MX367230B - Dispositivo lector y método de amplificación de señal. - Google Patents

Dispositivo lector y método de amplificación de señal.

Info

Publication number
MX367230B
MX367230B MX2016011451A MX2016011451A MX367230B MX 367230 B MX367230 B MX 367230B MX 2016011451 A MX2016011451 A MX 2016011451A MX 2016011451 A MX2016011451 A MX 2016011451A MX 367230 B MX367230 B MX 367230B
Authority
MX
Mexico
Prior art keywords
electrochemical cell
wall
microfluidic channel
sample
signal amplification
Prior art date
Application number
MX2016011451A
Other languages
English (en)
Inventor
A Samproni Jennifer
Original Assignee
Siemens Healthcare Diagnostics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Siemens Healthcare Diagnostics Inc filed Critical Siemens Healthcare Diagnostics Inc
Publication of MX367230B publication Critical patent/MX367230B/es

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/28—Electrolytic cell components
    • G01N27/30—Electrodes, e.g. test electrodes; Half-cells
    • G01N27/327—Biochemical electrodes, e.g. electrical or mechanical details for in vitro measurements
    • G01N27/3271—Amperometric enzyme electrodes for analytes in body fluids, e.g. glucose in blood
    • G01N27/3273—Devices therefor, e.g. test element readers, circuitry
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/001—Enzyme electrodes
    • C12Q1/004—Enzyme electrodes mediator-assisted
    • C—CHEMISTRY; METALLURGY
    • C25—ELECTROLYTIC OR ELECTROPHORETIC PROCESSES; APPARATUS THEREFOR
    • C25B—ELECTROLYTIC OR ELECTROPHORETIC PROCESSES FOR THE PRODUCTION OF COMPOUNDS OR NON-METALS; APPARATUS THEREFOR
    • C25B9/00—Cells or assemblies of cells; Constructional parts of cells; Assemblies of constructional parts, e.g. electrode-diaphragm assemblies; Process-related cell features
    • C25B9/70—Assemblies comprising two or more cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/28—Electrolytic cell components
    • G01N27/30—Electrodes, e.g. test electrodes; Half-cells
    • G01N27/327—Biochemical electrodes, e.g. electrical or mechanical details for in vitro measurements
    • G01N27/3271—Amperometric enzyme electrodes for analytes in body fluids, e.g. glucose in blood
    • G01N27/3272—Test elements therefor, i.e. disposable laminated substrates with electrodes, reagent and channels
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/28—Electrolytic cell components
    • G01N27/30—Electrodes, e.g. test electrodes; Half-cells
    • G01N27/327—Biochemical electrodes, e.g. electrical or mechanical details for in vitro measurements
    • G01N27/3275—Sensing specific biomolecules, e.g. nucleic acid strands, based on an electrode surface reaction
    • G01N27/3277—Sensing specific biomolecules, e.g. nucleic acid strands, based on an electrode surface reaction being a redox reaction, e.g. detection by cyclic voltammetry
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/487—Physical analysis of biological material of liquid biological material
    • G01N33/48707—Physical analysis of biological material of liquid biological material by electrical means
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/487—Physical analysis of biological material of liquid biological material
    • G01N33/49—Blood
    • G01N33/4915—Blood using flow cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/487—Physical analysis of biological material of liquid biological material
    • G01N33/49—Blood
    • G01N33/492—Determining multiple analytes
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T29/00—Metal working
    • Y10T29/49—Method of mechanical manufacture
    • Y10T29/49002—Electrical device making
    • Y10T29/49117—Conductor or circuit manufacturing

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Biomedical Technology (AREA)
  • Electrochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Biophysics (AREA)
  • Organic Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Metallurgy (AREA)
  • Materials Engineering (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • General Engineering & Computer Science (AREA)
  • Cell Biology (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)

