MX2023008691A - Anticuerpos anti- pdgf-b y metodos de su uso para tratar la hipertension arterial pulmonar (pah). - Google Patents
Anticuerpos anti- pdgf-b y metodos de su uso para tratar la hipertension arterial pulmonar (pah).Info
- Publication number
- MX2023008691A MX2023008691A MX2023008691A MX2023008691A MX2023008691A MX 2023008691 A MX2023008691 A MX 2023008691A MX 2023008691 A MX2023008691 A MX 2023008691A MX 2023008691 A MX2023008691 A MX 2023008691A MX 2023008691 A MX2023008691 A MX 2023008691A
- Authority
- MX
- Mexico
- Prior art keywords
- antibodies
- pah
- pdgf
- arterial hypertension
- pulmonary arterial
- Prior art date
Links
- 206010064911 Pulmonary arterial hypertension Diseases 0.000 title abstract 3
- 239000000427 antigen Substances 0.000 abstract 2
- 102000036639 antigens Human genes 0.000 abstract 2
- 108091007433 antigens Proteins 0.000 abstract 2
- 239000012634 fragment Substances 0.000 abstract 2
- 239000003102 growth factor Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pulmonology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
La presente descripción proporciona anticuerpos anti-subunidad B del factor de crecimiento derivado de plaquetas (PDGF-B), y fragmentos de unión al antígeno de este, así como métodos de uso de dichos anticuerpos, o fragmentos de unión al antígeno de este, para tratar un sujeto que padece hipertensión arterial pulmonar (PAH).
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US202163141030P | 2021-01-25 | 2021-01-25 | |
PCT/US2022/013666 WO2022159875A1 (en) | 2021-01-25 | 2022-01-25 | Anti-pdgf-b antibodies and mehods of use for treating pulmonary arterial hypertension (pah) |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2023008691A true MX2023008691A (es) | 2023-08-01 |
Family
ID=80446637
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2023008691A MX2023008691A (es) | 2021-01-25 | 2022-01-25 | Anticuerpos anti- pdgf-b y metodos de su uso para tratar la hipertension arterial pulmonar (pah). |
Country Status (12)
Country | Link |
---|---|
EP (1) | EP4281475A1 (es) |
JP (1) | JP2024505195A (es) |
KR (1) | KR20230135627A (es) |
CN (1) | CN116964088A (es) |
AU (1) | AU2022210475A1 (es) |
BR (1) | BR112023014337A8 (es) |
CA (1) | CA3205846A1 (es) |
CL (1) | CL2023002148A1 (es) |
CO (1) | CO2023010900A2 (es) |
IL (1) | IL304505A (es) |
MX (1) | MX2023008691A (es) |
WO (1) | WO2022159875A1 (es) |
Family Cites Families (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2437213A1 (fr) | 1978-09-28 | 1980-04-25 | Cm Ind | Produits cytotoxiques formes par liaison covalente de la chaine a de la ricine avec un anticorps et leur procede de preparation |
US7087411B2 (en) | 1999-06-08 | 2006-08-08 | Regeneron Pharmaceuticals, Inc. | Fusion protein capable of binding VEGF |
US6573096B1 (en) | 2000-04-01 | 2003-06-03 | The Research Foundation At State University Of New York | Compositions and methods for inhibition of cancer invasion and angiogenesis |
US6596541B2 (en) | 2000-10-31 | 2003-07-22 | Regeneron Pharmaceuticals, Inc. | Methods of modifying eukaryotic cells |
US20040101920A1 (en) | 2002-11-01 | 2004-05-27 | Czeslaw Radziejewski | Modification assisted profiling (MAP) methodology |
