MX375554B - Dispositivo de doble poro. - Google Patents
Dispositivo de doble poro.Info
- Publication number
- MX375554B MX375554B MX2016008367A MX2016008367A MX375554B MX 375554 B MX375554 B MX 375554B MX 2016008367 A MX2016008367 A MX 2016008367A MX 2016008367 A MX2016008367 A MX 2016008367A MX 375554 B MX375554 B MX 375554B
- Authority
- MX
- Mexico
- Prior art keywords
- chamber
- pore
- pore device
- double pore
- communication
- Prior art date
Links
- 239000011148 porous material Substances 0.000 title abstract 5
- 238000000034 method Methods 0.000 abstract 1
- 102000040430 polynucleotide Human genes 0.000 abstract 1
- 108091033319 polynucleotide Proteins 0.000 abstract 1
- 239000002157 polynucleotide Substances 0.000 abstract 1
- 238000012163 sequencing technique Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
- C12M41/48—Automatic or computerized control
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
- G01N27/416—Systems
- G01N27/447—Systems using electrophoresis
- G01N27/44756—Apparatus specially adapted therefor
- G01N27/44765—Apparatus specially adapted therefor of the counter-flow type
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
- C12M41/46—Means for regulation, monitoring, measurement or control, e.g. flow regulation of cellular or enzymatic activity or functionality, e.g. cell viability
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6869—Methods for sequencing
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
- G01N27/416—Systems
- G01N27/447—Systems using electrophoresis
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
- G01N27/416—Systems
- G01N27/447—Systems using electrophoresis
- G01N27/44704—Details; Accessories
- G01N27/44713—Particularly adapted electric power supply
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
- G01N27/416—Systems
- G01N27/447—Systems using electrophoresis
- G01N27/44704—Details; Accessories
- G01N27/44717—Arrangements for investigating the separated zones, e.g. localising zones
- G01N27/4473—Arrangements for investigating the separated zones, e.g. localising zones by electric means
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
- G01N27/416—Systems
- G01N27/447—Systems using electrophoresis
- G01N27/44704—Details; Accessories
- G01N27/44743—Introducing samples
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
- G01N27/416—Systems
- G01N27/447—Systems using electrophoresis
- G01N27/44756—Apparatus specially adapted therefor
- G01N27/44791—Microapparatus
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/483—Physical analysis of biological material
- G01N33/487—Physical analysis of biological material of liquid biological material
- G01N33/48707—Physical analysis of biological material of liquid biological material by electrical means
- G01N33/48721—Investigating individual macromolecules, e.g. by translocation through nanopores
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y30/00—Nanotechnology for materials or surface science, e.g. nanocomposites
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Organic Chemistry (AREA)
- Electrochemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biophysics (AREA)
- Nanotechnology (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Genetics & Genomics (AREA)
- Sustainable Development (AREA)
- Dispersion Chemistry (AREA)
- Power Engineering (AREA)
