MX2008015158A - Ensayo biomarcador de espectrometria de masa. - Google Patents
Ensayo biomarcador de espectrometria de masa.Info
- Publication number
- MX2008015158A MX2008015158A MX2008015158A MX2008015158A MX2008015158A MX 2008015158 A MX2008015158 A MX 2008015158A MX 2008015158 A MX2008015158 A MX 2008015158A MX 2008015158 A MX2008015158 A MX 2008015158A MX 2008015158 A MX2008015158 A MX 2008015158A
- Authority
- MX
- Mexico
- Prior art keywords
- signal
- biomarker
- mass
- con
- intensity
- Prior art date
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
- G01N33/6848—Methods of protein analysis involving mass spectrometry
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/62—Detectors specially adapted therefor
- G01N30/72—Mass spectrometers
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/62—Detectors specially adapted therefor
- G01N30/74—Optical detectors
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/62—Detectors specially adapted therefor
- G01N30/72—Mass spectrometers
- G01N30/7233—Mass spectrometers interfaced to liquid or supercritical fluid chromatograph
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Physics & Mathematics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Biochemistry (AREA)
- Analytical Chemistry (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biotechnology (AREA)
- Cell Biology (AREA)
- Bioinformatics & Computational Biology (AREA)
- Microbiology (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Biophysics (AREA)
- Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
Abstract
La presente invención proporciona un método para determinar la presencia de uno o más biomarcadores de polipéptido en una muestra, en donde el método comprende los pasos de: (a) someter la muestra a un análisis espectrométrico de masa (MS) y registrar el índice del tiempo de retención y masa correspondiente de cada señal detectada; (b) correlacionar la masa que corresponde a cada señal con una base de datos de referencia de masas de biomarcador para formar una correlación entre cada señal y un biomarcador de referencia, y desechar las señales cuyas masas no se correlacionen con una masa de biomarcador de referencia; (c) almacenar las señales cuyas masas se correlacionen con un biomarcador de referencia; (d) confirmar la correlación entre cada señal almacenada y un biomarcador de referencia, mediante el acoplamiento del espectro MS de cada señal con el espectro MS del biomarcador de referencia en la base de datos utilizando una medida de similitud, para definir un conjunto de señales de correlación positiva; (d) medir la intensidad de cada señal de correlación positiva y registrar su intensidad de señal absoluta o su intensidad de señal relativa utilizando una función de discriminación; (e) aplicar un valor de umbral a los valores de calificación obtenidos de la función de discriminación para determinar la presencia o ausencia del biomarcador.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0611669.3A GB0611669D0 (en) | 2006-06-13 | 2006-06-13 | Mass spectrometry biomarker assay |
| PCT/GB2007/002187 WO2007144606A2 (en) | 2006-06-13 | 2007-06-13 | Mass spectrometry biomarker assay |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2008015158A true MX2008015158A (es) | 2009-04-30 |
Family
ID=36745797
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2008015158A MX2008015158A (es) | 2006-06-13 | 2007-06-13 | Ensayo biomarcador de espectrometria de masa. |
Country Status (10)
| Country | Link |
|---|---|
| EP (1) | EP2035829A2 (es) |
| JP (1) | JP2009540319A (es) |
| KR (1) | KR20090068199A (es) |
| CN (1) | CN101611313A (es) |
| AU (1) | AU2007258970A1 (es) |
| BR (1) | BRPI0711967A2 (es) |
| CA (1) | CA2651934A1 (es) |
| GB (1) | GB0611669D0 (es) |
| MX (1) | MX2008015158A (es) |
| WO (1) | WO2007144606A2 (es) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102138069A (zh) * | 2008-07-23 | 2011-07-27 | P设备有限公司 | 便携式基于等离子体的诊断设备和诊断方法 |
| GB0906698D0 (en) | 2009-04-17 | 2009-06-03 | Queen Mary & Westfield College | Method for quantifying modified peptides |
| KR101144237B1 (ko) * | 2009-12-29 | 2012-05-11 | 한국기초과학지원연구원 | 고분해능 질량분석법과 약리활성검사를 이용한 천연물의 약리 활성물질 발굴 방법 |
| GB201006360D0 (en) * | 2010-04-16 | 2010-06-02 | Immatics Biotechnologies Gmbh | Method for differentially quantifying naturally processed HLA-restricted peptides for cancer, autoimmune and infectious diseases immunotherapy development |
