MX2022004588A - Método para producir anticuerpo marcado con metal radioactivo. - Google Patents
Método para producir anticuerpo marcado con metal radioactivo.Info
- Publication number
- MX2022004588A MX2022004588A MX2022004588A MX2022004588A MX2022004588A MX 2022004588 A MX2022004588 A MX 2022004588A MX 2022004588 A MX2022004588 A MX 2022004588A MX 2022004588 A MX2022004588 A MX 2022004588A MX 2022004588 A MX2022004588 A MX 2022004588A
- Authority
- MX
- Mexico
- Prior art keywords
- radioactive metal
- atomic group
- labeled antibody
- producing radioactive
- peptide
- Prior art date
Links
- 230000002285 radioactive effect Effects 0.000 title abstract 5
- 239000002184 metal Substances 0.000 title abstract 3
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 150000004696 coordination complex Chemical class 0.000 abstract 2
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 2
- 150000001540 azides Chemical class 0.000 abstract 1
- 238000012650 click reaction Methods 0.000 abstract 1
- URYYVOIYTNXXBN-OWOJBTEDSA-N trans-cyclooctene Chemical compound C1CCC\C=C\CC1 URYYVOIYTNXXBN-OWOJBTEDSA-N 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
- A61K51/0482—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group chelates from cyclic ligands, e.g. DOTA
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6889—Conjugates wherein the antibody being the modifying agent and wherein the linker, binder or spacer confers particular properties to the conjugates, e.g. peptidic enzyme-labile linkers or acid-labile linkers, providing for an acid-labile immuno conjugate wherein the drug may be released from its antibody conjugated part in an acidic, e.g. tumoural or environment
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
- A61K51/0478—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group complexes from non-cyclic ligands, e.g. EDTA, MAG3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
- A61K51/1093—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody conjugates with carriers being antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
- A61K51/1093—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody conjugates with carriers being antibodies
- A61K51/1096—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody conjugates with carriers being antibodies radioimmunotoxins, i.e. conjugates being structurally as defined in A61K51/1093, and including a radioactive nucleus for use in radiotherapeutic applications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2887—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD20
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Immunology (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Optics & Photonics (AREA)
- Physics & Mathematics (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oncology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
El método de producción de un anticuerpo marcado con metal radioactivo de la presente invención incluye un paso de realizar una reacción de clic de un complejo de metal radioactivo y un anticuerpo modificado específicamente en el sitio con un péptido para producir un anticuerpo marcado con metal radioactivo; la reacción de clic se realiza entre un primer grupo atómico del complejo de metal radioactivo y un segundo grupo atómico ligado directamente o indirectamente al péptido; el segundo grupo atómico es un grupo atómico que contiene un grupo azida o un grupo atómico que contiene transcicloocteno.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2019191561 | 2019-10-18 | ||