- Cell Biology (AREA)
- Computer Hardware Design (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Composite Materials (AREA)
Abstract
Se proporciona un dispositivo que comprende una cámara superior, una cámara intermedia y una cámara inferior, donde la cámara superior está en comunicación con la cámara intermedia a través de un primer poro, y la cámara intermedia está en comunicación con la cámara inferior a través de un segundo poro, donde el primer poro y el segundo poro son de aproximadamente 1 nm a aproximadamente 100 nm de diámetro, y están de aproximadamente 10 nm a aproximadamente 1000 nm de separación entre sí, y donde cada una de las cámaras comprende un electrodo para conectarse con una fuente de alimentación. También se proporcionan los métodos para usar el dispositivo, particularmente para secuenciar un polinucleótido.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161572843P | 2011-07-20 | 2011-07-20 | |
| PCT/US2012/047107 WO2013012881A2 (en) | 2011-07-20 | 2012-07-18 | Dual-pore device |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX375554B true MX375554B (es) | 2025-03-06 |
Family
ID=47558702
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2016008367A MX375554B (es) | 2011-07-20 | 2012-07-18 | Dispositivo de doble poro. |
| MX2013008539A MX342569B (es) | 2011-07-20 | 2012-07-18 | Dispositivo de doble poro. |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2013008539A MX342569B (es) | 2011-07-20 | 2012-07-18 | Dispositivo de doble poro. |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US8961763B2 (es) |
| EP (3) | EP2734840B3 (es) |
| JP (1) | JP6364348B2 (es) |
| KR (2) | KR101661297B1 (es) |
| CN (2) | CN103328973B (es) |
| AU (1) | AU2012284137C1 (es) |
| CA (2) | CA2944478A1 (es) |
| ES (2) | ES2659343T3 (es) |
| IL (1) | IL228337A (es) |
| MX (2) | MX375554B (es) |
| WO (1) | WO2013012881A2 (es) |
Families Citing this family (67)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0724736D0 (en) | 2007-12-19 | 2008-01-30 | Oxford Nanolabs Ltd | Formation of layers of amphiphilic molecules |
| CN103328973B (zh) | 2011-07-20 | 2015-04-01 | 加利福尼亚大学董事会 | 双孔装置 |
| GB201202519D0 (en) | 2012-02-13 | 2012-03-28 | Oxford Nanopore Tech Ltd | Apparatus for supporting an array of layers of amphiphilic molecules and method of forming an array of layers of amphiphilic molecules |
| JP6063693B2 (ja) * | 2012-10-03 | 2017-01-18 | 株式会社日立ハイテクノロジーズ | 分析装置及び分析方法 |
| US20140099726A1 (en) * | 2012-10-10 | 2014-04-10 | Two Pore Guys, Inc. | Device for characterizing polymers |
| GB201313121D0 (en) | 2013-07-23 | 2013-09-04 | Oxford Nanopore Tech Ltd | Array of volumes of polar medium |
| EP2962117B1 (en) * | 2013-02-28 | 2019-10-09 | The University of North Carolina At Chapel Hill | Nanofluidic devices with integrated components for the controlled capture, trapping, and transport of macromolecules and related methods of analysis |
| KR102245192B1 (ko) * | 2013-05-06 | 2021-04-29 | 온테라 인크. | 나노포어를 이용한 표적 검출 |
| WO2014182634A1 (en) | 2013-05-06 | 2014-11-13 | Two Pore Guys, Inc. | A method of biological target detection using a nanopore and a fusion protein binding agent |
| EP3014264A4 (en) * | 2013-06-25 | 2016-11-16 | Two Pore Guys Inc | QUANTIFICATION OF MULTIPLEXED BIOMARKERS BY NANOPORENT ANALYSIS OF BIOMARKER POLYMER COMPLEXES |
