WO2014060443A3 - A composite scaffold for use as a tissue engineering implant - Google Patents

A composite scaffold for use as a tissue engineering implant Download PDF

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Publication number
WO2014060443A3
WO2014060443A3 PCT/EP2013/071566 EP2013071566W WO2014060443A3 WO 2014060443 A3 WO2014060443 A3 WO 2014060443A3 EP 2013071566 W EP2013071566 W EP 2013071566W WO 2014060443 A3 WO2014060443 A3 WO 2014060443A3
Authority
WO
WIPO (PCT)
Prior art keywords
matrix
scaffold
microparticle
tissue engineering
active agent
Prior art date
Application number
PCT/EP2013/071566
Other languages
French (fr)
Other versions
WO2014060443A2 (en
Inventor
Fergal O'brien
Adolfo LOPEZ-NORIEGA
Elaine QUINLAN
Sonia PARTAP
Helena Kelly
Sally-Ann Cryan
Original Assignee
Royal College Of Surgeons In Ireland
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Royal College Of Surgeons In Ireland filed Critical Royal College Of Surgeons In Ireland
Publication of WO2014060443A2 publication Critical patent/WO2014060443A2/en
Publication of WO2014060443A3 publication Critical patent/WO2014060443A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
    • A61L27/44—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
    • A61L27/46—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix with phosphorus-containing inorganic fillers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
    • A61L27/44—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
    • A61L27/48—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix with macromolecular fillers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/56—Porous materials, e.g. foams or sponges
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/58—Materials at least partially resorbable by the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/412—Tissue-regenerating or healing or proliferative agents
    • A61L2300/414—Growth factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
    • A61L2300/62—Encapsulated active agents, e.g. emulsified droplets
    • A61L2300/622—Microcapsules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Dermatology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Epidemiology (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Materials Engineering (AREA)
  • Composite Materials (AREA)
  • Inorganic Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Materials For Medical Uses (AREA)

Abstract

A composite scaffold for use as a tissue engineering implant A composite scaffold for use in tissue engineering applications comprises a porous scaffold matrix comprising at least an organic material, a first microparticle preparation distributed in the scaffold matrix, and a second microparticle preparation distributed in the scaffold matrix. The first microparticle preparation comprises microparticles having a first polymeric microparticle matrix and a first active agent within the matrix such that the first active agent is capable of being released from the microparticle matrix/scaffold at a controlled rate. The second microparticle preparation comprises microparticles having a second microparticle matrix and a second active agent within the matrix such that the second active agent is capable of being released from the second microparticle matrix/scaffold at a controlled rate.
PCT/EP2013/071566 2012-10-15 2013-10-15 A composite scaffold for use as a tissue engineering implant WO2014060443A2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP12188511.5 2012-10-15
EP12188511 2012-10-15
US201261716644P 2012-10-22 2012-10-22
US61/716,644 2012-10-22

Publications (2)

Publication Number Publication Date
WO2014060443A2 WO2014060443A2 (en) 2014-04-24
WO2014060443A3 true WO2014060443A3 (en) 2014-10-30

Family

ID=47022568

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2013/071566 WO2014060443A2 (en) 2012-10-15 2013-10-15 A composite scaffold for use as a tissue engineering implant

Country Status (1)

Country Link
WO (1) WO2014060443A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017146819A1 (en) * 2016-02-22 2017-08-31 The Methodist Hospital Implantable drug delivery systems
CN110801513A (en) * 2019-12-17 2020-02-18 河南汇博医疗股份有限公司 Composite sustained-release particle loaded with growth factor and preparation method thereof
CN114504679A (en) * 2021-11-17 2022-05-17 上海交通大学医学院附属第九人民医院 Biological scaffold, biological scaffold-microsphere slow release system, preparation method and application thereof
CN114404663A (en) * 2022-01-07 2022-04-29 浙江瑞谷生物科技有限公司 Bone repair material with inflammation relieving characteristic and preparation method thereof

