MX346995B - Anticuerpos anti-notch1. - Google Patents

Anticuerpos anti-notch1.

Info

Publication number
MX346995B
MX346995B MX2013006875A MX2013006875A MX346995B MX 346995 B MX346995 B MX 346995B MX 2013006875 A MX2013006875 A MX 2013006875A MX 2013006875 A MX2013006875 A MX 2013006875A MX 346995 B MX346995 B MX 346995B
Authority
MX
Mexico
Prior art keywords
antibodies
notch1 antibodies
notch1
pharmaceutical compositions
methods
Prior art date
Application number
MX2013006875A
Other languages
English (en)
Spanish (es)
Other versions
MX2013006875A (es
Inventor
Kenneth G Geles
Bin-Bing Stephen Zhou
Lioudmila Gennadievna Tchistiakova
Yijie Gao
Joel Bard
Original Assignee
Wyeth Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Llc filed Critical Wyeth Llc
Publication of MX2013006875A publication Critical patent/MX2013006875A/es
Publication of MX346995B publication Critical patent/MX346995B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
MX2013006875A 2010-12-15 2011-12-09 Anticuerpos anti-notch1. MX346995B (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US42357810P 2010-12-15 2010-12-15
US201161552578P 2011-10-28 2011-10-28
PCT/IB2011/055595 WO2012080926A2 (en) 2010-12-15 2011-12-09 Anti-notch1 antibodies

Publications (2)

Publication Number Publication Date
MX2013006875A MX2013006875A (es) 2013-07-05
MX346995B true MX346995B (es) 2017-04-06

Family

ID=45444674

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2013006875A MX346995B (es) 2010-12-15 2011-12-09 Anticuerpos anti-notch1.

Country Status (19)

Country Link
US (2) US9127060B2 (OSRAM)
EP (1) EP2651977A2 (OSRAM)
JP (1) JP6016800B2 (OSRAM)
KR (2) KR20150088334A (OSRAM)
CN (2) CN103547594B (OSRAM)
AR (1) AR084315A1 (OSRAM)
AU (2) AU2011342799B2 (OSRAM)
BR (1) BR112013015122A2 (OSRAM)
CA (1) CA2821130C (OSRAM)
CO (1) CO6791565A2 (OSRAM)
MX (1) MX346995B (OSRAM)
NZ (1) NZ611785A (OSRAM)
PE (1) PE20141109A1 (OSRAM)
PH (2) PH12013501255A1 (OSRAM)
RU (1) RU2622083C2 (OSRAM)
SA (1) SA111330060B1 (OSRAM)
SG (1) SG191039A1 (OSRAM)
TW (1) TWI471333B (OSRAM)
WO (1) WO2012080926A2 (OSRAM)

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EP2032166B1 (en) 2006-06-13 2013-04-10 OncoMed Pharmaceuticals, Inc. Compositions and methods for diagnosing and treating cancer
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CA2676008A1 (en) 2007-01-24 2008-07-31 Oncomed Pharmaceuticals, Inc. Compositions and methods for diagnosing and treating cancer
PE20090321A1 (es) 2007-06-04 2009-04-20 Genentech Inc Anticuerpos anti-notch1 nrr, metodo de preparacion y composicion farmaceutica
EP2443151A1 (en) 2009-06-18 2012-04-25 Pfizer Inc. Anti notch-1 antibodies
JP6016800B2 (ja) 2010-12-15 2016-10-26 ワイス・エルエルシー 抗ノッチ１抗体
US20150209406A1 (en) 2012-09-07 2015-07-30 Massachusetts Eye And Ear Infirmary Methods and compositions for regenerating hair cells and/or supporting cells
WO2014047426A1 (en) * 2012-09-21 2014-03-27 Oncomed Pharmaceuticals, Inc. Methods of treating hematological malignancies with notch1 antibodies
TW201431880A (zh) 2012-11-07 2014-08-16 Pfizer 抗切口３（ａｎｔｉ－ｎｏｔｃｈ３）抗體及抗體－藥物共軛體
BR112017000130A2 (pt) 2014-07-11 2018-01-09 Genentech Inc método para atenuar a toxicidade associada à inibição da via de notch e método de tratamento do câncer
US11370823B2 (en) 2014-10-29 2022-06-28 Massachusetts Eye And Ear Infirmary Efficient delivery of therapeutic molecules to cells of the inner ear
WO2017072208A1 (en) * 2015-10-29 2017-05-04 F. Hoffmann-La Roche Ag Transgenic rabbit with common light chain
CN105585636B (zh) * 2015-11-24 2020-03-03 南方医科大学 一种人NOTCH1 NICD蛋白Ser2162位点磷酸化抗体及其制备方法和应用
US11590152B2 (en) 2018-01-26 2023-02-28 Massachusetts Eye And Ear Infirmary Treatment of hearing loss
JP7562417B2 (ja) * 2018-04-10 2024-10-07 スティヒティング・サンクイン・ブルートフォールズィーニング キメラノッチ受容体
CN113365697B (zh) * 2018-09-25 2024-07-19 百进生物科技公司 抗tlr9药剂和组合物及其制备方法和使用方法
KR102499678B1 (ko) * 2020-02-27 2023-02-15 주식회사 베르티스 암의 진단용 조성물
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WO2025149667A1 (en) 2024-01-12 2025-07-17 Pheon Therapeutics Ltd Antibody drug conjugates and uses thereof

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Also Published As

Publication number Publication date
CN103547594B (zh) 2016-05-11
PE20141109A1 (es) 2014-09-24
AU2011342799B2 (en) 2016-06-09
PH12017500864A1 (en) 2017-12-11
AR084315A1 (es) 2013-05-08
KR20150088334A (ko) 2015-07-31
JP6016800B2 (ja) 2016-10-26
TWI471333B (zh) 2015-02-01
WO2012080926A3 (en) 2012-10-04
CO6791565A2 (es) 2013-11-14
CN103547594A (zh) 2014-01-29
AU2016219704A1 (en) 2016-09-15
NZ611785A (en) 2015-04-24
MX2013006875A (es) 2013-07-05
JP2014503205A (ja) 2014-02-13
CA2821130A1 (en) 2012-06-21
SG191039A1 (en) 2013-08-30
RU2622083C2 (ru) 2017-06-09
EP2651977A2 (en) 2013-10-23
US9127060B2 (en) 2015-09-08
PH12013501255A1 (en) 2013-08-05
US20160002331A1 (en) 2016-01-07
KR101580726B1 (ko) 2015-12-29
AU2011342799A1 (en) 2013-07-04
HK1194388A1 (zh) 2014-10-17
TW201302787A (zh) 2013-01-16
US20130266594A1 (en) 2013-10-10
CA2821130C (en) 2017-11-07
WO2012080926A2 (en) 2012-06-21
RU2013126494A (ru) 2015-01-20
KR20130108430A (ko) 2013-10-02
SA111330060B1 (ar) 2015-06-04
CN105884896A (zh) 2016-08-24
BR112013015122A2 (pt) 2017-05-30

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