MX2023002424A - Perforacion de mucosa. - Google Patents

Perforacion de mucosa.

Info

Publication number
MX2023002424A
MX2023002424A MX2023002424A MX2023002424A MX2023002424A MX 2023002424 A MX2023002424 A MX 2023002424A MX 2023002424 A MX2023002424 A MX 2023002424A MX 2023002424 A MX2023002424 A MX 2023002424A MX 2023002424 A MX2023002424 A MX 2023002424A
Authority
MX
Mexico
Prior art keywords
active ingredient
pharmaceutically active
mucosa
microneedle system
patient
Prior art date
Application number
MX2023002424A
Other languages
English (en)
Inventor
Dr Andreas Koch
Original Assignee
Lts Lohmann Therapie Systeme Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lts Lohmann Therapie Systeme Ag filed Critical Lts Lohmann Therapie Systeme Ag
Publication of MX2023002424A publication Critical patent/MX2023002424A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0021—Intradermal administration, e.g. through microneedle arrays, needleless injectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0023—Drug applicators using microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0046—Solid microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0061—Methods for using microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2210/00—Anatomical parts of the body
    • A61M2210/06—Head
    • A61M2210/0625—Mouth
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
    • A61M5/3295—Multiple needle devices, e.g. a plurality of needles arranged coaxially or in parallel
    • A61M5/3298—Needles arranged in parallel

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Anesthesiology (AREA)
  • Medical Informatics (AREA)
  • Inorganic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Medicinal Preparation (AREA)
  • Media Introduction/Drainage Providing Device (AREA)
  • Materials For Medical Uses (AREA)

Abstract

La presente invención se refiere a un kit que comprende por lo menos un sistema de microagujas y por lo menos una forma de dosificación para administrar transmucosalmente por lo menos un ingrediente farmacéuticamente activo, en donde la por lo menos una forma de dosificación para la administración transmucosal comprende por lo menos un ingrediente farmacéuticamente activo, de preferencia una delgada película oral, a este kit para usarlo en el tratamiento de un paciente, al uso de un sistema de microagujas para reducir la barrera de permeación de una mucosa para por lo menos un ingrediente farmacéuticamente activo, y a un método para el tratamiento de un paciente, en donde el sistema de microagujas primero es aplicado a un punto de una mucosa de un paciente y vuelve a ser removido, y después una delgada película oral que comprende por lo menos un polímero de matriz y por lo menos un ingrediente farmacéuticamente activo es aplicada al punto de la mucosa en donde fue aplicado el sistema de microagujas y removido otra vez, o en donde el sistema de microagujas es aplicado a la mucosa en forma simultánea con una forma de dosificación para administrar de manera transmucosal por lo menos un ingrediente farmacéuticamente activo; la presente invención también se refiere a un sistema de microagujas biodegradable que comprende por lo menos un ingrediente farmacéuticamente activo y por lo menos un polímero biodegradable.
MX2023002424A 2020-08-28 2021-08-25 Perforacion de mucosa. MX2023002424A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102020122557.1A DE102020122557A1 (de) 2020-08-28 2020-08-28 Mucosa-Perforierung
PCT/DE2021/100715 WO2022042799A1 (de) 2020-08-28 2021-08-25 Mucosa-perforierung

Publications (1)

Publication Number Publication Date
MX2023002424A true MX2023002424A (es) 2023-03-22

Family

ID=77801423

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2023002424A MX2023002424A (es) 2020-08-28 2021-08-25 Perforacion de mucosa.

Country Status (11)

Country Link
US (1) US20240024647A1 (es)
EP (1) EP4203916A1 (es)
JP (1) JP2023546646A (es)
KR (1) KR20230058452A (es)
CN (1) CN116056738A (es)
AU (1) AU2021334058A1 (es)
BR (1) BR112023003399A2 (es)
CA (1) CA3192247A1 (es)
DE (1) DE102020122557A1 (es)
MX (1) MX2023002424A (es)
WO (1) WO2022042799A1 (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115969771B (zh) * 2023-01-31 2024-05-10 四川大学 一种可溶性载药微针及其制备方法

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10226494A1 (de) * 2002-06-14 2004-01-08 Lts Lohmann Therapie-Systeme Ag Filmförmige mucoadhäsive Darreichungsformen zur Verabreichung von Cannabis-Wirkstoffen
US7658728B2 (en) 2006-01-10 2010-02-09 Yuzhakov Vadim V Microneedle array, patch, and applicator for transdermal drug delivery
US20090099502A1 (en) * 2006-04-07 2009-04-16 Hisamitsu Pharmaceutical Co., Inc. Microneedle Device And Transdermal Administration Device Provided With Microneedles
US7785301B2 (en) 2006-11-28 2010-08-31 Vadim V Yuzhakov Tissue conforming microneedle array and patch for transdermal drug delivery or biological fluid collection
EP2271301A4 (en) 2008-03-27 2014-07-02 Agigma Inc METHODS AND COMPOSITIONS FOR THE DELIVERY OF AGENTS
US20110150946A1 (en) * 2008-08-22 2011-06-23 Al-Ghananeem Abeer M Transdermal Delivery of Apomorphine Using Microneedles
KR101033514B1 (ko) * 2009-06-02 2011-05-09 (주)마이티시스템 유연한 미세바늘 패치 시스템 및 그 제작방법
CN102039000B (zh) * 2009-10-20 2015-08-26 苏州纳通生物纳米技术有限公司 一种透皮给药试剂盒
US20160128947A1 (en) 2012-10-22 2016-05-12 Stc. Unm Bioadhesive films for local and/or systemic delivery
WO2016155082A1 (zh) * 2015-04-03 2016-10-06 苏州大学 一种溶胀型丝素蛋白微针给药系统及其制备方法
US20190022022A1 (en) 2016-05-05 2019-01-24 Aquestive Therapeutics, Inc. Pharmaceutical compositions with enhanced permeation
CN209316551U (zh) * 2018-05-24 2019-08-30 优微（珠海）生物科技有限公司 一种可溶性微针贴片
CN108837299B (zh) * 2018-07-18 2020-08-07 武汉大学 一种智能调节血糖的微针贴片及其制备方法
DE102019100483A1 (de) * 2019-01-10 2020-07-16 Lts Lohmann Therapie-Systeme Ag Oraler Dünnfilm

Also Published As

Publication number Publication date
CN116056738A (zh) 2023-05-02
EP4203916A1 (de) 2023-07-05
DE102020122557A1 (de) 2022-03-03
BR112023003399A2 (pt) 2023-04-11
JP2023546646A (ja) 2023-11-07
US20240024647A1 (en) 2024-01-25
CA3192247A1 (en) 2022-03-03
WO2022042799A1 (de) 2022-03-03
KR20230058452A (ko) 2023-05-03
AU2021334058A1 (en) 2023-05-11

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