MX2022009390A - Compuestos de unión a il-7r¿¿c. - Google Patents

Compuestos de unión a il-7r¿¿c.

Info

Publication number
MX2022009390A
MX2022009390A MX2022009390A MX2022009390A MX2022009390A MX 2022009390 A MX2022009390 A MX 2022009390A MX 2022009390 A MX2022009390 A MX 2022009390A MX 2022009390 A MX2022009390 A MX 2022009390A MX 2022009390 A MX2022009390 A MX 2022009390A
Authority
MX
Mexico
Prior art keywords
binding compounds
compounds
diseases
binding
agonists
Prior art date
Application number
MX2022009390A
Other languages
English (en)
Inventor
William J Dower
Michael C Needels
Ronald W Barrett
Alice V Bakker
Steven E Cwirla
Original Assignee
Medikine Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medikine Inc filed Critical Medikine Inc
Publication of MX2022009390A publication Critical patent/MX2022009390A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • C07K14/7155—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for interleukins [IL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/5418—IL-7
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Health & Medical Sciences (AREA)
  • Toxicology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Cell Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)

Abstract

Se describen compuestos de unión a IL-7R¿¿c y composiciones farmacéuticas que comprenden los compuestos de unión a IL-7R¿¿c. Los compuestos de unión a IL-7R¿¿c pueden actuar como agonistas IL-7R y son útiles para tratar el cáncer, las enfermedades virales, las enfermedades autoinmunitarias y las enfermedades inflamatorias.
MX2022009390A 2020-02-03 2021-02-03 Compuestos de unión a il-7r¿¿c. MX2022009390A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202062969432P 2020-02-03 2020-02-03
US202063041158P 2020-06-19 2020-06-19
PCT/US2021/016361 WO2021158623A1 (en) 2020-02-03 2021-02-03 IL-7Rαγc BINDING COMPOUNDS

Publications (1)

Publication Number Publication Date
MX2022009390A true MX2022009390A (es) 2022-11-16

Family

ID=77200524

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2022009390A MX2022009390A (es) 2020-02-03 2021-02-03 Compuestos de unión a il-7r¿¿c.

Country Status (12)

Country Link
US (2) US11746139B2 (es)
EP (1) EP4100427A4 (es)
JP (1) JP2023514128A (es)
KR (1) KR20220139918A (es)
CN (1) CN115315435A (es)
AU (2) AU2021217353A1 (es)
BR (1) BR112022015002A2 (es)
CA (1) CA3166816A1 (es)
IL (1) IL295304A (es)
MX (1) MX2022009390A (es)
TW (2) TWI812918B (es)
WO (1) WO2021158623A1 (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2021105821A (ru) 2018-08-06 2021-05-27 Медикайн, Инк. Соединения, связывающие рецептор il-2
CA3160133A1 (en) 2019-11-05 2021-05-14 Medikine, Inc. Il-2rbyc binding compounds
IL292803A (en) 2019-11-05 2022-07-01 Medikine Inc Compounds that bind to both 2-il and 7-il receptors, preparations containing them and their uses
IL295304A (en) 2020-02-03 2022-10-01 Medikine Inc 7-il alpha gamma c receptor binding compounds, preparations containing them and their uses
KR20220156533A (ko) * 2020-02-03 2022-11-25 메디카인 인코포레이티드 IL-7Rα 결합 화합물
WO2023133595A2 (en) 2022-01-10 2023-07-13 Sana Biotechnology, Inc. Methods of ex vivo dosing and administration of lipid particles or viral vectors and related systems and uses
WO2023193015A1 (en) 2022-04-01 2023-10-05 Sana Biotechnology, Inc. Cytokine receptor agonist and viral vector combination therapies
US11999771B2 (en) 2022-04-07 2024-06-04 Medikine, Inc. IL-7Rαγc ligand immunoglobulin fusion proteins
US20240101959A1 (en) 2022-09-06 2024-03-28 Medikine, Inc. Use of il-2r-beta-gamma agonist peptides in cell manufacturing
WO2024054870A1 (en) 2022-09-06 2024-03-14 Medikine, Inc. Use of il-7r-alpha-gamma agonist peptides in cell manufacturing