WO2005103081A2 (en) | 2004-04-20 | 2005-11-03 | Genmab A/S | Human monoclonal antibodies against cd20 |
US8257740B1 (en) | 2011-08-15 | 2012-09-04 | Gp Medical, Inc. | Pharmaceutical composition of nanoparticles |
US8246995B2 (en) | 2005-05-10 | 2012-08-21 | The Board Of Trustees Of The Leland Stanford Junior University | Hydrophobic nanotubes and nanoparticles as transporters for the delivery of drugs into cells |
US7411046B2 (en) | 2005-08-02 | 2008-08-12 | Arius Research Inc | Cancerous disease modifying antibodies |
US8258256B2 (en) | 2006-01-05 | 2012-09-04 | The Johns Hopkins University | Compositions and methods for the treatment of cancer |
US7420040B2 (en) | 2006-02-24 | 2008-09-02 | Arius Research Inc. | Cytotoxicity mediation of cells evidencing surface expression of TROP-2 |
NO347649B1 (no) | 2006-12-14 | 2024-02-12 | Regeneron Pharma | Humant antistoff eller antistoff fragment som spesifikt binder human deltaliknende ligand 4 (hDII4), nukleinsyremolekyl som koder for slike og vektor og vert-vektorsystemer, samt fremgangsmåte for fremstilling, sammensetning og anvendelse. |
EP2136788B1 (en) | 2007-03-30 | 2011-10-26 | Bind Biosciences, Inc. | Cancer cell targeting using nanoparticles |
US8277812B2 (en) | 2008-10-12 | 2012-10-02 | Massachusetts Institute Of Technology | Immunonanotherapeutics that provide IgG humoral response without T-cell antigen |
JO3182B1 (ar) | 2009-07-29 | 2018-03-08 | Regeneron Pharma | مضادات حيوية بشرية عالية الالفة مع تولد الاوعية البشرية - 2 |
KR20150082503A (ko) * | 2012-11-09 | 2015-07-15 | 화이자 인코포레이티드 | 혈소판 유래 성장 인자 b 특이적 항체, 및 그의 조성물 및 용도 |
JP6946184B2 (ja) * | 2014-11-10 | 2021-10-06 | エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft | 抗pdgf−b抗体及び使用法 |
-
2022
- 2022-01-25 WO PCT/US2022/013666 patent/WO2022159875A1/en active Application Filing
- 2022-01-25 BR BR112023014337A patent/BR112023014337A8/pt unknown
- 2022-01-25 KR KR1020237028422A patent/KR20230135627A/ko unknown
- 2022-01-25 EP EP22704144.9A patent/EP4281475A1/en active Pending
- 2022-01-25 JP JP2023544526A patent/JP2024505195A/ja active Pending
- 2022-01-25 CN CN202280017601.6A patent/CN116964088A/zh active Pending
- 2022-01-25 CA CA3205846A patent/CA3205846A1/en active Pending
- 2022-01-25 MX MX2023008691A patent/MX2023008691A/es unknown
- 2022-01-25 AU AU2022210475A patent/AU2022210475A1/en active Pending
-
2023
- 2023-07-17 IL IL304505A patent/IL304505A/en unknown
- 2023-07-21 CL CL2023002148A patent/CL2023002148A1/es unknown
- 2023-08-22 CO CONC2023/0010900A patent/CO2023010900A2/es unknown
Also Published As
Publication number | Publication date |
---|---|
BR112023014337A2 (pt) | 2023-09-26 |
JP2024505195A (ja) | 2024-02-05 |
BR112023014337A8 (pt) | 2024-03-05 |
AU2022210475A1 (en) | 2023-08-10 |
CN116964088A (zh) | 2023-10-27 |
EP4281475A1 (en) | 2023-11-29 |
KR20230135627A (ko) | 2023-09-25 |
US20220242943A1 (en) | 2022-08-04 |
CL2023002148A1 (es) | 2024-04-12 |
IL304505A (en) | 2023-09-01 |
WO2022159875A1 (en) | 2022-07-28 |
CA3205846A1 (en) | 2022-07-28 |
CO2023010900A2 (es) | 2023-08-28 |
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