DK3827092T3 - Detektion af metylering af nukleotider i nukleinsyrer. - Google Patents
Detektion af metylering af nukleotider i nukleinsyrer. Download PDFInfo
- Publication number
- DK3827092T3 DK3827092T3 DK20853612.8T DK20853612T DK3827092T3 DK 3827092 T3 DK3827092 T3 DK 3827092T3 DK 20853612 T DK20853612 T DK 20853612T DK 3827092 T3 DK3827092 T3 DK 3827092T3
- Authority
- DK
- Denmark
- Prior art keywords
- methylation
- nucleotides
- detection
- nucleic acids
- nucleic
- Prior art date
Links
- 238000001514 detection method Methods 0.000 title 1
- 230000011987 methylation Effects 0.000 title 1
- 238000007069 methylation reaction Methods 0.000 title 1
- 150000007523 nucleic acids Chemical class 0.000 title 1
- 102000039446 nucleic acids Human genes 0.000 title 1
- 108020004707 nucleic acids Proteins 0.000 title 1
- 239000002773 nucleotide Substances 0.000 title 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6869—Methods for sequencing
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- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B30/00—ICT specially adapted for sequence analysis involving nucleotides or amino acids
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6816—Hybridisation assays characterised by the detection means
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
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- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
- C12N9/22—Ribonucleases RNAses, DNAses
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6844—Nucleic acid amplification reactions
- C12Q1/6851—Quantitative amplification
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- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B15/00—ICT specially adapted for analysing two-dimensional or three-dimensional molecular structures, e.g. structural or functional relations or structure alignment
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- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
- G16B20/10—Ploidy or copy number detection
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- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
- G16B20/20—Allele or variant detection, e.g. single nucleotide polymorphism [SNP] detection
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- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B40/00—ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
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- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B40/00—ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
- G16B40/10—Signal processing, e.g. from mass spectrometry [MS] or from PCR
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- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B40/00—ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
- G16B40/20—Supervised data analysis
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2537/00—Reactions characterised by the reaction format or use of a specific feature
- C12Q2537/10—Reactions characterised by the reaction format or use of a specific feature the purpose or use of
- C12Q2537/164—Methylation detection other then bisulfite or methylation sensitive restriction endonucleases
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2565/00—Nucleic acid analysis characterised by mode or means of detection
- C12Q2565/60—Detection means characterised by use of a special device
- C12Q2565/601—Detection means characterised by use of a special device being a microscope, e.g. atomic force microscopy [AFM]
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/154—Methylation markers
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- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Physics & Mathematics (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medical Informatics (AREA)
- Organic Chemistry (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Computational Biology (AREA)
- Evolutionary Biology (AREA)
- Theoretical Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Analytical Chemistry (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Data Mining & Analysis (AREA)
- Immunology (AREA)
- Computer Vision & Pattern Recognition (AREA)
- Artificial Intelligence (AREA)
- Databases & Information Systems (AREA)
- Epidemiology (AREA)
- Evolutionary Computation (AREA)
- Public Health (AREA)
- Software Systems (AREA)
- Bioethics (AREA)
- Biomedical Technology (AREA)
- Signal Processing (AREA)
- Crystallography & Structural Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Plant Pathology (AREA)
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201962887987P | 2019-08-16 | 2019-08-16 | |
US202062970586P | 2020-02-05 | 2020-02-05 | |
US202062991891P | 2020-03-19 | 2020-03-19 | |
US202063019790P | 2020-05-04 | 2020-05-04 | |
US202063051210P | 2020-07-13 | 2020-07-13 | |
PCT/CN2020/109602 WO2021032060A1 (en) | 2019-08-16 | 2020-08-17 | Determination of base modifications of nucleic acids |
Publications (1)
Publication Number | Publication Date |
---|---|
DK3827092T3 true DK3827092T3 (da) | 2024-04-22 |
Family
ID=74567577
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK20853612.8T DK3827092T3 (da) | 2019-08-16 | 2020-08-17 | Detektion af metylering af nukleotider i nukleinsyrer. |
Country Status (18)
Country | Link |
---|---|
US (4) | US11091794B2 (da) |
EP (3) | EP4357461A3 (da) |
JP (4) | JP7264534B2 (da) |
KR (3) | KR102658592B1 (da) |
CN (5) | CN112752853B (da) |
AU (4) | AU2020323958B2 (da) |
BR (1) | BR122021009560B1 (da) |
CA (1) | CA3110884A1 (da) |
DK (1) | DK3827092T3 (da) |
GB (13) | GB2608713B (da) |
IL (3) | IL294153B2 (da) |
