MX365501B - Eliminacion de ligandos lixiviados de purificacion de afinidad. - Google Patents
Eliminacion de ligandos lixiviados de purificacion de afinidad.Info
- Publication number
- MX365501B MX365501B MX2015011994A MX2015011994A MX365501B MX 365501 B MX365501 B MX 365501B MX 2015011994 A MX2015011994 A MX 2015011994A MX 2015011994 A MX2015011994 A MX 2015011994A MX 365501 B MX365501 B MX 365501B
- Authority
- MX
- Mexico
- Prior art keywords
- removal
- leaked
- affinity purification
- purification ligand
- contaminants
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
- C07K1/18—Ion-exchange chromatography
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
- B01D15/36—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving ionic interaction
- B01D15/361—Ion-exchange
- B01D15/363—Anion-exchange
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
- B01D15/38—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups B01D15/265 - B01D15/36
- B01D15/3804—Affinity chromatography
- B01D15/3809—Affinity chromatography of the antigen-antibody type, e.g. protein A, G, L chromatography
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70575—NGF/TNF-superfamily, e.g. CD70, CD95L, CD153, CD154
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
- C07K14/7151—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for tumor necrosis factor [TNF], for lymphotoxin [LT]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
- B01D15/18—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns
- B01D15/1864—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns using two or more columns
- B01D15/1871—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns using two or more columns placed in series
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
- C07K1/22—Affinity chromatography or related techniques based upon selective absorption processes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Analytical Chemistry (AREA)
- Cell Biology (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Dermatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Peptides Or Proteins (AREA)
- Treatment Of Liquids With Adsorbents In General (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
La presente invención se refiere a la eliminación de una porción grande de contaminantes de preparaciones de proteína manteniendo un alto nivel de recuperación mediante el uso de un medio de cromatografía de matriz de intercambio aniónico con tentáculos. Usando los métodos de la invención, los contaminantes lixiviados por cromatografía de afinidad pueden ser eliminados de preparaciones de proteínas recombinantes.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201361785038P | 2013-03-14 | 2013-03-14 | |
PCT/US2014/023682 WO2014159441A1 (en) | 2013-03-14 | 2014-03-11 | Removal of leaked affinity purification ligand |
Publications (2)
Publication Number | Publication Date |
---|---|
MX2015011994A MX2015011994A (es) | 2015-12-01 |
MX365501B true MX365501B (es) | 2019-06-05 |
Family
ID=50424772
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2015011994A MX365501B (es) | 2013-03-14 | 2014-03-11 | Eliminacion de ligandos lixiviados de purificacion de afinidad. |
MX2019006568A MX2019006568A (es) | 2013-03-14 | 2015-09-09 | Eliminacion de ligandos lixiviados de purificacion de afinidad. |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2019006568A MX2019006568A (es) | 2013-03-14 | 2015-09-09 | Eliminacion de ligandos lixiviados de purificacion de afinidad. |
Country Status (18)
Country | Link |
---|---|
US (3) | US20160024144A1 (es) |
EP (3) | EP3395423B1 (es) |
JP (1) | JP6457479B2 (es) |
AU (1) | AU2014240596B2 (es) |
CA (1) | CA2904411A1 (es) |
CY (1) | CY1120353T1 (es) |
DK (2) | DK2969099T4 (es) |
ES (2) | ES2964601T3 (es) |
