MX375554B - Dispositivo de doble poro. - Google Patents

Dispositivo de doble poro.

Info

Publication number
MX375554B
MX375554B MX2016008367A MX2016008367A MX375554B MX 375554 B MX375554 B MX 375554B MX 2016008367 A MX2016008367 A MX 2016008367A MX 2016008367 A MX2016008367 A MX 2016008367A MX 375554 B MX375554 B MX 375554B
Authority
MX
Mexico
Prior art keywords
chamber
pore
pore device
double pore
communication
Prior art date
Application number
MX2016008367A
Other languages
English (en)
Inventor
Jungsuk Kim
William Dunbar
Original Assignee
Univ California
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ California filed Critical Univ California
Publication of MX375554B publication Critical patent/MX375554B/es

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/48Automatic or computerized control
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/416Systems
    • G01N27/447Systems using electrophoresis
    • G01N27/44756Apparatus specially adapted therefor
    • G01N27/44765Apparatus specially adapted therefor of the counter-flow type
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/46Means for regulation, monitoring, measurement or control, e.g. flow regulation of cellular or enzymatic activity or functionality, e.g. cell viability
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869Methods for sequencing
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/416Systems
    • G01N27/447Systems using electrophoresis
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/416Systems
    • G01N27/447Systems using electrophoresis
    • G01N27/44704Details; Accessories
    • G01N27/44713Particularly adapted electric power supply
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/416Systems
    • G01N27/447Systems using electrophoresis
    • G01N27/44704Details; Accessories
    • G01N27/44717Arrangements for investigating the separated zones, e.g. localising zones
    • G01N27/4473Arrangements for investigating the separated zones, e.g. localising zones by electric means
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/416Systems
    • G01N27/447Systems using electrophoresis
    • G01N27/44704Details; Accessories
    • G01N27/44743Introducing samples
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/416Systems
    • G01N27/447Systems using electrophoresis
    • G01N27/44756Apparatus specially adapted therefor
    • G01N27/44791Microapparatus
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483Physical analysis of biological material
    • G01N33/487Physical analysis of biological material of liquid biological material
    • G01N33/48707Physical analysis of biological material of liquid biological material by electrical means
    • G01N33/48721Investigating individual macromolecules, e.g. by translocation through nanopores
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B82NANOTECHNOLOGY
    • B82YSPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y30/00Nanotechnology for materials or surface science, e.g. nanocomposites

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Organic Chemistry (AREA)
  • Electrochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Nanotechnology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Sustainable Development (AREA)
  • Dispersion Chemistry (AREA)
  • Power Engineering (AREA)
  • Computer Hardware Design (AREA)
  • Cell Biology (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Composite Materials (AREA)

Abstract

Se proporciona un dispositivo que comprende una cámara superior, una cámara intermedia y una cámara inferior, donde la cámara superior está en comunicación con la cámara intermedia a través de un primer poro, y la cámara intermedia está en comunicación con la cámara inferior a través de un segundo poro, donde el primer poro y el segundo poro son de aproximadamente 1 nm a aproximadamente 100 nm de diámetro, y están de aproximadamente 10 nm a aproximadamente 1000 nm de separación entre sí, y donde cada una de las cámaras comprende un electrodo para conectarse con una fuente de alimentación. También se proporcionan los métodos para usar el dispositivo, particularmente para secuenciar un polinucleótido.
MX2016008367A 2011-07-20 2012-07-18 Dispositivo de doble poro. MX375554B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161572843P 2011-07-20 2011-07-20
PCT/US2012/047107 WO2013012881A2 (en) 2011-07-20 2012-07-18 Dual-pore device

Publications (1)

Publication Number Publication Date
MX375554B true MX375554B (es) 2025-03-06

Family

ID=47558702

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2016008367A MX375554B (es) 2011-07-20 2012-07-18 Dispositivo de doble poro.
MX2013008539A MX342569B (es) 2011-07-20 2012-07-18 Dispositivo de doble poro.