| US10597702B2 (en) | 2013-08-26 | 2020-03-24 | Ontera Inc. | Molecule detection using boronic acid substituted probes |
| CN105531360B (zh) * | 2013-11-08 | 2017-07-11 | 株式会社日立高新技术 | Dna输送控制设备及其制造方法、以及dna测序装置 |
| US9765326B2 (en) | 2014-04-03 | 2017-09-19 | Stmicroelectronics S.R.L. | Apparatus and method for nucleic acid sequencing based on nanochannels |
| US10190161B2 (en) * | 2014-04-03 | 2019-01-29 | Stmicroelectronics S.R.L. | Apparatus and method for nucleic acid sequencing based on nanowire detectors |
| CA2947978A1 (en) | 2014-05-13 | 2015-11-19 | Wake Forest University | Selective analysis of modified biological molecules with solid-state nanopores |
| US20170074855A1 (en) * | 2014-05-15 | 2017-03-16 | Two Pore Guys, Inc. | Scaffold Data Storage and Target Detection in a Sample Using a Nanopore |
| AU2015319825A1 (en) * | 2014-09-26 | 2017-04-27 | Nooma Bio, Inc. | Target sequence detection by nanopore sensing of synthetic probes |
| JP6472208B2 (ja) * | 2014-10-24 | 2019-02-20 | 株式会社日立ハイテクノロジーズ | 核酸搬送制御デバイス及びその製造方法、並びに核酸シーケンシング装置 |
| CA2973753A1 (en) | 2015-02-02 | 2016-08-11 | Two Pore Guys, Inc. | Nanopore detection of target polynucleotides from sample background |
| EP3268732A4 (en) | 2015-03-11 | 2018-07-25 | Two Pore Guys, Inc. | Nanopore detection of small molecules through competition assays |
| US9983191B2 (en) | 2015-03-11 | 2018-05-29 | Two Pore Guys, Inc. | Nanopore detection of small molecules through competition assays |
| IN2015CH01270A (es) * | 2015-03-13 | 2015-04-10 | Wipro Ltd | |
| US10640822B2 (en) | 2016-02-29 | 2020-05-05 | Iridia, Inc. | Systems and methods for writing, reading, and controlling data stored in a polymer |
| US10438662B2 (en) | 2016-02-29 | 2019-10-08 | Iridia, Inc. | Methods, compositions, and devices for information storage |
| US10859562B2 (en) | 2016-02-29 | 2020-12-08 | Iridia, Inc. | Methods, compositions, and devices for information storage |
| CA3018069C (en) * | 2016-03-21 | 2019-09-03 | Two Pore Guys, Inc. | Wafer-scale assembly of insulator-membrane-insulator devices for nanopore sensing |
| US11486873B2 (en) | 2016-03-31 | 2022-11-01 | Ontera Inc. | Multipore determination of fractional abundance of polynucleotide sequences in a sample |
| JP2017187443A (ja) * | 2016-04-08 | 2017-10-12 | Towa株式会社 | 分析装置用ポリマー膜、分析装置、分析装置用基板、分析装置用ポリマー膜の製造方法、および分析装置用基板の製造方法 |
| US11333655B2 (en) | 2016-09-07 | 2022-05-17 | The Board Of Trustees Of The University Of Illinois | Nanopore-based system for trapping, controlled displacement, and sequencing of (bio)macromolecules |
| KR101895123B1 (ko) * | 2016-10-24 | 2018-09-04 | 고려대학교 산학협력단 | 이중 나노 포어 소자 및 이의 제조 방법 |
| ES2848715T3 (es) | 2016-10-24 | 2021-08-11 | Ontera Inc | Abundancia fraccional de secuencias de polinucleótidos en una muestra |
| US10650312B2 (en) | 2016-11-16 | 2020-05-12 | Catalog Technologies, Inc. | Nucleic acid-based data storage |
| CA3043884A1 (en) | 2016-11-16 | 2018-05-24 | Catalog Technologies, Inc. | Systems for nucleic acid-based data storage |
| WO2018183380A1 (en) * | 2017-03-28 | 2018-10-04 | Two Pore Guys, Inc. | Target polynucleotide detection and sequencing by incorporation of modified nucleotides for nanopore analysis |
| KR101903723B1 (ko) | 2017-04-27 | 2018-10-02 | 주식회사라이브셀인스트루먼트 | 나노포어 멤브레인 격자 구조물 및 자성체 샘플 회전 구조물이 구비된 생체조직 투명화 장치 |
| KR102076592B1 (ko) * | 2017-05-25 | 2020-02-13 | 가천대학교 산학협력단 | 나노기공 센서를 사용한 dna 농도 측정 장치 및 방법 |
