MX369347B - Derivados de pirrolidinilsulfona y su uso como moduladores del receptor huerfano relacionado con retinoide gamma (ror gamma). - Google Patents

Derivados de pirrolidinilsulfona y su uso como moduladores del receptor huerfano relacionado con retinoide gamma (ror gamma).

Info

Publication number
MX369347B
MX369347B MX2016008845A MX2016008845A MX369347B MX 369347 B MX369347 B MX 369347B MX 2016008845 A MX2016008845 A MX 2016008845A MX 2016008845 A MX2016008845 A MX 2016008845A MX 369347 B MX369347 B MX 369347B
Authority
MX
Mexico
Prior art keywords
ror
pyrrolidinyl
sulfone derivatives
ror gamma
gamma modulators
Prior art date
Application number
MX2016008845A
Other languages
English (en)
Spanish (es)
Other versions
MX2016008845A (es
Inventor
G Murali Dhar T
Xiao Hai-Yun
Jiang Bin
Lu Zhonghui
Duan Jingwu
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of MX2016008845A publication Critical patent/MX2016008845A/es
Publication of MX369347B publication Critical patent/MX369347B/es

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    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/12—Oxygen or sulfur atoms
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    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Dermatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Biomedical Technology (AREA)
  • Transplantation (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pyrrole Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
MX2016008845A 2014-01-06 2015-01-05 Derivados de pirrolidinilsulfona y su uso como moduladores del receptor huerfano relacionado con retinoide gamma (ror gamma). MX369347B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201461923896P 2014-01-06 2014-01-06
PCT/US2015/010089 WO2015103509A1 (en) 2014-01-06 2015-01-05 Pyrrolidinyl sulfone derivatives and their use as ror gamma modulators

Publications (2)

Publication Number Publication Date
MX2016008845A MX2016008845A (es) 2016-09-07
MX369347B true MX369347B (es) 2019-11-06

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MX2016008845A MX369347B (es) 2014-01-06 2015-01-05 Derivados de pirrolidinilsulfona y su uso como moduladores del receptor huerfano relacionado con retinoide gamma (ror gamma).

Country Status (11)

Country Link
US (2) US20160326108A1 (OSRAM)
EP (1) EP3092229B1 (OSRAM)
JP (1) JP6530764B2 (OSRAM)
CN (1) CN106061971B (OSRAM)
AR (1) AR099029A1 (OSRAM)
CA (1) CA2936116A1 (OSRAM)
EA (1) EA030849B1 (OSRAM)
ES (1) ES2669208T3 (OSRAM)
MX (1) MX369347B (OSRAM)
TW (1) TW201609634A (OSRAM)
WO (1) WO2015103509A1 (OSRAM)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105705501B (zh) 2013-09-09 2019-04-19 百时美施贵宝公司 RORγ调节剂
CN105555768B (zh) 2013-09-20 2018-10-16 百时美施贵宝公司 RORγ调节剂
JP6548664B2 (ja) * 2014-01-06 2019-07-24 ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ シクロヘキシルスルホンＲＯＲγ調節因子
EP3092221B1 (en) 2014-01-06 2018-10-17 Bristol-Myers Squibb Company Heterocyclic sulfones as ror-gamma modulators
ES2713681T3 (es) 2014-01-06 2019-05-23 Bristol Myers Squibb Co Moduladores de ROR gamma de sulfona carbocíclica
PT3212641T (pt) 2014-10-30 2019-02-11 Janssen Pharmaceutica Nv Tiazoles como moduladores de rorãt
JOP20200117A1 (ar) 2014-10-30 2017-06-16 Janssen Pharmaceutica Nv كحولات ثلاثي فلوروميثيل كمُعدلات للمستقبل النووي جاما تي المرتبط بحمض الريتيونَويك ROR?t
PT3212642T (pt) 2014-10-30 2019-12-19 Janssen Pharmaceutica Nv Tiazóis com amida substituída como moduladores de rorgammat
KR102114536B1 (ko) 2015-05-07 2020-05-22 브리스톨-마이어스 스큅 컴퍼니 RORγ 조정제로서의 트리시클릭 술폰
EP3438109B1 (en) * 2016-03-31 2021-08-25 Takeda Pharmaceutical Company Limited Heterocyclic compound
TW201803869A (zh) 2016-04-27 2018-02-01 健生藥品公司 作為ＲＯＲγＴ調節劑之６－胺基吡啶－３－基噻唑
EP3523279A1 (en) * 2016-10-10 2019-08-14 Bristol-Myers Squibb Company Tricyclic sulfones as ror gamma modulators
ES2872005T3 (es) * 2016-10-13 2021-11-02 Bristol Myers Squibb Co Sulfonas heterocíclicas como moduladores de ROR gamma
AR110152A1 (es) 2016-11-09 2019-02-27 Bristol Myers Squibb Co SULFONAS TRICÍCLICAS COMO MODULADORES DE RORg
US11078186B2 (en) * 2016-11-10 2021-08-03 Bristol-Myers Squibb Company ROR γ modulators
JP2021527660A (ja) 2018-06-18 2021-10-14 ヤンセン ファーマシューティカ エヌ．ベー． ＲＯＲγｔのモジュレータとしてのフェニル及びピリジニル置換イミダゾール
US11034658B2 (en) 2018-06-18 2021-06-15 Janssen Pharmaceutica Nv Pyridinyl pyrazoles as modulators of RORγT
JP2021528398A (ja) 2018-06-18 2021-10-21 ヤンセン ファーマシューティカ エヌ．ベー． ＲＯＲγＴのモジュレーターとしての６−アミノピリジン−３−イルピラゾール
WO2019243999A1 (en) 2018-06-18 2019-12-26 Janssen Pharmaceutica Nv Phenyl substituted pyrazoles as modulators of roryt
CA3121202A1 (en) 2018-11-30 2020-06-04 Nuvation Bio Inc. Pyrrole and pyrazole compounds and methods of use thereof
US12012374B2 (en) 2019-05-13 2024-06-18 Bristol-Myers Squibb Company Agonists of ROR GAMMAt

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0108591D0 (en) * 2001-04-05 2001-05-23 Merck Sharp & Dohme Therapeutic agents
EP2723737A1 (en) 2011-06-27 2014-04-30 Kyorin Pharmaceutical Co., Ltd. Bridged bicyclic compounds for the treatment of bacterial infections
US20130190356A1 (en) * 2011-12-22 2013-07-25 Genentech, Inc. Benzyl sulfonamide derivatives as rorc modulators
AU2013259904A1 (en) * 2012-05-08 2014-10-02 Lycera Corporation Bicyclic sulfone compounds for inhibition of RORy activity and the treatment of disease
AR091279A1 (es) 2012-06-08 2015-01-21 Gilead Sciences Inc Inhibidores macrociclicos de virus flaviviridae
WO2014028669A1 (en) * 2012-08-15 2014-02-20 Biogen Idec Ma Inc. Novel compounds for modulation of ror-gamma activity
EP3092221B1 (en) 2014-01-06 2018-10-17 Bristol-Myers Squibb Company Heterocyclic sulfones as ror-gamma modulators
JP6548664B2 (ja) 2014-01-06 2019-07-24 ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ シクロヘキシルスルホンＲＯＲγ調節因子
ES2713681T3 (es) 2014-01-06 2019-05-23 Bristol Myers Squibb Co Moduladores de ROR gamma de sulfona carbocíclica

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