MX2022009390A - Compuestos de unión a il-7r¿¿c. - Google Patents

Compuestos de unión a il-7r¿¿c.

Info

Publication number
MX2022009390A
MX2022009390A MX2022009390A MX2022009390A MX2022009390A MX 2022009390 A MX2022009390 A MX 2022009390A MX 2022009390 A MX2022009390 A MX 2022009390A MX 2022009390 A MX2022009390 A MX 2022009390A MX 2022009390 A MX2022009390 A MX 2022009390A
Authority
MX
Mexico
Prior art keywords
binding compounds
compounds
diseases
binding
agonists
Prior art date
Application number
MX2022009390A
Other languages
English (en)
Inventor
William J Dower
Michael C Needels
Ronald W Barrett
Alice V Bakker
Steven E Cwirla
Original Assignee
Medikine Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medikine Inc filed Critical Medikine Inc
Publication of MX2022009390A publication Critical patent/MX2022009390A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • C07K14/7155—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for interleukins [IL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/5418—IL-7
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Cell Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

Se describen compuestos de unión a IL-7R¿¿c y composiciones farmacéuticas que comprenden los compuestos de unión a IL-7R¿¿c. Los compuestos de unión a IL-7R¿¿c pueden actuar como agonistas IL-7R y son útiles para tratar el cáncer, las enfermedades virales, las enfermedades autoinmunitarias y las enfermedades inflamatorias.
MX2022009390A 2020-02-03 2021-02-03 Compuestos de unión a il-7r¿¿c. MX2022009390A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202062969432P 2020-02-03 2020-02-03
US202063041158P 2020-06-19 2020-06-19
PCT/US2021/016361 WO2021158623A1 (en) 2020-02-03 2021-02-03 IL-7Rαγc BINDING COMPOUNDS

Publications (1)

Publication Number Publication Date
MX2022009390A true MX2022009390A (es) 2022-11-16

Family

ID=77200524

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2022009390A MX2022009390A (es) 2020-02-03 2021-02-03 Compuestos de unión a il-7r¿¿c.

Country Status (12)

Country Link
US (2) US11746139B2 (es)
EP (1) EP4100427A4 (es)
JP (1) JP2023514128A (es)
KR (1) KR20220139918A (es)
CN (1) CN115315435A (es)
AU (2) AU2021217353A1 (es)
BR (1) BR112022015002A2 (es)
CA (1) CA3166816A1 (es)
IL (1) IL295304A (es)
MX (1) MX2022009390A (es)
TW (2) TW202342505A (es)
WO (1) WO2021158623A1 (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA3108865A1 (en) 2018-08-06 2020-02-13 Medikine, Inc. Il-2 receptor binding compounds
MX2022005411A (es) 2019-11-05 2022-08-10 Medikine Inc COMPUESTOS DE UNIÓN A IL-2RßYC.
WO2021092081A1 (en) 2019-11-05 2021-05-14 Medikine, Inc. Dual il-2r and il-7r binding compounds
US11746139B2 (en) 2020-02-03 2023-09-05 Medikine, Inc. IL-7Rαγc binding compounds
WO2023133595A2 (en) 2022-01-10 2023-07-13 Sana Biotechnology, Inc. Methods of ex vivo dosing and administration of lipid particles or viral vectors and related systems and uses
WO2023193015A1 (en) 2022-04-01 2023-10-05 Sana Biotechnology, Inc. Cytokine receptor agonist and viral vector combination therapies
WO2023196876A1 (en) * 2022-04-07 2023-10-12 Medikine, Inc. Il-7ralpha-gamma ligand immunoglobulin fusion proteins
WO2024054874A1 (en) 2022-09-06 2024-03-14 Medikine, Inc. Use of il-2r-beta-gamma agonist peptides in cell manufacturing
WO2024054870A1 (en) * 2022-09-06 2024-03-14 Medikine, Inc. Use of il-7r-alpha-gamma agonist peptides in cell manufacturing

