MX2022014247A - Biomarcadores tumorales para inmunoterapia. - Google Patents
Biomarcadores tumorales para inmunoterapia.Info
- Publication number
- MX2022014247A MX2022014247A MX2022014247A MX2022014247A MX2022014247A MX 2022014247 A MX2022014247 A MX 2022014247A MX 2022014247 A MX2022014247 A MX 2022014247A MX 2022014247 A MX2022014247 A MX 2022014247A MX 2022014247 A MX2022014247 A MX 2022014247A
- Authority
- MX
- Mexico
- Prior art keywords
- icos
- foxp3
- biomarkers
- positive
- positive cells
- Prior art date
Links
- 239000000090 biomarker Substances 0.000 title abstract 4
- 206010028980 Neoplasm Diseases 0.000 title abstract 3
- 238000009169 immunotherapy Methods 0.000 title 1
- 210000004027 cell Anatomy 0.000 abstract 7
- 102100027581 Forkhead box protein P3 Human genes 0.000 abstract 4
- 101000861452 Homo sapiens Forkhead box protein P3 Proteins 0.000 abstract 4
- 238000011224 anti-cancer immunotherapy Methods 0.000 abstract 1
- 206010073071 hepatocellular carcinoma Diseases 0.000 abstract 1
- 231100000844 hepatocellular carcinoma Toxicity 0.000 abstract 1
- 238000005259 measurement Methods 0.000 abstract 1
- 238000004393 prognosis Methods 0.000 abstract 1
- 210000003289 regulatory T cell Anatomy 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5011—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing antineoplastic activity
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
Abstract
Biomarcadores para el pronóstico de tumores, en el carcinoma hepatocelular y otros cánceres. Medición de biomarcadores para la prescripción de inmunoterapia anticancerosa dirigida contra las células T reguladoras ICOS+ (TReg), por ejemplo, la selección de pacientes para el tratamiento con un anticuerpo anti-ICOS. Biomarcadores que comprenden: (i) relación entre el número de células ICOS FOXP3 doblemente positivas dentro de un radio de influencia definido entorno a las células ICOS simples positivas y el número total de células ICOS simples positivas, (ii) distancia media entre cada célula ICOS positiva FOXP3 negativa y su célula ICOS FOXP3 doblemente positiva más cercana, (iii) proporción de células FOXP3 positivas que son ICOS positivas, y (iv) densidad de células ICOS positivas.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB2007099.1A GB202007099D0 (en) | 2020-05-14 | 2020-05-14 | Tumour biomarkers for immunotherapy |
PCT/EP2021/062778 WO2021229032A1 (en) | 2020-05-14 | 2021-05-13 | Tumour biomarkers for immunotherapy |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2022014247A true MX2022014247A (es) | 2022-12-02 |
Family
ID=71135069
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2022014247A MX2022014247A (es) | 2020-05-14 | 2021-05-13 | Biomarcadores tumorales para inmunoterapia. |
Country Status (12)
Country | Link |
---|---|
US (1) | US20230176060A1 (es) |
EP (1) | EP4150347A1 (es) |
JP (1) | JP2023526044A (es) |
KR (1) | KR20230009507A (es) |
CN (1) | CN117581101A (es) |
AU (1) | AU2021271120A1 (es) |
BR (1) | BR112022022250A2 (es) |
CA (1) | CA3178642A1 (es) |
GB (1) | GB202007099D0 (es) |
IL (1) | IL298164A (es) |
MX (1) | MX2022014247A (es) |
WO (1) | WO2021229032A1 (es) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR20230044038A (ko) | 2016-08-09 | 2023-03-31 | 키맵 리미티드 | 항-icos 항체 |
Family Cites Families (42)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NL1003648C2 (nl) | 1996-07-19 | 1998-01-21 | Carino Cornelis Sunderman | Werkwijze en inrichting voor het bevorderen van de rookgasafvoer van een openhaardvuur. |
US7112655B1 (en) | 1997-02-27 | 2006-09-26 | Japan Tobacco, Inc. | JTT-1 protein and methods of inhibiting lymphocyte activation |
