MX339096B - Compuestos inhibidores de metaloproteasa a base de feniletiniltiofeno y su uso en el tratamiento del dolor y otras enfermedades. - Google Patents
Compuestos inhibidores de metaloproteasa a base de feniletiniltiofeno y su uso en el tratamiento del dolor y otras enfermedades.Info
- Publication number
- MX339096B MX339096B MX2011006791A MX2011006791A MX339096B MX 339096 B MX339096 B MX 339096B MX 2011006791 A MX2011006791 A MX 2011006791A MX 2011006791 A MX2011006791 A MX 2011006791A MX 339096 B MX339096 B MX 339096B
- Authority
- MX
- Mexico
- Prior art keywords
- pain
- present
- diseases
- compounds
- treatment
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 4
- 201000010099 disease Diseases 0.000 title abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title abstract 2
- VFSMPIIWVPBPLL-UHFFFAOYSA-N 2-(2-phenylethynyl)thiophene Chemical compound C1=CSC(C#CC=2C=CC=CC=2)=C1 VFSMPIIWVPBPLL-UHFFFAOYSA-N 0.000 abstract 1
- 229940124761 MMP inhibitor Drugs 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 101000998548 Yersinia ruckeri Alkaline proteinase inhibitor Proteins 0.000 abstract 1
- 150000001345 alkine derivatives Chemical class 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 230000002503 metabolic effect Effects 0.000 abstract 1
- 239000003475 metalloproteinase inhibitor Substances 0.000 abstract 1
- 239000008177 pharmaceutical agent Substances 0.000 abstract 1
- 230000001988 toxicity Effects 0.000 abstract 1
- 231100000419 toxicity Toxicity 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
- A61K31/4045—Indole-alkylamines; Amides thereof, e.g. serotonin, melatonin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A61P37/00—Drugs for immunological or allergic disorders
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- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Diabetes (AREA)
- Dermatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Psychiatry (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Oncology (AREA)
- Vascular Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Hematology (AREA)
- Communicable Diseases (AREA)
- Pulmonology (AREA)
- Hospice & Palliative Care (AREA)
- Virology (AREA)
- Emergency Medicine (AREA)
- Ophthalmology & Optometry (AREA)
- Psychology (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US20354808P | 2008-12-23 | 2008-12-23 | |
| US21486309P | 2009-04-29 | 2009-04-29 | |
| PCT/US2009/069005 WO2010075287A2 (en) | 2008-12-23 | 2009-12-21 | Compounds and methods for the treatment of pain and other diseases |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX2011006791A MX2011006791A (es) | 2011-07-20 |
| MX339096B true MX339096B (es) | 2016-05-11 |
Family
ID=42288397
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2011006791A MX339096B (es) | 2008-12-23 | 2009-12-21 | Compuestos inhibidores de metaloproteasa a base de feniletiniltiofeno y su uso en el tratamiento del dolor y otras enfermedades. |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US8765953B2 (https=) |
| EP (1) | EP2382206B1 (https=) |
| JP (2) | JP5710498B2 (https=) |
| KR (1) | KR101682427B1 (https=) |
| CN (1) | CN102325768B (https=) |
| AU (2) | AU2009330131B2 (https=) |
| BR (1) | BRPI0923688A2 (https=) |
| CA (1) | CA2747957C (https=) |
| ES (1) | ES2575689T3 (https=) |
| IL (1) | IL213703A (https=) |
| MX (1) | MX339096B (https=) |
| RU (1) | RU2528333C2 (https=) |
| WO (1) | WO2010075287A2 (https=) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8530453B2 (en) | 2009-09-28 | 2013-09-10 | Aquilus Pharmaceuticals, Inc. | Compounds and methods for the treatment of pain and other diseases |
| EP2681209B1 (en) * | 2011-03-02 | 2018-05-09 | Aquilus Pharmaceuticals, Inc | Compounds and methods for the treatment of pain and other disorders |
| JP2015166385A (ja) * | 2015-05-29 | 2015-09-24 | アクイラス ファーマシューティカルズ， インコーポレイテッド | 疼痛および他の障害の処置のための化合物および方法 |
| ES2974634T3 (es) | 2018-12-21 | 2024-06-28 | Celgene Corp | Inhibidores de tienopiridinas de RIPK2 |
| WO2020154243A1 (en) * | 2019-01-24 | 2020-07-30 | Aquilus Pharmaceuticals, Inc. | Compounds and methods for the treatment of degenerative disorders |
| EP3952882A4 (en) * | 2019-04-09 | 2023-01-18 | Intrinsic Medicine, Inc. | IMMUNO-MODULATORY OLIGOSACCHARIDES FOR PAIN TREATMENT |