| MX2019015156A (es) * | 2017-06-21 | 2020-08-17 | Ontera Inc | Dispositivo de control y sensor de poro dual. |
| WO2019000158A1 (zh) * | 2017-06-26 | 2019-01-03 | 武汉科技大学 | 一种基于隧道识别技术的纳米检测装置及方法 |
| CN107402199B (zh) * | 2017-07-31 | 2019-09-10 | 京东方科技集团股份有限公司 | 基因测序芯片及其测序方法以及基因测序装置 |
| JP6831521B2 (ja) * | 2018-02-15 | 2021-02-17 | アイポア株式会社 | 分析素子及び分析装置 |
| KR102351743B1 (ko) | 2018-02-16 | 2022-01-14 | 일루미나, 인코포레이티드 | 시퀀싱을 위한 디바이스 |
| CA3094077A1 (en) | 2018-03-16 | 2019-09-19 | Catalog Technologies, Inc. | Chemical methods for nucleic acid-based data storage |
| US20200193301A1 (en) | 2018-05-16 | 2020-06-18 | Catalog Technologies, Inc. | Compositions and methods for nucleic acid-based data storage |
| WO2020028912A2 (en) | 2018-08-03 | 2020-02-06 | Catolog Technologies, Inc | Systems and methods for storing and reading nucleic acid-based data with error protection |
| US10976233B2 (en) * | 2018-08-15 | 2021-04-13 | Taiwan Semiconductor Manufacturing Company, Ltd. | Particle detector |
| JP7082020B2 (ja) | 2018-09-28 | 2022-06-07 | 株式会社アドバンテスト | ポアチップケースおよび微粒子測定システム |
| US11249067B2 (en) | 2018-10-29 | 2022-02-15 | Applied Materials, Inc. | Nanopore flow cells and methods of fabrication |
| CN109612890B (zh) * | 2018-12-28 | 2021-02-02 | 瑞芯智造(深圳)科技有限公司 | 一种微粒计数系统及应用、检测金属离子和微粒的方法 |
| US20200216892A1 (en) * | 2019-01-04 | 2020-07-09 | Lab79 Technologies, Inc. | Force based sequencing of biopolymers |
| EP4607190A3 (en) | 2019-03-12 | 2025-09-03 | Oxford Nanopore Technologies PLC | Nanopore sensing device and method |
| CA3139819A1 (en) | 2019-05-09 | 2020-11-12 | Catalog Technologies, Inc. | Data structures and operations for searching, computing, and indexing in dna-based data storage |
| WO2020235111A1 (ja) * | 2019-05-23 | 2020-11-26 | 株式会社寿通商 | フィルターユニット、流体の分離装置及び分離方法 |
| WO2020247071A1 (en) * | 2019-06-07 | 2020-12-10 | Applied Materials, Inc. | Dual pore sensors |
| EP3980557A4 (en) * | 2019-06-07 | 2023-07-26 | Applied Materials, Inc. | METHODS OF MAKING TWO-PORE SENSORS |
| CN114502741A (zh) * | 2019-08-06 | 2022-05-13 | 诺玛生物公司 | 用于在纳米孔隙装置中定位特征的逻辑驱动多核苷酸扫描 |
| AU2020364250A1 (en) | 2019-10-11 | 2022-04-28 | Catalog Technologies, Inc. | Nucleic acid security and authentication |
| CN112746006B (zh) * | 2019-10-31 | 2022-04-22 | 中国科学院物理研究所 | 控制生物分子在纳米孔中运动的装置和方法 |
| US20210172929A1 (en) * | 2019-12-05 | 2021-06-10 | Nooma Bio, Inc. | Multi-Pore Device with Material Sorting Applications |
| US11536708B2 (en) * | 2020-01-09 | 2022-12-27 | Applied Materials, Inc. | Methods to fabricate dual pore devices |
| CN113493735B (zh) * | 2020-04-02 | 2023-06-16 | 成都今是科技有限公司 | 基因测序阵列结构和基因测序装置 |
| KR20230008877A (ko) | 2020-05-11 | 2023-01-16 | 카탈로그 테크놀로지스, 인크. | Dna 기반 데이터 스토리지의 프로그램 및 기능 |
| MX2022014720A (es) | 2020-07-02 | 2023-03-06 | Illumina Inc | Dispositivos con transistores de efecto de campo. |
| EP4675256A3 (en) | 2020-07-17 | 2026-01-28 | Oxford Nanopore Technologies PLC | Nanopore sensing device |
| US11837302B1 (en) | 2020-08-07 | 2023-12-05 | Iridia, Inc. | Systems and methods for writing and reading data stored in a polymer using nano-channels |
| CN115125131A (zh) * | 2021-03-29 | 2022-09-30 | 上海近观科技有限责任公司 | 基于场效应晶体管的纳米孔阵列结构及其制备方法 |
| JP2024512838A (ja) | 2021-03-31 | 2024-03-21 | イルミナ インコーポレイテッド | 分子検出のためのスケーラブル回路 |
