MX359749B - 6h-pirrolo[1,2-a][1,4] benzodiazepinas y 5,6-dihidro-4h-pirrolo[1, 2-a][1,4]benzodiazepinas antifúngicidas novedosas sustituidas con derivados heterocíclicos. - Google Patents

6h-pirrolo[1,2-a][1,4] benzodiazepinas y 5,6-dihidro-4h-pirrolo[1, 2-a][1,4]benzodiazepinas antifúngicidas novedosas sustituidas con derivados heterocíclicos.

Info

Publication number
MX359749B
MX359749B MX2013012884A MX2013012884A MX359749B MX 359749 B MX359749 B MX 359749B MX 2013012884 A MX2013012884 A MX 2013012884A MX 2013012884 A MX2013012884 A MX 2013012884A MX 359749 B MX359749 B MX 359749B
Authority
MX
Mexico
Prior art keywords
pyrrolo
dihydro
substituted
heterocyclic derivatives
benzodi
Prior art date
Application number
MX2013012884A
Other languages
English (en)
Other versions
MX2013012884A (es
Inventor
Lieven Meerpoel
Louis Jules Roger Marie Maes
Wit Kelly De
Koen Jan Ludovicus Augustyns
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of MX2013012884A publication Critical patent/MX2013012884A/es
Publication of MX359749B publication Critical patent/MX359749B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
    • A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4866—Organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

La presente invención se refiere a 6H-pirrolo[1,2-a][1,4]benzodiaz epinas y 5,6-dihidro-4H-pirrolo-[1,2-a][1 ,4]benzodiazepinas antifúngicas novedosas sustituidas con derivados heterocíclicos de Fórmula (I) (Ver Formula) donde R1, R2, R3, R4 y Het tienen el significado definido en las reivindicaciones;, los compuestos de acuerdo con la presente invención son activos principalmente contra dermatofitos e infecciones fúngicas sistémicas; la invención también se refiere a procesos para preparar tales compuestos novedosos, composiciones farmacéuticas que comprenden dichos compuestos como principio activo, así como al uso de dichos compuestos como un medicamento.
MX2013012884A 2011-05-05 2012-05-03 6h-pirrolo[1,2-a][1,4] benzodiazepinas y 5,6-dihidro-4h-pirrolo[1, 2-a][1,4]benzodiazepinas antifúngicidas novedosas sustituidas con derivados heterocíclicos. MX359749B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP11164960 2011-05-05
PCT/EP2012/058142 WO2012150305A1 (en) 2011-05-05 2012-05-03 NOVEL ANTIFUNGAL 5,6-DIHYDRO-4H-PYRROLO[1,2-a][1,4]BENZO- DIAZEPINES AND 6H-PYRROLO[1,2-a][1,4]BENZODIAZEPINES SUBSTITUTED WITH HETEROCYCLIC DERIVATIVES

Publications (2)

Publication Number Publication Date
MX2013012884A MX2013012884A (es) 2014-02-20
MX359749B true MX359749B (es) 2018-10-08

Family

ID=46022282

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2013012884A MX359749B (es) 2011-05-05 2012-05-03 6h-pirrolo[1,2-a][1,4] benzodiazepinas y 5,6-dihidro-4h-pirrolo[1, 2-a][1,4]benzodiazepinas antifúngicidas novedosas sustituidas con derivados heterocíclicos.