Family Applications After (1)

Application Number Title Priority Date Filing Date
MX2013008539A MX342569B (es) 2011-07-20 2012-07-18 Dispositivo de doble poro.

Country Status (11)

Country Link
US (2) US8961763B2 (es)
EP (3) EP2734840B3 (es)
JP (1) JP6364348B2 (es)
KR (2) KR101820834B1 (es)
CN (2) CN103328973B (es)
AU (1) AU2012284137C1 (es)
CA (2) CA2944478A1 (es)
ES (2) ES2565634T7 (es)
IL (1) IL228337A (es)
MX (2) MX375554B (es)
WO (1) WO2013012881A2 (es)

Families Citing this family (69)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0724736D0 (en) 2007-12-19 2008-01-30 Oxford Nanolabs Ltd Formation of layers of amphiphilic molecules
CN103328973B (zh) 2011-07-20 2015-04-01 加利福尼亚大学董事会 双孔装置
GB201202519D0 (en) 2012-02-13 2012-03-28 Oxford Nanopore Tech Ltd Apparatus for supporting an array of layers of amphiphilic molecules and method of forming an array of layers of amphiphilic molecules
JP6063693B2 (ja) * 2012-10-03 2017-01-18 株式会社日立ハイテクノロジーズ 分析装置及び分析方法
US20140099726A1 (en) * 2012-10-10 2014-04-10 Two Pore Guys, Inc. Device for characterizing polymers
GB201313121D0 (en) 2013-07-23 2013-09-04 Oxford Nanopore Tech Ltd Array of volumes of polar medium
US10261065B2 (en) * 2013-02-28 2019-04-16 The University Of North Carolina At Chapel Hill Nanofluidic devices with integrated components for the controlled capture, trapping, and transport of macromolecules and related methods of analysis
ES2704902T3 (es) * 2013-05-06 2019-03-20 Two Pore Guys Inc Un método de detección de objetivos biológicos usando un nanoporo y un agente de unión a proteínas de fusión
KR102245192B1 (ko) * 2013-05-06 2021-04-29 온테라 인크. 나노포어를 이용한 표적 검출
EP3014264A4 (en) * 2013-06-25 2016-11-16 Two Pore Guys Inc QUANTIFICATION OF MULTIPLEXED BIOMARKERS BY NANOPORENT ANALYSIS OF BIOMARKER POLYMER COMPLEXES
WO2015031399A1 (en) 2013-08-26 2015-03-05 Two Pore Guys, Inc. Molecule detection using boronic acid substituted probes
CN105531360B (zh) * 2013-11-08 2017-07-11 株式会社日立高新技术 Dna输送控制设备及其制造方法、以及dna测序装置
US10190161B2 (en) * 2014-04-03 2019-01-29 Stmicroelectronics S.R.L. Apparatus and method for nucleic acid sequencing based on nanowire detectors
US9765326B2 (en) * 2014-04-03 2017-09-19 Stmicroelectronics S.R.L. Apparatus and method for nucleic acid sequencing based on nanochannels
JP6513705B2 (ja) 2014-05-13 2019-05-15 ウェイク・フォレスト・ユニヴァーシティ・ヘルス・サイエンシズ 固体状態ナノ細孔を用いた修飾生物学的分子の選択的分析
US20170074855A1 (en) * 2014-05-15 2017-03-16 Two Pore Guys, Inc. Scaffold Data Storage and Target Detection in a Sample Using a Nanopore
IL251274B2 (en) * 2014-09-26 2026-01-01 Ontera Inc Target Sequence Detection Using Synthetic Detector Nanochannel Sensors
