MX3217E - Procedimiento para la preparacion de derivados de propoxi -3,4- di hidro carbo estirilo substituidos - Google Patents
Procedimiento para la preparacion de derivados de propoxi -3,4- di hidro carbo estirilo substituidosInfo
- Publication number
- MX3217E MX3217E MX000107U MX10776U MX3217E MX 3217 E MX3217 E MX 3217E MX 000107 U MX000107 U MX 000107U MX 10776 U MX10776 U MX 10776U MX 3217 E MX3217 E MX 3217E
- Authority
- MX
- Mexico
- Prior art keywords
- derivatives
- preparation
- substituted
- stirile
- propoxi
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- 238000002360 preparation method Methods 0.000 title abstract 2
- ZZUFCTLCJUWOSV-UHFFFAOYSA-N furosemide Chemical compound C1=C(Cl)C(S(=O)(=O)N)=CC(C(O)=O)=C1NCC1=CC=CO1 ZZUFCTLCJUWOSV-UHFFFAOYSA-N 0.000 title 1
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 abstract 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 2
- 239000004593 Epoxy Substances 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 150000001412 amines Chemical class 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000003960 organic solvent Substances 0.000 abstract 1
- 238000010992 reflux Methods 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
- C07D215/22—Oxygen atoms attached in position 2 or 4
- C07D215/227—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Quinoline Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
Abstract
La presente invención se refiere a un procedimiento para la preparación de derivados de propoxi-3,4-dihidrocarboestirilo substituídos de la fórmula: (VER GACETA) en donde R es (VER GACETA) y sus sales de adición de ácido fisiológicamente aceptables, caracterizado porque comprende poner a reflujo, por un tiempo de 3 a 72 horas en un disolvente orgánico, de preferencia metanol o etanol, la amina correspondiente con 5-(2,3-epoxi) propoxi-3,4-dihicarboestirilo para obtener el compuesto deseado.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US05/566,600 US4081447A (en) | 1975-04-09 | 1975-04-09 | 5-[2-Hydroxy-3-(3,4-dimethoxy phenethylamino)]-propoxy-3,4-dihydro carbostyril and pharmaceutically acceptable salts thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
MX3217E true MX3217E (es) | 1980-07-22 |
Family
ID=24263564
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX000107U MX3217E (es) | 1975-04-09 | 1976-03-24 | Procedimiento para la preparacion de derivados de propoxi -3,4- di hidro carbo estirilo substituidos |
Country Status (14)
Country | Link |
---|---|
US (1) | US4081447A (es) |
JP (1) | JPS5919539B2 (es) |
CA (1) | CA1066282A (es) |
CH (1) | CH597193A5 (es) |
DE (1) | DE2615406A1 (es) |
DK (1) | DK156776A (es) |
FR (1) | FR2306696A1 (es) |
GB (1) | GB1496995A (es) |
MX (1) | MX3217E (es) |
NL (1) | NL7603586A (es) |
NO (1) | NO146432C (es) |
PH (1) | PH12215A (es) |
SE (1) | SE428470B (es) |
ZA (1) | ZA761727B (es) |
Families Citing this family (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2609645A1 (de) * | 1976-03-09 | 1977-09-15 | Boehringer Sohn Ingelheim | Aminoalkylheterocyclen |
CH619453A5 (es) * | 1976-03-17 | 1980-09-30 | Otsuka Pharma Co Ltd | |
GB1574665A (en) * | 1976-05-08 | 1980-09-10 | Otsuka Pharma Co Ltd | 3,4-dihydrocarbostyril derivatives and process for preparing the same |
DE2644833A1 (de) * | 1976-10-05 | 1978-04-20 | Boehringer Sohn Ingelheim | Neue 1-aryloxy-2-hydroxy-3-alkylenaminopropane und verfahren zu ihrer herstellung |
DE2702600A1 (de) * | 1977-01-22 | 1978-07-27 | Thomae Gmbh Dr K | Neue aminoalkoxyphenyl-derivate |
NZ187066A (en) * | 1977-05-03 | 1981-02-11 | Hoffmann La Roche | 4-(3-substitutedamino-2-hydroxypropoxy)-benzimidazolidin-2-(ones or thiones) |
US4314943A (en) * | 1977-07-13 | 1982-02-09 | Mead Johnson & Company | Heterocyclic substituted aryloxy 3-indolyl-tertiary butylaminopropanols |
CA1108619A (en) * | 1977-08-12 | 1981-09-08 | Carl H. Ross | 4-hydroxy-2-benzimidazolinone derivatives and the preparation thereof |
