MX2022004988A - Metodos de tratamiento del cancer con una combinacion de un agente basado en platino y un conjugado de anticuerpo anti-factor tisular-farmaco. - Google Patents
Metodos de tratamiento del cancer con una combinacion de un agente basado en platino y un conjugado de anticuerpo anti-factor tisular-farmaco.Info
- Publication number
- MX2022004988A MX2022004988A MX2022004988A MX2022004988A MX2022004988A MX 2022004988 A MX2022004988 A MX 2022004988A MX 2022004988 A MX2022004988 A MX 2022004988A MX 2022004988 A MX2022004988 A MX 2022004988A MX 2022004988 A MX2022004988 A MX 2022004988A
- Authority
- MX
- Mexico
- Prior art keywords
- platinum
- drug conjugate
- based agent
- methods
- combination
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/243—Platinum; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
- A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6849—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a receptor, a cell surface antigen or a cell surface determinant
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/555—Heterocyclic compounds containing heavy metals, e.g. hemin, hematin, melarsoprol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/05—Dipeptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/65—Peptidic linkers, binders or spacers, e.g. peptidic enzyme-labile linkers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/36—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against blood coagulation factors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Abstract
La invención proporciona un agente basado en platino (por ejemplo, carboplatino) en combinación con un conjugado de anticuerpo-fármaco que se une a factor tisular (TF) (por ejemplo, tisotumab vedotina) y sus usos en métodos para tratar cáncer, tal como cáncer de vejiga y cáncer cervical. La invención también proporciona composiciones y kits que comprenden al agente basado en platino (por ejemplo, carboplatino) y el conjugado de anticuerpo-fármaco que se une a TF (por ejemplo, tisotumab vedotina) para uso en el tratamiento de cáncer, tal como cáncer de vejiga y cáncer cervical.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201962932181P | 2019-11-07 | 2019-11-07 | |
PCT/EP2020/081314 WO2021089794A1 (en) | 2019-11-07 | 2020-11-06 | Methods of treating cancer with a combination of a platinum-based agent and an anti-tissue factor antibody-drug conjugate |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2022004988A true MX2022004988A (es) | 2022-05-13 |
Family
ID=73198303
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2022004988A MX2022004988A (es) | 2019-11-07 | 2020-11-06 | Metodos de tratamiento del cancer con una combinacion de un agente basado en platino y un conjugado de anticuerpo anti-factor tisular-farmaco. |
Country Status (12)
Country | Link |
---|---|
US (1) | US20220387485A1 (es) |
EP (1) | EP4054645A1 (es) |
JP (1) | JP2023500697A (es) |
KR (1) | KR20220097435A (es) |
CN (1) | CN114650846A (es) |
AU (1) | AU2020379219A1 (es) |
BR (1) | BR112022007168A2 (es) |
CA (1) | CA3156022A1 (es) |
IL (1) | IL292600A (es) |
MX (1) | MX2022004988A (es) |
TW (1) | TW202131954A (es) |
WO (1) | WO2021089794A1 (es) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2023213960A1 (en) * | 2022-05-06 | 2023-11-09 | Genmab A/S | Methods of treating cancer with anti-tissue factor antibody-drug conjugates |
Family Cites Families (62)
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US4714681A (en) | 1981-07-01 | 1987-12-22 | The Board Of Reagents, The University Of Texas System Cancer Center | Quadroma cells and trioma cells and methods for the production of same |
US4474893A (en) | 1981-07-01 | 1984-10-02 | The University of Texas System Cancer Center | Recombinant monoclonal antibodies |
US5981216A (en) | 1985-04-01 | 1999-11-09 | Alusuisse Holdings A.G. | Transformed myeloma cell-line and a process for the expression of a gene coding for a eukaryotic polypeptide employing same |
WO1986005807A1 (en) | 1985-04-01 | 1986-10-09 | Celltech Limited | Transformed myeloma cell-line and a process for the expression of a gene coding for a eukaryotic polypeptide employing same |
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US5750172A (en) | 1987-06-23 | 1998-05-12 | Pharming B.V. | Transgenic non human mammal milk |
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US5879936A (en) | 1988-04-18 | 1999-03-09 | Aluguisse Holding A.G. | Recombinant DNA methods, vectors and host cells |
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-
2020
- 2020-11-04 TW TW109138405A patent/TW202131954A/zh unknown
- 2020-11-06 JP JP2022525992A patent/JP2023500697A/ja active Pending
- 2020-11-06 WO PCT/EP2020/081314 patent/WO2021089794A1/en active Application Filing
- 2020-11-06 BR BR112022007168A patent/BR112022007168A2/pt unknown
- 2020-11-06 CN CN202080078040.1A patent/CN114650846A/zh active Pending
- 2020-11-06 AU AU2020379219A patent/AU2020379219A1/en active Pending
- 2020-11-06 MX MX2022004988A patent/MX2022004988A/es unknown
- 2020-11-06 EP EP20803801.8A patent/EP4054645A1/en active Pending
- 2020-11-06 US US17/771,784 patent/US20220387485A1/en active Pending
- 2020-11-06 KR KR1020227018016A patent/KR20220097435A/ko unknown
- 2020-11-06 CA CA3156022A patent/CA3156022A1/en active Pending
-
2022
- 2022-04-28 IL IL292600A patent/IL292600A/en unknown
Also Published As
Publication number | Publication date |
---|---|
WO2021089794A1 (en) | 2021-05-14 |
TW202131954A (zh) | 2021-09-01 |
EP4054645A1 (en) | 2022-09-14 |
AU2020379219A1 (en) | 2022-04-21 |
CA3156022A1 (en) | 2021-05-14 |
CN114650846A (zh) | 2022-06-21 |
IL292600A (en) | 2022-07-01 |
US20220387485A1 (en) | 2022-12-08 |
KR20220097435A (ko) | 2022-07-07 |
JP2023500697A (ja) | 2023-01-10 |
BR112022007168A2 (pt) | 2022-12-13 |
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