AU2017365123B2 - Heteroarylphenoxy benzamide kappa opioid ligands - Google Patents
Heteroarylphenoxy benzamide kappa opioid ligands Download PDFInfo
- Publication number
- AU2017365123B2 AU2017365123B2 AU2017365123A AU2017365123A AU2017365123B2 AU 2017365123 B2 AU2017365123 B2 AU 2017365123B2 AU 2017365123 A AU2017365123 A AU 2017365123A AU 2017365123 A AU2017365123 A AU 2017365123A AU 2017365123 B2 AU2017365123 B2 AU 2017365123B2
- Authority
- AU
- Australia
- Prior art keywords
- methyl
- disorder
- pyrazol
- phenoxy
- benzamide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D231/18—One oxygen or sulfur atom
- C07D231/20—One oxygen atom attached in position 3 or 5
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662426980P | 2016-11-28 | 2016-11-28 | |
| US62/426,980 | 2016-11-28 | ||
| US201762576435P | 2017-10-24 | 2017-10-24 | |
| US62/576,435 | 2017-10-24 | ||
| US201762585016P | 2017-11-13 | 2017-11-13 | |
| US62/585,016 | 2017-11-13 | ||
| PCT/IB2017/057418 WO2018096510A1 (en) | 2016-11-28 | 2017-11-27 | Heteroarylphenoxy benzamide kappa opioid ligands |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU2017365123A1 AU2017365123A1 (en) | 2019-07-11 |
| AU2017365123B2 true AU2017365123B2 (en) | 2022-02-17 |
Family
ID=60782279
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2017365123A Active AU2017365123B2 (en) | 2016-11-28 | 2017-11-27 | Heteroarylphenoxy benzamide kappa opioid ligands |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US10316021B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP3544972B8 (cg-RX-API-DMAC7.html) |
| JP (1) | JP7051853B2 (cg-RX-API-DMAC7.html) |
| CN (1) | CN110234638B (cg-RX-API-DMAC7.html) |
| AU (1) | AU2017365123B2 (cg-RX-API-DMAC7.html) |
| DK (1) | DK3544972T3 (cg-RX-API-DMAC7.html) |
| ES (1) | ES2947293T3 (cg-RX-API-DMAC7.html) |
| FI (1) | FI3544972T3 (cg-RX-API-DMAC7.html) |
| HR (1) | HRP20230518T1 (cg-RX-API-DMAC7.html) |
| HU (1) | HUE061945T2 (cg-RX-API-DMAC7.html) |
| IL (1) | IL266962B (cg-RX-API-DMAC7.html) |
| MX (1) | MX389806B (cg-RX-API-DMAC7.html) |
| PH (1) | PH12019501172A1 (cg-RX-API-DMAC7.html) |
| PL (1) | PL3544972T3 (cg-RX-API-DMAC7.html) |
| PT (1) | PT3544972T (cg-RX-API-DMAC7.html) |
| RS (1) | RS64258B1 (cg-RX-API-DMAC7.html) |
| TW (1) | TWI720272B (cg-RX-API-DMAC7.html) |
| WO (1) | WO2018096510A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2018154118A2 (en) * | 2017-02-24 | 2018-08-30 | Reinmueller Viktoria | Novel aromatic compounds |
| EP3585485A2 (en) | 2017-02-24 | 2020-01-01 | Xeniopro GmbH | Aromatic compounds which enhance notch signaling, for use in therapy |
| US11266627B1 (en) | 2021-05-04 | 2022-03-08 | Janssen Pharmaceuticals, Inc. | Compositions and methods for the treatment of depression |
| CN111233768B (zh) * | 2020-03-18 | 2021-08-03 | 徐州圣元化工有限公司 | 一种3-(二氟甲基)-1-甲基-1h-吡唑-4-羧酸乙酯的制备方法 |
| MX2021013934A (es) * | 2020-04-05 | 2021-12-15 | Pfizer | Compuestos y metodos para el tratamiento de covid-19. |
| US12161622B2 (en) | 2021-05-04 | 2024-12-10 | Janssen Pharmaceuticals, Inc. | Compositions and methods for the treatment of depression |
| CN119156202A (zh) | 2022-03-07 | 2024-12-17 | 杨森制药公司 | 包含阿替卡普兰的组合物 |
| JP2025508071A (ja) * | 2022-03-07 | 2025-03-21 | ヤンセン ファーマシューティカルズ，インコーポレーテッド | 純粋な形態の結晶質アチカプラント |
| JP2025508051A (ja) | 2022-03-07 | 2025-03-21 | ヤンセン ファーマシューティカルズ，インコーポレーテッド | 大うつ病性障害の治療に使用するためのアチカプラントの多形形態 |
| WO2024079733A1 (en) * | 2022-10-12 | 2024-04-18 | Adama Makhteshim Ltd. | Process for the preparation of aminopyridazine derivatives |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1132379A1 (en) * | 1998-09-21 | 2001-09-12 | Takeda Chemical Industries, Ltd. | Novel thiol derivatives, process for producing the same and utilization thereof |
| US20090186873A1 (en) * | 2008-01-22 | 2009-07-23 | Nuria Diaz Buezo | Kappa selective opioid receptor antagonist |
Family Cites Families (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5376645A (en) | 1990-01-23 | 1994-12-27 | University Of Kansas | Derivatives of cyclodextrins exhibiting enhanced aqueous solubility and the use thereof |
| KR0166088B1 (ko) | 1990-01-23 | 1999-01-15 | . | 수용해도가 증가된 시클로덱스트린 유도체 및 이의 용도 |
| GB9518953D0 (en) | 1995-09-15 | 1995-11-15 | Pfizer Ltd | Pharmaceutical formulations |
| WO2000035298A1 (en) | 1996-11-27 | 2000-06-22 | Wm. Wrigley Jr. Company | Chewing gum containing medicament active agents |
| GB9711643D0 (en) | 1997-06-05 | 1997-07-30 | Janssen Pharmaceutica Nv | Glass thermoplastic systems |
| JP2000159747A (ja) * | 1998-09-21 | 2000-06-13 | Takeda Chem Ind Ltd | 新規チオ―ル誘導体、その製造法および用途 |
| IT1303737B1 (it) | 1998-11-11 | 2001-02-23 | Smithkline Beecham Spa | Derivati fenilpiperidinici procedimento per la loro preparazione eloro uso come ligandi del recettore orl-1. |
| JP4646628B2 (ja) | 2002-09-19 | 2011-03-09 | イーライ リリー アンド カンパニー | オピオイド受容体アンタゴニストとしてのジアリールエーテル類 |
| US7365209B2 (en) | 2003-02-11 | 2008-04-29 | Pharmacopeia, Inc. | Nitrogen heterocycle biaryls for osteoporosis and other diseases |
| CA2513791A1 (en) | 2003-03-07 | 2004-09-23 | Eli Lilly And Company | Opioid receptor antagonists |
| TW201018661A (en) | 2003-03-14 | 2010-05-16 | Ono Pharmaceutical Co | Heterocyclic rinf having nitrogen atom derivatives and medicament containing the derivatives as active ingredient |
| AU2005268030B2 (en) | 2004-08-06 | 2009-02-19 | Otsuka Pharmaceutical Co., Ltd. | Aromatic compounds |
| KR100922093B1 (ko) | 2005-02-18 | 2009-10-16 | 닛뽕소다 가부시키가이샤 | 유기 무기 복합체 |
| JPWO2007105637A1 (ja) | 2006-03-10 | 2009-07-30 | 小野薬品工業株式会社 | 含窒素複素環誘導体およびそれらを有効成分とする薬剤 |
| CA2646899C (en) | 2006-04-04 | 2014-05-06 | Holger Lars Hermann | Use of compositions containing kappa-opioid receptor antagonists for the treatment of dissociative disorders |
| US8242145B2 (en) | 2008-02-14 | 2012-08-14 | Panmira Pharmaceuticals, Llc | Cyclic diaryl ether compounds as antagonists of prostaglandin D2 receptors |
| CR11559A (es) | 2008-03-25 | 2010-10-20 | Lilly Co Eli | Antagonista del receptor opioide selectivo kappa |
| US8048895B2 (en) | 2008-04-18 | 2011-11-01 | Research Triangle Institute | Kappa opioid receptor ligands |
| CA2986640C (en) | 2008-06-27 | 2019-03-26 | Celgene Avilomics Research, Inc. | Heteroaryl compounds and uses thereof |
| CA2746943A1 (en) | 2008-12-18 | 2010-07-15 | Boehringer Ingelheim International Gmbh | Serotonin 5-ht2b receptor inhibitors |
| HN2010001319A (es) | 2009-01-26 | 2013-01-15 | Lilly Co Eli | Antagonista del receptor opioide selectivo kappa |