Abstract

Se divulgan dispositivos de acumulación de fluido, instrumentos de análisis y métodos para hacer y utilizar los mismos. El dispositivo de acumulación de fluido es provisto con un dispositivo y una célula electroquímica. El dispositivo tiene una primera y segunda paredes que definen un canal microfluídico, y un puerto de aplicación de muestras que comunica con el canal microfluídico. La primera pared y la segunda pared están espaciadas a una distancia menor que 150 micrómetros. La célula electroquímica se dispone en la primera pared para contactar una muestra que viaja a través del canal microfluídico. La célula electroquímica que comprende receptores moleculares de tal forma que se afecta una propiedad física de la primera célula electroquímica con uno o más de los receptores moleculares que se unen a una especie electroactiva en la muestra.
MX2016011451A 2012-06-28 2013-06-27 Dispositivo lector y método de amplificación de señal. MX367230B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261665353P 2012-06-28 2012-06-28
PCT/US2013/048108 WO2014004781A2 (en) 2012-06-28 2013-06-27 Reader device and method of signal amplification

Publications (1)

Publication Number Publication Date
MX367230B true MX367230B (es) 2019-08-09

Family

ID=49784017

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2016011451A MX367230B (es) 2012-06-28 2013-06-27 Dispositivo lector y método de amplificación de señal.
MX2014015162A MX2014015162A (es) 2012-06-28 2013-06-27 Dispositivo lector y metodo de amplificacion de señal.

Family Applications After (1)

Application Number Title Priority Date Filing Date
MX2014015162A MX2014015162A (es) 2012-06-28 2013-06-27 Dispositivo lector y metodo de amplificacion de señal.

Country Status (11)

Country Link
US (3) US20150176143A1 (es)
EP (2) EP3101415A1 (es)
JP (1) JP5781256B2 (es)
KR (1) KR101563486B1 (es)
CN (1) CN104380091B (es)
AU (1) AU2013280268B2 (es)
BR (1) BR112014032656B1 (es)
CA (1) CA2877888C (es)
MX (2) MX367230B (es)
RU (2) RU2713046C2 (es)
WO (1) WO2014004781A2 (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWM467058U (zh) * 2013-05-10 2013-12-01 Rapha Bio Ltd 生化感測器
KR101582098B1 (ko) * 2015-09-08 2016-01-04 대윤계기산업주식회사 전자기 유도식 전기전도도 센서를 이용한 고농도 액체 측정기
JP6988761B2 (ja) 2018-10-11 2022-01-05 信越半導体株式会社 半導体シリコンウェーハの洗浄処理装置および洗浄方法

