MX2022001226A - Proceso para preparar la forma ii cristalina de sotagliflozina. - Google Patents

Proceso para preparar la forma ii cristalina de sotagliflozina.

Info

Publication number
MX2022001226A
MX2022001226A MX2022001226A MX2022001226A MX2022001226A MX 2022001226 A MX2022001226 A MX 2022001226A MX 2022001226 A MX2022001226 A MX 2022001226A MX 2022001226 A MX2022001226 A MX 2022001226A MX 2022001226 A MX2022001226 A MX 2022001226A
Authority
MX
Mexico
Prior art keywords
sotagliflozin
crystalline form
preparing
crystallineform
xylene
Prior art date
Application number
MX2022001226A
Other languages
English (en)
Inventor
Bruno Burel
Jérome Cezerac
Stéphane Dutheil
Martial Etienne
Richard Flacher
Antonio Nobrega
Original Assignee
Lexicon Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lexicon Pharmaceuticals Inc filed Critical Lexicon Pharmaceuticals Inc
Publication of MX2022001226A publication Critical patent/MX2022001226A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
    • C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
    • C07H13/08—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals directly attached to carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C07H1/06—Separation; Purification
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/10—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/14—Acyclic radicals, not substituted by cyclic structures attached to a sulfur, selenium or tellurium atom of a saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H7/00—Compounds containing non-saccharide radicals linked to saccharide radicals by a carbon-to-carbon bond
    • C07H7/04—Carbocyclic radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Endocrinology (AREA)
  • Veterinary Medicine (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Emergency Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

El presente documento se refiere a un proceso para la preparación de la Forma II cristalina de sotagliflozina, en donde dicha Forma II cristalina de sotagliflozina se obtiene directamente a partir del siguiente compuesto de fórmula (A): (ver Fórmula) y utilizando tolueno o xileno o mezcla de los mismos como medio solvente para la cristalización.
MX2022001226A 2019-08-01 2020-07-31 Proceso para preparar la forma ii cristalina de sotagliflozina. MX2022001226A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP19305999.5A EP3771718A1 (en) 2019-08-01 2019-08-01 Process for preparing the crystalline form ii of sotagliflozin
PCT/IB2020/057257 WO2021019507A1 (en) 2019-08-01 2020-07-31 Process for preparing the crystalline form ii of sotagliflozin

Publications (1)

Publication Number Publication Date
MX2022001226A true MX2022001226A (es) 2022-04-11

Family

ID=67659166

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2022001226A MX2022001226A (es) 2019-08-01 2020-07-31 Proceso para preparar la forma ii cristalina de sotagliflozina.

Country Status (12)

Country Link
US (1) US20220235085A1 (es)
EP (2) EP3771718A1 (es)
JP (1) JP2022543057A (es)
KR (1) KR20220039771A (es)
CN (1) CN114258397A (es)
AU (1) AU2020320499A1 (es)
BR (1) BR112022001535A2 (es)
CA (1) CA3149131A1 (es)
IL (1) IL290215A (es)
MX (1) MX2022001226A (es)
WO (1) WO2021019507A1 (es)
ZA (1) ZA202201470B (es)

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI472521B (zh) 2008-07-17 2015-02-11 Lexicon Pharmaceuticals Inc （２ｓ，３ｒ，４ｒ，５ｓ，６ｒ）－２－（４－氯－３－（４－乙氧苄基）苯基）－６－（甲硫）四氫－２ｈ－哌喃－３，４，５－三醇的固體形態與其使用方法
EP3466958B1 (en) * 2016-05-25 2020-04-29 Crystal Pharmaceutical (Suzhou) Co., Ltd. New crystal forms of sodium-glucose co-transporter inhibitor, processes for preparation and use thereof
WO2018067805A1 (en) * 2016-10-06 2018-04-12 Teva Pharmaceutical Industries Ltd. Solid state forms of sotagliflozin

Also Published As

Publication number Publication date
ZA202201470B (en) 2024-06-26
AU2020320499A1 (en) 2022-03-03
US20220235085A1 (en) 2022-07-28
JP2022543057A (ja) 2022-10-07
BR112022001535A2 (pt) 2022-05-03
IL290215A (en) 2022-03-01
WO2021019507A1 (en) 2021-02-04
CN114258397A (zh) 2022-03-29
EP4007761A1 (en) 2022-06-08
CA3149131A1 (en) 2021-02-04
KR20220039771A (ko) 2022-03-29
EP3771718A1 (en) 2021-02-03

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