MX389806B - Ligandos opioides kappa de heteroaril fenoxi benzamida - Google Patents
Ligandos opioides kappa de heteroaril fenoxi benzamidaInfo
- Publication number
- MX389806B MX389806B MX2019006220A MX2019006220A MX389806B MX 389806 B MX389806 B MX 389806B MX 2019006220 A MX2019006220 A MX 2019006220A MX 2019006220 A MX2019006220 A MX 2019006220A MX 389806 B MX389806 B MX 389806B
- Authority
- MX
- Mexico
- Prior art keywords
- sub
- disorder
- heteroaryl
- kappa opioid
- phenoxy benzamide
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D231/18—One oxygen or sulfur atom
- C07D231/20—One oxygen atom attached in position 3 or 5
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662426980P | 2016-11-28 | 2016-11-28 | |
| US201762576435P | 2017-10-24 | 2017-10-24 | |
| US201762585016P | 2017-11-13 | 2017-11-13 | |
| PCT/IB2017/057418 WO2018096510A1 (en) | 2016-11-28 | 2017-11-27 | Heteroarylphenoxy benzamide kappa opioid ligands |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX2019006220A MX2019006220A (es) | 2019-10-07 |
| MX389806B true MX389806B (es) | 2025-03-20 |
Family
ID=60782279
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2019006220A MX389806B (es) | 2016-11-28 | 2017-11-27 | Ligandos opioides kappa de heteroaril fenoxi benzamida |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US10316021B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP3544972B8 (cg-RX-API-DMAC7.html) |
| JP (1) | JP7051853B2 (cg-RX-API-DMAC7.html) |
| CN (1) | CN110234638B (cg-RX-API-DMAC7.html) |
| AU (1) | AU2017365123B2 (cg-RX-API-DMAC7.html) |
| DK (1) | DK3544972T3 (cg-RX-API-DMAC7.html) |
| ES (1) | ES2947293T3 (cg-RX-API-DMAC7.html) |
| FI (1) | FI3544972T3 (cg-RX-API-DMAC7.html) |
| HR (1) | HRP20230518T1 (cg-RX-API-DMAC7.html) |
| HU (1) | HUE061945T2 (cg-RX-API-DMAC7.html) |
| IL (1) | IL266962B (cg-RX-API-DMAC7.html) |
| MX (1) | MX389806B (cg-RX-API-DMAC7.html) |
| PH (1) | PH12019501172A1 (cg-RX-API-DMAC7.html) |
| PL (1) | PL3544972T3 (cg-RX-API-DMAC7.html) |
| PT (1) | PT3544972T (cg-RX-API-DMAC7.html) |
| RS (1) | RS64258B1 (cg-RX-API-DMAC7.html) |
| TW (1) | TWI720272B (cg-RX-API-DMAC7.html) |
| WO (1) | WO2018096510A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2018223177B2 (en) * | 2017-02-24 | 2024-05-02 | Xeniopro GmbH | Aromatic compounds which enhance notch signaling, for use in therapy |
| WO2018154118A2 (en) * | 2017-02-24 | 2018-08-30 | Reinmueller Viktoria | Novel aromatic compounds |
| US11266627B1 (en) | 2021-05-04 | 2022-03-08 | Janssen Pharmaceuticals, Inc. | Compositions and methods for the treatment of depression |
| CN111233768B (zh) * | 2020-03-18 | 2021-08-03 | 徐州圣元化工有限公司 | 一种3-(二氟甲基)-1-甲基-1h-吡唑-4-羧酸乙酯的制备方法 |
| CR20210563A (es) * | 2020-04-05 | 2022-01-24 | Pfizer | Compuestos y métodos para el tratamiento de covid-19 |
| US12161622B2 (en) | 2021-05-04 | 2024-12-10 | Janssen Pharmaceuticals, Inc. | Compositions and methods for the treatment of depression |