JP6472208B2 (ja) * 2014-10-24 2019-02-20 株式会社日立ハイテクノロジーズ 核酸搬送制御デバイス及びその製造方法、並びに核酸シーケンシング装置
KR20170106487A (ko) * 2015-02-02 2017-09-20 투 포어 가이즈, 인코포레이티드 시료 배경으로부터의 표적 폴리뉴클레오티드의 나노포어 검출
KR101945366B1 (ko) 2015-03-11 2019-02-07 투 포어 가이즈, 인코포레이티드 경쟁 검정법을 통한 저분자의 나노포어 검출
US9983191B2 (en) 2015-03-11 2018-05-29 Two Pore Guys, Inc. Nanopore detection of small molecules through competition assays
IN2015CH01270A (es) * 2015-03-13 2015-04-10 Wipro Ltd
US10859562B2 (en) 2016-02-29 2020-12-08 Iridia, Inc. Methods, compositions, and devices for information storage
US10438662B2 (en) 2016-02-29 2019-10-08 Iridia, Inc. Methods, compositions, and devices for information storage
US10640822B2 (en) 2016-02-29 2020-05-05 Iridia, Inc. Systems and methods for writing, reading, and controlling data stored in a polymer
US10488394B2 (en) * 2016-03-21 2019-11-26 Ontera Inc. Wafer-scale assembly of insulator-membrane-insulator devices for nanopore sensing
US11486873B2 (en) 2016-03-31 2022-11-01 Ontera Inc. Multipore determination of fractional abundance of polynucleotide sequences in a sample
JP2017187443A (ja) * 2016-04-08 2017-10-12 Towa株式会社 分析装置用ポリマー膜、分析装置、分析装置用基板、分析装置用ポリマー膜の製造方法、および分析装置用基板の製造方法
US11333655B2 (en) 2016-09-07 2022-05-17 The Board Of Trustees Of The University Of Illinois Nanopore-based system for trapping, controlled displacement, and sequencing of (bio)macromolecules
MX2018013686A (es) 2016-10-24 2019-05-02 Two Pore Guys Inc Abundancia fraccional de secuencias de polinucleotidos en una muestra.
KR101895123B1 (ko) * 2016-10-24 2018-09-04 고려대학교 산학협력단 이중 나노 포어 소자 및 이의 제조 방법
US10650312B2 (en) 2016-11-16 2020-05-12 Catalog Technologies, Inc. Nucleic acid-based data storage
ES2979182T3 (es) 2016-11-16 2024-09-24 Catalog Tech Inc Almacenamiento de datos basado en ácidos nucleicos
WO2018183380A1 (en) * 2017-03-28 2018-10-04 Two Pore Guys, Inc. Target polynucleotide detection and sequencing by incorporation of modified nucleotides for nanopore analysis
KR101903723B1 (ko) 2017-04-27 2018-10-02 주식회사라이브셀인스트루먼트 나노포어 멤브레인 격자 구조물 및 자성체 샘플 회전 구조물이 구비된 생체조직 투명화 장치
KR102076592B1 (ko) * 2017-05-25 2020-02-13 가천대학교 산학협력단 나노기공 센서를 사용한 dna 농도 측정 장치 및 방법
JP7038147B2 (ja) * 2017-06-21 2022-03-17 ヌーマ バイオ インコーポレイテッド 二重細孔制御およびセンサデバイス
WO2019000158A1 (zh) * 2017-06-26 2019-01-03 武汉科技大学 一种基于隧道识别技术的纳米检测装置及方法
CN107402199B (zh) * 2017-07-31 2019-09-10 京东方科技集团股份有限公司 基因测序芯片及其测序方法以及基因测序装置
JP6831521B2 (ja) * 2018-02-15 2021-02-17 アイポア株式会社 分析素子及び分析装置
AU2019222673B2 (en) 2018-02-16 2022-01-20 Illumina, Inc. Device for sequencing
KR20200132921A (ko) 2018-03-16 2020-11-25 카탈로그 테크놀로지스, 인크. 핵산-기반 데이터를 저장하기 위한 화학적 방법들
