MX3239E - Metodo para producir granulos de acido l - ascorbico - Google Patents
Metodo para producir granulos de acido l - ascorbicoInfo
- Publication number
- MX3239E MX3239E MX12876U MX12876U MX3239E MX 3239 E MX3239 E MX 3239E MX 12876 U MX12876 U MX 12876U MX 12876 U MX12876 U MX 12876U MX 3239 E MX3239 E MX 3239E
- Authority
- MX
- Mexico
- Prior art keywords
- producing
- powder
- ascorbic acid
- ascorbic
- granules
- Prior art date
Links
- 239000008187 granular material Substances 0.000 title abstract 3
- 239000002253 acid Substances 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 abstract 6
- 239000002211 L-ascorbic acid Substances 0.000 abstract 3
- 235000000069 L-ascorbic acid Nutrition 0.000 abstract 3
- 229960005070 ascorbic acid Drugs 0.000 abstract 3
- 239000000843 powder Substances 0.000 abstract 3
- 239000011230 binding agent Substances 0.000 abstract 2
- 238000005469 granulation Methods 0.000 abstract 1
- 230000003179 granulation Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 238000005507 spraying Methods 0.000 abstract 1
- 238000003756 stirring Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
- A61K31/375—Ascorbic acid, i.e. vitamin C; Salts thereof
Landscapes
- Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
La presente invención se refiere a un método para producir gránulos de ácido L-ascórbico que comprende revestir por aspersión polvo de ácido L-ascórbico, cuyo polvo puede pasar a través de una tamíz de malla 200 y no menos de 50 por ciento en peso del polvo puede pasar a través de una tamíz de malla 325, con una solución de un alglutinante de una concentración de cerca de alrededor de 10 por ciento en peso, a una temperatura de entre cerca de 0 grados centígrados a aproximadamente 100 grados centígrados, bajo agitación constante en un aparato de granulación de lecho fluidizado hasta que la cantidad de aglutinante ha alcanzado de aproximadamente 2 a alrededor de 4 por ciento en peso con relación del ácido L-ascórbico y luego secar los gránulos.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP50090742A JPS58403B2 (ja) | 1975-07-24 | 1975-07-24 | Ｌ− アスコルビンサンセイザイノ セイゾウホウ |
| US05/610,003 US4036948A (en) | 1975-07-24 | 1975-09-03 | L-ascorbic acid tablets |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX3239E true MX3239E (es) | 1980-08-06 |
Family
ID=26432181
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX12876U MX3239E (es) | 1975-07-24 | 1976-03-30 | Metodo para producir granulos de acido l - ascorbico |
Country Status (8)
| Country | Link |
|---|---|
| CA (1) | CA1054520A (es) |
| DE (1) | DE2616078C2 (es) |
| ES (1) | ES446464A1 (es) |
| FR (1) | FR2318621A1 (es) |
| GB (1) | GB1534066A (es) |
| HK (1) | HK2182A (es) |
| MX (1) | MX3239E (es) |
| NL (1) | NL184308C (es) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5759803A (en) * | 1980-09-30 | 1982-04-10 | Takeda Chem Ind Ltd | Granule of l-sodium ascorbate, its preparation, and tablet comprising it |
| JPH02502998A (ja) * | 1988-01-22 | 1990-09-20 | ハルコフスキ ナウチノ‐イススレドバテルスキ インスティテュト エンドクリノロギイ イ ヒミイ ゴルモノフ | ｎ‐クロロフェノキシイソ酪酸ウンデシルエステルおよびそれを基剤とした高類脂血症の治療用医薬製剤 |
| US5837292A (en) * | 1996-07-03 | 1998-11-17 | Yamanouchi Europe B.V. | Granulate for the preparation of fast-disintegrating and fast-dissolving compositions containing a high amount of drug |
| JP4098376B2 (ja) * | 1996-09-05 | 2008-06-11 | ビーエーエスエフ ソシエタス・ヨーロピア | 錠剤特性の優れた水溶性ビタミン組成物およびその製造法 |
| DE19733094A1 (de) * | 1997-07-31 | 1999-02-04 | Merck Patent Gmbh | Formulierung auf der Basis von Ascorbinsäure mit verbesserter Farbstabilität |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3453368A (en) * | 1966-01-13 | 1969-07-01 | Hoffmann La Roche | Smaller high potency compressed tablets of ascorbic acid |
-
1976
- 1976-03-12 NL NL7602657A patent/NL184308C/xx not_active IP Right Cessation
- 1976-03-26 GB GB1221176A patent/GB1534066A/en not_active Expired
- 1976-03-29 ES ES446464A patent/ES446464A1/es not_active Expired
- 1976-03-29 FR FR7609066A patent/FR2318621A1/fr active Granted
- 1976-03-29 CA CA249,080A patent/CA1054520A/en not_active Expired
- 1976-03-30 MX MX12876U patent/MX3239E/es unknown
- 1976-04-13 DE DE19762616078 patent/DE2616078C2/de not_active Expired
-
1982
- 1982-01-14 HK HK2182A patent/HK2182A/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DE2616078A1 (de) | 1977-02-10 |
| NL7602657A (nl) | 1977-01-26 |
| CA1054520A (en) | 1979-05-15 |
| NL184308C (nl) | 1989-06-16 |
| HK2182A (en) | 1982-01-22 |
| FR2318621B1 (es) | 1979-03-30 |
| FR2318621A1 (fr) | 1977-02-18 |
| ES446464A1 (es) | 1977-10-16 |
| GB1534066A (en) | 1978-11-29 |
| NL184308B (nl) | 1989-01-16 |
| DE2616078C2 (de) | 1985-05-15 |
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