MX2022006732A - Conjugados peptidicos y metodos de uso. - Google Patents
Conjugados peptidicos y metodos de uso.Info
- Publication number
- MX2022006732A MX2022006732A MX2022006732A MX2022006732A MX2022006732A MX 2022006732 A MX2022006732 A MX 2022006732A MX 2022006732 A MX2022006732 A MX 2022006732A MX 2022006732 A MX2022006732 A MX 2022006732A MX 2022006732 A MX2022006732 A MX 2022006732A
- Authority
- MX
- Mexico
- Prior art keywords
- peptide
- receptor
- modulates
- peptide conjugates
- glp
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/605—Glucagons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/542—Carboxylic acids, e.g. a fatty acid or an amino acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/26—Glucagons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Endocrinology (AREA)
- Diabetes (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Toxicology (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Child & Adolescent Psychology (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Psychology (AREA)
- Immunology (AREA)
- Emergency Medicine (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Peptides Or Proteins (AREA)
Abstract
Se divulgan en la presente conjugados peptídicos que comprenden un péptido seleccionado de un péptido que modula el receptor del PYY, un péptido que modula tanto el receptor del GLP-1 como el receptor del GCG, un péptido que modula tanto el receptor del GLP-1 como el receptor del GIP, y un péptido que modula el receptor del GLP-1; y una estructura tipo grapa unida al péptido en un primer aminoácido y en un segundo aminoácido. También se proporcionan conjugados peptídicos que comprenden el péptido liberador de prolactina. Los conjugados peptídicos pueden utilizarse para tratar afecciones tales como la obesidad. Además se proporcionan péptidos liberadores de prolactina engrapados.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201962943667P | 2019-12-04 | 2019-12-04 | |
US202062994791P | 2020-03-25 | 2020-03-25 | |
PCT/US2020/063149 WO2021113535A1 (en) | 2019-12-04 | 2020-12-03 | Peptide conjugates and methods of use |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2022006732A true MX2022006732A (es) | 2022-08-19 |
Family
ID=76222285
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2022006861A MX2022006861A (es) | 2019-12-04 | 2020-12-03 | Agonistas del receptor glp2 y metodos de uso. |
MX2022006732A MX2022006732A (es) | 2019-12-04 | 2020-12-03 | Conjugados peptidicos y metodos de uso. |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2022006861A MX2022006861A (es) | 2019-12-04 | 2020-12-03 | Agonistas del receptor glp2 y metodos de uso. |
Country Status (10)
Country | Link |
---|---|
US (2) | US20230057847A1 (es) |
EP (2) | EP4069274A4 (es) |
JP (2) | JP2023513658A (es) |
KR (2) | KR20220123648A (es) |
CN (2) | CN115052886A (es) |
AU (2) | AU2020397917A1 (es) |
CA (2) | CA3163507A1 (es) |
IL (2) | IL293522A (es) |
MX (2) | MX2022006861A (es) |
WO (2) | WO2021113535A1 (es) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL293522A (en) * | 2019-12-04 | 2022-08-01 | Scripps Research Inst | Peptide conjugates and methods of use |
WO2023207106A1 (zh) * | 2022-04-29 | 2023-11-02 | 苏州星洲生物科技有限公司 | Glp-1/gip受体共激动剂、包含其的药物组合物及其用途 |
CN114949183B (zh) * | 2022-05-07 | 2023-02-28 | 山东京卫制药有限公司 | 一种替尔泊肽粉雾剂及其制备方法 |
TW202410918A (zh) * | 2022-05-27 | 2024-03-16 | 韓商D&D製藥科技股份有限公司 | 用於治療神經病症之組合物及方法 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2012006598A2 (en) * | 2010-07-09 | 2012-01-12 | Dana-Farber Cancer Institute, Inc. | Stabilized insulinotropic peptides and methods of use |
WO2014178018A1 (en) * | 2013-05-02 | 2014-11-06 | Glaxosmithkline Intellectual Property Development Limited | Therapeutic peptides |
KR102455171B1 (ko) * | 2013-12-18 | 2022-10-14 | 더 스크립스 리서치 인스티튜트 | 변형된 치료제, 스테이플드 펩티드 지질 접합체, 및 이의 조성물 |
WO2016205488A1 (en) * | 2015-06-17 | 2016-12-22 | The California Institute For Biomedical Research | Modified therapeutic agents and compositions thereof |
EP3781682A1 (en) * | 2018-04-19 | 2021-02-24 | Stichting VU | Protein macrocyclization |
IL293522A (en) * | 2019-12-04 | 2022-08-01 | Scripps Research Inst | Peptide conjugates and methods of use |
-
2020
- 2020-12-03 IL IL293522A patent/IL293522A/en unknown
- 2020-12-03 MX MX2022006861A patent/MX2022006861A/es unknown
- 2020-12-03 CA CA3163507A patent/CA3163507A1/en active Pending
- 2020-12-03 AU AU2020397917A patent/AU2020397917A1/en active Pending
- 2020-12-03 WO PCT/US2020/063149 patent/WO2021113535A1/en unknown
- 2020-12-03 CA CA3163522A patent/CA3163522A1/en active Pending
- 2020-12-03 JP JP2022531616A patent/JP2023513658A/ja active Pending
- 2020-12-03 EP EP20896451.0A patent/EP4069274A4/en active Pending
- 2020-12-03 EP EP20896436.1A patent/EP4069726A4/en active Pending
- 2020-12-03 JP JP2022532862A patent/JP2023504184A/ja active Pending
- 2020-12-03 AU AU2020397918A patent/AU2020397918A1/en active Pending
- 2020-12-03 KR KR1020227022197A patent/KR20220123648A/ko unknown
- 2020-12-03 CN CN202080095661.0A patent/CN115052886A/zh active Pending
- 2020-12-03 CN CN202080095675.2A patent/CN115052615A/zh active Pending
- 2020-12-03 IL IL293460A patent/IL293460A/en unknown
- 2020-12-03 US US17/782,560 patent/US20230057847A1/en active Pending
- 2020-12-03 KR KR1020227022195A patent/KR20220110244A/ko unknown
- 2020-12-03 MX MX2022006732A patent/MX2022006732A/es unknown
- 2020-12-03 US US17/782,573 patent/US20230071371A1/en active Pending
- 2020-12-03 WO PCT/US2020/063130 patent/WO2021113524A2/en unknown
Also Published As
Publication number | Publication date |
---|---|
US20230071371A1 (en) | 2023-03-09 |
MX2022006861A (es) | 2022-07-11 |
EP4069274A1 (en) | 2022-10-12 |
KR20220123648A (ko) | 2022-09-08 |
EP4069726A2 (en) | 2022-10-12 |
JP2023504184A (ja) | 2023-02-01 |
CA3163507A1 (en) | 2021-06-10 |
JP2023513658A (ja) | 2023-04-03 |
IL293460A (en) | 2022-07-01 |
CA3163522A1 (en) | 2021-06-10 |
AU2020397918A1 (en) | 2022-06-23 |
AU2020397917A1 (en) | 2022-06-23 |
WO2021113524A3 (en) | 2021-07-15 |
EP4069726A4 (en) | 2024-03-20 |
WO2021113524A2 (en) | 2021-06-10 |
WO2021113535A1 (en) | 2021-06-10 |
US20230057847A1 (en) | 2023-02-23 |
IL293522A (en) | 2022-08-01 |
EP4069274A4 (en) | 2024-04-10 |
CN115052886A (zh) | 2022-09-13 |
KR20220110244A (ko) | 2022-08-05 |
CN115052615A (zh) | 2022-09-13 |
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