MX2023000504A - Anticuerpos tetrahedricos. - Google Patents

Anticuerpos tetrahedricos.

Info

Publication number
MX2023000504A
MX2023000504A MX2023000504A MX2023000504A MX2023000504A MX 2023000504 A MX2023000504 A MX 2023000504A MX 2023000504 A MX2023000504 A MX 2023000504A MX 2023000504 A MX2023000504 A MX 2023000504A MX 2023000504 A MX2023000504 A MX 2023000504A
Authority
MX
Mexico
Prior art keywords
domain
terminus
tetrahedral
antibodies
linkage
Prior art date
Application number
MX2023000504A
Other languages
English (en)
Inventor
Daniel J Capon
Original Assignee
Biomolecular Holdings Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biomolecular Holdings Llc filed Critical Biomolecular Holdings Llc
Publication of MX2023000504A publication Critical patent/MX2023000504A/es

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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/485—Exopeptidases (3.4.11-3.4.19)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4422—1,4-Dihydropyridines, e.g. nifedipine, nicardipine
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/20—Interleukins [IL]
    • A61K38/2086—IL-13 to IL-16
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
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    • A61K47/6883—Polymer-drug antibody conjugates, e.g. mitomycin-dextran-Ab; DNA-polylysine-antibody complex or conjugate used for therapy
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    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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    • C07K14/52—Cytokines; Lymphokines; Interferons
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    • C07K14/5443—IL-15
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    • C07K16/1003—Severe acute respiratory syndrome coronavirus 2 [SARS‐CoV‐2 or Covid-19]
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
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    • C07—ORGANIC CHEMISTRY
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    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/283—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against Fc-receptors, e.g. CD16, CD32, CD64
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2887—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD20
    • C—CHEMISTRY; METALLURGY
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    • C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
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    • C07K16/46—Hybrid immunoglobulins
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    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/17—Metallocarboxypeptidases (3.4.17)
    • C12Y304/17023—Angiotensin-converting enzyme 2 (3.4.17.23)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
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    • C07K2317/66—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising a swap of domains, e.g. CH3-CH2, VH-CL or VL-CH1
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
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    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
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    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
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Abstract

Está invención proporciona un anticuerpo tetrahédrico que comprende un primer, segundo, tercer y cuarto dominios, en donde: a) cada uno del primer y segundo dominios se seleccionan del grupo que consiste en un dominio Fab y un dominio Fc, b) cada uno del primer y segundo dominios comprende: i) una primera cadena de polipéptido que comprende una primera N-terminal del dominio, y ii) una segunda cadena de polipéptidos que comprende una segunda N-terminal del dominio, c) la primera N-terminal del primer dominio y la primera N-terminal del segundo dominio se unen entre sí por una ligación no de peptidilo en donde ligación no de peptidilo es: i) una ligación covalente, o ii) una ligación no covalente entre (1) un primer polipéptido de polimerización unido por una unión de péptido o a través de un ligador de péptido a la primera N-terminal del primer dominio, y (2) un segundo polipéptido de dimerización unido por una unión de péptido o a través de un ligador de péptido a la primera N-terminal del segundo dominio, en donde el primer y segundo polipéptidos de dimerización no son polipéptidos de inmunoglobulina, d) el tercer dominio se une en su C-terminal por una unión de péptido o a través de un ligador de péptido a: i) la segunda N-terminal del primer dominio, o ii) la N-terminal del primer polipéptido de dimerización, y e) el cuarto dominio se une en su C-terminal por una unión de péptido o a través de un ligador de péptido a: i) la segunda N-terminal del segundo dominio, o ii) la N-terminal del segundo polipéptido de dimerización.
MX2023000504A 2020-07-10 2021-07-12 Anticuerpos tetrahedricos. MX2023000504A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202063050738P 2020-07-10 2020-07-10
PCT/US2021/041346 WO2022011358A1 (en) 2020-07-10 2021-07-12 Tetrahedral antibodies

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MX2023000504A true MX2023000504A (es) 2023-04-14

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US (1) US20220025071A1 (es)
EP (1) EP4178615A1 (es)
JP (1) JP2023535677A (es)
KR (1) KR20230066317A (es)
CN (1) CN116348492A (es)
AU (1) AU2021304372A1 (es)
CA (1) CA3185344A1 (es)
IL (1) IL299741A (es)
MX (1) MX2023000504A (es)
TW (1) TW202216777A (es)
WO (1) WO2022011358A1 (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX339809B (es) * 2010-05-27 2016-06-09 Merck Sharp & Dohme Corp * Metodo para preparar anticuerpos con propiedades mejoradas.
US20230220116A1 (en) * 2022-01-12 2023-07-13 Biomolecular Holdings Llc Tetrahedral antibodies

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6645727B2 (en) * 2000-05-26 2003-11-11 Stemcell Technologies Inc. Antibody compositions for preparing enriched mesenchymal progenitor preparations
CA2411392C (en) * 2001-11-07 2012-10-16 Stemcell Technologies Inc. Tetrameric antibody complexes for blocking non-specific binding of antigens
EP1786918A4 (en) * 2004-07-17 2009-02-11 Imclone Systems Inc NEW BISPECIFIC ANTIBODY TETRAVALENT
AT505262A1 (de) * 2007-06-12 2008-12-15 Apeiron Biolog Forschungs Und Rekombinantes ace2 polypeptid
US8268314B2 (en) * 2008-10-08 2012-09-18 Hoffmann-La Roche Inc. Bispecific anti-VEGF/anti-ANG-2 antibodies
DK3116486T3 (da) * 2014-03-14 2020-03-09 Biomolecular Holdings Llc Hybrid immunoglobulin indeholdende ikke-peptidylbinding
EP3736294A3 (en) * 2014-10-10 2021-02-17 Innate Pharma Cd73 blockade

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CA3185344A1 (en) 2022-01-13
IL299741A (en) 2023-03-01
WO2022011358A1 (en) 2022-01-13
US20220025071A1 (en) 2022-01-27
EP4178615A1 (en) 2023-05-17
KR20230066317A (ko) 2023-05-15
WO2022011358A9 (en) 2022-03-03
AU2021304372A1 (en) 2023-03-02
TW202216777A (zh) 2022-05-01
JP2023535677A (ja) 2023-08-21
CN116348492A (zh) 2023-06-27

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