| EP4489730A1 (en) | 2022-03-07 | 2025-01-15 | Janssen Pharmaceuticals, Inc. | Compositions comprising aticaprant |
| IL315411A (en) * | 2022-03-07 | 2024-11-01 | Janssen Pharmaceuticals Inc | Pure forms of crystalline eticarpant |
| US11998524B2 (en) * | 2022-03-07 | 2024-06-04 | Janssen Pharmaceuticals, Inc. | Forms of aticaprant |
| CN120019046A (zh) * | 2022-10-12 | 2025-05-16 | 安道麦马克西姆有限公司 | 用于制备氨基哒嗪衍生物的方法 |
Family Cites Families (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR0166088B1 (ko) | 1990-01-23 | 1999-01-15 | . | 수용해도가 증가된 시클로덱스트린 유도체 및 이의 용도 |
| US5376645A (en) | 1990-01-23 | 1994-12-27 | University Of Kansas | Derivatives of cyclodextrins exhibiting enhanced aqueous solubility and the use thereof |
| GB9518953D0 (en) | 1995-09-15 | 1995-11-15 | Pfizer Ltd | Pharmaceutical formulations |
| WO2000035296A1 (en) | 1996-11-27 | 2000-06-22 | Wm. Wrigley Jr. Company | Improved release of medicament active agents from a chewing gum coating |
| GB9711643D0 (en) | 1997-06-05 | 1997-07-30 | Janssen Pharmaceutica Nv | Glass thermoplastic systems |
| US6420415B1 (en) | 1998-09-21 | 2002-07-16 | Takeda Chemical Industries, Ltd. | Thiol compounds, their production and use |
| JP2000159747A (ja) | 1998-09-21 | 2000-06-13 | Takeda Chem Ind Ltd | 新規チオ―ル誘導体、その製造法および用途 |
| IT1303737B1 (it) | 1998-11-11 | 2001-02-23 | Smithkline Beecham Spa | Derivati fenilpiperidinici procedimento per la loro preparazione eloro uso come ligandi del recettore orl-1. |
| CN1305852C (zh) | 2002-09-19 | 2007-03-21 | 伊莱利利公司 | 作为阿片受体拮抗剂的二芳基醚 |
| US7365209B2 (en) | 2003-02-11 | 2008-04-29 | Pharmacopeia, Inc. | Nitrogen heterocycle biaryls for osteoporosis and other diseases |
| JP2006519855A (ja) | 2003-03-07 | 2006-08-31 | イーライ リリー アンド カンパニー | オピオイド受容体アンタゴニスト |
| JP4736043B2 (ja) | 2003-03-14 | 2011-07-27 | 小野薬品工業株式会社 | 含窒素複素環誘導体およびそれらを有効成分とする薬剤 |
| CA2573223C (en) | 2004-08-06 | 2013-05-21 | Otsuka Pharmaceutical Co., Ltd. | Aromatic compound |
| EP1849835B1 (en) | 2005-02-18 | 2017-08-30 | Nippon Soda Co., Ltd. | Organic-inorganic composite body |
| AU2007225836A1 (en) | 2006-03-10 | 2007-09-20 | Ono Pharmaceutical Co., Ltd. | Nitrogenated heterocyclic derivative, and pharmaceutical agent comprising the derivative as active ingredient |
| EA014820B1 (ru) | 2006-04-04 | 2011-02-28 | Эмодис Гмбх | Применение композиций, содержащих антагонист каппа-опиоидных рецепторов бупренорфин, для лечения эмоционально неустойчивых расстройств личности |
| SI2252581T1 (sl) | 2008-01-22 | 2012-09-28 | Lilly Co Eli | Antagonist kappa selektivnega opioidnega receptorja |
| US8242145B2 (en) | 2008-02-14 | 2012-08-14 | Panmira Pharmaceuticals, Llc | Cyclic diaryl ether compounds as antagonists of prostaglandin D2 receptors |
| CR11559A (es) | 2008-03-25 | 2010-10-20 | Lilly Co Eli | Antagonista del receptor opioide selectivo kappa |
| US8048895B2 (en) | 2008-04-18 | 2011-11-01 | Research Triangle Institute | Kappa opioid receptor ligands |
| CA3031835C (en) | 2008-06-27 | 2021-09-07 | Celgene Car Llc | Heteroaryl compounds and uses thereof |
