MX358636B - Formulaciones farmacéuticas de naproxeno para la encapsulación en gel blando y combinaciones de las mismas. - Google Patents
Formulaciones farmacéuticas de naproxeno para la encapsulación en gel blando y combinaciones de las mismas.Info
- Publication number
- MX358636B MX358636B MX2012008300A MX2012008300A MX358636B MX 358636 B MX358636 B MX 358636B MX 2012008300 A MX2012008300 A MX 2012008300A MX 2012008300 A MX2012008300 A MX 2012008300A MX 358636 B MX358636 B MX 358636B
- Authority
- MX
- Mexico
- Prior art keywords
- nsaid
- fill
- naproxen
- concentration
- soft gel
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4833—Encapsulating processes; Filling of capsules
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4858—Organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4866—Organic macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Una formulación de NSAID para la encapsulación en una cápsula de gel blando con estabilidad, concentración y biodisponibilidad incrementadas del NSAID. Los NSAIDS preferidos son naproxeno, ibuprofeno, indometacina y diclofenaco, que se proporcionan en una forma tanto acídica como básica en la formulación de relleno. Los valores de pH de las formulaciones de relleno se pueden ajustar sin etapas de proceso adicionales. También se proporciona un proceso para incrementar la concentración lograble de un ingrediente farmacéutico de NSAID activo en una composición de relleno para unidades de dosificación. La formulación de NSAID altamente concentrada permite una reducción en el volumen de relleno o tamaño de unidad de dosificación, o un incremento en la concentración del NSAID en cada unidad de dosificación.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CA2690488A CA2690488C (en) | 2010-01-19 | 2010-01-19 | Pharmaceutical formulations of naproxen for soft gel encapsulation and combinations thereof |
| PCT/CA2011/000059 WO2011088553A1 (en) | 2010-01-19 | 2011-01-19 | Pharmaceutical formulations of naproxen for soft gel encapsulation and combinations thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX2012008300A MX2012008300A (es) | 2012-11-23 |
| MX358636B true MX358636B (es) | 2018-08-29 |
Family
ID=44303618
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2012008300A MX358636B (es) | 2010-01-19 | 2011-01-19 | Formulaciones farmacéuticas de naproxeno para la encapsulación en gel blando y combinaciones de las mismas. |
Country Status (13)
| Country | Link |
|---|---|
| US (4) | US9480667B2 (es) |
| EP (2) | EP2525789B1 (es) |
| JP (2) | JP5975884B2 (es) |
| AU (1) | AU2011207061B2 (es) |
| CA (1) | CA2690488C (es) |
| DK (1) | DK2525789T3 (es) |
| ES (1) | ES2880813T3 (es) |
| HU (1) | HUE055771T2 (es) |
| MX (1) | MX358636B (es) |
| PL (1) | PL2525789T3 (es) |
| PT (1) | PT2525789T (es) |
| SI (1) | SI2525789T1 (es) |
| WO (1) | WO2011088553A1 (es) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201301626D0 (en) | 2013-01-30 | 2013-03-13 | Dignity Sciences Ltd | Composition comprising 15-OHEPA and methods of using the same |
| US9682055B2 (en) | 2014-06-04 | 2017-06-20 | Dignity Sciences Limted | Pharmaceutical compositions comprising DGLA and use of same |
| CN104083339A (zh) * | 2014-08-04 | 2014-10-08 | 人福普克药业（武汉）有限公司 | 萘普生钠软胶囊及其制备方法 |
| US10368284B2 (en) * | 2014-11-12 | 2019-07-30 | T-Mobile Usa, Inc. | Quality of experience-based handover management |
| ES2851525T3 (es) | 2015-07-21 | 2021-09-07 | Afimmune Ltd | Composiciones que comprenden 15(S)-HEPE para su uso en la sensibilización de las células cancerosas a la radioterapia |
| US11911517B2 (en) | 2018-05-16 | 2024-02-27 | Bayer Healthcare Llc | High concentration suspension formulation for cold and flu soft gel capsule medications |
| CN109692127A (zh) * | 2019-03-15 | 2019-04-30 | 王征 | 一种密封小胶囊的制备方法 |
| US20220202751A1 (en) * | 2019-04-26 | 2022-06-30 | R.P. Scherer Technologies, Llc | Mini softgel naproxen composition |
| US20220233452A1 (en) * | 2021-01-25 | 2022-07-28 | R.P. Scherer Technologies, Llc | Mini softgel naproxen composition |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4443428A (en) * | 1982-06-21 | 1984-04-17 | Euroceltique, S.A. | Extended action controlled release compositions |