FI (1) | FI3395423T3 (es) |
HK (1) | HK1220159A1 (es) |
HU (2) | HUE038565T2 (es) |
LT (2) | LT2969099T (es) |
MX (2) | MX365501B (es) |
PL (2) | PL2969099T5 (es) |
PT (2) | PT2969099T (es) |
SI (2) | SI2969099T2 (es) |
TR (1) | TR201809050T4 (es) |
WO (1) | WO2014159441A1 (es) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SI2969099T2 (sl) | 2013-03-14 | 2022-04-29 | Amgen Inc. | Odstranjevanje izluženega afinitetnega purifikacijskega liganda |
AR096713A1 (es) * | 2013-06-25 | 2016-01-27 | Cadila Healthcare Ltd | Proceso de purificación para anticuerpos monoclonales |
CN106536565A (zh) * | 2014-06-13 | 2017-03-22 | 鲁宾有限公司 | 一种用于纯化TNFR‑Fc融合蛋白的方法 |
CN105214341B (zh) * | 2015-09-17 | 2017-12-15 | 广州康盛生物科技有限公司 | 组合型吸附柱及其制备方法 |
US20200283472A1 (en) * | 2016-03-29 | 2020-09-10 | Navya Biologicals Pvt. Ltd | A process for purification of fc-fusion proteins |
JP7065105B2 (ja) * | 2017-02-09 | 2022-05-11 | ブラッコ・スイス・ソシエテ・アノニム | 可溶性psgl-1タンパク質変異体の精製のための方法 |
Family Cites Families (38)
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US6936694B1 (en) | 1982-05-06 | 2005-08-30 | Intermune, Inc. | Manufacture and expression of large structural genes |
AU588819B2 (en) | 1984-10-29 | 1989-09-28 | Immunex Corporation | Cloning of human granulocyte-macrophage colony stimulating factor gene |
US4968607A (en) | 1987-11-25 | 1990-11-06 | Immunex Corporation | Interleukin-1 receptors |
DE3811042A1 (de) | 1988-03-31 | 1989-10-19 | Merck Patent Gmbh | Ionenaustauscher |
US5075222A (en) | 1988-05-27 | 1991-12-24 | Synergen, Inc. | Interleukin-1 inhibitors |
WO1990005183A1 (en) | 1988-10-31 | 1990-05-17 | Immunex Corporation | Interleukin-4 receptors |
US5395760A (en) | 1989-09-05 | 1995-03-07 | Immunex Corporation | DNA encoding tumor necrosis factor-α and -β receptors |
ATE236249T1 (de) | 1989-09-12 | 2003-04-15 | Hoffmann La Roche | Tfn-bindende proteine |
US6204363B1 (en) | 1989-10-16 | 2001-03-20 | Amgen Inc. | Stem cell factor |
US5149792A (en) | 1989-12-19 | 1992-09-22 | Amgen Inc. | Platelet-derived growth factor B chain analogs |
US5272064A (en) | 1989-12-19 | 1993-12-21 | Amgen Inc. | DNA molecules encoding platelet-derived growth factor B chain analogs and method for expression thereof |
WO1991018982A1 (en) | 1990-06-05 | 1991-12-12 | Immunex Corporation | Type ii interleukin-1 receptors |
US5350683A (en) | 1990-06-05 | 1994-09-27 | Immunex Corporation | DNA encoding type II interleukin-1 receptors |
DE69332981T2 (de) | 1992-10-23 | 2004-05-19 | Immunex Corp., Seattle | Methoden zur herstellung löslicher, oligomerer proteine |
US5554512A (en) | 1993-05-24 | 1996-09-10 | Immunex Corporation | Ligands for flt3 receptors |
DE4333821A1 (de) | 1993-10-04 | 1995-04-06 | Merck Patent Gmbh | Ionenaustauscher |
US5981713A (en) | 1994-10-13 | 1999-11-09 | Applied Research Systems Ars Holding N.V. | Antibodies to intereleukin-1 antagonists |
DE19501726A1 (de) | 1995-01-20 | 1996-07-25 | Merck Patent Gmbh | Polymerisationsfähige Derivate von Polyamiden |
AU708239B2 (en) | 1995-06-29 | 1999-07-29 | Immunex Corporation | Cytokine that induces apoptosis |
US6613544B1 (en) | 1995-12-22 | 2003-09-02 | Amgen Inc. | Osteoprotegerin |
US6096728A (en) | 1996-02-09 | 2000-08-01 | Amgen Inc. | Composition and method for treating inflammatory diseases |
US6149994A (en) | 1996-06-21 | 2000-11-21 | Merck Patent Gesellschaft Mit Beschrankter Haftung | Polymerisable polyamide derivatives |
US6271349B1 (en) | 1996-12-23 | 2001-08-07 | Immunex Corporation | Receptor activator of NF-κB |
US6235883B1 (en) | 1997-05-05 | 2001-05-22 | Abgenix, Inc. | Human monoclonal antibodies to epidermal growth factor receptor |
WO1998058253A1 (de) | 1997-06-18 | 1998-12-23 | Merck Patent Gmbh | Verwendung monolithischer sorbentien für präparative chromatographische trennverfahren |