PCT/JP2020/039076 WO2021075546A1 (ja) | 2019-10-18 | 2020-10-16 | 放射性金属標識抗体の製造方法 |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2022004588A true MX2022004588A (es) | 2022-07-21 |
Family
ID=75538111
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2022004588A MX2022004588A (es) | 2019-10-18 | 2020-10-16 | Método para producir anticuerpo marcado con metal radioactivo. |
Country Status (13)
Country | Link |
---|---|
US (1) | US20230248854A1 (es) |
EP (1) | EP4047010A4 (es) |
JP (1) | JPWO2021075546A1 (es) |
KR (1) | KR20220083768A (es) |
CN (1) | CN114555132A (es) |
AU (1) | AU2020367624A1 (es) |
BR (1) | BR112022007240A2 (es) |
CA (1) | CA3158344A1 (es) |
IL (1) | IL292312A (es) |
MX (1) | MX2022004588A (es) |
TW (1) | TW202128732A (es) |
WO (1) | WO2021075546A1 (es) |
ZA (1) | ZA202205154B (es) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR20230088764A (ko) * | 2020-10-16 | 2023-06-20 | 니혼 메디피직스 가부시키가이샤 | 항her2 항체의 방사성 복합체, 및 방사성 의약 |
JP7154465B1 (ja) | 2021-01-08 | 2022-10-17 | 日本メジフィジックス株式会社 | Ac-225溶液の製造方法およびAc-225溶液を用いた医薬の製造方法 |
WO2022224980A1 (ja) * | 2021-04-20 | 2022-10-27 | 日本メジフィジックス株式会社 | 抗cd20抗体の放射性複合体、及び、放射性医薬 |
TW202325343A (zh) * | 2021-08-31 | 2023-07-01 | 日商日本醫事物理股份有限公司 | 去醣基化抗體之放射性複合體,及放射性醫藥 |
WO2023190402A1 (ja) * | 2022-03-30 | 2023-10-05 | 日本メジフィジックス株式会社 | 複合体の製造方法 |
WO2024108304A1 (en) * | 2022-11-23 | 2024-05-30 | Standard Biotools Canada Inc. | Dithiol chelators for metal conjugation to antibodies |
CN117466980A (zh) * | 2023-11-02 | 2024-01-30 | 浙江普罗亭健康科技有限公司 | 基于多肽链骨架应用于金属抗体标记的负载金属缀合物及其应用 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK3160513T3 (da) * | 2014-06-30 | 2020-04-06 | Glykos Finland Oy | Saccharidderivat af en toksisk payload og antistofkonjugater deraf |
WO2016186206A1 (ja) | 2015-05-20 | 2016-11-24 | 国立大学法人鹿児島大学 | IgG結合ペプチドによる抗体の特異的修飾 |
JP6959616B2 (ja) | 2016-06-13 | 2021-11-02 | 国立大学法人 鹿児島大学 | IgG結合ペプチドによる部位特異的RI標識抗体 |
JP7291395B2 (ja) | 2017-06-16 | 2023-06-15 | 国立大学法人 鹿児島大学 | IgG結合ペプチド、及び該ペプチドによる抗体の特異的修飾 |
AU2018388467A1 (en) | 2017-12-18 | 2020-06-11 | Janssen Biotech, Inc. | Radiolabeling of polypeptides |
KR20200143366A (ko) * | 2018-04-16 | 2020-12-23 | 니혼 메디피직스 가부시키가이샤 | 수식 항체 및 방사성 금속 표지 항체 |
-
2020
- 2020-10-16 KR KR1020227016140A patent/KR20220083768A/ko unknown
- 2020-10-16 AU AU2020367624A patent/AU2020367624A1/en active Pending
- 2020-10-16 CA CA3158344A patent/CA3158344A1/en active Pending
- 2020-10-16 TW TW109135916A patent/TW202128732A/zh unknown
- 2020-10-16 IL IL292312A patent/IL292312A/en unknown
- 2020-10-16 BR BR112022007240A patent/BR112022007240A2/pt unknown
- 2020-10-16 MX MX2022004588A patent/MX2022004588A/es unknown
- 2020-10-16 WO PCT/JP2020/039076 patent/WO2021075546A1/ja unknown
- 2020-10-16 US US17/769,657 patent/US20230248854A1/en active Pending
- 2020-10-16 CN CN202080072618.2A patent/CN114555132A/zh active Pending
- 2020-10-16 EP EP20877197.2A patent/EP4047010A4/en active Pending
- 2020-10-16 JP JP2021552464A patent/JPWO2021075546A1/ja active Pending
-
2022
- 2022-05-10 ZA ZA2022/05154A patent/ZA202205154B/en unknown
Also Published As
Publication number | Publication date |
---|---|
IL292312A (en) | 2022-06-01 |
CA3158344A1 (en) | 2021-04-22 |
EP4047010A4 (en) | 2024-01-10 |
WO2021075546A1 (ja) | 2021-04-22 |
TW202128732A (zh) | 2021-08-01 |
BR112022007240A2 (pt) | 2022-07-05 |
AU2020367624A1 (en) | 2022-05-19 |
ZA202205154B (en) | 2023-11-29 |
US20230248854A1 (en) | 2023-08-10 |
KR20220083768A (ko) | 2022-06-20 |
CN114555132A (zh) | 2022-05-27 |
EP4047010A1 (en) | 2022-08-24 |
JPWO2021075546A1 (es) | 2021-04-22 |
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