MX2021011272A - Composiciones y metodos para tratar el cancer. - Google Patents
Composiciones y metodos para tratar el cancer.Info
- Publication number
- MX2021011272A MX2021011272A MX2021011272A MX2021011272A MX2021011272A MX 2021011272 A MX2021011272 A MX 2021011272A MX 2021011272 A MX2021011272 A MX 2021011272A MX 2021011272 A MX2021011272 A MX 2021011272A MX 2021011272 A MX2021011272 A MX 2021011272A
- Authority
- MX
- Mexico
- Prior art keywords
- methods
- compositions
- treating cancer
- egfr
- present disclosure
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
- C07D239/94—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/95—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in positions 2 and 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/056—Ortho-condensed systems with two or more oxygen atoms as ring hetero atoms in the oxygen-containing ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/05—Isotopically modified compounds, e.g. labelled
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
La presente descripción se refiere a compuestos que son capaces de penetrar hasta la barrera hematoencefálica para modular la actividad de la tirosina cinasa EGFR. La descripción se refiere además a métodos para tratar el glioblastoma y otros cánceres mediados por EGFR. La descripción se refiere además a métodos para tratar el glioblastoma y otros cánceres mediados por EGFR que se ha determinado que tienen un metabolismo de glucosa alterado en presencia de inhibidores. La presente descripción también proporciona métodos para administrarle a un sujeto un inhibidor del metabolismo de la glucosa y un estabilizador de p53 citoplasmática.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201962819322P | 2019-03-15 | 2019-03-15 | |
US201962904241P | 2019-09-23 | 2019-09-23 | |
PCT/US2020/022743 WO2020190765A2 (en) | 2019-03-15 | 2020-03-13 | Compositions and methods for treating cancer |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2021011272A true MX2021011272A (es) | 2021-10-01 |
Family
ID=72521289
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2021011272A MX2021011272A (es) | 2019-03-15 | 2020-03-13 | Composiciones y metodos para tratar el cancer. |
Country Status (15)
Country | Link |
---|---|
US (2) | US11377451B2 (es) |
EP (1) | EP3938354A4 (es) |
JP (1) | JP7474269B2 (es) |
KR (1) | KR20210151820A (es) |
CN (2) | CN115215808A (es) |
AU (1) | AU2020241703A1 (es) |
BR (1) | BR112021018295A2 (es) |
CA (1) | CA3133688A1 (es) |
CL (1) | CL2021002409A1 (es) |
CO (1) | CO2021013496A2 (es) |
CR (1) | CR20210498A (es) |
IL (1) | IL286350A (es) |
MX (1) | MX2021011272A (es) |
SG (1) | SG11202109662YA (es) |
WO (1) | WO2020190765A2 (es) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN111868039A (zh) * | 2017-09-26 | 2020-10-30 | 加利福尼亚大学董事会 | 用于治疗癌症的组合物和方法 |
KR20210151820A (ko) | 2019-03-15 | 2021-12-14 | 더 리전트 오브 더 유니버시티 오브 캘리포니아 | 암을 치료하기 위한 조성물 및 방법 |
US20240058340A1 (en) * | 2020-09-21 | 2024-02-22 | The Regents Of The University Of California | Compositions and methods for treating cancer |
US20230364091A1 (en) * | 2020-09-21 | 2023-11-16 | The Regents Of The University Of California | Compositions and methods for treating cancer |
WO2022155311A1 (en) * | 2021-01-14 | 2022-07-21 | The Regents Of The University Of California | Methods and systems for analysis of drug target engagement and treatment of cancer |
US20240165132A1 (en) * | 2021-05-12 | 2024-05-23 | Mayo Foundation For Medical Education And Research | Methods and materials for treating cancer |
CN113307799B (zh) * | 2021-05-21 | 2022-07-19 | 大连医科大学 | 一种检测葡萄糖醛酸转移酶1a1荧光探针及其应用 |
WO2023049312A1 (en) * | 2021-09-23 | 2023-03-30 | Erasca, Inc. | Egfr inhibitor polymorph forms |
WO2023244639A1 (en) * | 2022-06-14 | 2023-12-21 | The Regents Of The University Of California | Methods of predicting cns cancer response to treatment with egfr inhibitors |
WO2024081447A1 (en) * | 2022-10-14 | 2024-04-18 | The Regents Of The University Of California | Egfr inhibitors for treating lung cancer |
