MX361463B - Derivado de indol carboxamida. - Google Patents

Derivado de indol carboxamida.

Info

Publication number
MX361463B
MX361463B MX2015000431A MX2015000431A MX361463B MX 361463 B MX361463 B MX 361463B MX 2015000431 A MX2015000431 A MX 2015000431A MX 2015000431 A MX2015000431 A MX 2015000431A MX 361463 B MX361463 B MX 361463B
Authority
MX
Mexico
Prior art keywords
alkyl
halogen
formula
receptor agonist
symptoms
Prior art date
Application number
MX2015000431A
Other languages
English (en)
Other versions
MX2015000431A (es
Inventor
Kanayama Takatoshi
Kubota Hideki
Matsumoto Shunichiro
Saito Tomoyuki
Shimizu Takafumi
Katoh Naoto
Matsui Shigeo
Original Assignee
Astellas Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astellas Pharma Inc filed Critical Astellas Pharma Inc
Publication of MX2015000431A publication Critical patent/MX2015000431A/es
Publication of MX361463B publication Critical patent/MX361463B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C07D491/052—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being six-membered
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A61K31/4045—Indole-alkylamines; Amides thereof, e.g. serotonin, melatonin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
    • C07D491/14—Ortho-condensed systems
    • C07D491/147—Ortho-condensed systems the condensed system containing one ring with oxygen as ring hetero atom and two rings with nitrogen as ring hetero atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Urology & Nephrology (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Se proporciona un compuesto que es útil como agonista de los receptores de MT1 y/o MT2. Los inventores de la presente han llevado a cabo estudios sobre los agonistas de los receptores de MT1 y/o MT2 y han descubierto que un compuesto de indol carboxamida tiene acción agonista de los receptores de MT1 y/o MT2, con lo cual se completa la presente invención. El compuesto de indol carboxamida de la presente invención tiene la acción agonista de los receptores de MT1 y/o MT2, así como una baja penetración del SNC y, por lo tanto, puede usarse como agente para prevenir y/o tratar enfermedades urológicas; en una modalidad, síntomas del tracto urinario inferior; en otra modalidad, síntoma de acumulación de orina, en otra modalidad, incontinencia urinaria; aún en otra modalidad, incontinencia urinaria por estrés; y similares.
MX2015000431A 2012-07-10 2013-07-09 Derivado de indol carboxamida. MX361463B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2012154322 2012-07-10
PCT/JP2013/068780 WO2014010602A1 (ja) 2012-07-10 2013-07-09 インドールカルボキサミド誘導体

Publications (2)

Publication Number Publication Date
MX2015000431A MX2015000431A (es) 2015-03-12
MX361463B true MX361463B (es) 2018-12-06

Family

ID=49916054

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2015000431A MX361463B (es) 2012-07-10 2013-07-09 Derivado de indol carboxamida.

Country Status (18)

Country Link
US (1) US9376449B2 (es)
EP (1) EP2873660B1 (es)
JP (1) JP6131951B2 (es)
KR (1) KR102119372B1 (es)
CN (1) CN104428286B (es)
AR (1) AR091699A1 (es)
AU (1) AU2013287758A1 (es)
BR (1) BR112015000709B1 (es)
CA (1) CA2878663C (es)
EA (1) EA026090B1 (es)
ES (1) ES2630653T3 (es)
IL (1) IL236406A0 (es)
MX (1) MX361463B (es)
PH (1) PH12015500003A1 (es)
PL (1) PL2873660T3 (es)
PT (1) PT2873660T (es)
TW (1) TW201416351A (es)
WO (1) WO2014010602A1 (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014010603A1 (ja) * 2012-07-10 2014-01-16 アステラス製薬株式会社 腹圧性尿失禁又は混合型尿失禁の治療又は予防用医薬組成物、及び該医薬組成物に含有される化合物のスクリーニング方法
RU2016133277A (ru) 2014-01-14 2018-02-19 Астеллас Фарма Инк. C0единение индола
MX2018009759A (es) 2016-02-12 2018-11-29 Astellas Pharma Inc Derivados de tetrahidroisoquinolina.
CN116496251A (zh) * 2023-04-25 2023-07-28 浙江理工大学 一种1h-吲哚-2-酰胺化合物的制备方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2658818B1 (fr) 1990-02-27 1993-12-31 Adir Cie Nouveaux derives a structure naphtalenique, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
FR2737725B1 (fr) 1995-08-08 1997-10-31 Valentonine Nouveaux derives acyles de la melatonine et d'analogues melatoninergiques, leur procede de preparation et leur utilisation en tant que medicament
KR100494214B1 (ko) 1996-03-08 2005-11-25 다케다 야쿠힌 고교 가부시키가이샤 삼환화합물,그의제조방법및용도
BR9713690B1 (pt) 1996-12-10 2009-08-11 agentes melatoninérgicos benzodioxola, benzofurano, diidrobenzofurano e benzodioxano.
FR2907452B1 (fr) 2006-10-18 2008-12-12 Servier Lab "nouveaux derives indoliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent"
MX2009006078A (es) * 2006-12-08 2009-09-18 Takeda Pharmaceutical Compuesto triciclico y su uso medico.
MX2011001062A (es) * 2008-07-30 2011-03-24 Ferrer Int Compuestos de 1,6-dihidro-2h-3-oxa-6-aza-as-indaceno.

Also Published As

Publication number Publication date
CN104428286B (zh) 2017-03-08
JP6131951B2 (ja) 2017-05-24
ES2630653T3 (es) 2017-08-22
EP2873660B1 (en) 2016-10-26
EA201590185A1 (ru) 2015-04-30
EA026090B1 (ru) 2017-02-28
EP2873660A1 (en) 2015-05-20
MX2015000431A (es) 2015-03-12
US20150203505A1 (en) 2015-07-23
AU2013287758A1 (en) 2015-01-22
IL236406A0 (en) 2015-02-26
CA2878663C (en) 2020-08-04
CA2878663A1 (en) 2014-01-16
BR112015000709A2 (pt) 2019-11-05
EP2873660A4 (en) 2015-11-25
AR091699A1 (es) 2015-02-25
KR102119372B1 (ko) 2020-06-05
PT2873660T (pt) 2016-12-05
KR20150028340A (ko) 2015-03-13
PL2873660T3 (pl) 2017-02-28
BR112015000709B1 (pt) 2021-10-13
US9376449B2 (en) 2016-06-28
JPWO2014010602A1 (ja) 2016-06-23
WO2014010602A1 (ja) 2014-01-16
PH12015500003A1 (en) 2015-03-02
CN104428286A (zh) 2015-03-18
TW201416351A (zh) 2014-05-01

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