MX389656B - Variantes de quimosina con propiedades mejoradas de coagulación de leche. - Google Patents

Variantes de quimosina con propiedades mejoradas de coagulación de leche.

Info

Publication number
MX389656B
MX389656B MX2018013924A MX2018013924A MX389656B MX 389656 B MX389656 B MX 389656B MX 2018013924 A MX2018013924 A MX 2018013924A MX 2018013924 A MX2018013924 A MX 2018013924A MX 389656 B MX389656 B MX 389656B
Authority
MX
Mexico
Prior art keywords
milk clotting
improved milk
clotting properties
chymosin variants
chymosin
Prior art date
Application number
MX2018013924A
Other languages
English (en)
Other versions
MX2018013924A (es
Inventor
Christian Jaeckel
Den Brink Johannes Maarten Van
Martin Lund
Original Assignee
Chr Hansen As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chr Hansen As filed Critical Chr Hansen As
Publication of MX2018013924A publication Critical patent/MX2018013924A/es
Publication of MX389656B publication Critical patent/MX389656B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6478—Aspartic endopeptidases (3.4.23)
    • C12N9/6483—Chymosin (3.4.23.4), i.e. rennin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/23—Aspartic endopeptidases (3.4.23)
    • C12Y304/23004—Chymosin (3.4.23.4), i.e. rennin
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING OR TREATMENT THEREOF
    • A23C19/00—Cheese; Cheese preparations; Making thereof
    • A23C19/02—Making cheese curd
    • A23C19/04—Making cheese curd characterised by the use of specific enzymes of vegetable or animal origin
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING OR TREATMENT THEREOF
    • A23C19/00—Cheese; Cheese preparations; Making thereof
    • A23C19/06—Treating cheese curd after whey separation; Products obtained thereby
    • A23C19/068—Particular types of cheese
    • A23C19/0684—Soft uncured Italian cheeses, e.g. Mozarella, Ricotta, Pasta filata cheese; Other similar stretched cheeses
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING OR TREATMENT THEREOF
    • A23C19/00—Cheese; Cheese preparations; Making thereof
    • A23C19/06—Treating cheese curd after whey separation; Products obtained thereby
    • A23C19/068—Particular types of cheese
    • A23C19/072—Cheddar type or similar hard cheeses without eyes
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING OR TREATMENT THEREOF
    • A23C19/00—Cheese; Cheese preparations; Making thereof
    • A23C19/06—Treating cheese curd after whey separation; Products obtained thereby
    • A23C19/068—Particular types of cheese
    • A23C19/076—Soft unripened cheese, e.g. cottage or cream cheese
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING OR TREATMENT THEREOF
    • A23C9/00—Milk preparations; Milk powder or milk powder preparations
    • A23C9/12—Fermented milk preparations; Treatment using microorganisms or enzymes
    • A23C9/1203—Addition of, or treatment with, enzymes or microorganisms other than lactobacteriaceae
    • A23C9/1209—Proteolytic or milk coagulating enzymes, e.g. trypsine

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • Zoology (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Dairy Products (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • General Preparation And Processing Of Foods (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Fodder In General (AREA)
  • Detergent Compositions (AREA)

Abstract

La presente invención se refiere a una variante de polipéptido de quimosina aislada caracterizada porque tiene una alteración en su secuencia de aminoácidos en relación a un polipéptido parental que parental que tiene actividad de quimosina, en donde la alteración comprende una sustitución, una supresión, o una inserción en posición de aminoácido N249 del polipéptido parental.
MX2018013924A 2016-05-19 2017-05-19 Variantes de quimosina con propiedades mejoradas de coagulación de leche. MX389656B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP16170409 2016-05-19
PCT/EP2017/062128 WO2017198829A1 (en) 2016-05-19 2017-05-19 Variants of chymosin with improved milk-clotting properties

Publications (2)

Publication Number Publication Date
MX2018013924A MX2018013924A (es) 2019-03-28
MX389656B true MX389656B (es) 2025-03-20

Family

ID=56026710

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2018013924A MX389656B (es) 2016-05-19 2017-05-19 Variantes de quimosina con propiedades mejoradas de coagulación de leche.