Country Status (18)

Country Link
US (2) US9493468B2 (es)
EP (1) EP2707370B1 (es)
JP (1) JP6018179B2 (es)
KR (1) KR20140021630A (es)
CN (2) CN106674226B (es)
AP (1) AP3511A (es)
AU (1) AU2012251661C1 (es)
BR (1) BR112013028415A8 (es)
CA (1) CA2833509C (es)
EA (1) EA022852B1 (es)
ES (1) ES2542900T3 (es)
IL (1) IL229181A (es)
MX (1) MX359749B (es)
MY (1) MY170601A (es)
SG (1) SG194781A1 (es)
UA (1) UA110640C2 (es)
WO (1) WO2012150305A1 (es)
ZA (1) ZA201308261B (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101858630B1 (ko) * 2010-11-24 2018-05-16 얀센 파마슈티카 엔.브이. 페닐 유도체로 치환된, 항진균성 5,6-디하이드로-4H-피롤로-[1,2-α][1,4]벤조디아제핀 및 6H-피롤로-[1,2-α][1,4]벤조디아제핀

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA85362B (en) * 1984-01-19 1985-09-25 Hoffmann La Roche Imidazodiazepine derivatives
CS249148B2 (en) 1984-01-19 1987-03-12 Hoffmann La Roche Method of new imidazodiazepine's derivatives production
US4959361A (en) 1987-12-18 1990-09-25 Hoffmann-La Roche Inc. Triazolo(4,3-A)(1,4)benzodiazepines and thieno (3,2-F)(1,2,4)triazolo(4,3-A)(1,4)diazepine compounds which have useful activity as platelet activating factor (PAF) antagonists
MC1999A1 (fr) * 1987-12-18 1990-01-26 Hoffmann La Roche Composes tricycliques
CA2184802C (en) 1995-10-10 2007-07-31 Karl-Heinz Bender Process for manufacture of imidazo benzodiazepine derivatives
GB9818731D0 (en) * 1998-08-27 1998-10-21 Univ Portsmouth Compounds
WO2002034752A1 (en) * 2000-10-23 2002-05-02 Janssen Pharmaceutica N.V. Antifungal 4-substituted 5,6-dihydro-4h-pyrrolo[1,2-a][1,4]benzodiazepines
AU2003300883A1 (en) * 2002-12-12 2004-07-09 Cytovia, Inc. Substituted 1-benzoyl-3-cyano-pyrrolo(1,2-a)quinolines
AU2005249527B2 (en) * 2004-06-01 2011-08-04 University Of Virginia Patent Foundation Dual small molecule inhibitors of cancer and angiogenesis

Also Published As

Publication number Publication date
BR112013028415A2 (pt) 2017-01-24
MY170601A (en) 2019-08-20
CN106674226B (zh) 2020-05-26
MX2013012884A (es) 2014-02-20
AP2013007177A0 (en) 2013-10-31
ZA201308261B (en) 2018-05-30
US20170073348A1 (en) 2017-03-16
EA022852B1 (ru) 2016-03-31
US9975899B2 (en) 2018-05-22
CA2833509A1 (en) 2012-11-08
IL229181A (en) 2015-09-24
NZ618456A (en) 2015-05-29
UA110640C2 (uk) 2016-01-25
AU2012251661C1 (en) 2016-11-03
SG194781A1 (en) 2013-12-30
CN106674226A (zh) 2017-05-17
CN103502250A (zh) 2014-01-08
CA2833509C (en) 2019-11-26
KR20140021630A (ko) 2014-02-20
EP2707370A1 (en) 2014-03-19
EA201391630A1 (ru) 2014-04-30
ES2542900T3 (es) 2015-08-13
EP2707370B1 (en) 2015-04-29
AP3511A (en) 2016-01-04
JP6018179B2 (ja) 2016-11-02
US9493468B2 (en) 2016-11-15
AU2012251661B2 (en) 2016-08-11
WO2012150305A1 (en) 2012-11-08
AU2012251661A1 (en) 2013-10-24
US20140045827A1 (en) 2014-02-13
JP2014513114A (ja) 2014-05-29
IL229181A0 (en) 2013-12-31
BR112013028415A8 (pt) 2017-12-19
CN103502250B (zh) 2016-10-26

