JP5710498B2 - 疼痛および他の疾患の処置のための化合物および方法 - Google Patents

疼痛および他の疾患の処置のための化合物および方法 Download PDF

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JP5710498B2
JP5710498B2 JP2011543616A JP2011543616A JP5710498B2 JP 5710498 B2 JP5710498 B2 JP 5710498B2 JP 2011543616 A JP2011543616 A JP 2011543616A JP 2011543616 A JP2011543616 A JP 2011543616A JP 5710498 B2 JP5710498 B2 JP 5710498B2
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pain
alkyl
group
mmp
hydrogen
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JP2012513472A (ja
JP2012513472A5 (https=
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アービング サチャレイキ，
アービング サチャレイキ，
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アクイラス ファーマシューティカルズ， インコーポレイテッド
アクイラス ファーマシューティカルズ， インコーポレイテッド
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A61K31/4045—Indole-alkylamines; Amides thereof, e.g. serotonin, melatonin
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    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
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  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Dermatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Psychiatry (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Oncology (AREA)
  • Vascular Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Hematology (AREA)
  • Communicable Diseases (AREA)
  • Pulmonology (AREA)
  • Hospice & Palliative Care (AREA)
  • Virology (AREA)
  • Emergency Medicine (AREA)
  • Ophthalmology & Optometry (AREA)
  • Psychology (AREA)
JP2011543616A 2008-12-23 2009-12-21 疼痛および他の疾患の処置のための化合物および方法 Expired - Fee Related JP5710498B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US20354808P 2008-12-23 2008-12-23
US61/203,548 2008-12-23
US21486309P 2009-04-29 2009-04-29
US61/214,863 2009-04-29
PCT/US2009/069005 WO2010075287A2 (en) 2008-12-23 2009-12-21 Compounds and methods for the treatment of pain and other diseases

Related Child Applications (1)

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JP2015015025A Division JP5913651B2 (ja) 2008-12-23 2015-01-29 疼痛および他の疾患の処置のための化合物および方法

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JP2012513472A JP2012513472A (ja) 2012-06-14
JP2012513472A5 JP2012513472A5 (https=) 2013-02-14
JP5710498B2 true JP5710498B2 (ja) 2015-04-30

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JP2011543616A Expired - Fee Related JP5710498B2 (ja) 2008-12-23 2009-12-21 疼痛および他の疾患の処置のための化合物および方法
JP2015015025A Active JP5913651B2 (ja) 2008-12-23 2015-01-29 疼痛および他の疾患の処置のための化合物および方法

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Country Link
US (1) US8765953B2 (https=)
EP (1) EP2382206B1 (https=)
JP (2) JP5710498B2 (https=)
KR (1) KR101682427B1 (https=)
CN (1) CN102325768B (https=)
AU (2) AU2009330131B2 (https=)
BR (1) BRPI0923688A2 (https=)
CA (1) CA2747957C (https=)
ES (1) ES2575689T3 (https=)
IL (1) IL213703A (https=)
MX (1) MX339096B (https=)
RU (1) RU2528333C2 (https=)
WO (1) WO2010075287A2 (https=)

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US8530453B2 (en) 2009-09-28 2013-09-10 Aquilus Pharmaceuticals, Inc. Compounds and methods for the treatment of pain and other diseases
EP2681209B1 (en) * 2011-03-02 2018-05-09 Aquilus Pharmaceuticals, Inc Compounds and methods for the treatment of pain and other disorders
JP2015166385A (ja) * 2015-05-29 2015-09-24 アクイラス ファーマシューティカルズ， インコーポレイテッド 疼痛および他の障害の処置のための化合物および方法
ES2974634T3 (es) 2018-12-21 2024-06-28 Celgene Corp Inhibidores de tienopiridinas de RIPK2
WO2020154243A1 (en) * 2019-01-24 2020-07-30 Aquilus Pharmaceuticals, Inc. Compounds and methods for the treatment of degenerative disorders
EP3952882A4 (en) * 2019-04-09 2023-01-18 Intrinsic Medicine, Inc. IMMUNO-MODULATORY OLIGOSACCHARIDES FOR PAIN TREATMENT
EP3980007A1 (en) * 2019-06-07 2022-04-13 Selectimmune Pharma AB Treatment and diagnosis of chronic inflammatory conditions in the lower urinary tract