Family Cites Families (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5635597A (en) 1994-05-27 1997-06-03 Affymax Technologies, N.V. Peptides that bind IL-2 receptors
CN100390282C (zh) 2001-12-04 2008-05-28 默克专利有限公司 具有调节的选择性的il-2融合蛋白
US20050054054A1 (en) * 2002-11-12 2005-03-10 Foss Francine M. Interleukin-7 molecules with altered biological properties
ATE393169T1 (de) 2003-12-30 2008-05-15 Merck Patent Gmbh Il-7-fusionsproteine mit antikörperportionen, deren herstellung und deren verwendung
ATE465176T1 (de) 2004-12-09 2010-05-15 Merck Patent Gmbh Il-7-varianten mit reduzierter immunogenität
EP1828231A2 (en) 2004-12-22 2007-09-05 Novartis Vaccines and Diagnostics, Inc. Group b streptococcus
US20120210458A9 (en) 2009-02-27 2012-08-16 Yongwei Cao Isolated Novel Nucleic Acid and Protein Molecules from Corn and Methods of Using Thereof
PT2637694T (pt) 2010-11-12 2021-05-05 Nektar Therapeutics Conjugados de uma fração de il-2 e um polímero
WO2012128806A1 (en) * 2010-12-10 2012-09-27 University Of Central Florida Research Foundation, Inc. Methods and compositions comprising il-7 receptor ligands
ES2778053T3 (es) 2011-01-18 2020-08-07 Bioniz Llc Composiciones para modular la actividad de la citocina gamma-c
CN106659757B (zh) 2014-04-24 2022-01-28 利兰斯坦福初级大学董事会 白介素2的超级激动剂、部分激动剂和拮抗剂
RS59789B1 (sr) 2014-07-21 2020-02-28 Delinia Inc Molekuli koji selektivno aktiviraju regulatorne t ćelije u tretmanima autoimunih bolesti
KR20170035910A (ko) 2014-08-11 2017-03-31 데리니아, 인크. 자가면역 질환의 치료를 위한 조절 t 세포를 선택적으로 활성화시키는 변형된 il-2 변이체
CN107922496B (zh) 2015-08-06 2022-11-01 新加坡科技研究局 IL2Rβ/通用γ链抗体
MA45488A (fr) 2015-10-22 2018-08-29 Juno Therapeutics Gmbh Procédés, kits et appareil de culture de cellules
US20170204154A1 (en) 2016-01-20 2017-07-20 Delinia, Inc. Molecules that selectively activate regulatory t cells for the treatment of autoimmune diseases
CA3011374A1 (en) 2016-02-05 2017-08-10 Washington University Compositions and methods for targeted cytokine delivery
WO2018089420A1 (en) 2016-11-08 2018-05-17 Delinia, Inc. Il-2 variants for the treatment of autoimmune diseases
AR110326A1 (es) * 2016-12-09 2019-03-20 Ose Immunotherapeutics Anticuerpos y polipéptidos dirigidos contra cd127
RU2769871C2 (ru) 2016-12-13 2022-04-07 Делиниа, Инк. Поливалентные модуляторы регуляторных t-клеток
CA3108865A1 (en) 2018-08-06 2020-02-13 Medikine, Inc. Il-2 receptor binding compounds
WO2020247388A2 (en) 2019-06-03 2020-12-10 Medikine, Inc. Il-2alpha receptor subunit binding compounds
WO2021092081A1 (en) 2019-11-05 2021-05-14 Medikine, Inc. Dual il-2r and il-7r binding compounds
US20220119492A1 (en) 2019-11-05 2022-04-21 Medikine, Inc. Il-2r-beta-gamma binding compounds and uses thereof
MX2022005411A (es) 2019-11-05 2022-08-10 Medikine Inc COMPUESTOS DE UNIÓN A IL-2RßYC.
TW202136287A (zh) 2019-12-17 2021-10-01 法商Ｏｓｅ免疫治療公司 包含il-7變體之雙官能分子
WO2021158619A1 (en) 2020-02-03 2021-08-12 Medikine, Inc. IL-7Rα BINDING COMPOUNDS
US11746139B2 (en) 2020-02-03 2023-09-05 Medikine, Inc. IL-7Rαγc binding compounds
AU2021376351A1 (en) 2020-11-04 2023-06-08 Medikine, Inc. IL-2Rβγc BINDING COMPOUNDS AND USES THEREOF
WO2023196876A1 (en) 2022-04-07 2023-10-12 Medikine, Inc. Il-7ralpha-gamma ligand immunoglobulin fusion proteins

