MX2023002603A - Celulas b modificadas y metodos de uso de las mismas. - Google Patents

Celulas b modificadas y metodos de uso de las mismas.

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Publication number
MX2023002603A
MX2023002603A MX2023002603A MX2023002603A MX2023002603A MX 2023002603 A MX2023002603 A MX 2023002603A MX 2023002603 A MX2023002603 A MX 2023002603A MX 2023002603 A MX2023002603 A MX 2023002603A MX 2023002603 A MX2023002603 A MX 2023002603A
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MX
Mexico
Prior art keywords
cell
payload
modified
disease
domain
Prior art date
Application number
MX2023002603A
Other languages
English (en)
Inventor
Mark Selby
Thomas Brennan
Hangil Park
Kathleen Boyle
Srinivas Kothakota
Lewis T Williams
Original Assignee
Walking Fish Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Walking Fish Therapeutics Inc filed Critical Walking Fish Therapeutics Inc
Publication of MX2023002603A publication Critical patent/MX2023002603A/es

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    • C12N5/0602—Vertebrate cells
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    • C12N5/0635—B lymphocytes
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Abstract

La presente invención se refiere a células B modificadas por modificación genética y sus usos de las mismas, por ejemplo, para el tratamiento de una variedad de enfermedades y trastornos, que incluyen cáncer, enfermedad cardíaca, enfermedad inflamatoria, enfermedad de desgaste muscular, enfermedad neurológica y similares. En ciertas modalidades, la invención se refiere a una célula B modificada aislada ("célula CAR-B"), capaz de expresar un receptor quimérico ("receptor CAR-B"), en donde el receptor quimérico comprende (a) un dominio extracelular; (b) un dominio transmembrana; y (c) un dominio citoplasmático que comprende al menos un dominio de señalización. En varias modalidades, la invención comprende una célula B modificada aislada, en donde la célula B es capaz de expresar y secretar una carga útil, en donde la carga útil no se expresa naturalmente en una célula B o se expresa a niveles más altos que los expresados naturalmente en una célula B. En varias modalidades, la carga útil es un anticuerpo o fragmento del mismo.
MX2023002603A 2020-09-02 2021-09-02 Celulas b modificadas y metodos de uso de las mismas. MX2023002603A (es)

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Application Number Priority Date Filing Date Title
US202063073799P 2020-09-02 2020-09-02
PCT/US2021/048944 WO2022051556A1 (en) 2020-09-02 2021-09-02 Modified b cells and methods of use thereof

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MX2023002603A true MX2023002603A (es) 2023-07-06

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EP (1) EP4203978A1 (es)
JP (1) JP2023539382A (es)
KR (1) KR20230091865A (es)
CN (1) CN116829160A (es)
AU (1) AU2021337680A1 (es)
CA (1) CA3191390A1 (es)
CL (1) CL2023000602A1 (es)
IL (1) IL301078A (es)
MX (1) MX2023002603A (es)
WO (1) WO2022051556A1 (es)

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002092792A2 (de) * 2001-05-16 2002-11-21 Genethor Gmbh Antigen-abhängige reduktion von spezifischen immunreaktionen durch beeinflussung der co-stimulation
US20060165668A1 (en) * 2004-12-10 2006-07-27 Liu Linda N Genetically modified tumor cells as cancer vaccines
WO2006119083A2 (en) * 2005-04-29 2006-11-09 Cbr Institute For Biomedical Research, Inc. Treating gastrointestinal diseases with modulation of retonic acid
CA2971430A1 (en) * 2014-12-19 2016-06-23 Immusoft Corporation B cells for in vivo delivery of therapeutic agents
EP3458157A4 (en) * 2016-05-19 2020-05-27 Momenta Pharmaceuticals, Inc. METHOD FOR TREATING DISEASES RELATING TO FIBROSE AND SYSTEMIC Sclerosis

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