AU518814B2 (en) * | 1979-01-30 | 1981-10-22 | Otsuka Pharamaceutical Co. | Glaucoma treatment |
US4495352A (en) * | 1979-02-13 | 1985-01-22 | Mead Johnson & Company | Heterocyclic substituted aryloxy 3-indolyl-tertiary butylaminopropanols |
DD150456A5 (de) * | 1979-03-01 | 1981-09-02 | Ciba Geigy Ag | Verfahren zur herstellung von derivaten des 3-amino-1,2-propandiols |
JPS56122356A (en) * | 1980-02-29 | 1981-09-25 | Otsuka Pharmaceut Co Ltd | Carbostyril derivative |
US4349673A (en) * | 1980-12-23 | 1982-09-14 | Merck & Co., Inc. | Benzoxazines |
US4656168A (en) * | 1980-12-23 | 1987-04-07 | Merck & Co., Inc. | (3-aralkylamino-2-or-propoxy)heterocyclic compounds in method of effecting bronchodilation |
US4331679A (en) * | 1980-12-23 | 1982-05-25 | Merck Sharp & Dohme (I.A.) Corp. | (3-Aralkylamino-2-or-propoxy) heterocyclic compounds |
US4442094A (en) * | 1980-12-23 | 1984-04-10 | Merck & Co., Inc. | (3-Aralkylamino-2-or-propoxy)heterocyclic compounds |
AU532361B2 (en) * | 1981-09-01 | 1983-09-29 | Otsuka Pharmaceutical Co., Ltd. | Carbostyril derivatives |
CH655110A5 (de) * | 1982-09-03 | 1986-03-27 | Otsuka Pharma Co Ltd | Carbostyrilderivate, verfahren zu deren herstellung und arzneimittel, welche diese enthalten. |
DE3544172A1 (de) * | 1985-12-13 | 1987-06-19 | Lentia Gmbh | Neue kristalline salze von aryloxy-propanolaminen, verfahren zu ihrer herstellung und ihre verwendung |
JPH07285940A (ja) * | 1988-08-10 | 1995-10-31 | Otsuka Pharmaceut Co Ltd | カルボスチリル誘導体 |
JP2711437B2 (ja) * | 1988-08-10 | 1998-02-10 | 大塚製薬 株式会社 | カルボスチリル誘導体 |
WO1994003425A2 (en) * | 1992-07-31 | 1994-02-17 | Syntex (U.S.A.) Inc. | Carbostyril derivatives for the treatment of arrhythmia |
WO1994006427A1 (en) * | 1992-09-18 | 1994-03-31 | Otsuka Pharmaceutical Company, Limited | Carbostyril derivatives as antiarrhythmic agents |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1058822A (en) * | 1963-07-30 | 1967-02-15 | Ici Ltd | 3-amino-2-hydroxypropoxy heterocyclic derivatives |
BE790165A (fr) * | 1971-12-14 | 1973-02-15 | Parke Davis & Co | Nouveaux aminoalcanols et procede pour les preparer |
US3910924A (en) * | 1972-04-13 | 1975-10-07 | Otsuka Pharma Co Ltd | 3,4-Dihydrocarbostyril derivatives and a process for preparing the same |
JPS48103590A (es) * | 1972-04-13 | 1973-12-25 |
-
1975
- 1975-04-09 US US05/566,600 patent/US4081447A/en not_active Expired - Lifetime
-
1976
- 1976-03-22 ZA ZA761727A patent/ZA761727B/xx unknown
- 1976-03-24 CA CA248,674A patent/CA1066282A/en not_active Expired
- 1976-03-24 MX MX000107U patent/MX3217E/es unknown
- 1976-03-26 PH PH18264A patent/PH12215A/en unknown
- 1976-03-31 DK DK156776A patent/DK156776A/da not_active Application Discontinuation
- 1976-04-06 NL NL7603586A patent/NL7603586A/xx not_active Application Discontinuation
- 1976-04-07 CH CH438376A patent/CH597193A5/xx not_active IP Right Cessation
- 1976-04-07 FR FR7610109A patent/FR2306696A1/fr active Granted
- 1976-04-08 SE SE7604171A patent/SE428470B/xx unknown
- 1976-04-08 DE DE19762615406 patent/DE2615406A1/de not_active Ceased
- 1976-04-08 GB GB14453/76A patent/GB1496995A/en not_active Expired
- 1976-04-08 NO NO761216A patent/NO146432C/no unknown
- 1976-04-09 JP JP51039464A patent/JPS5919539B2/ja not_active Expired
Also Published As
Publication number | Publication date |
---|---|
NO146432B (no) | 1982-06-21 |
JPS51122077A (en) | 1976-10-25 |
SE428470B (sv) | 1983-07-04 |
NL7603586A (nl) | 1976-10-12 |
FR2306696A1 (fr) | 1976-11-05 |
GB1496995A (en) | 1978-01-05 |
ZA761727B (en) | 1977-03-30 |
AU1226076A (en) | 1977-09-29 |
DE2615406A1 (de) | 1976-10-14 |
JPS5919539B2 (ja) | 1984-05-07 |
CA1066282A (en) | 1979-11-13 |
NO146432C (no) | 1982-09-29 |
NO761216L (es) | 1976-10-12 |
US4081447A (en) | 1978-03-28 |
PH12215A (en) | 1978-11-29 |
DK156776A (da) | 1976-10-10 |
CH597193A5 (es) | 1978-03-31 |
FR2306696B1 (es) | 1979-09-21 |
SE7604171L (sv) | 1976-10-10 |
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