MX339460B - Derivados de benzazol como ligandos del receptor h4 de histamina. - Google Patents

Derivados de benzazol como ligandos del receptor h4 de histamina.

Info

Publication number
MX339460B
MX339460B MX2013003479A MX2013003479A MX339460B MX 339460 B MX339460 B MX 339460B MX 2013003479 A MX2013003479 A MX 2013003479A MX 2013003479 A MX2013003479 A MX 2013003479A MX 339460 B MX339460 B MX 339460B
Authority
MX
Mexico
Prior art keywords
histamine
receptor ligands
benzazole derivatives
benzazole
derivatives
Prior art date
Application number
MX2013003479A
Other languages
English (en)
Spanish (es)
Other versions
MX2013003479A (es
Inventor
Marc Capet
Jean-Charles Schwartz
Jeanne-Marie Lecomte
Denis Danvy
Xavier Ligneau
Nicolas Levoin
Isabelle Berrebi-Bertrand
Philippe Robert
Xavier Billot
Thierry Calmels
Stéphane Krief
Olivier Labeeuw
Original Assignee
Bioprojet Soc Civ
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bioprojet Soc Civ filed Critical Bioprojet Soc Civ
Publication of MX2013003479A publication Critical patent/MX2013003479A/es
Publication of MX339460B publication Critical patent/MX339460B/es

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    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/428—Thiazoles condensed with carbocyclic rings
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
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    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
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    • A61K31/5375—1,4-Oxazines, e.g. morpholine
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MX2013003479A 2010-09-27 2011-09-27 Derivados de benzazol como ligandos del receptor h4 de histamina. MX339460B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP20100306038 EP2447263A1 (en) 2010-09-27 2010-09-27 Benzazole derivatives as histamine H4 receptor ligands
PCT/EP2011/066782 WO2012041860A1 (en) 2010-09-27 2011-09-27 Benzazole derivatives as histamine h4 receptor ligands

Publications (2)

Publication Number Publication Date
MX2013003479A MX2013003479A (es) 2013-06-24
MX339460B true MX339460B (es) 2016-05-27

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MX2013003479A MX339460B (es) 2010-09-27 2011-09-27 Derivados de benzazol como ligandos del receptor h4 de histamina.

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US (2) US8802664B2 (enExample)
EP (2) EP2447263A1 (enExample)
JP (1) JP5922128B2 (enExample)
CN (1) CN103228643B (enExample)
CA (1) CA2812686C (enExample)
CY (1) CY1117416T1 (enExample)
DK (1) DK2621916T3 (enExample)
ES (1) ES2571335T3 (enExample)
HR (1) HRP20160398T1 (enExample)
HU (1) HUE027252T2 (enExample)
MX (1) MX339460B (enExample)
PL (1) PL2621916T3 (enExample)
RS (1) RS54737B1 (enExample)
SI (1) SI2621916T1 (enExample)
SM (1) SMT201600262B (enExample)
WO (1) WO2012041860A1 (enExample)

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Publication number Priority date Publication date Assignee Title
CN103648639B (zh) 2011-04-19 2016-10-12 沙特基础工业公司 碳负载的钴和钼催化剂
CA2872000A1 (en) * 2012-05-04 2013-11-07 Novartis Ag Complement pathway modulators and uses thereof
EP2671870A1 (en) * 2012-06-05 2013-12-11 Bioprojet Novel (aza)benzhydryl ether derivatives, their process of preparation and their use as H4-receptor ligands for therapeutical applications
EP2858647B1 (en) 2012-06-08 2018-05-23 Sensorion H4 receptor inhibitors for treating tinnitus
CN106800524A (zh) * 2015-02-13 2017-06-06 佛山市赛维斯医药科技有限公司 一类含双酰肼和萘基结构的化合物、制备方法及其用途
JP7447002B2 (ja) * 2017-09-11 2024-03-11 クルーゾン・ファーマシューティカルズ・インコーポレイテッド ＳＨＰ２のオクタヒドロシクロペンタ［ｃ］ピロールのアロステリック阻害剤
RS60320B1 (sr) * 2017-11-15 2020-07-31 Bioprojet Soc Civ Derivati benzimidazola kao dvostruki ligandi histaminskog h1 i histaminskog h4 receptora
CN113278409B (zh) * 2021-06-22 2022-04-29 西南石油大学 一种高温酸化缓蚀剂
CN119086786B (zh) * 2024-11-08 2025-02-14 南京恒远科技开发有限公司 叔丁基-(s)-[2-(2-氰基-4,4-二氟吡咯烷-1-基)-2-氧乙基]氨基甲酸酯光学异构体的检测方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI803127A7 (fi) * 1979-10-03 1981-04-04 Glaxo Group Ltd Heterosyklisiä yhdisteitä.
IT1154888B (it) * 1980-11-12 1987-01-21 Menarini Sas Derivati del benzofurano 2-sostituiti e relativi metodi di preparazione
US4908372A (en) * 1988-10-13 1990-03-13 Merrell Dow Pharmaceuticals Inc. Antihistaminic piperidinyl benzimidazoles
JPH05339266A (ja) * 1992-06-05 1993-12-21 Kaken Pharmaceut Co Ltd 新規なピペリジン誘導体
US6476041B1 (en) 1999-10-29 2002-11-05 Merck & Co., Inc. 1,4 substituted piperidinyl NMDA/NR2B antagonists
KR20040068339A (ko) 2001-12-21 2004-07-30 아노르메드 인코포레이티드 효능이 강화된 케모카인 수용체 결합 헤테로사이클릭 화합물
NZ546259A (en) * 2003-09-30 2009-05-31 Janssen Pharmaceutica Nv Benzoimidazole compounds
US20060127404A1 (en) * 2003-09-30 2006-06-15 Chichi Huang Hinge core mimetibodies, compositions, methods and uses
EP1642577A1 (en) * 2004-09-07 2006-04-05 Laboratorios del Dr. Esteve S.A. Derivatives of aryl (or heteroaryl) azolylcarbinols for the treatment of central neuropathic pain
US7557103B2 (en) 2005-04-05 2009-07-07 Eli Lilly And Company Imidazopyridazine compounds
JP2011509296A (ja) 2008-01-09 2011-03-24 レノビス， インコーポレイテッド イオンチャネルリガンドとしてのアミド誘導体およびそれを使用する薬学的組成物および方法

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