KR102956991B1 (ko) 2018-05-16 2026-04-24 카탈로그 테크놀로지스, 인크. 핵산-기반 데이터를 저장하기 위한 조성물 및 방법
GB2574048B (en) 2018-05-24 2021-06-16 Oxford Nanopore Tech Ltd Nanopore sensor component with electrostatic discharge protection
KR20210053292A (ko) 2018-08-03 2021-05-11 카탈로그 테크놀로지스, 인크. 오류 방지 기능을 갖춘 핵산 기반 데이터 저장 및 판독 시스템 및 방법
US10976233B2 (en) 2018-08-15 2021-04-13 Taiwan Semiconductor Manufacturing Company, Ltd. Particle detector
JP7082020B2 (ja) 2018-09-28 2022-06-07 株式会社アドバンテスト ポアチップケースおよび微粒子測定システム
US11249067B2 (en) 2018-10-29 2022-02-15 Applied Materials, Inc. Nanopore flow cells and methods of fabrication
CN109612890B (zh) * 2018-12-28 2021-02-02 瑞芯智造(深圳)科技有限公司 一种微粒计数系统及应用、检测金属离子和微粒的方法
EP3906322A1 (en) * 2019-01-04 2021-11-10 Lab79 Technologies, Inc. Force based sequencing of biopolymers
JP7492200B2 (ja) * 2019-03-12 2024-05-29 オックスフォード ナノポール テクノロジーズ ピーエルシー ナノ細孔センシングデバイスと操作方法およびその成形方法
WO2020227718A1 (en) 2019-05-09 2020-11-12 Catalog Technologies, Inc. Data structures and operations for searching, computing, and indexing in dna-based data storage
US20220226780A1 (en) * 2019-05-23 2022-07-21 Kotobuki Holdings Co., Ltd. Filter unit and separation device and separation method for fluid
US20220236250A1 (en) * 2019-06-07 2022-07-28 Applied Materials, Inc. Dual pore sensors
KR102852663B1 (ko) * 2019-06-07 2025-08-28 어플라이드 머티어리얼스, 인코포레이티드 이중 포어 센서들을 위한 제조 방법들
EP4010492B1 (en) * 2019-08-06 2026-04-15 Oxford Nanopore Technologies plc Recapturing a polynucleotide in a nanopore device
JP7726874B2 (ja) 2019-10-11 2025-08-20 カタログ テクノロジーズ, インコーポレイテッド 核酸セキュリティーおよび認証
CN112746006B (zh) * 2019-10-31 2022-04-22 中国科学院物理研究所 控制生物分子在纳米孔中运动的装置和方法
US20210172929A1 (en) * 2019-12-05 2021-06-10 Nooma Bio, Inc. Multi-Pore Device with Material Sorting Applications
US11536708B2 (en) * 2020-01-09 2022-12-27 Applied Materials, Inc. Methods to fabricate dual pore devices
CN113493735B (zh) * 2020-04-02 2023-06-16 成都今是科技有限公司 基因测序阵列结构和基因测序装置
EP4150622B1 (en) 2020-05-11 2024-09-25 Catalog Technologies, Inc. Programs and functions in dna-based data storage
US11898983B2 (en) 2020-07-02 2024-02-13 Illumina, Inc. Devices with field effect transistors
EP4675256A3 (en) 2020-07-17 2026-01-28 Oxford Nanopore Technologies PLC Nanopore sensing device
US11837302B1 (en) 2020-08-07 2023-12-05 Iridia, Inc. Systems and methods for writing and reading data stored in a polymer using nano-channels
CN115125131A (zh) * 2021-03-29 2022-09-30 上海近观科技有限责任公司 基于场效应晶体管的纳米孔阵列结构及其制备方法
JP2024512838A (ja) 2021-03-31 2024-03-21 イルミナ インコーポレイテッド 分子検出のためのスケーラブル回路
US12455277B2 (en) 2021-09-30 2025-10-28 Illumina, Inc. Isolation of cells in a nanopore sensor array
CN120435657A (zh) 2022-10-28 2025-08-05 格罗宁根大学 蛋白质的基于纳米孔的分析