| US12455277B2 (en) | 2021-09-30 | 2025-10-28 | Illumina, Inc. | Isolation of cells in a nanopore sensor array |
Family Cites Families (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6267872B1 (en) | 1998-11-06 | 2001-07-31 | The Regents Of The University Of California | Miniature support for thin films containing single channels or nanopores and methods for using same |
| US7410564B2 (en) * | 2003-01-27 | 2008-08-12 | Agilent Technologies, Inc. | Apparatus and method for biopolymer identification during translocation through a nanopore |
| US20070042366A1 (en) * | 2003-02-28 | 2007-02-22 | Brown University | Nanopores, methods for using same, methods for making same and methods for characterizing biomolecules using same |
| BRPI0412380A (pt) | 2003-07-08 | 2006-09-19 | Novartis Ag | compostos de benzenossulfonilamino e composições farmacêuticas que contêm esses compostos |
| US20050020446A1 (en) | 2003-07-23 | 2005-01-27 | Choudhary Tushar V. | Desulfurization and novel process for same |
| US20050227239A1 (en) * | 2004-04-08 | 2005-10-13 | Joyce Timothy H | Microarray based affinity purification and analysis device coupled with solid state nanopore electrodes |
| US8563237B2 (en) * | 2004-09-30 | 2013-10-22 | Agilent Technologies, Inc. | Biopolymer resonant tunneling with a gate voltage source |
| US20060073489A1 (en) * | 2004-10-05 | 2006-04-06 | Gangqiang Li | Nanopore separation devices and methods of using same |
| US20060086626A1 (en) | 2004-10-22 | 2006-04-27 | Joyce Timothy H | Nanostructure resonant tunneling with a gate voltage source |
| US20060275911A1 (en) | 2005-06-03 | 2006-12-07 | Shih-Yuan Wang | Method and apparatus for moleclular analysis using nanostructure-enhanced Raman spectroscopy |
| GB0523282D0 (en) * | 2005-11-15 | 2005-12-21 | Isis Innovation | Methods using pores |
| CN100445397C (zh) * | 2006-12-14 | 2008-12-24 | 上海交通大学 | 电磁力控制单链核酸穿孔速度的方法与装置 |
| JP5309145B2 (ja) * | 2007-10-02 | 2013-10-09 | プレジデント アンド フェロウズ オブ ハーバード カレッジ | ナノポアによる分子の捕捉、再捕捉およびトラッピング |
| US7771944B2 (en) | 2007-12-14 | 2010-08-10 | The Board Of Trustees Of The University Of Illinois | Methods for determining genetic haplotypes and DNA mapping |
| US20100122907A1 (en) * | 2008-05-06 | 2010-05-20 | Government of the United States of America, | Single molecule mass or size spectrometry in solution using a solitary nanopore |
| US8784623B2 (en) * | 2008-07-17 | 2014-07-22 | Koninklijke Philips N.V. | Nanopore device and a method for nucleic acid analysis |
| WO2010082860A1 (en) * | 2009-01-19 | 2010-07-22 | Instituto De Biologia Experimental E Tecnologia (Ibet) | Method and device for nanopore based single-molecule protein/ protein interaction detection |
| US8294092B2 (en) * | 2009-03-23 | 2012-10-23 | Yale University | System and method for trapping and measuring a charged particle in a liquid |
| EP2411536B1 (en) * | 2009-03-27 | 2014-09-17 | Nabsys, Inc. | Methods for analyzing biomolecules and probes bound thereto |
| EP2311975A1 (en) * | 2009-10-13 | 2011-04-20 | Iee International Electronics & Engineering S.A. | Electrophoretic biomolecules separation device |
| US8748091B2 (en) * | 2009-12-18 | 2014-06-10 | The Board Of Trustees Of The University Of Illinois | Characterizing stretched polynucleotides in a synthetic nanopassage |
| WO2011097171A1 (en) | 2010-02-02 | 2011-08-11 | Arizona Board Of Regents | Controlled tunnel gap device for sequencing polymers |