Country Status (11)

Country Link
US (1) US10961524B2 (es)
EP (1) EP3457860A1 (es)
JP (1) JP7084317B2 (es)
KR (1) KR102448390B1 (es)
CN (1) CN109640677A (es)
AR (1) AR108526A1 (es)
AU (1) AU2017266397B2 (es)
CA (1) CA3024211A1 (es)
EA (1) EA201892531A1 (es)
MX (1) MX389656B (es)
WO (1) WO2017198829A1 (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2015518718A (ja) 2012-05-25 2015-07-06 セーホーエル．ハンセン アクティーゼルスカブ 凝乳特性が改善されたキモシン変異体
CN106062187B (zh) 2014-02-26 2020-09-15 科.汉森有限公司 具有提高的凝乳特性的凝乳酶变体
CA2989488A1 (en) * 2015-06-22 2016-12-29 Chr. Hansen A/S Variants of chymosin with improved properties
KR102500777B1 (ko) 2016-05-19 2023-02-16 시에이치알. 한센 에이/에스 우유-응고 특성이 개선된 키모신 변이체
CN111601509A (zh) * 2018-01-11 2020-08-28 科·汉森有限公司 提高干酪产量的培养物、促凝剂和技术之间的相互作用
WO2023001832A1 (en) 2021-07-20 2023-01-26 Chr. Hansen A/S Composition for clotting milk, methods and uses thereof
CA3245506A1 (en) 2022-04-06 2023-10-12 Chr. Hansen A/S ASPARTIC PROTEASE, PROCESSES AND ASSOCIATED USES

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI841288L (fi) 1983-03-31 1984-10-01 Codon Genetic Eng Lab Rekombinant-dna-kod foer uttryckning av polypeptid.
US7390936B1 (en) 1999-08-23 2008-06-24 Sembiosys Genetics Inc. Commercial production of chymosin in plants
RU2192137C2 (ru) 2000-08-07 2002-11-10 Открытое акционерное общество "Уфамолагропром" Способ производства сыра
DE60143406D1 (de) 2000-11-06 2010-12-16 Chr Hansen As Verfahren zur herstellung von nicht aus dem rind stammendem chymosin und dessen anwendung
WO2003013514A1 (en) 2001-08-08 2003-02-20 Carn-Aware Llc Improving neurological functions
US20040146938A1 (en) 2002-10-02 2004-07-29 Jack Nguyen Methods of generating and screening for proteases with altered specificity
CN1836041A (zh) 2003-06-27 2006-09-20 比奥伦公司 浏览突变
WO2005094185A2 (en) 2004-03-30 2005-10-13 Sudershan Biotech Limited Recombinant calf-chymosin and a process for producing the same
US20110008492A1 (en) 2007-02-13 2011-01-13 Chr. Hansen A/S Coagulation of milk
JP2010046034A (ja) 2008-08-22 2010-03-04 Toyota Central R&D Labs Inc 変異体のスクリーニング方法
RU2495931C2 (ru) 2009-03-24 2013-10-20 Меито Санге Ко., Лтд. Полученная из микроорганизма протеаза усовершенствованного типа, обеспечивающая свертывание молока
LT2844750T (lt) * 2012-05-03 2018-09-10 Dsm Ip Assets B.V. Pagerinti fermento variantai
JP2015518718A (ja) 2012-05-25 2015-07-06 セーホーエル．ハンセン アクティーゼルスカブ 凝乳特性が改善されたキモシン変異体
CN106062187B (zh) 2014-02-26 2020-09-15 科.汉森有限公司 具有提高的凝乳特性的凝乳酶变体
AU2016217885B2 (en) 2015-02-10 2020-01-23 Chr. Hansen A/S Blends of Chymosins with improved milk-clotting properties
CA2989488A1 (en) 2015-06-22 2016-12-29 Chr. Hansen A/S Variants of chymosin with improved properties
AR105867A1 (es) * 2015-08-31 2017-11-15 Chr Hansen As VARIANTES DE QUIMOSINA CON PROPIEDADES MEJORADAS DE a-S1-CASEÍNA
KR102500777B1 (ko) 2016-05-19 2023-02-16 시에이치알. 한센 에이/에스 우유-응고 특성이 개선된 키모신 변이체

Also Published As

Publication number Publication date
US10961524B2 (en) 2021-03-30
JP2019526226A (ja) 2019-09-19
AU2017266397B2 (en) 2021-03-11
AU2017266397A1 (en) 2018-11-29
CA3024211A1 (en) 2017-11-23
KR102448390B1 (ko) 2022-09-28
CN109640677A (zh) 2019-04-16
NZ748123A (en) 2024-12-20
JP7084317B2 (ja) 2022-06-14
AR108526A1 (es) 2018-08-29
MX2018013924A (es) 2019-03-28
KR20190010602A (ko) 2019-01-30
WO2017198829A1 (en) 2017-11-23
EA201892531A1 (ru) 2019-06-28
US20190174783A1 (en) 2019-06-13
BR112018073274A2 (pt) 2019-03-19
EP3457860A1 (en) 2019-03-27

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