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006095154A2 (en) * 2005-03-07 2006-09-14 Cambridge Enterprise Limited Biomaterial
WO2008096334A2 (en) * 2007-02-09 2008-08-14 Royal College Of Surgeons In Ireland A collagen/hydroxyapatite composite scaffold, and process for the production thereof
US20100112029A1 (en) * 2008-10-30 2010-05-06 Warsaw Orthopedic, Inc. Compositions and methods for nucleus pulposus regeneration
US20120253470A1 (en) * 2011-03-30 2012-10-04 President And Fellows Of Harvard College Compositions for bone tissue repair and uses thereof

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2407580B (en) 2003-10-28 2009-02-25 Univ Cambridge Tech Biomaterial
EP1958622A1 (en) 2006-11-07 2008-08-20 Royal College of Surgeons in Ireland Method of producing microcapsules

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006095154A2 (en) * 2005-03-07 2006-09-14 Cambridge Enterprise Limited Biomaterial
WO2008096334A2 (en) * 2007-02-09 2008-08-14 Royal College Of Surgeons In Ireland A collagen/hydroxyapatite composite scaffold, and process for the production thereof
US20100112029A1 (en) * 2008-10-30 2010-05-06 Warsaw Orthopedic, Inc. Compositions and methods for nucleus pulposus regeneration
US20120253470A1 (en) * 2011-03-30 2012-10-04 President And Fellows Of Harvard College Compositions for bone tissue repair and uses thereof

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
ALICIA J. DEFAIL ET AL: "Controlled release of bioactive doxorubicin from microspheres embedded within gelatin scaffolds", JOURNAL OF BIOMEDICAL MATERIALS RESEARCH. PART A, vol. 79A, no. 4, 29 August 2006 (2006-08-29), HOBOKEN, NY, US, pages 954 - 962, XP055135632, ISSN: 1549-3296, DOI: 10.1002/jbm.a.30865 *
CHEN F M ET AL: "Toward delivery of multiple growth factors in tissue engineering", BIOMATERIALS, ELSEVIER SCIENCE PUBLISHERS BV., BARKING, GB, vol. 31, no. 24, 1 August 2010 (2010-08-01), pages 6279 - 6308, XP027474530, ISSN: 0142-9612, [retrieved on 20100521], DOI: 10.1016/J.BIOMATERIALS.2010.04.053 *
K. WHANG ET AL: "Ectopic bone formation via rhBMP-2 delivery from porous bioabsorbable polymer scaffolds", JOURNAL OF BIOMEDICAL MATERIALS RESEARCH, vol. 42, no. 4, 15 December 1998 (1998-12-15), pages 491 - 499, XP055135603, ISSN: 0021-9304, DOI: 10.1002/(SICI)1097-4636(19981215)42:4<491::AID-JBM3>3.0.CO;2-F *
LIU ET AL: "A novel trans-lymphatic drug delivery system: Implantable gelatin sponge impregnated with PLGA-paclitaxel microspheres", BIOMATERIALS, ELSEVIER SCIENCE PUBLISHERS BV., BARKING, GB, vol. 28, no. 21, 29 April 2007 (2007-04-29), pages 3236 - 3244, XP022051971, ISSN: 0142-9612, DOI: 10.1016/J.BIOMATERIALS.2007.03.022 *
PATEL Z S ET AL: "Dual delivery of an angiogenic and an osteogenic growth factor for bone regeneration in a critical size defect model", BONE, PERGAMON PRESS., OXFORD, GB, vol. 43, no. 5, 1 November 2008 (2008-11-01), pages 931 - 940, XP025533554, ISSN: 8756-3282, [retrieved on 20080714], DOI: 10.1016/J.BONE.2008.06.019 *
TAN H ET AL: "Gelatin/chitosan/hyaluronan scaffold integrated with PLGA microspheres for cartilage tissue engineering", ACTA BIOMATERIALIA, ELSEVIER, AMSTERDAM, NL, vol. 5, no. 1, 1 January 2009 (2009-01-01), pages 328 - 337, XP025804548, ISSN: 1742-7061, [retrieved on 20080806], DOI: 10.1016/J.ACTBIO.2008.07.030 *

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