MX2022013362A - Composiciones para tratar cancer con mutaciones de kras y usos de las mismas. - Google Patents

Composiciones para tratar cancer con mutaciones de kras y usos de las mismas.

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Publication number
MX2022013362A
MX2022013362A MX2022013362A MX2022013362A MX2022013362A MX 2022013362 A MX2022013362 A MX 2022013362A MX 2022013362 A MX2022013362 A MX 2022013362A MX 2022013362 A MX2022013362 A MX 2022013362A MX 2022013362 A MX2022013362 A MX 2022013362A
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MX
Mexico
Prior art keywords
kras
mutations
compositions
treating cancer
genome
Prior art date
Application number
MX2022013362A
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English (en)
Inventor
Gilles Divita
Neil P Desai
Original Assignee
Aadigen Llc
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Publication date
Application filed by Aadigen Llc filed Critical Aadigen Llc
Publication of MX2022013362A publication Critical patent/MX2022013362A/es

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    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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Abstract

La presente invención se refiere a un ARN guía y complejos de edición del genoma o nanopartículas que son útiles para dirigirse específicamente a KRAS mutado. Los ejemplos de complejos de edición del genoma o nanopartículas comprenden péptidos que penetran en la célula y, opcionalmente, una nucleasa de ADN (tal como Cas9) o un polinucleótido que codifica la nucleasa de ADN.
MX2022013362A 2020-04-24 2021-04-23 Composiciones para tratar cancer con mutaciones de kras y usos de las mismas. MX2022013362A (es)

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CA3029908A1 (en) * 2016-07-05 2018-01-11 The Johns Hopkins University Crispr/cas9-based compositions and methods for treating cancer
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KR101796036B1 (ko) * 2016-12-29 2017-11-10 주식회사 무진메디 Cas9 단백질, KRAS 유전자의 발현을 억제하는 가이드 RNA 및 양이온성 폴리머의 복합체가 봉입된 나노 리포좀 전달체 조성물 또는 이를 함유하는 KRAS 유전자 변이에 따른 항암제 저항성 대장암 치료제

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