| US5071643A (en) | 1986-10-17 | 1991-12-10 | R. P. Scherer Corporation | Solvent system enhancing the solubility of pharmaceuticals for encapsulation |
| JPH09502201A (ja) * | 1993-09-07 | 1997-03-04 | ザ、プロクター、エンド、ギャンブル、カンパニー | プロピオン酸非ステロイド系抗炎症剤のアミノ酸塩とうっ血除去剤、去痰剤、抗ヒスタミン剤及び鎮咳剤のうち少くとも１種を含有した組成物 |
| WO1995019759A1 (en) * | 1994-01-24 | 1995-07-27 | The Procter & Gamble Company | Process for solubilizing difficultly soluble pharmaceutical actives |
| US5484606A (en) * | 1994-01-24 | 1996-01-16 | The Procter & Gamble Company | Process for reducing the precipitation of difficulty soluble pharmaceutical actives |
| US5641512A (en) | 1995-03-29 | 1997-06-24 | The Procter & Gamble Company | Soft gelatin capsule compositions |
| CA2318128C (en) * | 1998-01-20 | 2008-10-14 | Applied Analytical Industries, Inc. | Oral liquid compositions |
| US6383515B2 (en) * | 1999-05-28 | 2002-05-07 | Sawyer Maryjean | Solvent system for enhancing solubility |
| US6387400B1 (en) | 2000-08-29 | 2002-05-14 | R.P. Scherer Technologies, Inc. | Process for preparing pharmaceutical compositions for use with soft gelatin formulations |
| US20090318558A1 (en) * | 2003-02-12 | 2009-12-24 | Jae-Hwan Kim | Solvent system of hardly soluble drug with improved dissolution rate |
| EP1605916A4 (en) * | 2003-02-12 | 2012-02-22 | R & P Korea Co Ltd | SOLUBENT SOLVENT SYSTEM WITH SOLUBLE PEEL WITH IMPROVED ELUTION RATE |
| US20070053868A1 (en) | 2005-03-08 | 2007-03-08 | Banner Pharmacaps, Inc. | Solvent system for enhancing the solubility of pharmaceutical agents |
| US7582679B2 (en) | 2006-02-03 | 2009-09-01 | Pharmaceutics International Incorporated | Compositions containing solid ibuprofen concentrates and methods of making solid ibuprofen concentrates |
| US20080014274A1 (en) * | 2006-07-14 | 2008-01-17 | Wyeth | Enhanced stability phenylephrine liquid compositions |
| US20110052679A1 (en) | 2009-08-25 | 2011-03-03 | Pharmaceutics International, Inc. | Solid naproxen concentrates and related dosage forms |
-
2010
- 2010-01-19 CA CA2690488A patent/CA2690488C/en active Active
-
2011
- 2011-01-19 PT PT117342832T patent/PT2525789T/pt unknown
- 2011-01-19 EP EP11734283.2A patent/EP2525789B1/en active Active
- 2011-01-19 SI SI201131992T patent/SI2525789T1/sl unknown
- 2011-01-19 DK DK11734283.2T patent/DK2525789T3/da active
- 2011-01-19 US US13/574,159 patent/US9480667B2/en active Active
- 2011-01-19 ES ES11734283T patent/ES2880813T3/es active Active
- 2011-01-19 JP JP2012549215A patent/JP5975884B2/ja active Active
- 2011-01-19 HU HUE11734283A patent/HUE055771T2/hu unknown
- 2011-01-19 EP EP21177143.1A patent/EP3909567A1/en active Pending
- 2011-01-19 WO PCT/CA2011/000059 patent/WO2011088553A1/en active Application Filing
- 2011-01-19 MX MX2012008300A patent/MX358636B/es active IP Right Grant
- 2011-01-19 AU AU2011207061A patent/AU2011207061B2/en active Active
- 2011-01-19 PL PL11734283T patent/PL2525789T3/pl unknown
-
2016
- 2016-01-18 JP JP2016007253A patent/JP2016094462A/ja active Pending
- 2016-10-05 US US15/285,968 patent/US10463637B2/en active Active
-
2019
- 2019-09-26 US US16/583,903 patent/US11896566B2/en active Active
-
2023
- 2023-12-29 US US18/400,069 patent/US20240139132A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| AU2011207061A1 (en) | 2012-07-26 |
| US10463637B2 (en) | 2019-11-05 |
| AU2011207061B2 (en) | 2015-05-28 |
| EP2525789B1 (en) | 2021-06-02 |
| US20240139132A1 (en) | 2024-05-02 |
| CA2690488A1 (en) | 2011-07-19 |
| US9480667B2 (en) | 2016-11-01 |
| US20170020832A1 (en) | 2017-01-26 |
| EP2525789A4 (en) | 2014-04-30 |
| JP2013517304A (ja) | 2013-05-16 |
| JP2016094462A (ja) | 2016-05-26 |
| EP3909567A1 (en) | 2021-11-17 |
| DK2525789T3 (da) | 2021-07-19 |
| US11896566B2 (en) | 2024-02-13 |
| ES2880813T3 (es) | 2021-11-25 |
| PT2525789T (pt) | 2021-07-19 |
| JP5975884B2 (ja) | 2016-08-23 |
| SI2525789T1 (sl) | 2021-12-31 |
| CA2690488C (en) | 2013-06-11 |
| WO2011088553A1 (en) | 2011-07-28 |
| EP2525789A1 (en) | 2012-11-28 |
| US20130011470A1 (en) | 2013-01-10 |
| PL2525789T3 (pl) | 2022-01-03 |
| MX2012008300A (es) | 2012-11-23 |
| US20200046662A1 (en) | 2020-02-13 |
| HUE055771T2 (hu) | 2021-12-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant or registration |