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6267872B1 (en) * 1998-11-06 2001-07-31 The Regents Of The University Of California Miniature support for thin films containing single channels or nanopores and methods for using same
US7410564B2 (en) * 2003-01-27 2008-08-12 Agilent Technologies, Inc. Apparatus and method for biopolymer identification during translocation through a nanopore
AU2004223493A1 (en) * 2003-02-28 2004-10-07 Brown University Nanopores, methods for using same, methods for making same and methods for characterizing biomolecules using same
JP2009513523A (ja) 2003-07-08 2009-04-02 ノバルティス アクチエンゲゼルシャフト ベンゼンスルホニルアミノ化合物およびそれらを含む医薬組成物
US20050020446A1 (en) 2003-07-23 2005-01-27 Choudhary Tushar V. Desulfurization and novel process for same
US20050227239A1 (en) 2004-04-08 2005-10-13 Joyce Timothy H Microarray based affinity purification and analysis device coupled with solid state nanopore electrodes
US8563237B2 (en) * 2004-09-30 2013-10-22 Agilent Technologies, Inc. Biopolymer resonant tunneling with a gate voltage source
US20060073489A1 (en) * 2004-10-05 2006-04-06 Gangqiang Li Nanopore separation devices and methods of using same
US20060086626A1 (en) 2004-10-22 2006-04-27 Joyce Timothy H Nanostructure resonant tunneling with a gate voltage source
US20060275911A1 (en) 2005-06-03 2006-12-07 Shih-Yuan Wang Method and apparatus for moleclular analysis using nanostructure-enhanced Raman spectroscopy
GB0523282D0 (en) * 2005-11-15 2005-12-21 Isis Innovation Methods using pores
CN100445397C (zh) * 2006-12-14 2008-12-24 上海交通大学 电磁力控制单链核酸穿孔速度的方法与装置
EP2205765B1 (en) * 2007-10-02 2012-09-12 President and Fellows of Harvard College Capture, recapture, and trapping of molecules with a nanopore
US7771944B2 (en) 2007-12-14 2010-08-10 The Board Of Trustees Of The University Of Illinois Methods for determining genetic haplotypes and DNA mapping
US20100122907A1 (en) * 2008-05-06 2010-05-20 Government of the United States of America, Single molecule mass or size spectrometry in solution using a solitary nanopore
EP2313758B1 (en) * 2008-07-17 2012-02-01 Koninklijke Philips Electronics N.V. Nanopore device and a method for nucleic acid analysis
WO2010082860A1 (en) 2009-01-19 2010-07-22 Instituto De Biologia Experimental E Tecnologia (Ibet) Method and device for nanopore based single-molecule protein/ protein interaction detection
US8294092B2 (en) * 2009-03-23 2012-10-23 Yale University System and method for trapping and measuring a charged particle in a liquid
EP2411536B1 (en) * 2009-03-27 2014-09-17 Nabsys, Inc. Methods for analyzing biomolecules and probes bound thereto
EP2311975A1 (en) 2009-10-13 2011-04-20 Iee International Electronics & Engineering S.A. Electrophoretic biomolecules separation device
US8748091B2 (en) * 2009-12-18 2014-06-10 The Board Of Trustees Of The University Of Illinois Characterizing stretched polynucleotides in a synthetic nanopassage
EP2517028B1 (en) 2010-02-02 2017-12-13 Arizona Board Of Regents Controlled tunnel gap device for sequencing polymers
JP5427722B2 (ja) * 2010-07-28 2014-02-26 株式会社日立ハイテクノロジーズ ナノポア式分析装置及び試料分析用チャンバ
CN102095768B (zh) * 2010-11-16 2014-07-09 浙江大学 一种亚纳米厚度的纳米孔传感器
CN103328973B (zh) 2011-07-20 2015-04-01 加利福尼亚大学董事会 双孔装置