Also Published As

Publication number Publication date
US20230357358A1 (en) 2023-11-09
EP4100427A4 (en) 2024-01-17
CN115315435A (zh) 2022-11-08
IL295304A (en) 2022-10-01
KR20220139918A (ko) 2022-10-17
AU2024201860A1 (en) 2024-05-16
TWI812918B (zh) 2023-08-21
US11965015B2 (en) 2024-04-23
US11746139B2 (en) 2023-09-05
CA3166816A1 (en) 2021-08-12
JP2023514128A (ja) 2023-04-05
EP4100427A1 (en) 2022-12-14
TW202144390A (zh) 2021-12-01
TW202342505A (zh) 2023-11-01
US20210253670A1 (en) 2021-08-19
AU2021217353A1 (en) 2022-08-25
BR112022015002A2 (pt) 2022-12-06
WO2021158623A1 (en) 2021-08-12

Similar Documents

Publication Publication Date Title
MX2022009390A (es) Compuestos de unión a il-7r¿¿c.
MX2022005404A (es) Compuestos de fijación a il-2r e il-7r dual.
MX2022005411A (es) COMPUESTOS DE UNIÓN A IL-2RßYC.
NZ761434A (en) Cytokine conjugates for the treatment of autoimmune diseases
PH12020500396A1 (en) Ectonucleotide pyrophosphatase-phosphodiesterase 1 (enpp-1) inhibitors and uses thereof
MX2020001513A (es) Agentes de union a clec9a y su uso.
MX2019001517A (es) Complejos de nanopartículas de albúmina modificada con anticuerpos para el tratamiento del cáncer.
MX2022001776A (es) Terapias de combinacion de inmuno oncologia con conjugados de il-2.
MX2022009302A (es) Compuestos de unión a il-7r¿.
MX2019009566A (es) Proteinas de union a bcma, nkg2d y cd16.
MX2019009848A (es) Proteínas que se unen a her2, nkg2d y cd16.
MX2020014031A (es) Proteinas heterodimericas y usos de las mismas.
MX2022013944A (es) Proteinas que se unen al receptor activador de celulas asesinas naturales grupo 2 miembro d (nkg2d), cumulo de diferenciacion (cd16) y miembro a de la familia de dominios de lectina tipo c 12 (clec12a).
MX2020008208A (es) Agentes de unión a fibroblastos y uso de estos.
MX2021003773A (es) Composiciones farmacéuticas y métodos relacionados con los agentes terapéuticos óticos.
MX2022004430A (es) Proteinas que se unen al receptor activador de celulas asesinas naturales grupo 2 miembro d (nkg2d), al cumulo de diferenciacion 16 (cd16) y a la tirosina cinasa 3 similar a fms (flt3).
WO2020131586A3 (en) Methods for identifying neoantigens
MX2019009943A (es) Proteínas que se unen a gd2, nkg2d y cd16.
MX2022003217A (es) Conjugados terapeuticos.
MX2019009541A (es) Proteinas que se unen a psma, nkg2d y cd16.
WO2021090062A8 (en) Anti-mesothelin eribulin antibody-drug conjugates and methods of use
PH12020551556A1 (en) Drug conjugates of cmet monoclonal binding agents, and uses thereof
MX2023001555A (es) Proteinas que se unen a nkg2d, cd16 y egfr.
WO2021041324A3 (en) Compositions and methods for the treatment of pathological pain and itch
WO2018033941A3 (en) Pharmaceutical compositions of ibrutinib