox recombinantes
US7691368B2 (en) 2005-04-15 2010-04-06 Merial Limited Vaccine formulations
EP1951297A2 (en) 2005-11-10 2008-08-06 GenVec, Inc. Adenoviral vector-based foot-and-mouth disease vaccine
US9107859B2 (en) 2009-09-10 2015-08-18 Merial, Inc. Vaccine formulations comprising saponin-containing adjuvants
EP2944322B1 (en) * 2010-03-12 2018-01-17 Merial, Inc Bluetongue virus recombinant vaccines and uses thereof
US8765141B2 (en) * 2010-07-01 2014-07-01 The United States Of America, As Represented By The Secretary Of Agriculture Development of a marker foot and mouth disease virus vaccine candidate that is attenuated in the natural host
AR102006A1 (es) 2014-09-23 2017-01-25 Merial Inc Vacunas recombinantes contra el virus de la fiebre aftosa (fmdv) y sus usos
TWI760322B (zh) * 2016-01-29 2022-04-11 美商百靈佳殷格翰動物保健美國有限公司 重組腺病毒載體裝載之fmdv疫苗及其用途

Also Published As

Publication number Publication date
TW201735944A (zh) 2017-10-16
JOP20170022B1 (ar) 2021-08-17
UY37100A (es) 2017-08-31
EP3408398A1 (en) 2018-12-05
US10188721B2 (en) 2019-01-29
CY1124218T1 (el) 2022-11-25
PT3408398T (pt) 2020-02-25
KR102283303B1 (ko) 2021-07-28
AU2017212813B2 (en) 2020-10-08
NZ744786A (en) 2020-05-29
EP3408398B1 (en) 2019-11-27
MX2018009244A (es) 2019-07-10
BR112018015345A2 (pt) 2018-12-18
RU2725495C2 (ru) 2020-07-02
CA3012802A1 (en) 2017-08-03
PY1702922A (es) 2018-08-01
CN108779474B (zh) 2022-10-18
RU2725495C9 (ru) 2020-09-01
TWI760322B (zh) 2022-04-11
AR110458A1 (es) 2019-04-03
RU2018130813A (ru) 2020-03-03
KR20180121896A (ko) 2018-11-09
US20170216422A1 (en) 2017-08-03
MA43195A1 (fr) 2019-04-30
JP6878464B2 (ja) 2021-05-26
DK3408398T3 (da) 2020-02-10
JP2019507184A (ja) 2019-03-14
BR112018015345A8 (pt) 2022-06-28
ES2787902T3 (es) 2020-10-19
WO2017132666A1 (en) 2017-08-03
MA43195B1 (fr) 2020-11-30
US20190134183A1 (en) 2019-05-09
CN108779474A (zh) 2018-11-09
RU2018130813A3 (es) 2020-03-03
AU2017212813A1 (en) 2018-08-16
US10493144B2 (en) 2019-12-03
ZA201804965B (en) 2019-07-31

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