MX340458B - Método para elaborar micropartículas de liberación sostenida. - Google Patents
Método para elaborar micropartículas de liberación sostenida.Info
- Publication number
- MX340458B MX340458B MX2011005904A MX2011005904A MX340458B MX 340458 B MX340458 B MX 340458B MX 2011005904 A MX2011005904 A MX 2011005904A MX 2011005904 A MX2011005904 A MX 2011005904A MX 340458 B MX340458 B MX 340458B
- Authority
- MX
- Mexico
- Prior art keywords
- sustained release
- release microparticles
- active agent
- making sustained
- various embodiments
- Prior art date
Links
- 239000011859 microparticle Substances 0.000 title abstract 6
- 238000013268 sustained release Methods 0.000 title abstract 3
- 239000012730 sustained-release form Substances 0.000 title abstract 3
- 238000004519 manufacturing process Methods 0.000 title 1
- 238000000034 method Methods 0.000 abstract 3
- 239000013543 active substance Substances 0.000 abstract 2
- 238000010790 dilution Methods 0.000 abstract 2
- 239000012895 dilution Substances 0.000 abstract 2
- 239000006185 dispersion Substances 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 229920000642 polymer Polymers 0.000 abstract 1
- 230000002459 sustained effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
- A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
- A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Manufacturing Of Micro-Capsules (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Se describen diversas modalidades de un método para preparar micropartículas de liberación sostenida. En una modalidad, el método incluye las etapas de formar una fase dispersa de un agente activo en un polímero y combinar la fase dispersa con una fase continua para formar una dispersión de micropartículas. El método además incluye la etapa de agregar una cantidad medida de una composición de dilución a la dispersión de micropartículas. Se ha encontrado en este documento que las diversas modalidades para preparar micropartículas de liberación sostenida, al utilizar diversas cantidades de la composición de dilución, altera la tasa de liberación de la micropartícula de liberación sostenida para el agente activo específico.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12/328,136 US20100143479A1 (en) | 2008-12-04 | 2008-12-04 | Method of making sustained release microparticles |
| PCT/US2009/066212 WO2010065513A1 (en) | 2008-12-04 | 2009-12-01 | Method of making sustained release microparticles |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX2011005904A MX2011005904A (es) | 2011-09-27 |
| MX340458B true MX340458B (es) | 2016-07-08 |
Family
ID=42231354
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2011005904A MX340458B (es) | 2008-12-04 | 2009-12-01 | Método para elaborar micropartículas de liberación sostenida. |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US20100143479A1 (es) |
| EP (1) | EP2379055B1 (es) |
| JP (1) | JP6172887B2 (es) |
| CN (1) | CN102271660B (es) |
| BR (1) | BRPI0922821A2 (es) |
| CA (2) | CA2745784A1 (es) |
| ES (1) | ES2655890T3 (es) |
| MX (1) | MX340458B (es) |
| WO (1) | WO2010065513A1 (es) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2471303A (en) | 2009-06-24 | 2010-12-29 | Bell Flavors & Fragrances Duft Und Aroma Gmbh | Microparticles and method of making microparticles |
| CN103191021A (zh) * | 2012-01-10 | 2013-07-10 | 山东绿叶制药有限公司 | 一种连续生产微球的设备及其应用 |
| JP6135292B2 (ja) * | 2013-05-10 | 2017-05-31 | ニプロ株式会社 | マイクロカプセル製剤の製造方法 |
| JP2016102093A (ja) * | 2014-11-28 | 2016-06-02 | ニプロ株式会社 | 塩基性の求核化合物を含有するマイクロカプセルの製造方法 |
