MX353510B - Sulfuros y sulfonas de metiltetrazol. - Google Patents

Sulfuros y sulfonas de metiltetrazol.

Info

Publication number
MX353510B
MX353510B MX2013008288A MX2013008288A MX353510B MX 353510 B MX353510 B MX 353510B MX 2013008288 A MX2013008288 A MX 2013008288A MX 2013008288 A MX2013008288 A MX 2013008288A MX 353510 B MX353510 B MX 353510B
Authority
MX
Mexico
Prior art keywords
thio
methyltetrazole
sulfones
sulfides
tetrazole
Prior art date
Application number
MX2013008288A
Other languages
English (en)
Other versions
MX2013008288A (es
Inventor
De Lange Ben
Original Assignee
Dsm Sinochem Pharm Nl Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dsm Sinochem Pharm Nl Bv filed Critical Dsm Sinochem Pharm Nl Bv
Publication of MX2013008288A publication Critical patent/MX2013008288A/es
Publication of MX353510B publication Critical patent/MX353510B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D419/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms
    • C07D419/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D419/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

La presente invención se refiere a un procedimiento para la preparación de un derivado de 1-metil-1H-tetrazol-5-tio que comprende reacción de un sustrato de halometilo con 1-metil-1H-tetrazol-5-tiol para obtener un compuesto de tio-éter, y oxidar el compuesto de tio-éter a la sulfona correspondiente. En caso de un sustrato de halometilo quiral, el derivado de diolsulfona quiral resultante es adecuado como bloque de construcción para compuestos tipo estatina.
MX2013008288A 2011-01-18 2012-01-13 Sulfuros y sulfonas de metiltetrazol. MX353510B (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP11151280 2011-01-18
EP11184697 2011-10-11
PCT/EP2012/050471 WO2012098050A1 (en) 2011-01-18 2012-01-13 Methyltetrazole sulfides and sulfones

Publications (2)

Publication Number Publication Date
MX2013008288A MX2013008288A (es) 2013-09-13
MX353510B true MX353510B (es) 2018-01-17

Family

ID=45470578

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2013008288A MX353510B (es) 2011-01-18 2012-01-13 Sulfuros y sulfonas de metiltetrazol.

Country Status (8)

Country Link
US (1) US8865900B2 (es)
EP (1) EP2665721B1 (es)
CN (1) CN103313984B (es)
HU (1) HUE027729T2 (es)
IL (1) IL227166A (es)
MX (1) MX353510B (es)
SI (1) SI2665721T1 (es)
WO (1) WO2012098050A1 (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103360384A (zh) * 2013-07-30 2013-10-23 浙江京新药业股份有限公司 HMG-CoA还原酶抑制剂关键中间体的合成方法
CN112028881B (zh) * 2020-09-02 2023-08-15 能特科技有限公司 一种瑞舒伐他汀钙的高级中间体r-1的合成方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6041034A (ja) * 1983-08-15 1985-03-04 Fuji Photo Film Co Ltd ハロゲン化銀写真感光材料
DE69917204T2 (de) 1998-08-05 2005-06-23 Kaneka Corp. Verfahren zur herstellung optisch aktiver 2-(6-(hydroxymethyl)-1,3-dioxan-4-yl) -essigsäure-derivate
GB9903472D0 (en) 1999-02-17 1999-04-07 Zeneca Ltd Chemical process
US20020028826A1 (en) * 2000-06-15 2002-03-07 Robl Jeffrey A. HMG-CoA reductase inhibitors and method
NL1015744C2 (nl) 2000-07-19 2002-01-22 Dsm Nv Werkwijze voor de bereiding van 2-(6-gesubstitueerde-1,3-dioxan-4-yl) azijnzuurderivaten.
JP2004536813A (ja) 2001-06-06 2004-12-09 ブリストル−マイヤーズ　スクイブ　カンパニー キラルジオールスルホンおよびジヒドロキシ酸ＨＭＧＣｏＡレダクタ−ゼ阻害剤
GB0116212D0 (en) 2001-07-03 2001-08-29 Avecia Ltd Process
CZ299215B6 (cs) 2005-06-29 2008-05-21 Zentiva, A. S. Zpusob výroby hemivápenaté soli (E)-7-[4-(4-fluorofenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidin-5-yl] (3R,5S)-3,5-dihydroxy-6-heptenovékyseliny
KR101157314B1 (ko) * 2009-06-05 2012-06-15 주식회사종근당 로수바스타틴의 신규한 제조방법, 이 제조에 유용한 중간체 화합물 및 그의 제조방법

Also Published As

Publication number Publication date
US8865900B2 (en) 2014-10-21
CN103313984A (zh) 2013-09-18
CN103313984B (zh) 2016-01-13
MX2013008288A (es) 2013-09-13
IL227166A (en) 2015-11-30
HUE027729T2 (en) 2016-10-28
WO2012098050A1 (en) 2012-07-26
EP2665721A1 (en) 2013-11-27
US20130296563A1 (en) 2013-11-07
SI2665721T1 (sl) 2015-10-30
EP2665721B1 (en) 2015-07-08

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