Similar Documents

Publication Publication Date Title
MX2012008259A (es) Novedosos derivados biciclicos de triazol sustituidos como moduladores de gamma secretasa.
MX2014013957A (es) Derivados de 3,4-dihidro-2h-pirido[1,2-a]pirazin-1,6-diona sustituidos utiles para el tratamiento de la enfermedad de alzheimer (inter alia).
NZ593951A (en) Novel substituted bicyclic heterocyclic compounds as gamma secretase modulators
MY170878A (en) [1,2,3] triazolo [4,5-d] pyrimidine derivatives as agonists of the cannabinoid receptor 2
MX2014000626A (es) Nuevos derivados de indol sustituidos como moduladores de gamma secretasa.
MX2012007536A (es) Derivados de heteroarilo que contienen nitrogeno.
MX346248B (es) Derivados de [1,2,3]triazol[4,5-d]pirimidina como agonistas de los agonistas del receptor canabinoide 2.
MX2013002329A (es) Agonista de receptores de neutrofina y sus usos como medicamentos.
MX2013007166A (es) 5,6-dihidro-4h-pirrolo[1,2-a][1,4]-benzodiazepinas y 6h-pirrolo [1,2-a][1,4]benzodiazepinas antimicoticas novedosas sustituidas con derivados de benceno biciclicos.
MX367914B (es) Derivados de 4,5,6,7-tetrahidro-pirazolo[1,5-a]pirazina sustituidos y derivados de 5,6,7,8-tetrahidro-4h-pirazolo[1,5-a][1 ,4]diazepina como inhibidores de ros1.
PH12014501415A1 (en) Heterocyclic amide derivatives as p2x7 receptor antagonists
PH12014501540A1 (en) 4-(benzoimidazol-2-yl) - thiazole compounds and related aza derivatives
MX2015014025A (es) Derivados de n-(2,3-dihidro-1h-pirrolo[2,3,b]piridin-5-il)-4-quina zolinamina y n-(2,3-dihidro-1h-indol-5-il)-4-quinazolinamina novedosos como inhibidores de perk.
WO2009156951A3 (en) 5,6,7,8-tetrahydro-imidazo[1,5-a]pyrazine compounds
MX2016012669A (es) Derivados de 4,5,6,7-tetrahidro-pirazolo[1,5-a]pirimidina y 2,3-dihidro-1h-imidazo[1,2-b]pirazol sustituidos como inhibidores de ros1.
UA116801C2 (uk) ПОХІДНІ ПІРОЛО[2,3-d]ПІРИМІДИНУ ЯК АГОНІСТИ РЕЦЕПТОРА CB2
WO2014053968A8 (en) Pyrrolo[3,2-c]pyridine tropomyosin-related kinase inhibitors
JO3029B1 (ar) مشتقات مبتكرة مضادة للفطريات ل 5 ، 6 - ثاني هيدرو - 4- [(ثاني فلورو اثيل) فينيل] -4 H - بيرولو [2،1 -a ] [1،4] بينزوديازيبين و 4- ( ثاني فلورو اثيل ) فينيل - 6 H - بيرولو [2،1 -a ] [1،4] بينزوديازيبين
MY163185A (en) 2-methoxy-pyridin-4-yl derivatives
MY162808A (en) Antifungal 5,6-dihydro-4h-pyrrolo [1, 2-a] [1,4]- benzodiazepines and 6h-pyrrolo [1,2-a] [1,4] benzodiazepines substituted with phenyl derivatives
MX359749B (es) 6h-pirrolo[1,2-a][1,4] benzodiazepinas y 5,6-dihidro-4h-pirrolo[1, 2-a][1,4]benzodiazepinas antifúngicidas novedosas sustituidas con derivados heterocíclicos.
WO2012136356A8 (en) 6,7-diydro-[1,3,4]thiadiazolo-[3,2-a][1,3]diazepin derivatives and pharmaceutical compositions containing the same as hypnotic or anesthetic agent and method for their preparation
UA108365C2 (ru) Производные замещенного бициклического триазола как модуляторы гамма-секретазы

Legal Events

Date Code Title Description
HH Correction or change in general
FG Grant or registration