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US6221335B1 (en) * 1994-03-25 2001-04-24 Isotechnika, Inc. Method of using deuterated calcium channel blockers
CA2242416C (en) * 1996-01-23 2006-03-21 Shionogi & Co., Ltd. Sulfonated amino acid derivatives and metalloproteinase inhibitors containing the same
JP2002514179A (ja) * 1996-09-04 2002-05-14 ワーナー―ランバート・コンパニー マトリックスメタロプロテイナーゼの阻害剤としてのビフェニル酪酸およびその誘導体
DE19719621A1 (de) * 1997-05-09 1998-11-12 Hoechst Ag Sulfonylaminocarbonsäuren
CA2297011C (en) * 1997-07-22 2007-01-30 Shionogi & Co., Ltd. Sulfonamide derivatives as therapeutic or prophylactic agent for glomerulopathy
WO2000015213A1 (en) * 1998-09-11 2000-03-23 Shionogi & Co., Ltd. Remedal or preventive agent for congestive heart failure
US6440710B1 (en) * 1998-12-10 2002-08-27 The Scripps Research Institute Antibody-catalyzed deuteration, tritiation, dedeuteration or detritiation of carbonyl compounds
PT1104760E (pt) * 1999-12-03 2003-06-30 Pfizer Prod Inc Compostos de sulfamoil-heteroarilpirazole como agentes analgesicos e anti-inflamatorios
US6727266B2 (en) * 2000-01-26 2004-04-27 Shionogi & Co., Ltd. Substituted tryptophan derivatives
CA2406401A1 (en) * 2000-04-19 2002-10-16 Shionogi & Co., Ltd. Process for preparation of sulfonamide derivatives and crystals thereof
AR028606A1 (es) * 2000-05-24 2003-05-14 Smithkline Beecham Corp Nuevos inhibidores de mmp-2/mmp-9
TW200413273A (en) * 2002-11-15 2004-08-01 Wako Pure Chem Ind Ltd Heavy hydrogenation method of heterocyclic rings
JP2007516982A (ja) 2003-12-15 2007-06-28 日本たばこ産業株式会社 シクロプロパン化合物及びその医薬用途
CN101309917B (zh) * 2005-10-06 2013-09-11 奥斯拜客斯制药有限公司 具有增强治疗性质的胃h+，k+-atp酶氘代抑制剂
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WO2008071453A1 (en) * 2006-12-13 2008-06-19 Bayer Schering Pharma Aktiengesellschaft 1,2-diarylacetylene derivatives of acyltryptophanols

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EP2382206A4 (en) 2013-07-10
AU2015207867A1 (en) 2015-08-20
JP2012513472A (ja) 2012-06-14
IL213703A (en) 2016-08-31
ES2575689T3 (es) 2016-06-30
US8765953B2 (en) 2014-07-01
CN102325768A (zh) 2012-01-18
US20110257222A1 (en) 2011-10-20
IL213703A0 (en) 2011-07-31
WO2010075287A3 (en) 2010-10-28
CN102325768B (zh) 2016-11-09
CA2747957C (en) 2017-06-06
WO2010075287A2 (en) 2010-07-01
RU2528333C2 (ru) 2014-09-10
CA2747957A1 (en) 2010-07-01
JP5913651B2 (ja) 2016-04-27
MX2011006791A (es) 2011-07-20
KR20110117088A (ko) 2011-10-26
KR101682427B1 (ko) 2016-12-05
RU2011130381A (ru) 2013-01-27
EP2382206A2 (en) 2011-11-02
JP2015083610A (ja) 2015-04-30
EP2382206B1 (en) 2016-03-23
AU2009330131A1 (en) 2011-08-11
MX339096B (es) 2016-05-11
AU2009330131B2 (en) 2015-09-03
BRPI0923688A2 (pt) 2016-01-19

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