Family Cites Families (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5635597A (en) 1994-05-27 1997-06-03 Affymax Technologies, N.V. Peptides that bind IL-2 receptors
ES2381025T3 (es) 2001-12-04 2012-05-22 Merck Patent Gmbh Inmunocitocinas con selectividad modulada
US20050054054A1 (en) * 2002-11-12 2005-03-10 Foss Francine M. Interleukin-7 molecules with altered biological properties
WO2005063820A2 (en) 2003-12-30 2005-07-14 Merck Patent Gmbh Il-7 fusion proteins
CA2591297C (en) 2004-12-09 2015-01-13 Stephen D. Gillies Il-7 variants with reduced immunogenicity
MX2007007033A (es) 2004-12-22 2007-08-03 Novartis Vaccines & Diagnostic Estreptococus del grupo b.
US20120210458A9 (en) 2009-02-27 2012-08-16 Yongwei Cao Isolated Novel Nucleic Acid and Protein Molecules from Corn and Methods of Using Thereof
AU2011325990C1 (en) 2010-11-12 2017-06-08 Nektar Therapeutics Conjugates of an IL-2 moiety and a polymer
CA2820956C (en) * 2010-12-10 2016-05-03 University Of Central Florida Research Foundation, Inc. Methods and compositions comprising il-7 receptor ligands
RS60050B1 (sr) 2011-01-18 2020-04-30 Bioniz Llc Kompozicije za modulaciju aktivnosti gama-c-citokina
CN106659757B (zh) 2014-04-24 2022-01-28 利兰斯坦福初级大学董事会 白介素2的超级激动剂、部分激动剂和拮抗剂
EA202190903A3 (ru) 2014-07-21 2021-12-31 Делиниа, Инк. Молекулы, которые избирательно активируют регуляторные t-клетки, для лечения аутоиммунных заболеваний
ES2807260T3 (es) 2014-08-11 2021-02-22 Delinia Inc Variantes de IL-2 modificadas que activan selectivamente las células T reguladoras para el tratamiento de enfermedades autoinmunes
PT3328894T (pt) * 2015-08-06 2019-02-13 Agency Science Tech & Res Anticorpos de cadeia comum gama/il2rbeta
MA45488A (fr) 2015-10-22 2018-08-29 Juno Therapeutics Gmbh Procédés, kits et appareil de culture de cellules
US20170204154A1 (en) 2016-01-20 2017-07-20 Delinia, Inc. Molecules that selectively activate regulatory t cells for the treatment of autoimmune diseases
KR20180117116A (ko) 2016-02-05 2018-10-26 워싱턴 유니버시티 표적화된 사이토카인 전달을 위한 조성물 및 방법들
AU2017359172A1 (en) 2016-11-08 2019-05-16 Delinia, Inc. IL-2 variants for the treatment of autoimmune diseases
DK3551664T3 (da) * 2016-12-09 2021-05-03 Ose Immunotherapeutics Antistoffer og polypeptider rettet mod cd127
CN110177564A (zh) 2016-12-13 2019-08-27 德里尼亚公司 多价的调节t细胞调节剂
RU2021105821A (ru) 2018-08-06 2021-05-27 Медикайн, Инк. Соединения, связывающие рецептор il-2
WO2020247388A2 (en) 2019-06-03 2020-12-10 Medikine, Inc. Il-2alpha receptor subunit binding compounds
CA3160133A1 (en) 2019-11-05 2021-05-14 Medikine, Inc. Il-2rbyc binding compounds
US20220119492A1 (en) 2019-11-05 2022-04-21 Medikine, Inc. Il-2r-beta-gamma binding compounds and uses thereof
IL292803A (en) 2019-11-05 2022-07-01 Medikine Inc Compounds that bind to both 2-il and 7-il receptors, preparations containing them and their uses
TW202136287A (zh) 2019-12-17 2021-10-01 法商Ｏｓｅ免疫治療公司 包含il-7變體之雙官能分子
IL295304A (en) 2020-02-03 2022-10-01 Medikine Inc 7-il alpha gamma c receptor binding compounds, preparations containing them and their uses
KR20220156533A (ko) 2020-02-03 2022-11-25 메디카인 인코포레이티드 IL-7Rα 결합 화합물
CA3197344A1 (en) 2020-11-04 2022-05-12 William J. Dower Il-2r.beta.yc binding compounds and uses thereof
US11999771B2 (en) 2022-04-07 2024-06-04 Medikine, Inc. IL-7Rαγc ligand immunoglobulin fusion proteins

Also Published As

Publication number Publication date
JP2023514128A (ja) 2023-04-05
US20210253670A1 (en) 2021-08-19
EP4100427A1 (en) 2022-12-14
WO2021158623A1 (en) 2021-08-12
BR112022015002A2 (pt) 2022-12-06
TW202144390A (zh) 2021-12-01
US11746139B2 (en) 2023-09-05
AU2021217353A1 (en) 2022-08-25
CN115315435A (zh) 2022-11-08
KR20220139918A (ko) 2022-10-17
AU2024201860A1 (en) 2024-05-16
US11965015B2 (en) 2024-04-23
CA3166816A1 (en) 2021-08-12
IL295304A (en) 2022-10-01
TWI812918B (zh) 2023-08-21
EP4100427A4 (en) 2024-01-17
US20230357358A1 (en) 2023-11-09
TW202342505A (zh) 2023-11-01

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