MX2022015646A - Métodos para elaborar compuestos inhibidores de wee1. - Google Patents
Métodos para elaborar compuestos inhibidores de wee1.Info
- Publication number
- MX2022015646A MX2022015646A MX2022015646A MX2022015646A MX2022015646A MX 2022015646 A MX2022015646 A MX 2022015646A MX 2022015646 A MX2022015646 A MX 2022015646A MX 2022015646 A MX2022015646 A MX 2022015646A MX 2022015646 A MX2022015646 A MX 2022015646A
- Authority
- MX
- Mexico
- Prior art keywords
- making
- methods
- inhibitor compounds
- wee1 inhibitor
- wee1
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 2
- 239000003112 inhibitor Substances 0.000 title abstract 2
- 101100102932 Xenopus laevis wee2-b gene Proteins 0.000 title 1
- 101000621390 Homo sapiens Wee1-like protein kinase Proteins 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 102100023037 Wee1-like protein kinase Human genes 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 230000004663 cell proliferation Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/04—Ortho- or peri-condensed ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Polymerisation Methods In General (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Epidemiology (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Se proporciona un proceso para elaborar un inhibidor de WEE1 de la Fórmula (1A) útil en el tratamiento de afecciones caracterizadas por proliferación celular excesiva, tales como cáncer. En algunas modalidades, se proporcionan procesos para elaborar compuestos intermedios de las Fórmulas (3), (5) y (6) como se define en la presente descripción.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202063037766P | 2020-06-11 | 2020-06-11 | |
| PCT/US2021/036665 WO2021252667A1 (en) | 2020-06-11 | 2021-06-09 | Methods of making wee1 inhibitor compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2022015646A true MX2022015646A (es) | 2023-02-27 |
Family
ID=78846556
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2022015646A MX2022015646A (es) | 2020-06-11 | 2021-06-09 | Métodos para elaborar compuestos inhibidores de wee1. |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US20230234956A1 (es) |
| EP (1) | EP4153591A4 (es) |
| JP (1) | JP2023530085A (es) |
| KR (1) | KR20230038202A (es) |
| CN (1) | CN116056708A (es) |
| AU (1) | AU2021287910A1 (es) |
| CA (1) | CA3186632A1 (es) |
| IL (1) | IL298971A (es) |
| MX (1) | MX2022015646A (es) |
| TW (1) | TW202214638A (es) |
| WO (1) | WO2021252667A1 (es) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116462687A (zh) * | 2022-01-18 | 2023-07-21 | 江苏天士力帝益药业有限公司 | Wee1抑制剂及其制备和用途 |
| WO2024031048A1 (en) * | 2022-08-05 | 2024-02-08 | Recurium Ip Holdings, Llc | Wee1 compound for treating uterine serous carcinoma |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ITPI20150036A1 (it) * | 2015-05-08 | 2016-11-08 | Mac Design S R L | Capsula per contenere una polvere alimentare e dispositivo per preparare una bevanda a partire da detta polvere alimentare contenuta in detta capsula |
| EP3528816A4 (en) * | 2016-10-21 | 2020-04-08 | Nimbus Lakshmi, Inc. | TYK2 INHIBITORS AND USES THEREOF |
| IL276802B2 (en) * | 2018-03-09 | 2023-09-01 | Recurium Ip Holdings Llc | Transduced 2,1-dihydro-3h-pyrazolo[4,3-d]pyrimidine-3-ones |
-
2021
- 2021-06-09 EP EP21821961.6A patent/EP4153591A4/en active Pending
- 2021-06-09 AU AU2021287910A patent/AU2021287910A1/en active Pending
- 2021-06-09 KR KR1020237001260A patent/KR20230038202A/ko unknown
- 2021-06-09 WO PCT/US2021/036665 patent/WO2021252667A1/en active Application Filing
- 2021-06-09 CA CA3186632A patent/CA3186632A1/en active Pending
- 2021-06-09 CN CN202180058014.7A patent/CN116056708A/zh active Pending
- 2021-06-09 US US18/001,234 patent/US20230234956A1/en active Pending
- 2021-06-09 MX MX2022015646A patent/MX2022015646A/es unknown
- 2021-06-09 JP JP2022576010A patent/JP2023530085A/ja active Pending
- 2021-06-09 IL IL298971A patent/IL298971A/en unknown
- 2021-06-11 TW TW110121419A patent/TW202214638A/zh unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU2021287910A1 (en) | 2023-02-02 |
| EP4153591A4 (en) | 2024-01-24 |
| KR20230038202A (ko) | 2023-03-17 |
| CN116056708A (zh) | 2023-05-02 |
| IL298971A (en) | 2023-02-01 |
| CA3186632A1 (en) | 2021-12-16 |
| JP2023530085A (ja) | 2023-07-13 |
| WO2021252667A1 (en) | 2021-12-16 |
| EP4153591A1 (en) | 2023-03-29 |
| TW202214638A (zh) | 2022-04-16 |
| US20230234956A1 (en) | 2023-07-27 |
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