MX353510B - Sulfuros y sulfonas de metiltetrazol. - Google Patents
Sulfuros y sulfonas de metiltetrazol.Info
- Publication number
- MX353510B MX353510B MX2013008288A MX2013008288A MX353510B MX 353510 B MX353510 B MX 353510B MX 2013008288 A MX2013008288 A MX 2013008288A MX 2013008288 A MX2013008288 A MX 2013008288A MX 353510 B MX353510 B MX 353510B
- Authority
- MX
- Mexico
- Prior art keywords
- thio
- methyltetrazole
- sulfones
- sulfides
- tetrazole
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D419/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms
- C07D419/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D419/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
La presente invención se refiere a un procedimiento para la preparación de un derivado de 1-metil-1H-tetrazol-5-tio que comprende reacción de un sustrato de halometilo con 1-metil-1H-tetrazol-5-tiol para obtener un compuesto de tio-éter, y oxidar el compuesto de tio-éter a la sulfona correspondiente. En caso de un sustrato de halometilo quiral, el derivado de diolsulfona quiral resultante es adecuado como bloque de construcción para compuestos tipo estatina.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP11151280 | 2011-01-18 | ||
EP11184697 | 2011-10-11 | ||
PCT/EP2012/050471 WO2012098050A1 (en) | 2011-01-18 | 2012-01-13 | Methyltetrazole sulfides and sulfones |
Publications (2)
Publication Number | Publication Date |
---|---|
MX2013008288A MX2013008288A (es) | 2013-09-13 |
MX353510B true MX353510B (es) | 2018-01-17 |
Family
ID=45470578
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2013008288A MX353510B (es) | 2011-01-18 | 2012-01-13 | Sulfuros y sulfonas de metiltetrazol. |
Country Status (8)
Country | Link |
---|---|
US (1) | US8865900B2 (es) |
EP (1) | EP2665721B1 (es) |
CN (1) | CN103313984B (es) |
HU (1) | HUE027729T2 (es) |
IL (1) | IL227166A (es) |
MX (1) | MX353510B (es) |
SI (1) | SI2665721T1 (es) |
WO (1) | WO2012098050A1 (es) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103360384A (zh) * | 2013-07-30 | 2013-10-23 | 浙江京新药业股份有限公司 | HMG-CoA还原酶抑制剂关键中间体的合成方法 |
CN112028881B (zh) * | 2020-09-02 | 2023-08-15 | 能特科技有限公司 | 一种瑞舒伐他汀钙的高级中间体r-1的合成方法 |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS6041034A (ja) * | 1983-08-15 | 1985-03-04 | Fuji Photo Film Co Ltd | ハロゲン化銀写真感光材料 |
DE69917204T2 (de) | 1998-08-05 | 2005-06-23 | Kaneka Corp. | Verfahren zur herstellung optisch aktiver 2-(6-(hydroxymethyl)-1,3-dioxan-4-yl) -essigsäure-derivate |
GB9903472D0 (en) | 1999-02-17 | 1999-04-07 | Zeneca Ltd | Chemical process |
US20020028826A1 (en) * | 2000-06-15 | 2002-03-07 | Robl Jeffrey A. | HMG-CoA reductase inhibitors and method |
NL1015744C2 (nl) | 2000-07-19 | 2002-01-22 | Dsm Nv | Werkwijze voor de bereiding van 2-(6-gesubstitueerde-1,3-dioxan-4-yl) azijnzuurderivaten. |
JP2004536813A (ja) | 2001-06-06 | 2004-12-09 | ブリストル−マイヤーズ スクイブ カンパニー | キラルジオールスルホンおよびジヒドロキシ酸HMGCoAレダクタ−ゼ阻害剤 |
GB0116212D0 (en) | 2001-07-03 | 2001-08-29 | Avecia Ltd | Process |
CZ299215B6 (cs) | 2005-06-29 | 2008-05-21 | Zentiva, A. S. | Zpusob výroby hemivápenaté soli (E)-7-[4-(4-fluorofenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidin-5-yl] (3R,5S)-3,5-dihydroxy-6-heptenovékyseliny |
KR101157314B1 (ko) * | 2009-06-05 | 2012-06-15 | 주식회사종근당 | 로수바스타틴의 신규한 제조방법, 이 제조에 유용한 중간체 화합물 및 그의 제조방법 |
-
2012
- 2012-01-13 EP EP12700192.3A patent/EP2665721B1/en active Active
- 2012-01-13 MX MX2013008288A patent/MX353510B/es active IP Right Grant
- 2012-01-13 US US13/979,755 patent/US8865900B2/en active Active
- 2012-01-13 HU HUE12700192A patent/HUE027729T2/en unknown
- 2012-01-13 SI SI201230306T patent/SI2665721T1/sl unknown
- 2012-01-13 WO PCT/EP2012/050471 patent/WO2012098050A1/en active Application Filing
- 2012-01-13 CN CN201280005641.5A patent/CN103313984B/zh active Active
-
2013
- 2013-06-24 IL IL227166A patent/IL227166A/en active IP Right Grant
Also Published As
Publication number | Publication date |
---|---|
US8865900B2 (en) | 2014-10-21 |
CN103313984A (zh) | 2013-09-18 |
CN103313984B (zh) | 2016-01-13 |
MX2013008288A (es) | 2013-09-13 |
IL227166A (en) | 2015-11-30 |
HUE027729T2 (en) | 2016-10-28 |
WO2012098050A1 (en) | 2012-07-26 |
EP2665721A1 (en) | 2013-11-27 |
US20130296563A1 (en) | 2013-11-07 |
SI2665721T1 (sl) | 2015-10-30 |
EP2665721B1 (en) | 2015-07-08 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG | Grant or registration |