MX (3) | MX2021000931A (da) |
NZ (4) | NZ788335A (da) |
PH (1) | PH12021550223A1 (da) |
SG (1) | SG11202101070QA (da) |
TW (5) | TWI832482B (da) |
WO (1) | WO2021032060A1 (da) |
ZA (1) | ZA202100887B (da) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20230148447A9 (en) | 2008-12-11 | 2023-05-11 | Pacific Biosciences Of California, Inc. | Classification of nucleic acid templates |
TWI832482B (zh) | 2019-08-16 | 2024-02-11 | 香港中文大學 | 核酸鹼基修飾的測定 |
TWI771847B (zh) * | 2019-12-30 | 2022-07-21 | 財團法人工業技術研究院 | 擴增和確定目標核苷酸序列的方法 |
US20220237502A1 (en) * | 2021-01-25 | 2022-07-28 | Paypal, Inc. | Systems and methods for training and modifying a computer-based model to perform classification |
AU2022258155A1 (en) * | 2021-04-12 | 2023-11-30 | The Chinese University Of Hong Kong | Base modification analysis using electrical signals |
CN113409885B (zh) * | 2021-06-21 | 2022-09-20 | 天津金域医学检验实验室有限公司 | 一种自动化数据处理以及作图方法及系统 |
CN113981548B (zh) * | 2021-11-24 | 2023-07-11 | 竹石生物科技(苏州)有限公司 | Dna甲基化测序文库的制备方法和甲基化检测方法 |
WO2023183907A2 (en) * | 2022-03-25 | 2023-09-28 | The Penn State Research Foundation | Analysis of genomic word frameworks on genomic methylation data |
WO2023192337A1 (en) * | 2022-03-29 | 2023-10-05 | Ahead Medicine Corp | Methods and devices of processing cytometric data |
WO2023225004A1 (en) * | 2022-05-16 | 2023-11-23 | Bioscreening & Diagnostics Llc | Prediction of alzheimer's disease |
US20240018581A1 (en) * | 2022-07-15 | 2024-01-18 | Massachusetts Institute Of Technology | Mixture deconvolution method for identifying dna profiles |
WO2024031097A2 (en) * | 2022-08-05 | 2024-02-08 | The Board Of Trustees Of The Leland Stanford Junior University | Systems and methods for cancer screening |
US20240127906A1 (en) * | 2022-10-11 | 2024-04-18 | Illumina, Inc. | Detecting and correcting methylation values from methylation sequencing assays |
WO2024129712A1 (en) * | 2022-12-12 | 2024-06-20 | Flagship Pioneering Innovations, Vi, Llc | Phased sequencing information from circulating tumor dna |
CN116168761B (zh) * | 2023-04-18 | 2023-06-30 | 珠海圣美生物诊断技术有限公司 | 核酸序列特征区域确定方法、装置、电子设备及存储介质 |
Family Cites Families (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2002214811B2 (en) * | 2000-11-13 | 2004-09-09 | Human Genetic Signatures Pty Ltd | Detection of methylated DNA molecules |
AU2003900368A0 (en) * | 2003-01-24 | 2003-02-13 | Human Genetic Signatures Pty Ltd | Assay for nucleic acid molecules |
US7846693B2 (en) * | 2003-09-04 | 2010-12-07 | Human Genetic Signatures Pty. Ltd. | Nucleic acid detection assay |
KR101829565B1 (ko) | 2007-07-23 | 2018-03-29 | 더 차이니즈 유니버시티 오브 홍콩 | 핵산 서열 불균형의 결정 |
WO2010027484A2 (en) * | 2008-09-05 | 2010-03-11 | Pacific Biosciences Of California, Inc. | Engineering polymerases and reaction conditions for modified incorporation properties |
US8486630B2 (en) | 2008-11-07 | 2013-07-16 | Industrial Technology Research Institute | Methods for accurate sequence data and modified base position determination |
US9175338B2 (en) * | 2008-12-11 | 2015-11-03 | Pacific Biosciences Of California, Inc. | Methods for identifying nucleic acid modifications |
BRPI0922411A2 (pt) * | 2008-12-11 | 2018-06-05 | Pacific Biosciences California Inc | classificação de templates de ácido nucléico |
EP3241914B1 (en) | 2009-11-05 | 2019-03-06 | The Chinese University Of Hong Kong | Fetal genomic analysis from a maternal biological sample |
WO2012112606A1 (en) | 2011-02-15 | 2012-08-23 | Bio-Rad Laboratories, Inc. | Detecting methylati0n in a subpopulation of genomic dna |
US9016970B2 (en) * | 2011-06-08 | 2015-04-28 | United States Postal Service | Elastomeric force mitigating joint |
US9238836B2 (en) | 2012-03-30 | 2016-01-19 | Pacific Biosciences Of California, Inc. | Methods and compositions for sequencing modified nucleic acids |
US9175348B2 (en) | 2012-04-24 | 2015-11-03 | Pacific Biosciences Of California, Inc. | Identification of 5-methyl-C in nucleic acid templates |
US20150094210A1 (en) | 2012-05-14 | 2015-04-02 | Bgi Diagnosis Co., Ltd. | Method, system and computer readable medium for determining base information in predetermined area of fetus genome |
GB2517875A (en) | 2012-06-08 | 2015-03-04 | Pacific Biosciences California | Modified base detection with nanopore sequencing |
WO2013188846A1 (en) * | 2012-06-15 | 2013-12-19 | Harry Stylli | Methods of detecting diseases or conditions |
CN105051208B (zh) * | 2013-03-28 | 2017-04-19 | 深圳华大基因股份有限公司 | 确定胚胎基因组中预定区域碱基信息的方法、系统和计算机可读介质 |
CN109599148B (zh) | 2013-10-01 | 2022-03-25 | 深圳华大智造科技有限公司 | 鉴定基因组中的变异的定相和连接方法 |
WO2015054080A1 (en) | 2013-10-07 | 2015-04-16 | Sequenom, Inc. | Methods and processes for non-invasive assessment of chromosome alterations |
TWI703216B (zh) * | 2014-07-18 | 2020-09-01 | 香港中文大學 | Dna混合物中之組織甲基化模式分析 |
EP4063517A1 (en) * | 2015-07-20 | 2022-09-28 | The Chinese University Of Hong Kong | Methylation pattern analysis of haplotypes in tissues in dna mixture |
US10465232B1 (en) | 2015-10-08 | 2019-11-05 | Trace Genomics, Inc. | Methods for quantifying efficiency of nucleic acid extraction and detection |
TWI832482B (zh) | 2019-08-16 | 2024-02-11 | 香港中文大學 | 核酸鹼基修飾的測定 |
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2020
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2021
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- 2021-01-29 PH PH12021550223A patent/PH12021550223A1/en unknown
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- 2021-07-19 US US17/379,544 patent/US11466308B2/en active Active
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2022
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