| JP5427722B2 (ja) * | 2010-07-28 | 2014-02-26 | 株式会社日立ハイテクノロジーズ | ナノポア式分析装置及び試料分析用チャンバ |
| CN102095768B (zh) * | 2010-11-16 | 2014-07-09 | 浙江大学 | 一种亚纳米厚度的纳米孔传感器 |
| CN103328973B (zh) | 2011-07-20 | 2015-04-01 | 加利福尼亚大学董事会 | 双孔装置 |
-
2012
- 2012-07-18 CN CN201280005639.8A patent/CN103328973B/zh active Active
- 2012-07-18 CN CN201510199107.8A patent/CN104774757B/zh active Active
- 2012-07-18 EP EP12815570.2A patent/EP2734840B3/en active Active
- 2012-07-18 CA CA2944478A patent/CA2944478A1/en not_active Abandoned
- 2012-07-18 CA CA2823787A patent/CA2823787C/en active Active
- 2012-07-18 US US13/882,191 patent/US8961763B2/en active Active
- 2012-07-18 ES ES15190021.4T patent/ES2659343T3/es active Active
- 2012-07-18 KR KR1020137023965A patent/KR101661297B1/ko active Active
- 2012-07-18 ES ES12815570.2T patent/ES2565634T7/es active Active
- 2012-07-18 MX MX2016008367A patent/MX375554B/es unknown
- 2012-07-18 AU AU2012284137A patent/AU2012284137C1/en active Active
- 2012-07-18 EP EP15190021.4A patent/EP2988128B1/en active Active
- 2012-07-18 JP JP2014521721A patent/JP6364348B2/ja active Active
- 2012-07-18 MX MX2013008539A patent/MX342569B/es active IP Right Grant
- 2012-07-18 EP EP17208398.2A patent/EP3318872A1/en not_active Withdrawn
- 2012-07-18 KR KR1020167005366A patent/KR101820834B1/ko active Active
- 2012-07-18 WO PCT/US2012/047107 patent/WO2013012881A2/en not_active Ceased
-
2013
- 2013-09-10 IL IL228337A patent/IL228337A/en active IP Right Grant
-
2014
- 2014-11-29 US US14/556,134 patent/US9863912B2/en active Active
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| MX375554B (es) | Dispositivo de doble poro. | |
| IL233587B (en) | Pyrimido[4,5-b]indole derivatives and use thereof in the expansion of hematopoietic stem cells | |
| SG10201810110RA (en) | Extreme pcr | |
| GT201200029S (es) | Diseño de motocicleta | |
| DE112010005884T8 (de) | Membranelektrodenanordnung, Brennstoffzelle dieselbe verwendend und Herstellungsverfahren der Membranelektrodenanordnung | |
| GB2548740A (en) | Methods for generation of podocytes from pluripotent stem cells and cells produced by the same | |
| EA201492165A1 (ru) | Синтез пирроло[2,3-b]пиридинов | |
| GT201300006S (es) | Diseño de motoneta | |
| CR20130407A (es) | Método de producción de derivado de dihidrobenzofurano ópticamente activo | |
| GT201100041S (es) | Diseño de motocicleta | |
| IN2014DN06104A (es) | ||
| RU2014132585A (ru) | Импульсно-силовая ручная машина | |
| AR093986A1 (es) | Cuerpos de carbono ferromagneticos y proceso de produccion | |
| GT201000031S (es) | Diseño de confitería | |
| AR090321A1 (es) | Genes que codifican celulasa | |
| CR20130197S (es) | Una motocicleta tipo scooter | |
| CA140849S (en) | Solar cell | |
| IN2013MN02401A (es) | ||
| EA201490562A1 (ru) | Способы лечения связанной с инсультом сенсорно-двигательной недостаточности с использованием аминопиридинов | |
| TW201612313A (en) | Uses of ligustilide | |
| UA75156U (ru) | Кондуктометрический биосенсор для определения афлатоксинов в водных растворах | |
| RU2012111745A (ru) | Экстрасклеральный электрод для электрохимического лизиса внутриглазных новообразований | |
| AU336083S (en) | Solar cell | |
| UA76093U (uk) | Спосіб установки робочих валків в кліті кварто | |
| GT201200020S (es) | Bateria |