MX2022002466A - Iniciadores y constructo de car t del complejo de maduración de células b. - Google Patents
Iniciadores y constructo de car t del complejo de maduración de células b.Info
- Publication number
- MX2022002466A MX2022002466A MX2022002466A MX2022002466A MX2022002466A MX 2022002466 A MX2022002466 A MX 2022002466A MX 2022002466 A MX2022002466 A MX 2022002466A MX 2022002466 A MX2022002466 A MX 2022002466A MX 2022002466 A MX2022002466 A MX 2022002466A
- Authority
- MX
- Mexico
- Prior art keywords
- cell maturation
- car
- primers
- construct
- kits
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
- C12N15/90—Stable introduction of foreign DNA into chromosome
- C12N15/902—Stable introduction of foreign DNA into chromosome using homologous recombination
- C12N15/907—Stable introduction of foreign DNA into chromosome using homologous recombination in mammalian cells
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0636—T lymphocytes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/7051—T-cell receptor (TcR)-CD3 complex
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2545/00—Reactions characterised by their quantitative nature
- C12Q2545/10—Reactions characterised by their quantitative nature the purpose being quantitative analysis
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2563/00—Nucleic acid detection characterized by the use of physical, structural and functional properties
- C12Q2563/107—Nucleic acid detection characterized by the use of physical, structural and functional properties fluorescence
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Wood Science & Technology (AREA)
- Immunology (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Analytical Chemistry (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Biomedical Technology (AREA)
- Pathology (AREA)
- Cell Biology (AREA)
- Hospice & Palliative Care (AREA)
- Oncology (AREA)
- Medicinal Chemistry (AREA)
- Mycology (AREA)
- Plant Pathology (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Hematology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
Abstract
La presente invención proporciona conjuntos de sondas e iniciadores, y métodos y kits relacionados, para generar células T con receptor de antígeno quimérico (CAR) del antígeno de maduración de células B. La invención también proporciona conjuntos de sondas e iniciadores, y métodos y kits relacionados, para realizar reacciones en cadena de la polimerasa cuantitativas para cuantificar la integración transgénica del CAR del antígeno de maduración de células B en un producto farmacológico de CAR T.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201962894663P | 2019-08-30 | 2019-08-30 | |
PCT/IB2020/058070 WO2021038524A1 (en) | 2019-08-30 | 2020-08-28 | B-cell maturation complex car t construct and primers |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2022002466A true MX2022002466A (es) | 2022-06-02 |
Family
ID=72356220
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2022002466A MX2022002466A (es) | 2019-08-30 | 2020-08-28 | Iniciadores y constructo de car t del complejo de maduración de células b. |
Country Status (12)
Country | Link |
---|---|
US (1) | US20210164045A1 (es) |
EP (1) | EP4022091A1 (es) |
JP (1) | JP2022546978A (es) |
KR (1) | KR20220051002A (es) |
CN (1) | CN114341365A (es) |
AU (1) | AU2020339086A1 (es) |
BR (1) | BR112022003648A2 (es) |
CA (1) | CA3152237A1 (es) |
IL (1) | IL290926A (es) |
JO (1) | JOP20220049A1 (es) |
MX (1) | MX2022002466A (es) |
WO (1) | WO2021038524A1 (es) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2023516789A (ja) * | 2020-03-09 | 2023-04-20 | ヤンセン バイオテツク,インコーポレーテツド | 組換えベクター核酸の統合を定量化するための組成物及び方法 |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2909099B1 (fr) * | 2006-11-24 | 2012-10-19 | Univ Aix Marseille Ii | Methode de diagnostic et de suivi d'une vaginose bacterienne par quantification moleculaire. |
US20110251091A1 (en) * | 2008-09-12 | 2011-10-13 | Cornell University | Thyroid tumors identified |
US10301370B2 (en) * | 2014-05-02 | 2019-05-28 | The Trustees Of The University Of Pennsylvania | Compositions and methods of chimeric autoantibody receptor T cells |
CN107921148A (zh) * | 2015-05-08 | 2018-04-17 | 哈佛学院校长同事会 | 通用供体干细胞和相关方法 |
CN105384825B (zh) | 2015-08-11 | 2018-06-01 | 南京传奇生物科技有限公司 | 一种基于单域抗体的双特异性嵌合抗原受体及其应用 |
CN105837693A (zh) * | 2016-05-30 | 2016-08-10 | 李斯文 | 一种基于bcma的抗原嵌合受体及其制备方法和应用 |
CN109971836A (zh) * | 2017-12-28 | 2019-07-05 | 上海细胞治疗研究院 | 双重荧光定量pcr测定car拷贝数的方法和试剂盒 |
CN109722472A (zh) * | 2019-02-28 | 2019-05-07 | 上海邦耀生物科技有限公司 | 检测嵌合抗原受体基因的通用型pcr引物组合及应用 |
CN109722468A (zh) * | 2019-02-28 | 2019-05-07 | 上海邦耀生物科技有限公司 | 检测bcma嵌合抗原受体基因的pcr引物组合及应用 |
-
2020
- 2020-08-28 CA CA3152237A patent/CA3152237A1/en active Pending
- 2020-08-28 KR KR1020227010267A patent/KR20220051002A/ko active Search and Examination
- 2020-08-28 WO PCT/IB2020/058070 patent/WO2021038524A1/en active Application Filing
- 2020-08-28 US US17/005,858 patent/US20210164045A1/en active Pending
- 2020-08-28 AU AU2020339086A patent/AU2020339086A1/en active Pending
- 2020-08-28 CN CN202080061187.XA patent/CN114341365A/zh active Pending
- 2020-08-28 JO JOP/2022/0049A patent/JOP20220049A1/ar unknown
- 2020-08-28 EP EP20767618.0A patent/EP4022091A1/en active Pending
- 2020-08-28 MX MX2022002466A patent/MX2022002466A/es unknown
- 2020-08-28 JP JP2022513371A patent/JP2022546978A/ja active Pending
- 2020-08-28 BR BR112022003648A patent/BR112022003648A2/pt unknown
-
2022
- 2022-02-27 IL IL290926A patent/IL290926A/en unknown
Also Published As
Publication number | Publication date |
---|---|
US20210164045A1 (en) | 2021-06-03 |
KR20220051002A (ko) | 2022-04-25 |
AU2020339086A1 (en) | 2022-04-14 |
CN114341365A (zh) | 2022-04-12 |
CA3152237A1 (en) | 2021-03-04 |
EP4022091A1 (en) | 2022-07-06 |
JOP20220049A1 (ar) | 2023-01-30 |
IL290926A (en) | 2022-04-01 |
JP2022546978A (ja) | 2022-11-10 |
BR112022003648A2 (pt) | 2022-05-24 |
WO2021038524A1 (en) | 2021-03-04 |
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