JP3521382B2 (ja) | 1997-02-27 | 2004-04-19 | 日本たばこ産業株式会社 | 細胞間接着及びシグナル伝達を媒介する細胞表面分子 |
DE59813875D1 (de) | 1997-09-23 | 2007-02-22 | Bundesrepublik Deutschland Let | Ko-stimulierendes polypeptid von t-zellen, monoklonale antikörper sowie die herstellung und deren verwendung |
DE19821060A1 (de) | 1997-09-23 | 1999-04-15 | Bundesrepublik Deutschland Let | Ko-stimulierendes Polypeptid von T-Zellen, monoklonale Antikörper sowie die Herstellung und deren Verwendung |
JP3871503B2 (ja) | 1999-08-30 | 2007-01-24 | 日本たばこ産業株式会社 | 免疫性疾患治療剤 |
JP3597140B2 (ja) | 2000-05-18 | 2004-12-02 | 日本たばこ産業株式会社 | 副刺激伝達分子ailimに対するヒトモノクローナル抗体及びその医薬用途 |
JP4212278B2 (ja) | 2001-03-01 | 2009-01-21 | 日本たばこ産業株式会社 | 移植片拒絶反応抑制剤 |
EP1740617B1 (en) | 2004-04-23 | 2013-10-16 | BUNDESREPUBLIK DEUTSCHLAND letztvertreten durch das Robert Koch-Institut vertreten durch seinen Präsidenten | Method for the treatment of t cell mediated conditions by depletion of icos-positive cells in vivo |
GB0521621D0 (en) | 2005-10-24 | 2005-11-30 | Domantis Ltd | Tumor necrosis factor receptor 1 antagonists for treating respiratory diseases |
RS50752B (sr) | 2005-01-05 | 2010-08-31 | F-Star Biotechnologische Forschungs-Und Entwicklungsges M.B.H. | Domeni sintetskih imunoglobulina sa svojstvima vezivanja, konstruisani u regionima molekula, koji se razlikuju od regiona, koji određuju komplementarnost |
AT503902B1 (de) | 2006-07-05 | 2008-06-15 | F Star Biotech Forsch & Entw | Verfahren zur manipulation von immunglobulinen |
AT503889B1 (de) | 2006-07-05 | 2011-12-15 | Star Biotechnologische Forschungs Und Entwicklungsges M B H F | Multivalente immunglobuline |
BRPI0811466A2 (pt) | 2007-05-07 | 2014-10-14 | Medimmune Llc | Anticorpo anti-icos isolado, ácido nucleico, vetor, célula isolada, métodos para produzir um anticorpo, para tratar uma doença ou distúrbio, para tratar ou prevenir a rejeição em um paciente de transplante humano, para tratar uma malignidade de célula t em um ser humano, para esgotar células t que expressam icos em um paciente humano, para romper a arquitetura do centro germinal em um órgão linfóide secundário de um primata, para esgotar células b centrais germinais de órgão linfóide secundário de um primata, e para esgotar células b comutadas em classes circulantes em um primata, e, composição farmacêutica. |
EP3241842B1 (en) | 2007-06-26 | 2024-01-31 | F-star Therapeutics Limited | Display of binding agents |
EP2113255A1 (en) | 2008-05-02 | 2009-11-04 | f-star Biotechnologische Forschungs- und Entwicklungsges.m.b.H. | Cytotoxic immunoglobulin |
JP5933975B2 (ja) | 2008-11-12 | 2016-06-15 | メディミューン,エルエルシー | 抗体製剤 |
JP5883384B2 (ja) | 2009-08-13 | 2016-03-15 | ザ ジョンズ ホプキンス ユニバーシティー | 免疫機能を調節する方法 |
EA027623B1 (ru) | 2011-03-31 | 2017-08-31 | Инсэрм (Инститют Насиональ Де Ля Сантэ Э Де Ля Решерш Медикаль) | Антитела, направленные против icos, и их применения |
CA2841416A1 (en) | 2011-06-15 | 2012-12-20 | Glaxosmithkline Intellectual Property (No.2) Limited | Method of selecting therapeutic indications |
DE102012013637A1 (de) | 2012-07-09 | 2014-01-09 | Iwis Motorsysteme Gmbh & Co. Kg | Triebstockplanetengetriebe |
EP2872646B1 (en) | 2012-07-12 | 2017-08-30 | Institut National de la Sante et de la Recherche Medicale (INSERM) | Methods for predicting the survival time and treatment responsiveness of a patient suffering from a solid cancer with a signature of at least 7 genes |
CA2881389C (en) | 2012-08-06 | 2022-01-04 | Inserm (Institut National De La Sante Et De La Recherche Medicale) | Methods and kits for screening patients with a cancer |
