MX341241B - Derivados [2.2.2] bicíclicos y métodos de uso. - Google Patents
Derivados [2.2.2] bicíclicos y métodos de uso.Info
- Publication number
- MX341241B MX341241B MX2011006576A MX2011006576A MX341241B MX 341241 B MX341241 B MX 341241B MX 2011006576 A MX2011006576 A MX 2011006576A MX 2011006576 A MX2011006576 A MX 2011006576A MX 341241 B MX341241 B MX 341241B
- Authority
- MX
- Mexico
- Prior art keywords
- reduces
- methods
- bicyclic derivatives
- subjects
- alcoholics
- Prior art date
Links
- 125000002619 bicyclic group Chemical group 0.000 title 1
- BPYKTIZUTYGOLE-IFADSCNNSA-N Bilirubin Chemical compound N1C(=O)C(C)=C(C=C)\C1=C\C1=C(C)C(CCC(O)=O)=C(CC2=C(C(C)=C(\C=C/3C(=C(C=C)C(=O)N\3)C)N2)CCC(O)=O)N1 BPYKTIZUTYGOLE-IFADSCNNSA-N 0.000 abstract 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 2
- 206010010904 Convulsion Diseases 0.000 abstract 1
- 206010013954 Dysphoria Diseases 0.000 abstract 1
- 235000019788 craving Nutrition 0.000 abstract 1
- 230000001544 dysphoric effect Effects 0.000 abstract 1
- 230000001037 epileptic effect Effects 0.000 abstract 1
- 210000003743 erythrocyte Anatomy 0.000 abstract 1
- 230000003908 liver function Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 238000004062 sedimentation Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/28—Compounds containing heavy metals
- A61K31/315—Zinc compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/30—Zinc; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
Landscapes
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Emergency Medicine (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Addiction (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Toxicology (AREA)
- Inorganic Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
La administración de una sal del ácido biciclo [2.2.2] octano-2-carbónico reduce la diosforia en sujetos disfóricos, disminuye el anhelo de etanol en alcohólicos, reduce la tase de sedimentacon de eritrocitos y el nivel de maracadores de la función gepatica (ast, lat y bilirrubina) en sujetos humanos, y reduce el numero o intensidad de convulsiones en epilépticos.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13956208P | 2008-12-20 | 2008-12-20 | |
| PCT/US2009/068920 WO2010071872A2 (en) | 2008-12-20 | 2009-12-21 | [2.2.2] bicyclic derivatives and methods of use |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX2011006576A MX2011006576A (es) | 2011-11-04 |
| MX341241B true MX341241B (es) | 2016-08-08 |
Family
ID=42269293
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2011006576A MX341241B (es) | 2008-12-20 | 2009-12-21 | Derivados [2.2.2] bicíclicos y métodos de uso. |
Country Status (11)
| Country | Link |
|---|---|
| US (4) | US20110313037A1 (es) |
| EP (1) | EP2396002B1 (es) |
| JP (1) | JP6108423B2 (es) |
| KR (2) | KR101840178B1 (es) |
| CN (2) | CN102300573A (es) |
| AU (1) | AU2009327316B2 (es) |
| CA (2) | CA2747803C (es) |
| IL (2) | IL213609A (es) |
| MX (1) | MX341241B (es) |
| RU (2) | RU2545876C2 (es) |
| WO (1) | WO2010071872A2 (es) |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4235871A (en) | 1978-02-24 | 1980-11-25 | Papahadjopoulos Demetrios P | Method of encapsulating biologically active materials in lipid vesicles |
| US4501728A (en) | 1983-01-06 | 1985-02-26 | Technology Unlimited, Inc. | Masking of liposomes from RES recognition |
| US4837028A (en) | 1986-12-24 | 1989-06-06 | Liposome Technology, Inc. | Liposomes with enhanced circulation time |
| RU2091366C1 (ru) * | 1992-06-16 | 1997-09-27 | Инесса Ивановна Крицкая | Натриевая соль бицикло(2.2.2.)октан -2-карбоновой кислоты, проявляющая противосудорожную активность |
| DE4231085A1 (de) * | 1992-09-12 | 1994-03-17 | Desitin Arzneimittel Gmbh | VPA-analoge Antiepileptika |
| WO1999023056A1 (fr) * | 1997-11-05 | 1999-05-14 | Susanna Askanazovna Saakian | Nouveaux medicaments anti-convulsions |
| RU2183454C1 (ru) * | 2000-12-18 | 2002-06-20 | Чухрова Марина Геннадьевна | Средство для купирования наркотического абстинентного синдрома |
| DE10224170A1 (de) * | 2002-05-31 | 2003-12-11 | Desitin Arzneimittel Gmbh | Pharmazeutische Zusammensetzung mit verzögerter Wirkstofffreisetzung |
| RU2210360C1 (ru) * | 2002-09-19 | 2003-08-20 | Общество С Ограниченной Ответственностью "Консорциум-Пик" | Психотропное средство |
| JP2008126189A (ja) * | 2006-11-24 | 2008-06-05 | Hiroyuki Hoshino | 静電界式水素イオン低減装置 |
| RU2347523C2 (ru) * | 2007-10-29 | 2009-02-27 | Государственное учреждение здравоохранения "Свердловская областная клиническая больница N 1" (СОКБ N1) | Способ оценки тяжести состояния больного очаговой формой клещевого энцефалита |
-
2009
- 2009-12-21 CN CN2009801555955A patent/CN102300573A/zh active Pending
- 2009-12-21 JP JP2011542530A patent/JP6108423B2/ja active Active
- 2009-12-21 CA CA2747803A patent/CA2747803C/en active Active
- 2009-12-21 AU AU2009327316A patent/AU2009327316B2/en active Active
- 2009-12-21 KR KR1020177010257A patent/KR101840178B1/ko active IP Right Grant
- 2009-12-21 KR KR1020117016773A patent/KR20110116135A/ko active Search and Examination
- 2009-12-21 CN CN201610662515.7A patent/CN106309418A/zh active Pending
- 2009-12-21 EP EP09833871.8A patent/EP2396002B1/en active Active
- 2009-12-21 RU RU2011127331/15A patent/RU2545876C2/ru active
- 2009-12-21 US US13/140,259 patent/US20110313037A1/en not_active Abandoned
- 2009-12-21 RU RU2015103607A patent/RU2691406C2/ru active
- 2009-12-21 MX MX2011006576A patent/MX341241B/es active IP Right Grant
- 2009-12-21 CA CA3075760A patent/CA3075760C/en active Active
- 2009-12-21 WO PCT/US2009/068920 patent/WO2010071872A2/en active Application Filing
-
2011
- 2011-06-16 IL IL213609A patent/IL213609A/en active IP Right Grant
-
2016
- 2016-07-19 IL IL246841A patent/IL246841B/en active IP Right Grant
- 2016-09-15 US US15/265,983 patent/US9943493B2/en active Active
-
2018
- 2018-03-13 US US15/919,361 patent/US10751307B2/en active Active
-
2020
- 2020-03-18 US US16/823,309 patent/US10966944B2/en active Active
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| GB | Transfer or rights |
Owner name: ASE PHARMACEUTICALS, LLC |
|
| FG | Grant or registration |