US6337072B1 (en) | 1998-04-03 | 2002-01-08 | Hyseq, Inc. | Interleukin-1 receptor antagonist and recombinant production thereof |
WO2001036637A1 (en) | 1999-11-17 | 2001-05-25 | Immunex Corporation | Receptor activator of nf-kappa b |
FR2824568B1 (fr) * | 2001-05-11 | 2004-04-09 | Lab Francais Du Fractionnement | Procede de preparation de concentres d'immunoglobulines humaines a usage therapeutique |
CA2469815C (en) * | 2001-12-21 | 2011-05-03 | Immunex Corporation | Methods for purifying protein |
PL1869065T3 (pl) * | 2005-03-11 | 2020-09-21 | Wyeth Llc | Sposób prowadzenia chromatografii podziałowej ze słabym wiązaniem |
CA2668771C (en) * | 2006-11-08 | 2016-03-15 | Wyeth | Rationally designed media for cell culture |
CN102395597A (zh) * | 2009-03-11 | 2012-03-28 | 惠氏有限责任公司 | 纯化小模块免疫药物蛋白的方法 |
JP5980782B2 (ja) * | 2010-07-30 | 2016-08-31 | ファイザー・インク | タンパク質のタンデム精製 |
WO2012176158A1 (en) * | 2011-06-24 | 2012-12-27 | Dr. Reddy's Laboratories Limited | Purification of chimeric protein |
EP2729482B1 (en) * | 2011-07-08 | 2018-03-07 | Merck Sharp & Dohme Corp. | Method for purifying fc-fusion protein |
JP6326371B2 (ja) * | 2011-11-04 | 2018-05-16 | ザイムワークス,インコーポレイテッド | Fcドメインにおける変異を有する安定なヘテロ二量体抗体デザイン |
SG10201701224UA (en) * | 2012-03-12 | 2017-04-27 | Merck Patent Gmbh | Removal of protein aggregates from biopharmaceutical preparations in a flowthrough mode |
SI2969099T2 (sl) | 2013-03-14 | 2022-04-29 | Amgen Inc. | Odstranjevanje izluženega afinitetnega purifikacijskega liganda |
-
2014
- 2014-03-11 SI SI201430759T patent/SI2969099T2/sl unknown
- 2014-03-11 EP EP18168494.5A patent/EP3395423B1/en active Active
- 2014-03-11 EP EP14714890.2A patent/EP2969099B2/en active Active
- 2014-03-11 US US14/775,992 patent/US20160024144A1/en not_active Abandoned
- 2014-03-11 PL PL14714890T patent/PL2969099T5/pl unknown
- 2014-03-11 SI SI201432052T patent/SI3395423T1/sl unknown
- 2014-03-11 TR TR2018/09050T patent/TR201809050T4/tr unknown
- 2014-03-11 PT PT147148902T patent/PT2969099T/pt unknown
- 2014-03-11 MX MX2015011994A patent/MX365501B/es active IP Right Grant
- 2014-03-11 HU HUE14714890A patent/HUE038565T2/hu unknown
- 2014-03-11 AU AU2014240596A patent/AU2014240596B2/en active Active
- 2014-03-11 WO PCT/US2014/023682 patent/WO2014159441A1/en active Application Filing
- 2014-03-11 LT LTEP14714890.2T patent/LT2969099T/lt unknown
- 2014-03-11 EP EP22155498.3A patent/EP4026596A1/en active Pending
- 2014-03-11 DK DK14714890.2T patent/DK2969099T4/da active
- 2014-03-11 DK DK18168494.5T patent/DK3395423T3/da active
- 2014-03-11 CA CA2904411A patent/CA2904411A1/en not_active Abandoned
- 2014-03-11 PL PL18168494.5T patent/PL3395423T3/pl unknown
- 2014-03-11 LT LTEP18168494.5T patent/LT3395423T/lt unknown
- 2014-03-11 FI FIEP18168494.5T patent/FI3395423T3/fi active
- 2014-03-11 HU HUE18168494A patent/HUE064450T2/hu unknown
- 2014-03-11 JP JP2016501314A patent/JP6457479B2/ja active Active
- 2014-03-11 ES ES18168494T patent/ES2964601T3/es active Active
- 2014-03-11 ES ES14714890T patent/ES2674697T5/es active Active
- 2014-03-11 PT PT181684945T patent/PT3395423T/pt unknown
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2015
- 2015-09-09 MX MX2019006568A patent/MX2019006568A/es unknown
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2016
- 2016-07-14 HK HK16108300.0A patent/HK1220159A1/zh unknown
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2018
- 2018-06-20 CY CY20181100641T patent/CY1120353T1/el unknown
- 2018-07-23 US US16/042,965 patent/US11192919B2/en active Active
-
2021
- 2021-12-17 US US17/554,865 patent/US11492372B2/en active Active
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Legal Events
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