MX2023009323A - Inhibidores de oxadiazolil dihidropirano[2,3-b]piridina de la proteina cinasa 2 que interactua con el homeodominio (hipk2) para el tratamiento de la fibrosis renal. - Google Patents
Inhibidores de oxadiazolil dihidropirano[2,3-b]piridina de la proteina cinasa 2 que interactua con el homeodominio (hipk2) para el tratamiento de la fibrosis renal.Info
- Publication number
- MX2023009323A MX2023009323A MX2023009323A MX2023009323A MX2023009323A MX 2023009323 A MX2023009323 A MX 2023009323A MX 2023009323 A MX2023009323 A MX 2023009323A MX 2023009323 A MX2023009323 A MX 2023009323A MX 2023009323 A MX2023009323 A MX 2023009323A
- Authority
- MX
- Mexico
- Prior art keywords
- hipk2
- treatment
- renal fibrosis
- oxadiazolil
- dihydropyrane
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
- C07D491/052—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being six-membered
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Urology & Nephrology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Gastroenterology & Hepatology (AREA)
- Pulmonology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202163147859P | 2021-02-10 | 2021-02-10 | |
| PCT/US2022/015767 WO2022173795A1 (en) | 2021-02-10 | 2022-02-09 | OXADIAZOLYL DIHYDROPYRANO[2,3-b]PYRIDINE INHIBITORS OF HIPK2 FOR TREATING KIDNEY FIBROSIS |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2023009323A true MX2023009323A (es) | 2023-12-14 |
Family
ID=82837244
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2023009323A MX2023009323A (es) | 2021-02-10 | 2022-02-09 | Inhibidores de oxadiazolil dihidropirano[2,3-b]piridina de la proteina cinasa 2 que interactua con el homeodominio (hipk2) para el tratamiento de la fibrosis renal. |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US20250179084A1 (https=) |
| EP (1) | EP4291183B1 (https=) |
| JP (1) | JP2024506387A (https=) |
| KR (1) | KR20230154194A (https=) |
| CN (1) | CN117479934A (https=) |
| AU (1) | AU2022221336A1 (https=) |
| CA (1) | CA3210658A1 (https=) |
| MX (1) | MX2023009323A (https=) |
| WO (1) | WO2022173795A1 (https=) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20240051965A1 (en) * | 2022-08-05 | 2024-02-15 | Icahn School Of Medicine At Mount Sinai | Oxygen-containing heterocyclic compound and use thereof |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL2069335T3 (pl) * | 2006-09-08 | 2013-05-31 | Actelion Pharmaceuticals Ltd | Pochodne pirydyn-3-ylu jako środki immunomodulujące |
| PE20091339A1 (es) * | 2007-12-21 | 2009-09-26 | Glaxo Group Ltd | Derivados de oxadiazol con actividad sobre receptores s1p1 |
| EP2210890A1 (en) * | 2009-01-19 | 2010-07-28 | Almirall, S.A. | Oxadiazole derivatives as S1P1 receptor agonists |
| ES2907624T3 (es) * | 2017-01-06 | 2022-04-25 | Icahn School Med Mount Sinai | Inhibidores de oxadiazol de HIPK2 para el tratamiento de la fibrosis renal |
| JP7252908B2 (ja) * | 2017-06-14 | 2023-04-05 | トレベナ・インコーポレイテッド | Ｓ１ｐ１活性を調節するための化合物およびその使用法 |
-
2022
- 2022-02-09 AU AU2022221336A patent/AU2022221336A1/en active Pending
- 2022-02-09 CN CN202280014176.5A patent/CN117479934A/zh active Pending
- 2022-02-09 WO PCT/US2022/015767 patent/WO2022173795A1/en not_active Ceased
- 2022-02-09 MX MX2023009323A patent/MX2023009323A/es unknown
- 2022-02-09 JP JP2023548877A patent/JP2024506387A/ja active Pending
- 2022-02-09 KR KR1020237030728A patent/KR20230154194A/ko active Pending
- 2022-02-09 EP EP22753240.5A patent/EP4291183B1/en active Active
- 2022-02-09 US US18/264,809 patent/US20250179084A1/en active Pending
- 2022-02-09 CA CA3210658A patent/CA3210658A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| WO2022173795A1 (en) | 2022-08-18 |
| US20250179084A1 (en) | 2025-06-05 |
| CN117479934A (zh) | 2024-01-30 |
| JP2024506387A (ja) | 2024-02-13 |
| EP4291183A1 (en) | 2023-12-20 |
| AU2022221336A1 (en) | 2023-08-24 |
| EP4291183B1 (en) | 2026-04-08 |
| KR20230154194A (ko) | 2023-11-07 |
| EP4291183A4 (en) | 2025-01-08 |
| CA3210658A1 (en) | 2022-08-18 |
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