MX375353B - Compuesto de 7-(tiazol-5-il)pirrolopirimidina como agonista de tlr7 - Google Patents

Compuesto de 7-(tiazol-5-il)pirrolopirimidina como agonista de tlr7

Info

Publication number
MX375353B
MX375353B MX2018005708A MX2018005708A MX375353B MX 375353 B MX375353 B MX 375353B MX 2018005708 A MX2018005708 A MX 2018005708A MX 2018005708 A MX2018005708 A MX 2018005708A MX 375353 B MX375353 B MX 375353B
Authority
MX
Mexico
Prior art keywords
thiazole
tlr7 agonist
compound
pyrrolopyrimidine compound
pyrrolopyrimidine
Prior art date
Application number
MX2018005708A
Other languages
English (en)
Other versions
MX2018005708A (es
Inventor
Hao Wu
Lifang Wu
Ling Yang
Fei Sun
Shuhui Chen
Zhaozhong Ding
Original Assignee
Chia Tai Tianqing Pharmaceutical Group Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chia Tai Tianqing Pharmaceutical Group Co Ltd filed Critical Chia Tai Tianqing Pharmaceutical Group Co Ltd
Publication of MX2018005708A publication Critical patent/MX2018005708A/es
Publication of MX375353B publication Critical patent/MX375353B/es

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicinal Preparation (AREA)

Abstract

La presente invención se refiere a un compuesto de 7-(tiazol-5-il)pirrolopirimidina como una agonista de TLR7, y en particular se refiere a un compuesto de la fórmula (I) o una sal farmacéuticamente aceptable del mismo y a un método de fabricación del mismo, a una composición farmacéutica que contiene dicho compuesto, y a su uso en la preparación de un medicamento antiviral. (ver fórmula) (Ii)
MX2018005708A 2015-11-05 2016-11-04 Compuesto de 7-(tiazol-5-il)pirrolopirimidina como agonista de tlr7 MX375353B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN201510744651 2015-11-05
PCT/CN2016/104644 WO2017076346A1 (zh) 2015-11-05 2016-11-04 作为tlr7激动剂的7-(噻唑-5-基)吡咯并嘧啶化合物

Publications (2)

Publication Number Publication Date
MX2018005708A MX2018005708A (es) 2018-11-09
MX375353B true MX375353B (es) 2025-03-06

Family

ID=58662470

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2018005708A MX375353B (es) 2015-11-05 2016-11-04 Compuesto de 7-(tiazol-5-il)pirrolopirimidina como agonista de tlr7

Country Status (22)

Country Link
US (1) US10676478B2 (es)
EP (1) EP3381918B1 (es)
JP (1) JP6524355B2 (es)
KR (1) KR102112192B1 (es)
CN (1) CN108349982B (es)
AU (1) AU2016349080B2 (es)
BR (1) BR112018008880B1 (es)
CA (1) CA3004173C (es)
CL (1) CL2018001207A1 (es)
DK (1) DK3381918T3 (es)
EA (1) EA035116B1 (es)
ES (1) ES2833927T3 (es)
HU (1) HUE052770T2 (es)
IL (1) IL259115B (es)
MX (1) MX375353B (es)
MY (1) MY189991A (es)
NZ (1) NZ742453A (es)
PH (1) PH12018500975A1 (es)
SG (1) SG11201803699YA (es)
UA (1) UA121345C2 (es)
WO (1) WO2017076346A1 (es)
ZA (1) ZA201803705B (es)

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CN107043380A (zh) 2016-02-05 2017-08-15 正大天晴药业集团股份有限公司 一种tlr7激动剂的马来酸盐、其晶型c、晶型d、晶型e、制备方法和用途
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AU2016349080A1 (en) 2018-05-31
CA3004173A1 (en) 2017-05-11
NZ742453A (en) 2019-06-28
BR112018008880B1 (pt) 2023-01-17
BR112018008880A2 (pt) 2018-11-06
CN108349982B (zh) 2020-05-05
JP2018536702A (ja) 2018-12-13
MY189991A (en) 2022-03-22
BR112018008880A8 (pt) 2019-02-26
CA3004173C (en) 2020-07-14
EP3381918B1 (en) 2020-09-16
KR20180073676A (ko) 2018-07-02
UA121345C2 (uk) 2020-05-12
US10676478B2 (en) 2020-06-09
PH12018500975A1 (en) 2019-01-28
EA035116B1 (ru) 2020-04-29
IL259115A (en) 2018-06-28
EA201891099A1 (ru) 2018-10-31
SG11201803699YA (en) 2018-06-28
WO2017076346A1 (zh) 2017-05-11
JP6524355B2 (ja) 2019-06-05
ZA201803705B (en) 2025-10-29
AU2016349080B2 (en) 2019-03-14
CL2018001207A1 (es) 2018-12-21
DK3381918T3 (da) 2020-11-09
HUE052770T2 (hu) 2021-05-28
EP3381918A1 (en) 2018-10-03
MX2018005708A (es) 2018-11-09
ES2833927T3 (es) 2021-06-16
IL259115B (en) 2020-09-30
EP3381918A4 (en) 2019-04-03
KR102112192B1 (ko) 2020-05-19
US20180370976A1 (en) 2018-12-27
HK1250983A1 (zh) 2019-01-18
CN108349982A (zh) 2018-07-31

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