Family Cites Families (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH04118554A (ja) * 1989-12-28 1992-04-20 Tosoh Corp 電気化学的酵素測定方法およびバイオセンサ
KR0156176B1 (ko) * 1995-06-01 1998-12-01 구자홍 전기화학식 면역 바이오센서
US6413410B1 (en) 1996-06-19 2002-07-02 Lifescan, Inc. Electrochemical cell
AUPN363995A0 (en) * 1995-06-19 1995-07-13 Memtec Limited Electrochemical cell
US6338790B1 (en) 1998-10-08 2002-01-15 Therasense, Inc. Small volume in vitro analyte sensor with diffusible or non-leachable redox mediator
WO2001038873A2 (en) * 1999-11-24 2001-05-31 Biotronic Technologies, Inc. Devices and methods for detecting analytes using electrosensor having capture reagent
KR100340173B1 (ko) * 2000-03-22 2002-06-12 이동준 전기화학적 바이오센서 측정기
EP1292825B1 (en) * 2000-03-31 2006-08-23 Lifescan, Inc. Electrically-conductive patterns for monitoring the filling of medical devices
RU2267120C2 (ru) 2000-07-14 2005-12-27 Лайфскен, Инк. Электрохимический способ измерения скоростей химических реакций
WO2002006788A2 (en) 2000-07-14 2002-01-24 Usf Filtration And Separations Group Inc. Electrochemical method for measuring chemical reaction rates
ES2315407T3 (es) * 2001-05-29 2009-04-01 Panasonic Corporation Biosensor.
US6797150B2 (en) 2001-10-10 2004-09-28 Lifescan, Inc. Determination of sample volume adequacy in biosensor devices
GB0129816D0 (en) 2001-12-13 2002-01-30 The Technology Partnership Plc Testing device for chemical or biochemical analysis
GB0130684D0 (en) * 2001-12-21 2002-02-06 Oxford Biosensors Ltd Micro-band electrode
US20050164328A1 (en) * 2002-03-08 2005-07-28 Susumu Kuwabata Substrate determining method
US6843263B2 (en) 2002-06-24 2005-01-18 Industrial Technology Research Institute Partially closed microfluidic system and microfluidic driving method
US7399401B2 (en) * 2002-10-09 2008-07-15 Abbott Diabetes Care, Inc. Methods for use in assessing a flow condition of a fluid
US8486255B2 (en) * 2003-01-30 2013-07-16 Emisense Technologies, Llc System, apparatus, and method for measuring an ion concentration of a measured fluid
US20070264721A1 (en) * 2003-10-17 2007-11-15 Buck Harvey B System and method for analyte measurement using a nonlinear sample response
WO2004113901A1 (en) * 2003-06-20 2004-12-29 Roche Diagnostics Gmbh Test strip with slot vent opening
US20050067277A1 (en) * 2003-09-30 2005-03-31 Pierce Robin D. Low volume electrochemical biosensor
US7390622B2 (en) 2003-10-16 2008-06-24 Hai Kang Life Corporation Limited Apparatus and methods for detecting nucleic acid in biological samples
US20050150762A1 (en) * 2004-01-09 2005-07-14 Butters Colin W. Biosensor and method of manufacture
KR100698961B1 (ko) 2005-02-04 2007-03-26 주식회사 아이센스 전기화학적 바이오센서
DE102005007539A1 (de) * 2005-02-17 2006-08-31 Universität Rostock Einrichtung zur Bestimmung redoxaktiver Stoffe
DE102005037436A1 (de) * 2005-08-04 2007-02-15 Siemens Ag Verfahren und System zur Konzentrationsbestimmung eines Analyt-Enzym-Komplexes oder Analyt-Enzym-Konjugats, insbesondere zur elektrochemischen Detektion des Analyten, und zugehörige Messvorrichtung
US7955484B2 (en) * 2005-12-14 2011-06-07 Nova Biomedical Corporation Glucose biosensor and method
EP1813937A1 (de) 2006-01-25 2007-08-01 Roche Diagnostics GmbH Elektrochemisches Biosensor-Analysesystem
US20070266871A1 (en) * 2006-05-17 2007-11-22 Greta Wegner Diagnostic test media and methods for the manufacture thereof
EP2041573B1 (en) 2006-06-23 2019-09-04 PerkinElmer Health Sciences, Inc. Methods and devices for microfluidic point-of-care immunoassays
WO2008044530A1 (fr) * 2006-10-05 2008-04-17 Panasonic Corporation Capteur d'analyse multi composant et procédé de mesure de composants multiples
US7943034B2 (en) * 2006-10-19 2011-05-17 Agamatrix, Inc. Method and apparatus for providing a stable voltage to an analytical system
KR100834286B1 (ko) * 2007-01-23 2008-05-30 엘지전자 주식회사 생체 물질 측정용 다층 스트립 및 생체 물질 측정 장치
RU70580U1 (ru) * 2007-08-09 2008-01-27 Анатолий Николаевич Решетилов Многофункциональный автоматический биосенсорный анализатор органических соединений
EP2535703B1 (en) * 2007-09-24 2021-11-03 Ascensia Diabetes Care Holdings AG Multi-electrode biosensor system
US8628493B2 (en) * 2008-06-03 2014-01-14 The Feinstein Institute For Medical Research Flexible spirally-rolled polymer tube for monitoring and treatment of brain injuries
DE102008027038A1 (de) * 2008-06-06 2009-12-17 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Verfahren zum Detektieren von chemischen oder biologischen Species sowie Elektrodenanordnung hierfür
US8323467B2 (en) * 2009-10-27 2012-12-04 Lifescan Scotland Limited Dual chamber, multi-analyte test strip with opposing electrodes
US8940141B2 (en) 2010-05-19 2015-01-27 Lifescan Scotland Limited Analytical test strip with an electrode having electrochemically active and inert areas of a predetermined size and distribution
TWI453282B (zh) * 2010-09-17 2014-09-21 Univ Nat Taiwan 連接物、阻抗式生物晶片及使用該晶片在流體樣品中定量偵測目標分析物之方法
US8932445B2 (en) * 2010-09-30 2015-01-13 Cilag Gmbh International Systems and methods for improved stability of electrochemical sensors
KR101363020B1 (ko) * 2011-10-31 2014-02-26 주식회사 세라젬메디시스 다중 반응 바이오센서
CN104245042B (zh) * 2012-04-23 2018-03-06 西门子医疗保健诊断公司 传感器阵列