| US9141756B1 (en) | 2010-07-20 | 2015-09-22 | University Of Southern California | Multi-scale complex systems transdisciplinary analysis of response to therapy |
| CN102201039A (zh) * | 2010-08-19 | 2011-09-28 | 上海聚类生物科技有限公司 | 一种分析ltq数据的方法 |
| GB201204278D0 (en) | 2012-03-09 | 2012-04-25 | Queen Mary & Westfield College | Method |
| FR3016461B1 (fr) * | 2014-01-10 | 2017-06-23 | Imabiotech | Procede de traitement de donnees d'imagerie moleculaire et serveur de donnees correspondant |
| DE102014000646B4 (de) | 2014-01-17 | 2023-05-11 | Bruker Daltonics GmbH & Co. KG | Massenspektrometrische Resistenzbestimmung durch Metabolismus-Messung |
| GB201509313D0 (en) * | 2015-05-29 | 2015-07-15 | Micromass Ltd | Sample mass spectrum analysis |
| JP6613490B2 (ja) * | 2016-02-19 | 2019-12-04 | 国立大学法人 宮崎大学 | 腺癌の検出方法 |
| US20190113520A1 (en) * | 2016-03-31 | 2019-04-18 | Discerndx, Inc. | Biomarker Database Generation and Use |
| WO2017204636A2 (en) * | 2016-05-24 | 2017-11-30 | In Ovo B.V. | Method and system for the non-destructive in ovo determination of fowl gender |
| US20190187048A1 (en) * | 2016-08-19 | 2019-06-20 | Monash University | Spectroscopic systems and methods for the identification and quantification of pathogens |
| US9905405B1 (en) * | 2017-02-13 | 2018-02-27 | Thermo Finnigan Llc | Method of generating an inclusion list for targeted mass spectrometric analysis |
| SG11201908865WA (en) * | 2017-06-29 | 2019-10-30 | Quanticision Diagnostics Inc | Apparatus and method for absolute quantification of biomarkers for solid tumor diagnosis |
| WO2019046814A1 (en) | 2017-09-01 | 2019-03-07 | Venn Biosciences Corporation | IDENTIFICATION AND USE OF GLYCOPEPTIDES AS BIOMARKERS FOR THE DIAGNOSIS AND MONITORING OF TREATMENT |
| EP3679378A2 (en) * | 2017-09-05 | 2020-07-15 | DiscernDx, Inc. | Automated sample workflow gating and data analysis |
| GB2569805B (en) * | 2017-12-22 | 2023-03-08 | Asymptote Ltd | Method and system relating to cooling conditions for a biological sample |
| EP3794548A1 (en) * | 2018-05-15 | 2021-03-24 | Ventana Medical Systems, Inc. | Quantitation of signal in stain aggregates |
| CN111672658B (zh) * | 2020-06-08 | 2022-05-13 | 惠州市新泓威科技有限公司 | 电子雾化设备最佳雾化温度的检测与控制方法及其电子雾化设备 |
| EP4047371A1 (en) * | 2021-02-18 | 2022-08-24 | Thermo Fisher Scientific (Bremen) GmbH | Method and apparatus for analysing samples of biomolecules using mass spectrometry with data-independent acquisition |
| KR102632163B1 (ko) | 2022-04-13 | 2024-02-01 | 오보젠 주식회사 | 가금류 알(卵)의 암수 검사 및 선별장치 그리고 이를 이용한 선별방법 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8014952B2 (en) * | 2002-12-18 | 2011-09-06 | Queen Elizabeth Hospital | Serum biomarkers in lung cancer |
| DE10324149A1 (de) * | 2003-05-26 | 2004-12-16 | Imat-Uve Gmbh | Verfahren und Vorrichtung zur GC/MS- oder LC/MS-Screeninganalyse |
| CA2561535A1 (en) * | 2004-03-30 | 2005-10-20 | Eastern Virginia Medical School | Lung cancer biomarkers |
| DE112005001166B4 (de) * | 2004-05-20 | 2014-10-09 | Waters Technologies Corp. (N.D.Ges.D. Staates Delaware) | Verfahren und Vorrichtung zum Identifizieren von Proteinen in Gemischen |
-
2006
- 2006-06-13 GB GBGB0611669.3A patent/GB0611669D0/en not_active Ceased
-
2007
- 2007-06-13 WO PCT/GB2007/002187 patent/WO2007144606A2/en active Application Filing
- 2007-06-13 MX MX2008015158A patent/MX2008015158A/es not_active Application Discontinuation
- 2007-06-13 AU AU2007258970A patent/AU2007258970A1/en not_active Abandoned
- 2007-06-13 KR KR1020097000596A patent/KR20090068199A/ko not_active Application Discontinuation
- 2007-06-13 JP JP2009514893A patent/JP2009540319A/ja active Pending
- 2007-06-13 EP EP07733193A patent/EP2035829A2/en not_active Withdrawn
- 2007-06-13 BR BRPI0711967-4A patent/BRPI0711967A2/pt not_active IP Right Cessation
- 2007-06-13 CA CA002651934A patent/CA2651934A1/en not_active Abandoned
- 2007-06-13 CN CNA2007800219002A patent/CN101611313A/zh active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| CN101611313A (zh) | 2009-12-23 |
| KR20090068199A (ko) | 2009-06-25 |
| JP2009540319A (ja) | 2009-11-19 |
| CA2651934A1 (en) | 2007-12-21 |
| WO2007144606A3 (en) | 2008-04-03 |
| AU2007258970A1 (en) | 2007-12-21 |
| GB0611669D0 (en) | 2006-07-19 |
| BRPI0711967A2 (pt) | 2012-01-24 |
| EP2035829A2 (en) | 2009-03-18 |
| WO2007144606A2 (en) | 2007-12-21 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |