MX389746B - Esteviol glicosidos de alta pureza. - Google Patents

Esteviol glicosidos de alta pureza.

Info

Publication number
MX389746B
MX389746B MX2017003666A MX2017003666A MX389746B MX 389746 B MX389746 B MX 389746B MX 2017003666 A MX2017003666 A MX 2017003666A MX 2017003666 A MX2017003666 A MX 2017003666A MX 389746 B MX389746 B MX 389746B
Authority
MX
Mexico
Prior art keywords
steviol glycosides
reb
methods
highly purified
rebaudiosides
Prior art date
Application number
MX2017003666A
Other languages
English (en)
Other versions
MX2017003666A (es
Inventor
Aurelien Badie
Avetik Markosyan
Cynthia Bunders
Cyrille Jarrin
Daniel Auriol
Indra Prakash
Robert Ter Halle
Original Assignee
Purecircle Sdn Bhd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/US2015/045906 external-priority patent/WO2016028899A1/en
Application filed by Purecircle Sdn Bhd filed Critical Purecircle Sdn Bhd
Publication of MX2017003666A publication Critical patent/MX2017003666A/es
Publication of MX389746B publication Critical patent/MX389746B/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Preparation or treatment thereof
    • A23L2/52—Adding ingredients
    • A23L2/60—Sweeteners
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L27/00—Spices; Flavouring agents or condiments; Artificial sweetening agents; Table salts; Dietetic salt substitutes; Preparation or treatment thereof
    • A23L27/30—Artificial sweetening agents
    • A23L27/33—Artificial sweetening agents containing sugars or derivatives
    • A23L27/36—Terpene glycosides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C07H1/06—Separation; Purification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C07H15/256—Polyterpene radicals
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/18—Preparation of compounds containing saccharide radicals produced by the action of a glycosyl transferase, e.g. alpha-, beta- or gamma-cyclodextrins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • C12P19/56—Preparation of O-glycosides, e.g. glucosides having an oxygen atom of the saccharide radical directly bound to a condensed ring system having three or more carbocyclic rings, e.g. daunomycin, adriamycin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y204/00—Glycosyltransferases (2.4)
    • C12Y204/01—Hexosyltransferases (2.4.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
    • C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
    • C12Y302/01021—Beta-glucosidase (3.2.1.21)
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/582—Recycling of unreacted starting or intermediate materials

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Polymers & Plastics (AREA)
  • Food Science & Technology (AREA)
  • Nutrition Science (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Seasonings (AREA)

Abstract

La presente invención se refiere a métodos para preparar esteviol glicosidos altamente purificados, particularmente Rebaudiosidos A, D y M. Los métodos incluyen la utilización de microorganismos recombinantes para convertir varias composiciones de partida a estivol glicosidos objetivo. Además, se describen estivol glicosidos novedosos Reb D2, Reb M2 y Reb I, así como métodos para preparar los mismos. Los rebaudiosidos altamente purificados son útiles como edulcorantes no calóricos en composiciones comestibles y masticables tales como cualquiera de bebidas, confituras, productos de panadería, galletitas y gomas de mascar.
MX2017003666A 2014-09-19 2015-08-21 Esteviol glicosidos de alta pureza. MX389746B (es)

Applications Claiming Priority (10)

Application Number Priority Date Filing Date Title
US201462052544P 2014-09-19 2014-09-19
US201462061359P 2014-10-08 2014-10-08
US201462062288P 2014-10-10 2014-10-10
US201462064630P 2014-10-16 2014-10-16
US201462082446P 2014-11-20 2014-11-20
US201462097387P 2014-12-29 2014-12-29
US201562118132P 2015-02-19 2015-02-19
US201562185964P 2015-06-29 2015-06-29
PCT/US2015/045906 WO2016028899A1 (en) 2014-08-19 2015-08-19 Methods for preparing rebaudioside i and uses
PCT/US2015/046354 WO2016043926A1 (en) 2014-09-19 2015-08-21 High-purity steviol glycosides

Publications (2)

Publication Number Publication Date
MX2017003666A MX2017003666A (es) 2018-02-01
MX389746B true MX389746B (es) 2025-03-20

Family

ID=55533681

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2017003666A MX389746B (es) 2014-09-19 2015-08-21 Esteviol glicosidos de alta pureza.
MX2022001230A MX2022001230A (es) 2014-09-19 2017-03-17 Esteviol glicosidos de alta pureza.

Family Applications After (1)

Application Number Title Priority Date Filing Date
MX2022001230A MX2022001230A (es) 2014-09-19 2017-03-17 Esteviol glicosidos de alta pureza.

Country Status (6)

Country Link
US (1) US11653679B2 (es)
EP (2) EP4166010A1 (es)
CN (2) CN113549664B (es)
BR (1) BR112017005656A2 (es)
MX (2) MX389746B (es)
WO (1) WO2016043926A1 (es)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9752174B2 (en) * 2013-05-28 2017-09-05 Purecircle Sdn Bhd High-purity steviol glycosides
US10264811B2 (en) 2014-05-19 2019-04-23 Epc Natural Products Co., Ltd. Stevia sweetener with improved solubility
CA2970787C (en) 2014-12-17 2022-05-03 Cargill, Incorporated Steviol glycoside compounds, compositions for oral ingestion or use, and method for enhancing steviol glycoside solubility
BR112017021066B1 (pt) 2015-04-03 2022-02-08 Dsm Ip Assets B.V. Glicosídeos de esteviol, método para a produção de um glicosídeo de esteviol, composição, usos relacionados, gênero alimentício, alimento para animais e bebida
US10815514B2 (en) 2016-05-16 2020-10-27 Evolva Sa Production of steviol glycosides in recombinant hosts
WO2017218325A1 (en) 2016-06-15 2017-12-21 Codexis, Inc. Engineered beta-glucosidases and glucosylation methods
WO2017218888A1 (en) * 2016-06-17 2017-12-21 Cargill, Incorporated Steviol glycoside compositions for oral ingestion or use
WO2018071744A1 (en) * 2016-10-14 2018-04-19 Conagen Inc. Biosynthetic production of steviol glycosides and processes therefore
US11542536B2 (en) 2016-12-14 2023-01-03 The Coca-Cola Company Preparing novel steviol glycosides by bioconversion
WO2018144679A2 (en) 2017-02-03 2018-08-09 Codexis, Inc. Engineered glycosyltransferases and steviol glycoside glucosylation methods
EP3592157A4 (en) * 2017-03-06 2021-01-13 Conagen Inc. BIOSYNTHETIC PRODUCTION OF STEVIOL GLYCOSIDE REBAUDIOSIDE D4 FROM REBAUDIOSIDE E
EP3624599A4 (en) * 2017-05-15 2020-11-18 PureCircle USA Inc. HIGHLY PURE STEVIOL GLYCOSIDE
EP3644758A4 (en) 2017-06-30 2021-03-31 Conagen Inc. Hydrolysis of steviol glycosides by beta-glucosidase
GB201805578D0 (en) * 2018-04-04 2018-05-16 Optibiotix Health Ltd Prebiotic compositions and methods of production thereof
GB201805576D0 (en) 2018-04-04 2018-05-16 Optibiotix Ltd Sweeteners and methods of production thereof
WO2019217467A1 (en) * 2018-05-08 2019-11-14 Epc Natural Products Co., Ltd. Steviol glycoside compositions with improved flavor
MX2021001260A (es) 2018-07-30 2021-04-12 Tate & Lyle Solutions Usa Llc Glucosiltransferasas modificadas con ingenieria genetica y metodos de glucosilacion de glucosido de esteviol.
US12234464B2 (en) 2018-11-09 2025-02-25 Ginkgo Bioworks, Inc. Biosynthesis of mogrosides
US20220228186A1 (en) * 2019-05-23 2022-07-21 Arzeda Corp. Compositions and methods for producing steviol glycosides
WO2020264179A1 (en) 2019-06-25 2020-12-30 Manus Bio, Inc. Uridine diphosphate-dependent glycosyltransferase enzyme
NZ785122A (en) * 2019-08-23 2026-01-30 Suntory Holdings Ltd Method for producing aqueous composition containing rebaudioside d, sweetening composition containing rebaudioside d, and beverage containing sweetening composition
CN110592043B (zh) * 2019-11-01 2022-10-18 广西师范大学 一种udp-葡萄糖基转移酶突变体及其应用
CN110872586B (zh) * 2019-11-11 2024-01-30 天津大学 固定化葡萄糖基转移酶及制备方法及催化生产莱鲍迪苷d的方法
CN114703159B (zh) * 2022-03-15 2023-05-26 林影 一种葡糖基转移酶突变体及其应用
CN115975972B (zh) * 2022-12-20 2023-07-25 杭州力文所生物科技有限公司 一种糖基转移酶突变体及其编码基因

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ES2592377T3 (es) * 2008-10-03 2016-11-29 Morita Kagaku Kogyo Co., Ltd. Nuevos glucósidos de esteviol
MY185668A (en) * 2010-06-02 2021-05-28 Evolva Inc Recombinant production of steviol glycosides
KR102114493B1 (ko) * 2011-08-08 2020-05-26 에볼바 에스아 스테비올 글리코시드의 재조합 생산
CN103159808B (zh) * 2011-12-09 2017-03-29 上海泓博智源医药股份有限公司 一种制备天然甜味剂的工艺方法
LT2793618T (lt) 2011-12-19 2018-03-26 The Coca-Cola Company Gėrimas, apimantis steviolio glikozidus
EA201400836A8 (ru) 2012-01-23 2016-03-31 ДСМ АйПи АССЕТС Б.В. Получение дитерпена
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CN105051195B (zh) * 2013-02-06 2019-09-06 埃沃尔瓦公司 用于提高莱鲍迪苷d和莱鲍迪苷m之产生的方法
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US11091743B2 (en) 2016-08-12 2021-08-17 Amyris, Inc. UDP-dependent glycosyltransferase for high efficiency production of rebaudiosides
EP3592157A4 (en) * 2017-03-06 2021-01-13 Conagen Inc. BIOSYNTHETIC PRODUCTION OF STEVIOL GLYCOSIDE REBAUDIOSIDE D4 FROM REBAUDIOSIDE E
EP3644758A4 (en) * 2017-06-30 2021-03-31 Conagen Inc. Hydrolysis of steviol glycosides by beta-glucosidase

Also Published As

Publication number Publication date
EP3193636B1 (en) 2022-07-06
MX2022001230A (es) 2022-03-02
EP3193636A1 (en) 2017-07-26
BR112017005656A2 (pt) 2018-07-31
CN113549664A (zh) 2021-10-26
CN107105734A (zh) 2017-08-29
EP4166010A1 (en) 2023-04-19
US20170303565A1 (en) 2017-10-26
MX2017003666A (es) 2018-02-01
WO2016043926A1 (en) 2016-03-24
EP3193636A4 (en) 2018-06-20
US11653679B2 (en) 2023-05-23
CN113549664B (zh) 2025-10-28

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