MX2023004880A - AGONISTA DE IL-2/IL-15RßY PARA EL TRATAMIENTO DE CÁNCER DE PIEL QUE NO ES MELANOMA. - Google Patents
AGONISTA DE IL-2/IL-15RßY PARA EL TRATAMIENTO DE CÁNCER DE PIEL QUE NO ES MELANOMA.Info
- Publication number
- MX2023004880A MX2023004880A MX2023004880A MX2023004880A MX2023004880A MX 2023004880 A MX2023004880 A MX 2023004880A MX 2023004880 A MX2023004880 A MX 2023004880A MX 2023004880 A MX2023004880 A MX 2023004880A MX 2023004880 A MX2023004880 A MX 2023004880A
- Authority
- MX
- Mexico
- Prior art keywords
- agonist
- skin cancer
- melanoma skin
- 15rbî2ò
- treating non
- Prior art date
Links
- 239000000556 agonist Substances 0.000 title abstract 3
- 201000008261 skin carcinoma Diseases 0.000 title abstract 3
- 101150083678 IL2 gene Proteins 0.000 title 1
- 102000000588 Interleukin-2 Human genes 0.000 abstract 3
- 108010002350 Interleukin-2 Proteins 0.000 abstract 2
- 102000004556 Interleukin-15 Receptors Human genes 0.000 abstract 1
- 108010017535 Interleukin-15 Receptors Proteins 0.000 abstract 1
- 108010038453 Interleukin-2 Receptors Proteins 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/20—Interleukins [IL]
- A61K38/2086—IL-13 to IL-16
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
- A61K38/1793—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Cell Biology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Abstract
La presente invención se refiere a un agonista de interleucina-2/receptor ß? de interleucina-15 (IL-2/IL-15Rß?) para usarse en el tratamiento del cáncer de la piel que no es melanoma. También se proporcionan esquemas de dosificación para el tratamiento de los pacientes con cáncer de la piel que no es melanoma con un agonista de IL-2/IL-15Rß?.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP20203907 | 2020-10-26 | ||
PCT/EP2021/079635 WO2022090202A1 (en) | 2020-10-26 | 2021-10-26 | IL-2/IL-15RBβү AGONIST FOR TREATING NON-MELANOMA SKIN CANCER |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2023004880A true MX2023004880A (es) | 2023-05-11 |
Family
ID=73020106
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2023004880A MX2023004880A (es) | 2020-10-26 | 2021-10-26 | AGONISTA DE IL-2/IL-15RßY PARA EL TRATAMIENTO DE CÁNCER DE PIEL QUE NO ES MELANOMA. |
Country Status (9)
Country | Link |
---|---|
US (1) | US20230398185A1 (es) |
EP (1) | EP4232068A1 (es) |
JP (1) | JP2023550880A (es) |
KR (1) | KR20230096047A (es) |
AU (1) | AU2021372660A1 (es) |
CA (1) | CA3195276A1 (es) |
IL (1) | IL302313A (es) |
MX (1) | MX2023004880A (es) |
WO (1) | WO2022090202A1 (es) |
Family Cites Families (43)
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US5229109A (en) | 1992-04-14 | 1993-07-20 | Board Of Regents, The University Of Texas System | Low toxicity interleukin-2 analogues for use in immunotherapy |
US7371371B2 (en) | 2001-08-13 | 2008-05-13 | University Of Southern California | Interleukin-2 mutants with reduced toxicity |
EP1454138B1 (en) | 2001-12-04 | 2012-01-18 | Merck Patent GmbH | Immunocytokines with modulated selectivity |
JP5744369B2 (ja) | 2004-02-27 | 2015-07-08 | アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル | IL15−Rα用IL−15結合部位およびアゴニスト/アンタゴニスト活性を有する特異的IL−15突然変異体 |