Also Published As

Publication number Publication date
US20190285568A1 (en) 2019-09-19
CN104380091A (zh) 2015-02-25
US10921280B2 (en) 2021-02-16
US10330630B2 (en) 2019-06-25
JP2015522164A (ja) 2015-08-03
BR112014032656A2 (pt) 2017-06-27
RU2016128035A3 (es) 2019-10-03
BR112014032656B1 (pt) 2021-12-21
MX2014015162A (es) 2015-03-05
EP2867660A2 (en) 2015-05-06
US20150176143A1 (en) 2015-06-25
JP5781256B2 (ja) 2015-09-16
RU2713046C2 (ru) 2020-02-03
BR112014032656A8 (pt) 2020-10-13
CA2877888A1 (en) 2014-01-03
RU2016128035A (ru) 2018-12-06
US20170168006A1 (en) 2017-06-15
RU2015102604A (ru) 2016-08-20
WO2014004781A3 (en) 2014-03-20
EP3101415A1 (en) 2016-12-07
AU2013280268A1 (en) 2015-02-12
CN104380091B (zh) 2016-06-22
EP2867660A4 (en) 2015-12-23
KR20150023069A (ko) 2015-03-04
AU2013280268B2 (en) 2015-02-26
WO2014004781A2 (en) 2014-01-03
CA2877888C (en) 2016-02-02
KR101563486B1 (ko) 2015-10-27

Similar Documents

Publication Publication Date Title
AU2022200683A8 (en) Microfluidic devices having isolation pens and methods of testing biological micro-objects with same
WO2013112541A3 (en) Devices and methods for the rapid and accurate detection of analytes
MX2017003454A (es) Sistemas y metodos para la integracion de la recoleccion de microfluido lagrimal y el analisis por flujo lateral de analitos de interes.
WO2017181135A3 (en) METHODS, SYSTEMS AND KITS FOR IN PEN ASSAYS
EP4024029A3 (en) Systems and methods for sample use maximization
NZ709568A (en) Soil chemistry sensor
WO2014153651A8 (en) Microfluidic devices and methods for use thereof in multicellular assays of secretion
WO2012122536A3 (en) Systems and methods for high-throughput detection of an analyte in a sample
WO2015063552A3 (en) Microfluidic system and method with focused energy apparatus
IN2014MN02555A (es)
SG10201900209WA (en) Systems and methods for mobile device analysis of nucleic acids and proteins
CR20110567A (es) Dispositivos para diagnostico y metodos relacionados
EA201791300A1 (ru) Флюидные системы, содержащие канал инкубации, включающие в себя флюидные системы, образованные литьевым формованием
WO2014014587A3 (en) Capillary electrophoresis for reservoir fluid analysis at wellsite and laboratory
WO2016105464A3 (en) Mini point of care gas chromatographic test strip and method to measure analytes
MX2015014476A (es) Dispositivo de muestreo de fluidos biologicos.
GB2523419A (en) Test device for electrochemical analysis
WO2019075476A3 (en) Methods, systems and kits for in-pen assays
WO2015134497A8 (en) Devices and methods for analyzing a blood coagulation property
EA201390485A1 (ru) Способ и устройство для измерения окислительно-восстановительного потенциала
MX2009011307A (es) Metodos para contar celulas.
MX2019003927A (es) Sistema de analisis y metodo para analizar una muestra.
MX2016008447A (es) Metodos y sistemas para amplificacion de acido nucleico.
WO2018058113A3 (en) Systems and methods for analysis of liquids by covered fluidic channels integrated onto sensor platforms
MX2017002795A (es) Metodo y dispositivo de prueba.