MX2021011690A - Composiciones y métodos para la edición del gen ttr y el tratamiento de la amiloidosis attr que comprende un corticosteroide o uso de este. - Google Patents

Composiciones y métodos para la edición del gen ttr y el tratamiento de la amiloidosis attr que comprende un corticosteroide o uso de este.

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Publication number
MX2021011690A
MX2021011690A MX2021011690A MX2021011690A MX2021011690A MX 2021011690 A MX2021011690 A MX 2021011690A MX 2021011690 A MX2021011690 A MX 2021011690A MX 2021011690 A MX2021011690 A MX 2021011690A MX 2021011690 A MX2021011690 A MX 2021011690A
Authority
MX
Mexico
Prior art keywords
corticosteroid
compositions
methods
treatment
ttr gene
Prior art date
Application number
MX2021011690A
Other languages
English (en)
Spanish (es)
Inventor
Kristy M Wood
Yong Chang
Shobu Odate
Reynald Michael Lescarbeau
Seth C Alexander
Arti Mahendra Prakash Kanjolia
Jessica Lynn Seitzer
Walter Strapps
Original Assignee
Intellia Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Intellia Therapeutics Inc filed Critical Intellia Therapeutics Inc
Publication of MX2021011690A publication Critical patent/MX2021011690A/es

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    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
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    • A—HUMAN NECESSITIES
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MX2021011690A 2019-03-28 2020-03-27 Composiciones y métodos para la edición del gen ttr y el tratamiento de la amiloidosis attr que comprende un corticosteroide o uso de este. MX2021011690A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962825676P 2019-03-28 2019-03-28
US201962825637P 2019-03-28 2019-03-28
PCT/US2020/025533 WO2020198706A1 (en) 2019-03-28 2020-03-27 Compositions and methods for ttr gene editing and treating attr amyloidosis comprising a corticosteroid or use thereof

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MX2021011690A true MX2021011690A (es) 2022-01-06

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US (1) US20230035659A1 (https=)
EP (1) EP3946285A1 (https=)
JP (2) JP7636338B2 (https=)
KR (1) KR20220004984A (https=)
CN (1) CN113874004A (https=)
AU (1) AU2020248337A1 (https=)
CA (1) CA3134544A1 (https=)
CO (1) CO2021014562A2 (https=)
MX (1) MX2021011690A (https=)
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CR20230305A (es) * 2020-12-11 2023-11-10 Intellia Therapeutics Inc Polinucleótidos, composiciones y métodos para la edición del genoma que implican desaminación
BR112023021477A2 (pt) * 2021-04-17 2024-01-30 Intellia Therapeutics Inc Composições de nanopartículas lipídicas
WO2022246266A1 (en) * 2021-05-21 2022-11-24 Beam Therapeutics Inc. Base editing of transthyretin gene
KR20240038705A (ko) * 2021-06-22 2024-03-25 인텔리아 테라퓨틱스, 인크. 간 유전자의 생체 내 편집 방법
EP4531819A2 (en) 2022-05-25 2025-04-09 Akagera Medicines, Inc. Lipid nanoparticles for delivery of nucleic acids and methods of use thereof
WO2024003805A1 (en) * 2022-06-30 2024-01-04 Geneditbio Limited Methods and compositions for ttr gene editing and therapy using crispr system
CN120265763A (zh) * 2023-10-25 2025-07-04 上海津曼特生物科技有限公司 靶向ttr的基因编辑组合物
WO2025128871A2 (en) 2023-12-13 2025-06-19 Renagade Therapeutics Management Inc. Lipid nanoparticles comprising coding rna molecules for use in gene editing and as vaccines and therapeutic agents

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