WO2006017853A2 (en) | 2004-08-11 | 2006-02-16 | Beth Israel Deaconess Medical Center, Inc. | Mutant interleukin-15-containing compositions and suppression of an immune response |
EP1777294A1 (en) | 2005-10-20 | 2007-04-25 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | IL-15Ralpha sushi domain as a selective and potent enhancer of IL-15 action through IL-15Rbeta/gamma, and hyperagonist (IL15Ralpha sushi -IL15) fusion proteins |
AU2007271398B2 (en) | 2006-07-06 | 2013-06-20 | Merck Patent Gmbh | Compositions and methods for enhancing the efficacy of IL-2 mediated immune responses |
CA3028038C (en) | 2007-05-11 | 2021-08-10 | Altor Bioscience Corporation | Fusion molecules and il-15 variants |
WO2009135031A1 (en) | 2008-04-30 | 2009-11-05 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Servic | Substituted il-15 |
KR20230148396A (ko) | 2010-11-12 | 2023-10-24 | 넥타르 테라퓨틱스 | Il-2 부분 및 중합체의 접합체 |
SI2673294T1 (sl) | 2011-02-10 | 2016-08-31 | Roche Glycart Ag | Mutirani polipeptidi interlevkina-2 |
EP2537933A1 (en) | 2011-06-24 | 2012-12-26 | Institut National de la Santé et de la Recherche Médicale (INSERM) | An IL-15 and IL-15Ralpha sushi domain based immunocytokines |
AU2013334610B2 (en) | 2012-10-24 | 2018-09-13 | Novartis Ag | IL-15R alpha forms, cells expressing IL-15R alpha forms, and therapeutic uses of IL-15R alpha and IL-15/IL-15R alpha complexes |
KR102561553B1 (ko) | 2013-03-15 | 2023-07-31 | 젠코어 인코포레이티드 | 이형이량체 단백질 |
ES2698375T3 (es) | 2013-06-27 | 2019-02-04 | Inst Nat Sante Rech Med | Antagonistas de interleucina 15 (IL-15) y usos de los mismos para el tratamiento de enfermedades autoinmunes y enfermedades inflamatorias |
HRP20212023T1 (hr) | 2013-08-08 | 2022-04-01 | Cytune Pharma | Modulokini temeljeni na il-15 i il-15ralpha sushi domeni |
WO2015103928A1 (zh) | 2014-01-08 | 2015-07-16 | 上海恒瑞医药有限公司 | Il-15异源二聚体蛋白及其用途 |
PL3094351T3 (pl) | 2014-01-15 | 2022-06-27 | Kadmon Corporation, Llc | Środki immunomodulujące |
JP2017536098A (ja) | 2014-10-14 | 2017-12-07 | アルモ・バイオサイエンシーズ・インコーポレイテッド | インターロイキン−15組成物及びその使用 |
AU2015366795B2 (en) | 2014-12-19 | 2020-12-17 | Jiangsu Hengrui Medicine Co., Ltd. | Interleukin 15 protein complex and use thereof |
EP3064507A1 (en) | 2015-03-06 | 2016-09-07 | Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts | Fusion proteins comprising a binding protein and an interleukin-15 polypeptide having a reduced affinity for IL15ra and therapeutic uses thereof |
CN112574316A (zh) | 2015-07-02 | 2021-03-30 | 博际生物医药科技(杭州)有限公司 | 用于肿瘤靶向治疗的白细胞介素-15融合蛋白 |
WO2017046200A1 (en) | 2015-09-16 | 2017-03-23 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Specific interleukin-15 (il-15) antagonist polypeptide and uses thereof for the treatment of inflammatory and auto-immune diseases |
US20170088597A1 (en) | 2015-09-25 | 2017-03-30 | Altor Bioscience Corporation | Interleukin-15 superagonist significantly enhances graft-versus-tumor activity |
AU2016369537B2 (en) * | 2015-12-17 | 2024-03-14 | Novartis Ag | Antibody molecules to PD-1 and uses thereof |
