MX345820B - Formulacion del precursor de hidrogel y proceso de produccion del mismo. - Google Patents

Formulacion del precursor de hidrogel y proceso de produccion del mismo.

Info

Publication number
MX345820B
MX345820B MX2012012248A MX2012012248A MX345820B MX 345820 B MX345820 B MX 345820B MX 2012012248 A MX2012012248 A MX 2012012248A MX 2012012248 A MX2012012248 A MX 2012012248A MX 345820 B MX345820 B MX 345820B
Authority
MX
Mexico
Prior art keywords
precursor formulation
formulation
production process
hydrogel precursor
hydrogel
Prior art date
Application number
MX2012012248A
Other languages
English (en)
Other versions
MX2012012248A (es
Inventor
Rizzi Simone
Lutolf Matthias
Original Assignee
Qgel Sa *
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Qgel Sa * filed Critical Qgel Sa *
Publication of MX2012012248A publication Critical patent/MX2012012248A/es
Publication of MX345820B publication Critical patent/MX345820B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0068—General culture methods using substrates
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
    • C08G65/32—Polymers modified by chemical after-treatment
    • C08G65/329—Polymers modified by chemical after-treatment with organic compounds
    • C08G65/334—Polymers modified by chemical after-treatment with organic compounds containing sulfur
    • C08G65/3344—Polymers modified by chemical after-treatment with organic compounds containing sulfur containing oxygen in addition to sulfur
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/30—Synthetic polymers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/50—Proteins

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Polymers & Plastics (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
  • Processes Of Treating Macromolecular Substances (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Other Resins Obtained By Reactions Not Involving Carbon-To-Carbon Unsaturated Bonds (AREA)
  • Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
  • Materials For Medical Uses (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La presente invención se refiere a una formulación del precursor de hidrogel, su proceso de producción así como un kit que comprende tal formulación y un método de producción de un hidrogel usando tal formulación. La formulación del precursor comprende al menos un compuesto estructural, preferiblemente vinil sulfona (ramificada acrilada) poli(etilen glicol), y al menos un compuesto de ligadura, preferiblemente un péptido con dos cisteínas, en donde el compuesto estructural y el compuesto de ligadura son polimerizables por una reacción selectiva entre un nucleófilo y un grupo o enlace insaturado conjugado. La formulación del precursor está en la forma de un polvo.
MX2012012248A 2010-04-22 2011-04-19 Formulacion del precursor de hidrogel y proceso de produccion del mismo. MX345820B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP10160796A EP2380920A1 (en) 2010-04-22 2010-04-22 Hydrogel precursor formulation and production process thereof
PCT/EP2011/056187 WO2011131642A1 (en) 2010-04-22 2011-04-19 Hydrogel precursor formulation and production process thereof

Publications (2)

Publication Number Publication Date
MX2012012248A MX2012012248A (es) 2012-11-23
MX345820B true MX345820B (es) 2017-02-16

Family

ID=42224660

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2012012248A MX345820B (es) 2010-04-22 2011-04-19 Formulacion del precursor de hidrogel y proceso de produccion del mismo.

Country Status (9)

Country Link
US (3) US20130040357A1 (es)
EP (2) EP2380920A1 (es)
JP (2) JP6185837B2 (es)
CN (1) CN102858845B (es)
AU (1) AU2011244362B2 (es)
BR (1) BR112012027053B1 (es)
MX (1) MX345820B (es)
RU (1) RU2561108C2 (es)
WO (1) WO2011131642A1 (es)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2888951B1 (fr) 2005-07-20 2008-02-08 Essilor Int Composant optique pixellise aleatoirement, son procede de fabrication, et son utilisation dans la fabrication d'un element optique transparent
WO2011140441A2 (en) 2010-05-06 2011-11-10 Children's Hospital Medical Center Methods and systems for converting precursor cells into intestinal tissues through directed differentiation
WO2013078770A1 (en) * 2011-12-02 2013-06-06 The Hong Kong University Of Science And Technology Injectable gelling material
EP2796873A1 (en) * 2013-04-25 2014-10-29 QGel SA Method for a cell-based drug screening assay and the use thereof
WO2015183920A2 (en) 2014-05-28 2015-12-03 Children's Hospital Medical Center Methods and systems for converting precursor cells into gastric tissues through directed differentiation
WO2016061464A1 (en) 2014-10-17 2016-04-21 Children's Hospital Center, D/B/A Cincinnati Children's Hospital Medical Center In vivo model of human small intetine using pluripotent stem cells and methods of making and using same
WO2017040989A1 (en) * 2015-09-04 2017-03-09 Saint Louis University Custom multiwell plate design for rapid preparation and assembly of photo-patterned hydrogels
CN116790476A (zh) 2016-05-05 2023-09-22 儿童医院医疗中心 用于体外制造胃底组织的方法和与其相关的组合物
EP3275997A1 (en) * 2016-07-28 2018-01-31 QGel SA Hydrogel precursor formulation and the use thereof
WO2018106628A1 (en) 2016-12-05 2018-06-14 Children's Hospital Medical Center Colonic organoids and methods of making and using same
EP3789049A1 (en) 2019-09-06 2021-03-10 QGel SA Method for obtaining healthy intestinal organoids
BR112022010694A2 (pt) 2019-12-04 2022-08-23 Precision Cancer Tech Inc Método e kit para crescimento celular
CN113980292A (zh) * 2021-10-03 2022-01-28 淮阴工学院 一种新型生物相容性聚醚砜基水凝胶的制备方法
CN114652903A (zh) * 2022-05-06 2022-06-24 上海益思妙医疗器械有限公司 一种快速聚合医用水凝胶及其制备方法

