BR112022007168A2 - Método para tratar câncer, kit, conjugado de anticorpo-fármaco, usos de um conjugado de anticorpo-fármaco e de um agente à base de platina, e, agente à base de platina - Google Patents

Método para tratar câncer, kit, conjugado de anticorpo-fármaco, usos de um conjugado de anticorpo-fármaco e de um agente à base de platina, e, agente à base de platina

Info

Publication number
BR112022007168A2
BR112022007168A2 BR112022007168A BR112022007168A BR112022007168A2 BR 112022007168 A2 BR112022007168 A2 BR 112022007168A2 BR 112022007168 A BR112022007168 A BR 112022007168A BR 112022007168 A BR112022007168 A BR 112022007168A BR 112022007168 A2 BR112022007168 A2 BR 112022007168A2
Authority
BR
Brazil
Prior art keywords
platinum
antibody
drug conjugate
based agent
cancer
Prior art date
Application number
BR112022007168A
Other languages
English (en)
Inventor
A Rangwala Reshma
C W Breij Esther
Verploegen Sandra
O Abidoye Oyewale
V Nicacio Leonardo
Original Assignee
Genmab As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genmab As filed Critical Genmab As
Publication of BR112022007168A2 publication Critical patent/BR112022007168A2/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
    • A61K47/6849—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a receptor, a cell surface antigen or a cell surface determinant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/555—Heterocyclic compounds containing heavy metals, e.g. hemin, hematin, melarsoprol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/243—Platinum; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/05—Dipeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/65—Peptidic linkers, binders or spacers, e.g. peptidic enzyme-labile linkers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/36—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against blood coagulation factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Abstract

MÉTODO PARA TRATAR CÂNCER, KIT, CONJUGADO DE ANTICORPO-FÁRMACO, USOS DE UM CONJUGADO DE ANTICORPO-FÁRMACO E DE UM AGENTE À BASE DE PLATINA, E, AGENTE À BASE DE PLATINA. A invenção provê um agente à base de platina (por exemplo, carboplatina) em combinação com um conjugado de anticorpo-fármaco que se liga ao fator de tecido (TF) (por exemplo, tisotumabe vedotina) e seu uso nos métodos para tratar câncer, tal como câncer de bexiga e câncer cervical. A invenção também provê composições e kits compreendendo o agente à base de platina (por exemplo, carboplatina) e o conjugado de anticorpo-fármaco que se liga ao TF (por exemplo, tisotumabe vedotina) para o uso no tratamento de câncer, tal como câncer de bexiga e câncer cervical.
BR112022007168A 2019-11-07 2020-11-06 Método para tratar câncer, kit, conjugado de anticorpo-fármaco, usos de um conjugado de anticorpo-fármaco e de um agente à base de platina, e, agente à base de platina BR112022007168A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201962932181P 2019-11-07 2019-11-07
PCT/EP2020/081314 WO2021089794A1 (en) 2019-11-07 2020-11-06 Methods of treating cancer with a combination of a platinum-based agent and an anti-tissue factor antibody-drug conjugate

Publications (1)

Publication Number Publication Date
BR112022007168A2 true BR112022007168A2 (pt) 2022-12-13

Family

ID=73198303

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112022007168A BR112022007168A2 (pt) 2019-11-07 2020-11-06 Método para tratar câncer, kit, conjugado de anticorpo-fármaco, usos de um conjugado de anticorpo-fármaco e de um agente à base de platina, e, agente à base de platina

Country Status (12)

Country Link
US (1) US20220387485A1 (pt)
EP (1) EP4054645A1 (pt)
JP (1) JP2023500697A (pt)
KR (1) KR20220097435A (pt)
CN (1) CN114650846A (pt)
AU (1) AU2020379219A1 (pt)
BR (1) BR112022007168A2 (pt)
CA (1) CA3156022A1 (pt)
IL (1) IL292600A (pt)
MX (1) MX2022004988A (pt)
TW (1) TW202131954A (pt)
WO (1) WO2021089794A1 (pt)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2023213960A1 (en) * 2022-05-06 2023-11-09 Genmab A/S Methods of treating cancer with anti-tissue factor antibody-drug conjugates

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Also Published As

Publication number Publication date
WO2021089794A1 (en) 2021-05-14
TW202131954A (zh) 2021-09-01
EP4054645A1 (en) 2022-09-14
AU2020379219A1 (en) 2022-04-21
CA3156022A1 (en) 2021-05-14
CN114650846A (zh) 2022-06-21
IL292600A (en) 2022-07-01
US20220387485A1 (en) 2022-12-08
MX2022004988A (es) 2022-05-13
KR20220097435A (ko) 2022-07-07
JP2023500697A (ja) 2023-01-10

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