MX2022001469A - Determinacion de modificaciones de bases de acidos nucleicos. - Google Patents

Determinacion de modificaciones de bases de acidos nucleicos.

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Publication number
MX2022001469A
MX2022001469A MX2022001469A MX2022001469A MX2022001469A MX 2022001469 A MX2022001469 A MX 2022001469A MX 2022001469 A MX2022001469 A MX 2022001469A MX 2022001469 A MX2022001469 A MX 2022001469A MX 2022001469 A MX2022001469 A MX 2022001469A
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biomarker
embryo
correlating
characteristic
signal
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MX2022001469A
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Kwan Chee Chan
Yuk- Ming Dennis Lo
Rossa Wai Kwun Chiu
Peiyong Jiang
Suk Hang Cheng
Wenlei Peng
On Yee Tse
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Univ Hong Kong Chinese
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Application filed by Univ Hong Kong Chinese filed Critical Univ Hong Kong Chinese
Publication of MX2022001469A publication Critical patent/MX2022001469A/es

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Abstract

Se describen en la presente sistemas y métodos para usar la determinación de la modificación de bases para analizar moléculas de ácido nucleico y adquirir datos para el análisis de moléculas de ácido nucleico. Las modificaciones de bases pueden incluir metilaciones. Los métodos para determinar las modificaciones de bases pueden incluir el uso de características derivadas de la secuenciación. Estas características pueden incluir el ancho del pulso de una señal óptica a partir de la secuenciación de bases, la duración entre pulsos de las bases y la identidad de las bases. Los modelos de aprendizaje automático pueden entrenarse para detectar las modificaciones de bases mediante el uso de estas características. Los niveles de modificación o metilación relativos entre haplotipos pueden indicar un trastorno. También pueden usarse estados de modificación o metilación para detectar moléculas quiméricas.
MX2022001469A 2019-08-16 2021-01-22 Determinacion de modificaciones de bases de acidos nucleicos. MX2022001469A (es)

Applications Claiming Priority (5)

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US201962887987P 2019-08-16 2019-08-16
US202062970586P 2020-02-05 2020-02-05
US202062991891P 2020-03-19 2020-03-19
US202063019790P 2020-05-04 2020-05-04
US202063051210P 2020-07-13 2020-07-13

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MX2021000931A MX2021000931A (es) 2019-08-16 2020-08-17 Determinación de modificaciones de bases de ácidos nucleicos.
MX2022001469A MX2022001469A (es) 2019-08-16 2021-01-22 Determinacion de modificaciones de bases de acidos nucleicos.
MX2022001470A MX2022001470A (es) 2019-08-16 2021-01-22 Determinacion de modificaciones de bases de acidos nucleicos.

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Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20230148447A9 (en) 2008-12-11 2023-05-11 Pacific Biosciences Of California, Inc. Classification of nucleic acid templates
KR102427319B1 (ko) 2019-08-16 2022-08-01 더 차이니즈 유니버시티 오브 홍콩 핵산의 염기 변형의 결정
JP7104770B2 (ja) 2019-12-30 2022-07-21 財團法人工業技術研究院 標的ヌクレオチド配列を増幅及び確定する方法
US20220237502A1 (en) * 2021-01-25 2022-07-28 Paypal, Inc. Systems and methods for training and modifying a computer-based model to perform classification
CA3215066A1 (en) * 2021-04-12 2022-10-20 Yuk-Ming Dennis Lo Base modification analysis using electrical signals
CN113409885B (zh) * 2021-06-21 2022-09-20 天津金域医学检验实验室有限公司 一种自动化数据处理以及作图方法及系统
CN113981548B (zh) * 2021-11-24 2023-07-11 竹石生物科技(苏州)有限公司 Dna甲基化测序文库的制备方法和甲基化检测方法
WO2023183907A2 (en) * 2022-03-25 2023-09-28 The Penn State Research Foundation Analysis of genomic word frameworks on genomic methylation data
AU2023245692A1 (en) * 2022-03-29 2024-10-17 Ahead Intelligence Ltd. Methods and devices of processing cytometric data
WO2023225004A1 (en) * 2022-05-16 2023-11-23 Bioscreening & Diagnostics Llc Prediction of alzheimer's disease
US20240018581A1 (en) * 2022-07-15 2024-01-18 Massachusetts Institute Of Technology Mixture deconvolution method for identifying dna profiles
WO2024031097A2 (en) * 2022-08-05 2024-02-08 The Board Of Trustees Of The Leland Stanford Junior University Systems and methods for cancer screening
US20240127906A1 (en) * 2022-10-11 2024-04-18 Illumina, Inc. Detecting and correcting methylation values from methylation sequencing assays
WO2024129712A1 (en) * 2022-12-12 2024-06-20 Flagship Pioneering Innovations, Vi, Llc Phased sequencing information from circulating tumor dna
CN116168761B (zh) * 2023-04-18 2023-06-30 珠海圣美生物诊断技术有限公司 核酸序列特征区域确定方法、装置、电子设备及存储介质