| WO2013059648A1 (en) | 2011-10-21 | 2013-04-25 | Neurotherapeutics Pharma, Inc. | 2,3,5 trisubstituted aryl and heteroaryl amino derivatives, compositions, and methods of use |
| JP2015531382A (ja) | 2012-10-02 | 2015-11-02 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングＭｅｒｃｋ Ｐａｔｅｎｔ Ｇｅｓｅｌｌｓｃｈａｆｔ ｍｉｔ ｂｅｓｃｈｒａｅｎｋｔｅｒ Ｈａｆｔｕｎｇ | ピロリジン |
| WO2015109080A1 (en) | 2014-01-15 | 2015-07-23 | Research Triangle Institute | Kappa-opioid receptor selective opioid receptor antagonists |
| US10118896B2 (en) | 2014-11-26 | 2018-11-06 | University Of Kansas | Antagonists of the kappa opioid receptor |
-
2017
- 2017-11-22 US US15/820,679 patent/US10316021B2/en active Active
- 2017-11-27 ES ES17818281T patent/ES2947293T3/es active Active
- 2017-11-27 JP JP2019528746A patent/JP7051853B2/ja active Active
- 2017-11-27 FI FIEP17818281.2T patent/FI3544972T3/fi active
- 2017-11-27 HU HUE17818281A patent/HUE061945T2/hu unknown
- 2017-11-27 HR HRP20230518TT patent/HRP20230518T1/hr unknown
- 2017-11-27 RS RS20230453A patent/RS64258B1/sr unknown
- 2017-11-27 WO PCT/IB2017/057418 patent/WO2018096510A1/en not_active Ceased
- 2017-11-27 PL PL17818281.2T patent/PL3544972T3/pl unknown
- 2017-11-27 MX MX2019006220A patent/MX389806B/es unknown
- 2017-11-27 AU AU2017365123A patent/AU2017365123B2/en active Active
- 2017-11-27 PT PT178182812T patent/PT3544972T/pt unknown
- 2017-11-27 TW TW106141134A patent/TWI720272B/zh active
- 2017-11-27 DK DK17818281.2T patent/DK3544972T3/da active
- 2017-11-27 CN CN201780084763.0A patent/CN110234638B/zh active Active
- 2017-11-27 EP EP17818281.2A patent/EP3544972B8/en active Active
-
2019
- 2019-05-28 PH PH12019501172A patent/PH12019501172A1/en unknown
- 2019-05-28 IL IL266962A patent/IL266962B/en unknown
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1132379A1 (en) * | 1998-09-21 | 2001-09-12 | Takeda Chemical Industries, Ltd. | Novel thiol derivatives, process for producing the same and utilization thereof |
| US20090186873A1 (en) * | 2008-01-22 | 2009-07-23 | Nuria Diaz Buezo | Kappa selective opioid receptor antagonist |
Also Published As
| Publication number | Publication date |
|---|---|
| IL266962A (en) | 2019-07-31 |
| MX389806B (es) | 2025-03-20 |
| NZ754862A (en) | 2024-11-29 |
| CN110234638A (zh) | 2019-09-13 |
| HRP20230518T1 (hr) | 2023-08-04 |
| EP3544972A1 (en) | 2019-10-02 |
| CN110234638B (zh) | 2022-10-21 |
| JP7051853B2 (ja) | 2022-04-11 |
| PT3544972T (pt) | 2023-06-20 |
| US10316021B2 (en) | 2019-06-11 |
| CA3045242A1 (en) | 2018-05-31 |
| MX2019006220A (es) | 2019-10-07 |
| RS64258B1 (sr) | 2023-07-31 |
| HUE061945T2 (hu) | 2023-09-28 |
| EP3544972B1 (en) | 2023-04-26 |
| FI3544972T3 (fi) | 2023-06-02 |
| AU2017365123A1 (en) | 2019-07-11 |
| IL266962B (en) | 2022-02-01 |
| DK3544972T3 (da) | 2023-05-30 |
| EP3544972B8 (en) | 2023-06-07 |
| WO2018096510A1 (en) | 2018-05-31 |
| TW201831460A (zh) | 2018-09-01 |
| ES2947293T3 (es) | 2023-08-04 |
| US20180148432A1 (en) | 2018-05-31 |
| TWI720272B (zh) | 2021-03-01 |
| PH12019501172A1 (en) | 2019-12-11 |
| JP2019535799A (ja) | 2019-12-12 |
| PL3544972T3 (pl) | 2023-07-24 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FGA | Letters patent sealed or granted (standard patent) |