| US8609696B2 (en) | 2008-12-18 | 2013-12-17 | Boehringer Ingelheim International Gmbh | Serotonin 5-HT2B receptor inhibitors |
| HN2010001319A (es) | 2009-01-26 | 2013-01-15 | Lilly Co Eli | Antagonista del receptor opioide selectivo kappa |
| WO2013059648A1 (en) | 2011-10-21 | 2013-04-25 | Neurotherapeutics Pharma, Inc. | 2,3,5 trisubstituted aryl and heteroaryl amino derivatives, compositions, and methods of use |
| US20150274657A1 (en) | 2012-10-02 | 2015-10-01 | Merck Patent Gmbh | Pyrrolidines |
| WO2015109080A1 (en) | 2014-01-15 | 2015-07-23 | Research Triangle Institute | Kappa-opioid receptor selective opioid receptor antagonists |
| US10118896B2 (en) | 2014-11-26 | 2018-11-06 | University Of Kansas | Antagonists of the kappa opioid receptor |
-
2017
- 2017-11-22 US US15/820,679 patent/US10316021B2/en active Active
- 2017-11-27 JP JP2019528746A patent/JP7051853B2/ja active Active
- 2017-11-27 ES ES17818281T patent/ES2947293T3/es active Active
- 2017-11-27 DK DK17818281.2T patent/DK3544972T3/da active
- 2017-11-27 WO PCT/IB2017/057418 patent/WO2018096510A1/en not_active Ceased
- 2017-11-27 HU HUE17818281A patent/HUE061945T2/hu unknown
- 2017-11-27 MX MX2019006220A patent/MX389806B/es unknown
- 2017-11-27 PT PT178182812T patent/PT3544972T/pt unknown
- 2017-11-27 EP EP17818281.2A patent/EP3544972B8/en active Active
- 2017-11-27 AU AU2017365123A patent/AU2017365123B2/en active Active
- 2017-11-27 PL PL17818281.2T patent/PL3544972T3/pl unknown
- 2017-11-27 RS RS20230453A patent/RS64258B1/sr unknown
- 2017-11-27 TW TW106141134A patent/TWI720272B/zh active
- 2017-11-27 CN CN201780084763.0A patent/CN110234638B/zh active Active
- 2017-11-27 HR HRP20230518TT patent/HRP20230518T1/hr unknown
- 2017-11-27 FI FIEP17818281.2T patent/FI3544972T3/fi active
-
2019
- 2019-05-28 PH PH12019501172A patent/PH12019501172A1/en unknown
- 2019-05-28 IL IL266962A patent/IL266962B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| NZ754862A (en) | 2024-11-29 |
| EP3544972A1 (en) | 2019-10-02 |
| PT3544972T (pt) | 2023-06-20 |
| TW201831460A (zh) | 2018-09-01 |
| IL266962B (en) | 2022-02-01 |
| ES2947293T3 (es) | 2023-08-04 |
| JP2019535799A (ja) | 2019-12-12 |
| EP3544972B8 (en) | 2023-06-07 |
| TWI720272B (zh) | 2021-03-01 |
| US10316021B2 (en) | 2019-06-11 |
| US20180148432A1 (en) | 2018-05-31 |
| CN110234638A (zh) | 2019-09-13 |
| HRP20230518T1 (hr) | 2023-08-04 |
| EP3544972B1 (en) | 2023-04-26 |
| FI3544972T3 (fi) | 2023-06-02 |
| CA3045242A1 (en) | 2018-05-31 |
| PH12019501172A1 (en) | 2019-12-11 |
| DK3544972T3 (da) | 2023-05-30 |
| IL266962A (en) | 2019-07-31 |
| WO2018096510A1 (en) | 2018-05-31 |
| RS64258B1 (sr) | 2023-07-31 |
| AU2017365123A1 (en) | 2019-07-11 |
| HUE061945T2 (hu) | 2023-09-28 |
| PL3544972T3 (pl) | 2023-07-24 |
| CN110234638B (zh) | 2022-10-21 |
| MX2019006220A (es) | 2019-10-07 |
| AU2017365123B2 (en) | 2022-02-17 |
| JP7051853B2 (ja) | 2022-04-11 |
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