| EP3980007A1 (en) * | 2019-06-07 | 2022-04-13 | Selectimmune Pharma AB | Treatment and diagnosis of chronic inflammatory conditions in the lower urinary tract |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6221335B1 (en) * | 1994-03-25 | 2001-04-24 | Isotechnika, Inc. | Method of using deuterated calcium channel blockers |
| CA2242416C (en) * | 1996-01-23 | 2006-03-21 | Shionogi & Co., Ltd. | Sulfonated amino acid derivatives and metalloproteinase inhibitors containing the same |
| JP2002514179A (ja) * | 1996-09-04 | 2002-05-14 | ワーナー―ランバート・コンパニー | マトリックスメタロプロテイナーゼの阻害剤としてのビフェニル酪酸およびその誘導体 |
| DE19719621A1 (de) * | 1997-05-09 | 1998-11-12 | Hoechst Ag | Sulfonylaminocarbonsäuren |
| CA2297011C (en) * | 1997-07-22 | 2007-01-30 | Shionogi & Co., Ltd. | Sulfonamide derivatives as therapeutic or prophylactic agent for glomerulopathy |
| WO2000015213A1 (en) * | 1998-09-11 | 2000-03-23 | Shionogi & Co., Ltd. | Remedal or preventive agent for congestive heart failure |
| US6440710B1 (en) * | 1998-12-10 | 2002-08-27 | The Scripps Research Institute | Antibody-catalyzed deuteration, tritiation, dedeuteration or detritiation of carbonyl compounds |
| PT1104760E (pt) * | 1999-12-03 | 2003-06-30 | Pfizer Prod Inc | Compostos de sulfamoil-heteroarilpirazole como agentes analgesicos e anti-inflamatorios |
| US6727266B2 (en) * | 2000-01-26 | 2004-04-27 | Shionogi & Co., Ltd. | Substituted tryptophan derivatives |
| CA2406401A1 (en) * | 2000-04-19 | 2002-10-16 | Shionogi & Co., Ltd. | Process for preparation of sulfonamide derivatives and crystals thereof |
| AR028606A1 (es) * | 2000-05-24 | 2003-05-14 | Smithkline Beecham Corp | Nuevos inhibidores de mmp-2/mmp-9 |
| TW200413273A (en) * | 2002-11-15 | 2004-08-01 | Wako Pure Chem Ind Ltd | Heavy hydrogenation method of heterocyclic rings |
| JP2007516982A (ja) | 2003-12-15 | 2007-06-28 | 日本たばこ産業株式会社 | シクロプロパン化合物及びその医薬用途 |
| CN101309917B (zh) * | 2005-10-06 | 2013-09-11 | 奥斯拜客斯制药有限公司 | 具有增强治疗性质的胃h+，k+-atp酶氘代抑制剂 |
| US7750168B2 (en) * | 2006-02-10 | 2010-07-06 | Sigma-Aldrich Co. | Stabilized deuteroborane-tetrahydrofuran complex |
| WO2008071453A1 (en) * | 2006-12-13 | 2008-06-19 | Bayer Schering Pharma Aktiengesellschaft | 1,2-diarylacetylene derivatives of acyltryptophanols |
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2009
- 2009-12-21 KR KR1020117016625A patent/KR101682427B1/ko active Active
- 2009-12-21 AU AU2009330131A patent/AU2009330131B2/en active Active
- 2009-12-21 WO PCT/US2009/069005 patent/WO2010075287A2/en not_active Ceased
- 2009-12-21 CN CN200980157184.XA patent/CN102325768B/zh active Active
- 2009-12-21 RU RU2011130381/04A patent/RU2528333C2/ru active
- 2009-12-21 MX MX2011006791A patent/MX339096B/es active IP Right Grant
- 2009-12-21 JP JP2011543616A patent/JP5710498B2/ja not_active Expired - Fee Related
- 2009-12-21 BR BRPI0923688A patent/BRPI0923688A2/pt not_active Application Discontinuation
- 2009-12-21 US US13/141,384 patent/US8765953B2/en active Active
- 2009-12-21 CA CA2747957A patent/CA2747957C/en active Active
- 2009-12-21 EP EP09835701.5A patent/EP2382206B1/en active Active
- 2009-12-21 ES ES09835701.5T patent/ES2575689T3/es active Active
-
2011
- 2011-06-21 IL IL213703A patent/IL213703A/en active IP Right Grant
-
2015
- 2015-01-29 JP JP2015015025A patent/JP5913651B2/ja active Active
- 2015-07-29 AU AU2015207867A patent/AU2015207867A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| EP2382206A4 (en) | 2013-07-10 |
| AU2015207867A1 (en) | 2015-08-20 |
| JP2012513472A (ja) | 2012-06-14 |
| IL213703A (en) | 2016-08-31 |
| ES2575689T3 (es) | 2016-06-30 |
| US8765953B2 (en) | 2014-07-01 |
| CN102325768A (zh) | 2012-01-18 |
| US20110257222A1 (en) | 2011-10-20 |
| IL213703A0 (en) | 2011-07-31 |
| WO2010075287A3 (en) | 2010-10-28 |
| JP5710498B2 (ja) | 2015-04-30 |
| CN102325768B (zh) | 2016-11-09 |
| CA2747957C (en) | 2017-06-06 |
| WO2010075287A2 (en) | 2010-07-01 |
| RU2528333C2 (ru) | 2014-09-10 |
| CA2747957A1 (en) | 2010-07-01 |
| JP5913651B2 (ja) | 2016-04-27 |
| MX2011006791A (es) | 2011-07-20 |
| KR20110117088A (ko) | 2011-10-26 |
| KR101682427B1 (ko) | 2016-12-05 |
| RU2011130381A (ru) | 2013-01-27 |
| EP2382206A2 (en) | 2011-11-02 |
| JP2015083610A (ja) | 2015-04-30 |
| EP2382206B1 (en) | 2016-03-23 |
| AU2009330131A1 (en) | 2011-08-11 |
| AU2009330131B2 (en) | 2015-09-03 |
| BRPI0923688A2 (pt) | 2016-01-19 |
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