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2002214811B2 (en) * 2000-11-13 2004-09-09 Human Genetic Signatures Pty Ltd Detection of methylated DNA molecules
AU2003900368A0 (en) * 2003-01-24 2003-02-13 Human Genetic Signatures Pty Ltd Assay for nucleic acid molecules
DE602004018801D1 (de) * 2003-09-04 2009-02-12 Human Genetic Signatures Pty Nukleinsäurenachweistest
EP3770275A1 (en) 2007-07-23 2021-01-27 The Chinese University of Hong Kong Determining a fetal aneuploidy
US8530164B2 (en) 2008-09-05 2013-09-10 Pacific Biosciences Of California, Inc. Method for sequencing using branching fraction of incorporatable nucleotides
US8486630B2 (en) * 2008-11-07 2013-07-16 Industrial Technology Research Institute Methods for accurate sequence data and modified base position determination
BRPI0922411A2 (pt) * 2008-12-11 2018-06-05 Pacific Biosciences California Inc classificação de templates de ácido nucléico
US9175338B2 (en) * 2008-12-11 2015-11-03 Pacific Biosciences Of California, Inc. Methods for identifying nucleic acid modifications
HUE061110T2 (hu) 2009-11-05 2023-05-28 Univ Hong Kong Chinese Magzati genomelemzés anyai biológiai mintából
US20120208193A1 (en) 2011-02-15 2012-08-16 Bio-Rad Laboratories, Inc. Detecting methylation in a subpopulation of genomic dna
US9016970B2 (en) * 2011-06-08 2015-04-28 United States Postal Service Elastomeric force mitigating joint
US9238836B2 (en) 2012-03-30 2016-01-19 Pacific Biosciences Of California, Inc. Methods and compositions for sequencing modified nucleic acids
US9175348B2 (en) 2012-04-24 2015-11-03 Pacific Biosciences Of California, Inc. Identification of 5-methyl-C in nucleic acid templates
RU2597981C2 (ru) * 2012-05-14 2016-09-20 БГИ Диагносис Ко., Лтд. Способ и система для определения нуклеотидной последовательности в заданной области генома плода
US9116118B2 (en) 2012-06-08 2015-08-25 Pacific Biosciences Of California, Inc. Modified base detection with nanopore sequencing
MX2014015425A (es) 2012-06-15 2015-07-14 Harry Stylli Metodos para detectar enfermedades o condiciones.
WO2014153757A1 (zh) 2013-03-28 2014-10-02 深圳华大基因研究院 确定胚胎基因组中预定区域碱基信息的方法、系统和计算机可读介质
US10468121B2 (en) 2013-10-01 2019-11-05 Complete Genomics, Inc. Phasing and linking processes to identify variations in a genome
JP6680680B2 (ja) 2013-10-07 2020-04-15 セクエノム， インコーポレイテッド 染色体変化の非侵襲性評価のための方法およびプロセス
EP3169813B1 (en) 2014-07-18 2019-06-12 The Chinese University Of Hong Kong Methylation pattern analysis of tissues in dna mixture
PT3739061T (pt) 2015-07-20 2022-04-05 Univ Hong Kong Chinese Análise do padrão da metilação de haplótipos em tecidos em mistura de adn
US10465232B1 (en) 2015-10-08 2019-11-05 Trace Genomics, Inc. Methods for quantifying efficiency of nucleic acid extraction and detection
KR102427319B1 (ko) 2019-08-16 2022-08-01 더 차이니즈 유니버시티 오브 홍콩 핵산의 염기 변형의 결정

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