WO2014033327A1 (en) | 2012-09-03 | 2014-03-06 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Antibodies directed against icos for treating graft-versus-host disease |
EP2738557A1 (en) * | 2012-12-03 | 2014-06-04 | Université Libre de Bruxelles | Organized immune response in cancer |
WO2015103037A2 (en) | 2014-01-02 | 2015-07-09 | Memorial Sloan Kettering Cancer Center | Determinants of cancer response to immunotherapy |
US20160145344A1 (en) | 2014-10-20 | 2016-05-26 | University Of Southern California | Murine and human innate lymphoid cells and lung inflammation |
EP3240908A2 (en) | 2014-12-30 | 2017-11-08 | F. Hoffmann-La Roche AG | Methods and compositions for prognosis and treatment of cancers |
MA41414A (fr) | 2015-01-28 | 2017-12-05 | Centre Nat Rech Scient | Protéines de liaison agonistes d' icos |
PL3273992T3 (pl) | 2015-03-23 | 2020-11-16 | Jounce Therapeutics, Inc. | Przeciwciała przeciwko icos |
AU2016342269A1 (en) | 2015-10-22 | 2018-03-29 | Jounce Therapeutics, Inc. | Gene signatures for determining icos expression |
US9567399B1 (en) | 2016-06-20 | 2017-02-14 | Kymab Limited | Antibodies and immunocytokines |
WO2018029474A2 (en) | 2016-08-09 | 2018-02-15 | Kymab Limited | Anti-icos antibodies |
WO2018097166A1 (ja) * | 2016-11-24 | 2018-05-31 | 第一三共株式会社 | Pd-1免疫チェックポイント阻害剤による治療に対するがんの感受性を予測する方法 |
WO2018122245A1 (en) * | 2016-12-28 | 2018-07-05 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods of predicting the survival time of patients suffering from cms3 colorectal cancer |
TWI788340B (zh) | 2017-04-07 | 2023-01-01 | 美商必治妥美雅史谷比公司 | 抗icos促效劑抗體及其用途 |
JP2020525758A (ja) | 2017-06-04 | 2020-08-27 | ラパポート・ファミリー・インスティテュート・フォー・リサーチ・イン・ザ・メディカル・サイエンシーズRappaport Family Institute for Research in the Medical Sciences | 免疫チェックポイント阻害薬によるがん治療に対する個別化応答の予測方法およびそのためのキット |
GB201721338D0 (en) | 2017-12-19 | 2018-01-31 | Kymab Ltd | Anti-icos Antibodies |
US11629189B2 (en) | 2017-12-19 | 2023-04-18 | Kymab Limited | Bispecific antibody for ICOS and PD-L1 |
WO2019222188A1 (en) | 2018-05-14 | 2019-11-21 | Jounce Therapeutics, Inc. | Methods of treating cancer |
US20220049010A1 (en) | 2018-09-14 | 2022-02-17 | Université de Lausanne | Methods for modulating regulatory t cells and inhibiting tumor growth |
SG11202112712RA (en) | 2019-06-03 | 2021-12-30 | Inst Nat Sante Rech Med | Methods for modulating a treatment regimen |
-
2020
- 2020-05-14 GB GBGB2007099.1A patent/GB202007099D0/en not_active Ceased
-
2021
- 2021-05-13 KR KR1020227043808A patent/KR20230009507A/ko unknown
- 2021-05-13 MX MX2022014247A patent/MX2022014247A/es unknown
- 2021-05-13 US US17/921,822 patent/US20230176060A1/en active Pending
- 2021-05-13 BR BR112022022250A patent/BR112022022250A2/pt unknown
- 2021-05-13 JP JP2022568741A patent/JP2023526044A/ja active Pending
- 2021-05-13 CN CN202180061391.6A patent/CN117581101A/zh active Pending
- 2021-05-13 IL IL298164A patent/IL298164A/en unknown
- 2021-05-13 WO PCT/EP2021/062778 patent/WO2021229032A1/en active Application Filing
- 2021-05-13 CA CA3178642A patent/CA3178642A1/en active Pending
- 2021-05-13 AU AU2021271120A patent/AU2021271120A1/en active Pending
- 2021-05-13 EP EP21726873.9A patent/EP4150347A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
US20230176060A1 (en) | 2023-06-08 |
IL298164A (en) | 2023-01-01 |
CA3178642A1 (en) | 2021-11-18 |
AU2021271120A1 (en) | 2023-02-02 |
EP4150347A1 (en) | 2023-03-22 |
KR20230009507A (ko) | 2023-01-17 |
WO2021229032A1 (en) | 2021-11-18 |
CN117581101A (zh) | 2024-02-20 |
JP2023526044A (ja) | 2023-06-20 |
BR112022022250A2 (pt) | 2022-12-27 |
GB202007099D0 (en) | 2020-07-01 |
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