BR112018012262A2 (pt) | 2015-12-21 | 2018-12-04 | Armo Biosciences Inc | composições de interleucina-15 e seus usos |
SG11201903302UA (en) | 2016-10-14 | 2019-05-30 | Xencor Inc | Bispecific heterodimeric fusion proteins containing il-15/il-15ralpha fc-fusion proteins and pd-1 antibody fragments |
BR112019007920A2 (pt) * | 2016-10-21 | 2019-10-08 | Altor Bioscience Corp | moléculas multiméricas à base de il-15 |
MX2019006072A (es) | 2016-11-30 | 2019-08-14 | Oncomed Pharm Inc | Metodos para tratamiento de cancer que comprenden agentes de enlace al inmunoreceptor de celulas t con dominios ige itim (tigit). |
AU2018205276A1 (en) * | 2017-01-06 | 2019-07-18 | Synlogic Operating Company, Inc. | Microorganisms programmed to produce immune modulators and anti-cancer therapeutics in tumor cells |
US20200237874A1 (en) * | 2017-01-20 | 2020-07-30 | Novartis Ag | Combination therapy for the treatment of cancer |
WO2018151868A2 (en) | 2017-02-16 | 2018-08-23 | Sonnet Bio Therapeutics | Albumin binding domain fusion proteins |
US20200078467A1 (en) | 2017-05-15 | 2020-03-12 | Nektar Therapeutics | Long-acting interleukin-15 receptor agonists and related immunotherapeutic compositions and methods |
WO2019028425A1 (en) | 2017-08-03 | 2019-02-07 | Synthorx, Inc. | CONJUGATES OF CYTOKINE FOR THE TREATMENT OF AUTOIMMUNE DISEASES |
MX2020008772A (es) | 2018-02-26 | 2020-10-01 | Synthorx Inc | Conjugados de il-15, y sus usos. |
SG11202008261WA (en) | 2018-03-08 | 2020-09-29 | Rubius Therapeutics Inc | Therapeutic cell systems and methods for treating cancer and infectious diseases |
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MX2021013766A (es) | 2019-05-14 | 2022-02-21 | Werewolf Therapeutics Inc | Restos de separacion y metodos de uso de los mismos. |
WO2020234387A1 (en) * | 2019-05-20 | 2020-11-26 | Cytune Pharma | IL-2/IL-15Rßy AGONIST DOSING REGIMENS FOR TREATING CANCER OR INFECTIOUS DISEASES |
US20220370563A1 (en) | 2019-10-25 | 2022-11-24 | Neoleukin Therapeutics, Inc. | Methods of administration of il-2 receptor agonists |
MX2022009611A (es) | 2020-02-05 | 2022-11-07 | Novartis Ag | Celula cho que expresa heterodimeros il-15. |
-
2021
- 2021-10-26 WO PCT/EP2021/079635 patent/WO2022090202A1/en active Application Filing
- 2021-10-26 US US18/033,524 patent/US20230398185A1/en active Pending
- 2021-10-26 KR KR1020237017692A patent/KR20230096047A/ko unknown
- 2021-10-26 CA CA3195276A patent/CA3195276A1/en active Pending
- 2021-10-26 EP EP21794591.4A patent/EP4232068A1/en active Pending
- 2021-10-26 IL IL302313A patent/IL302313A/en unknown
- 2021-10-26 JP JP2023522869A patent/JP2023550880A/ja active Pending
- 2021-10-26 MX MX2023004880A patent/MX2023004880A/es unknown
- 2021-10-26 AU AU2021372660A patent/AU2021372660A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
AU2021372660A1 (en) | 2023-06-01 |
EP4232068A1 (en) | 2023-08-30 |
KR20230096047A (ko) | 2023-06-29 |
JP2023550880A (ja) | 2023-12-06 |
IL302313A (en) | 2023-06-01 |
CA3195276A1 (en) | 2022-05-05 |
US20230398185A1 (en) | 2023-12-14 |
AU2021372660A9 (en) | 2024-05-02 |
WO2022090202A8 (en) | 2023-05-11 |
WO2022090202A1 (en) | 2022-05-05 |
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