| BR112018009644A2 (pt) | 2015-11-12 | 2018-11-06 | Graybug Vision Inc | micropartículas agregantes sólidas modificadas na superfície, material injetável, processo para preparação de micropartículas agregantes sólidas modificadas na superfície, método para tratamento de um distúrbio ocular, e, uso de micropartículas agregantes sólidas modificadas na superfície |
| US20190380967A1 (en) * | 2017-01-23 | 2019-12-19 | Savior Lifetec Corporation | Preparation of microparticles of an active ingredient |
| WO2018175922A1 (en) | 2017-03-23 | 2018-09-27 | Graybug Vision, Inc. | Drugs and compositions for the treatment of ocular disorders |
| CN111201040A (zh) | 2017-05-10 | 2020-05-26 | 灰色视觉公司 | 用于医学疗法的缓释微粒及其悬浮液 |
| KR20210029210A (ko) | 2018-06-29 | 2021-03-15 | 악스톤 바이오사이언시스 코퍼레이션 | 초장기 작용 인슐린-fc 융합 단백질 및 사용 방법 |
| EP4125823A1 (en) | 2020-03-30 | 2023-02-08 | Biological E Limited | Risperidone microspheres, process for their prepartion and uses thereof |
| CA3267932A1 (en) | 2022-10-05 | 2024-04-11 | Mireca Medicines Gmbh | MICROPARCEL AND IMPLANT FORMULATIONS FOR ANALOGUE CGMP THERAPY |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5792477A (en) * | 1996-05-07 | 1998-08-11 | Alkermes Controlled Therapeutics, Inc. Ii | Preparation of extended shelf-life biodegradable, biocompatible microparticles containing a biologically active agent |
| US5945126A (en) * | 1997-02-13 | 1999-08-31 | Oakwood Laboratories L.L.C. | Continuous microsphere process |
| US6270802B1 (en) * | 1998-10-28 | 2001-08-07 | Oakwood Laboratories L.L.C. | Method and apparatus for formulating microspheres and microcapsules |
| US6495166B1 (en) | 1999-11-12 | 2002-12-17 | Alkermes Controlled Therapeutics Inc. | Apparatus and method for preparing microparticles using in-line solvent extraction |
| US6705757B2 (en) * | 1999-11-12 | 2004-03-16 | Alkermes Controlled Therapeutics, Inc. Ii | Method and apparatus for preparing microparticles using in-line solvent extraction |
| US20070207211A1 (en) * | 2003-04-10 | 2007-09-06 | Pr Pharmaceuticals, Inc. | Emulsion-based microparticles and methods for the production thereof |
| CA2915574C (en) * | 2003-07-18 | 2017-02-07 | Oakwood Laboratories, L.L.C. | Prevention of molecular weight reduction of the polymer, impurity formation and gelling in polymer compositions |
-
2008
- 2008-12-04 US US12/328,136 patent/US20100143479A1/en not_active Abandoned
-
2009
- 2009-12-01 CA CA2745784A patent/CA2745784A1/en active Pending
- 2009-12-01 CN CN200980153238.5A patent/CN102271660B/zh not_active Expired - Fee Related
- 2009-12-01 CA CA2765695A patent/CA2765695C/en not_active Expired - Fee Related
- 2009-12-01 JP JP2011539632A patent/JP6172887B2/ja not_active Expired - Fee Related
- 2009-12-01 BR BRPI0922821A patent/BRPI0922821A2/pt not_active IP Right Cessation
- 2009-12-01 WO PCT/US2009/066212 patent/WO2010065513A1/en not_active Ceased
- 2009-12-01 EP EP09830961.0A patent/EP2379055B1/en not_active Revoked
- 2009-12-01 ES ES09830961.0T patent/ES2655890T3/es active Active
- 2009-12-01 MX MX2011005904A patent/MX340458B/es active IP Right Grant
-
2018
- 2018-02-23 US US15/903,853 patent/US20180177785A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| EP2379055A1 (en) | 2011-10-26 |
| CA2745784A1 (en) | 2010-06-10 |
| EP2379055A4 (en) | 2012-06-13 |
| ES2655890T3 (es) | 2018-02-22 |
| MX2011005904A (es) | 2011-09-27 |
| WO2010065513A1 (en) | 2010-06-10 |
| JP6172887B2 (ja) | 2017-08-02 |
| JP2012511003A (ja) | 2012-05-17 |
| CA2765695A1 (en) | 2010-06-10 |
| BRPI0922821A2 (pt) | 2015-12-22 |
| CA2765695C (en) | 2018-01-02 |
| US20180177785A1 (en) | 2018-06-28 |
| EP2379055B1 (en) | 2017-11-08 |
| US20100143479A1 (en) | 2010-06-10 |
| CN102271660B (zh) | 2018-04-06 |
| CN102271660A (zh) | 2011-12-07 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant or registration |