Also Published As

Publication number Publication date
MX2013008539A (es) 2013-08-12
CN104774757A (zh) 2015-07-15
JP2014529296A (ja) 2014-11-06
CN103328973B (zh) 2015-04-01
EP2988128A1 (en) 2016-02-24
KR101820834B1 (ko) 2018-01-22
WO2013012881A2 (en) 2013-01-24
IL228337A0 (en) 2013-12-31
AU2012284137A1 (en) 2013-07-04
KR101661297B1 (ko) 2016-09-29
EP3318872A1 (en) 2018-05-09
ES2565634T7 (es) 2017-08-02
CA2823787C (en) 2017-04-11
KR20160028518A (ko) 2016-03-11
US8961763B2 (en) 2015-02-24
ES2659343T3 (es) 2018-03-14
JP6364348B2 (ja) 2018-07-25
KR20130130827A (ko) 2013-12-02
CA2944478A1 (en) 2013-01-24
US9863912B2 (en) 2018-01-09
US20150160160A1 (en) 2015-06-11
EP2734840A4 (en) 2014-11-05
CN103328973A (zh) 2013-09-25
EP2734840B1 (en) 2016-01-06
AU2012284137C1 (en) 2017-02-02
US20130233709A1 (en) 2013-09-12
EP2734840B3 (en) 2017-06-07
IL228337A (en) 2017-11-30
AU2012284137B2 (en) 2013-11-28
ES2565634T3 (es) 2016-04-06
CA2823787A1 (en) 2013-01-24
EP2734840A2 (en) 2014-05-28
EP2988128B1 (en) 2017-12-27
CN104774757B (zh) 2017-03-01
MX342569B (es) 2016-10-05
WO2013012881A3 (en) 2013-03-28

Similar Documents

Publication Publication Date Title
MX2013008539A (es) Dispositivo de doble poro.
IL233587B (en) Pyrimido[4,5-b]indole derivatives and use thereof in the expansion of hematopoietic stem cells
GT201200029S (es) Diseño de motocicleta
EA201492165A1 (ru) Синтез пирроло[2,3-b]пиридинов
UY33943A (es) Derivados espirocíclicos de isoxazolina como agentes antiparasitarios.
CR20130407A (es) Método de producción de derivado de dihidrobenzofurano ópticamente activo
GT201300002S (es) Diseño de una motocicleta
GT201100041S (es) Diseño de motocicleta
RU2014132585A (ru) Импульсно-силовая ручная машина
AR093986A1 (es) Cuerpos de carbono ferromagneticos y proceso de produccion
GT201000031S (es) Diseño de confitería
AR090321A1 (es) Genes que codifican celulasa
CR20130197S (es) Una motocicleta tipo scooter
CA140849S (en) Solar cell
DE102010032075A8 (de) Wasserstofferzeugung mittels hydrierten Polysilanen zum Betrieb von Brennstoffzellen
EA201490562A1 (ru) Способы лечения связанной с инсультом сенсорно-двигательной недостаточности с использованием аминопиридинов
GT200900017S (es) Diseño de motocicleta
TWD154764S (zh) 凳椅
EP2875124A4 (en) CELL CULTURE OF HORNHAUTENDOTHELZELLEN
UY34858A (es) Compuestos de azetidina y piperidina útiles como inhibidores de pde10
UA75156U (ru) Кондуктометрический биосенсор для определения афлатоксинов в водных растворах
RU2012111745A (ru) Экстрасклеральный электрод для электрохимического лизиса внутриглазных новообразований
AU336083S (en) Solar cell
EA201690709A1 (ru) Применение одипарцила в лечении мукополисахаридоза
UA76093U (uk) Спосіб установки робочих валків в кліті кварто