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9613858D0 (en) 1996-07-02 1996-09-04 Cortecs Ltd Hydrophobic preparations
US6201072B1 (en) * 1997-10-03 2001-03-13 Macromed, Inc. Biodegradable low molecular weight triblock poly(lactide-co- glycolide) polyethylene glycol copolymers having reverse thermal gelation properties
US6703047B2 (en) * 2001-02-02 2004-03-09 Incept Llc Dehydrated hydrogel precursor-based, tissue adherent compositions and methods of use
US6958212B1 (en) * 1999-02-01 2005-10-25 Eidgenossische Technische Hochschule Zurich Conjugate addition reactions for the controlled delivery of pharmaceutically active compounds
ATE514729T1 (de) 1999-02-01 2011-07-15 Eidgenoess Tech Hochschule Biomaterialien die durch nukleophile reaktion auf konjugierten ungesättigten gruppen addiert sind
DK1196442T3 (da) 1999-07-21 2006-05-08 Amgen Inc VGF-polypeptider og fremgangsmåder til behandling af VGF-relaterede lidelser
JP2003508564A (ja) * 1999-08-27 2003-03-04 コヒージョン テクノロジーズ， インコーポレイテッド 高強度の医療用シーラントとして使用するための相互侵入ポリマー網目構造を形成する組成物
BR0213937A (pt) * 2001-11-07 2004-10-26 Univ Zuerich Matriz sintética para encravamento celular controlado e regeneração de tecido
SE0403014D0 (sv) * 2004-12-10 2004-12-10 Straumann Holding Ag New protein formulation
AU2005318097A1 (en) * 2004-12-22 2006-06-29 Kuros Biosurgery Ag Michael-type addition reaction functionalised peg hydrogels with factor XIIIA incorporated biofactors
TWI436793B (zh) * 2006-08-02 2014-05-11 Baxter Int 快速作用之乾密封膠及其使用和製造方法
JP2010519183A (ja) 2007-02-06 2010-06-03 インセプト エルエルシー 生理溶液の溶出のためのタンパク質の沈殿を用いる重合
US20090042825A1 (en) 2007-08-06 2009-02-12 Majed Matar Composition, method of preparation & application of concentrated formulations of condensed nucleic acids with a cationic lipopolymer
AU2009240662B2 (en) * 2008-04-22 2015-07-02 Angiotech Pharmaceuticals, Inc. Biocompatible crosslinked hydrogels, drug-loaded hydrogels and methods of using the same

Also Published As

Publication number Publication date
MX2012012248A (es) 2012-11-23
US20180119092A1 (en) 2018-05-03
EP2561005A1 (en) 2013-02-27
AU2011244362A1 (en) 2012-11-15
BR112012027053B1 (pt) 2020-03-03
JP2016033139A (ja) 2016-03-10
US20150247119A1 (en) 2015-09-03
CN102858845A (zh) 2013-01-02
EP2561005B1 (en) 2016-11-09
JP6185837B2 (ja) 2017-08-23
RU2561108C2 (ru) 2015-08-20
EP2380920A1 (en) 2011-10-26
US9850461B2 (en) 2017-12-26
BR112012027053A2 (pt) 2016-07-19
RU2012149729A (ru) 2014-05-27
AU2011244362B2 (en) 2014-12-04
JP2013531691A (ja) 2013-08-08
CN102858845B (zh) 2017-05-03
US20130040357A1 (en) 2013-02-14
WO2011131642A1 (en) 2011-10-27

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