MX2023000492A - Proceso para producir un rabdovirus purificado a partir de cultivo celular. - Google Patents

Proceso para producir un rabdovirus purificado a partir de cultivo celular.

Info

Publication number
MX2023000492A
MX2023000492A MX2023000492A MX2023000492A MX2023000492A MX 2023000492 A MX2023000492 A MX 2023000492A MX 2023000492 A MX2023000492 A MX 2023000492A MX 2023000492 A MX2023000492 A MX 2023000492A MX 2023000492 A MX2023000492 A MX 2023000492A
Authority
MX
Mexico
Prior art keywords
rhabdovirus
purified
producing
cell culture
upstream
Prior art date
Application number
MX2023000492A
Other languages
English (en)
Inventor
Dethardt Mueller
Alan Pardo Garcia
Tanja Anneliese Grein
Friedrich Kaess
Judy Ng
Katharina Pesta
Sabrina Schneider
Jordan Turnbull
Original Assignee
Boehringer Ingelheim Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int
Publication of MX2023000492A publication Critical patent/MX2023000492A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/20011—Rhabdoviridae
    • C12N2760/20211—Vesiculovirus, e.g. vesicular stomatitis Indiana virus
    • C12N2760/20221—Viruses as such, e.g. new isolates, mutants or their genomic sequences
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/20011—Rhabdoviridae
    • C12N2760/20211—Vesiculovirus, e.g. vesicular stomatitis Indiana virus
    • C12N2760/20241—Use of virus, viral particle or viral elements as a vector
    • C12N2760/20244—Chimeric viral vector comprising heterologous viral elements for production of another viral vector
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/20011—Rhabdoviridae
    • C12N2760/20211—Vesiculovirus, e.g. vesicular stomatitis Indiana virus
    • C12N2760/20251—Methods of production or purification of viral material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/20011—Rhabdoviridae
    • C12N2760/20211—Vesiculovirus, e.g. vesicular stomatitis Indiana virus
    • C12N2760/20251—Methods of production or purification of viral material
    • C12N2760/20252—Methods of production or purification of viral material relating to complementing cells and packaging systems for producing virus or viral particles

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Virology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

La presente invención se refiere al campo del procesamiento corriente arriba y corriente abajo, y proporciona un proceso para producir un rabdovirus purificado a partir de un cultivo celular, preferentemente, un rabdovirus oncolítico purificado y, en particular, un virus de la estomatitis vesicular, que incluye composiciones farmacéuticas que comprenden el rabdovirus.
MX2023000492A 2020-07-10 2021-07-09 Proceso para producir un rabdovirus purificado a partir de cultivo celular. MX2023000492A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP20185118 2020-07-10
PCT/EP2021/069091 WO2022008700A1 (en) 2020-07-10 2021-07-09 Process for producing a purified rhabdovirus from cell culture

Publications (1)

Publication Number Publication Date
MX2023000492A true MX2023000492A (es) 2023-02-13

Family

ID=71575102

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2023000492A MX2023000492A (es) 2020-07-10 2021-07-09 Proceso para producir un rabdovirus purificado a partir de cultivo celular.

Country Status (13)

Country Link
US (1) US20220010286A1 (es)
EP (1) EP4179073A1 (es)
JP (1) JP2023532759A (es)
KR (1) KR20230035657A (es)
CN (1) CN116171322A (es)
AU (1) AU2021304892A1 (es)
BR (1) BR112022025251A2 (es)
CA (1) CA3187150A1 (es)
CL (1) CL2023000080A1 (es)
IL (1) IL299723A (es)
MX (1) MX2023000492A (es)
TW (1) TW202216992A (es)
WO (1) WO2022008700A1 (es)

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9716611D0 (en) * 1997-08-07 1997-10-08 Cantab Pharmaceuticals Res Ltd Virus preparations and methods
BR122019005271B1 (pt) * 2002-12-13 2020-10-13 Alphavax, Inc. método para a preparação de partículas de replicon de alfavírus (arps)
BRPI0710820A2 (pt) * 2006-04-20 2011-08-23 Wyeth Corp processo para a purificação do vìrus da estomatite vesicular (vsv) do fluido de cultura celular de uma cultura de células de mamìferos infectada com vsv; vsv purificado de acordo com o processo; composição farmacêutica; e composição imunogênica
DE102008050860A1 (de) * 2008-10-08 2010-04-15 Dorothee Von Laer LCMV-GP-VSV-Pseudotypvektoren und tumorinfiltrierende Virenproduzentenzellen zur Therapie von Tumoren
US20100143889A1 (en) * 2008-12-02 2010-06-10 Mayo Foundation For Medical Education And Research Rhabdoviridae virus preparations
WO2013106398A1 (en) * 2012-01-09 2013-07-18 Sanofi Pasteur Biologics, Llc Purification of herpes virus
CA3104392A1 (en) * 2018-07-04 2020-01-09 Probiogen Ag Method for purifying an enveloped virus
JP2021191232A (ja) * 2018-08-09 2021-12-16 昭和電工株式会社 ウイルス様粒子の精製法
TW202043466A (zh) * 2019-01-25 2020-12-01 德商百靈佳殷格翰國際股份有限公司 編碼ccl21之重組棒狀病毒

Also Published As

Publication number Publication date
CN116171322A (zh) 2023-05-26
BR112022025251A2 (pt) 2023-01-17
JP2023532759A (ja) 2023-07-31
CA3187150A1 (en) 2022-01-13
TW202216992A (zh) 2022-05-01
US20220010286A1 (en) 2022-01-13
IL299723A (en) 2023-03-01
AU2021304892A1 (en) 2023-01-19
CL2023000080A1 (es) 2023-09-08
EP4179073A1 (en) 2023-05-17
KR20230035657A (ko) 2023-03-14
WO2022008700A1 (en) 2022-01-13

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