Family Cites Families (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5538325A (en) * | 1978-09-11 | 1980-03-17 | Sankyo Co Ltd | 4-anilinoquinazoline derivative and its preparation |
US5747498A (en) | 1996-05-28 | 1998-05-05 | Pfizer Inc. | Alkynyl and azido-substituted 4-anilinoquinazolines |
US6706721B1 (en) | 1998-04-29 | 2004-03-16 | Osi Pharmaceuticals, Inc. | N-(3-ethynylphenylamino)-6,7-bis(2-methoxyethoxy)-4-quinazolinamine mesylate anhydrate and monohydrate |
KR100397792B1 (ko) * | 2001-06-28 | 2003-09-13 | 한국과학기술연구원 | 4-(페닐아미노)-[1,4]디옥사노[2,3-g]퀴나졸린 유도체 및그의 제조방법 |
CN1854130B (zh) | 2005-04-15 | 2011-04-20 | 中国医学科学院药物研究所 | 喹唑啉衍生物、及其制法和药物组合物与用途 |
WO2008046242A1 (fr) | 2006-10-16 | 2008-04-24 | Institute Of Mataria Medica, Chinese Academy Of Medical Sciences | Nouveaux dérivés quinazolines, leurs procédés de préparation et leurs utilisations |
US8916574B2 (en) | 2009-09-28 | 2014-12-23 | Qilu Pharmaceutical Co., Ltd. | 4-(substituted anilino)-quinazoline derivatives useful as tyrosine kinase inhibitors |
ITPD20110091A1 (it) | 2011-03-24 | 2012-09-25 | Univ Padova | Inibitori multitirosinchinasi utili per le patologie correlate: modelli farmacoforici, composti identificati tramite questi modelli, metodi per la loro preparazione, la loro formulazione e il loro impiego terapeutico. |
JP6559785B2 (ja) * | 2014-12-15 | 2019-08-14 | ザ リージェンツ オブ ザ ユニバーシティ オブ ミシガン | Egfr及びpi3kの小分子阻害剤 |
CN105017163A (zh) | 2015-08-25 | 2015-11-04 | 佛山市赛维斯医药科技有限公司 | 双乙氧基苯并喹唑啉类酪氨酸激酶抑制剂、制备方法及其用途 |
US10473255B2 (en) | 2015-12-29 | 2019-11-12 | Ge-Hitachi Nuclear Energy Americas Llc | Reactor pressure vessel including pipe restraint device, and/or a pipe restraint device |
EP3400216A4 (en) | 2016-01-06 | 2019-08-14 | Trillium Therapeutics Inc. | NOVEL FLUORINATED QUINAZOLINE DERIVATIVES AS INHIBITORS OF EPIDERMAL GROWTH FACTOR RECEPTOR (EGFR) |
CN106432202B (zh) | 2016-09-22 | 2019-04-02 | 郑州大学第一附属医院 | 喹唑啉类衍生物及其应用 |
CN111868039A (zh) | 2017-09-26 | 2020-10-30 | 加利福尼亚大学董事会 | 用于治疗癌症的组合物和方法 |
KR20210151820A (ko) | 2019-03-15 | 2021-12-14 | 더 리전트 오브 더 유니버시티 오브 캘리포니아 | 암을 치료하기 위한 조성물 및 방법 |
WO2022061299A1 (en) | 2020-09-21 | 2022-03-24 | The Regents Of The University Of California | Non-invasive functional companion assays for oncogene targeted therapy for brain cancer |
US20230364091A1 (en) | 2020-09-21 | 2023-11-16 | The Regents Of The University Of California | Compositions and methods for treating cancer |
US20240058340A1 (en) | 2020-09-21 | 2024-02-22 | The Regents Of The University Of California | Compositions and methods for treating cancer |
WO2023049312A1 (en) | 2021-09-23 | 2023-03-30 | Erasca, Inc. | Egfr inhibitor polymorph forms |
WO2023244639A1 (en) | 2022-06-14 | 2023-12-21 | The Regents Of The University Of California | Methods of predicting cns cancer response to treatment with egfr inhibitors |
-
2020
- 2020-03-13 KR KR1020217032873A patent/KR20210151820A/ko unknown
- 2020-03-13 MX MX2021011272A patent/MX2021011272A/es unknown
- 2020-03-13 AU AU2020241703A patent/AU2020241703A1/en active Pending
- 2020-03-13 EP EP20773177.9A patent/EP3938354A4/en active Pending
- 2020-03-13 JP JP2021555445A patent/JP7474269B2/ja active Active
- 2020-03-13 BR BR112021018295A patent/BR112021018295A2/pt unknown
- 2020-03-13 CA CA3133688A patent/CA3133688A1/en active Pending
- 2020-03-13 WO PCT/US2020/022743 patent/WO2020190765A2/en active Application Filing
- 2020-03-13 CN CN202210268803.XA patent/CN115215808A/zh active Pending
- 2020-03-13 SG SG11202109662Y patent/SG11202109662YA/en unknown
- 2020-03-13 CN CN202080034742.XA patent/CN113811528A/zh active Pending
- 2020-03-13 CR CR20210498A patent/CR20210498A/es unknown
-
2021
- 2021-09-13 IL IL286350A patent/IL286350A/en unknown
- 2021-09-14 US US17/475,144 patent/US11377451B2/en active Active
- 2021-09-15 CL CL2021002409A patent/CL2021002409A1/es unknown
- 2021-10-11 CO CONC2021/0013496A patent/CO2021013496A2/es unknown
-
2022
- 2022-06-29 US US17/853,573 patent/US20230115366A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
CN113811528A (zh) | 2021-12-17 |
WO2020190765A3 (en) | 2020-11-26 |
EP3938354A4 (en) | 2022-12-28 |
WO2020190765A2 (en) | 2020-09-24 |
CR20210498A (es) | 2022-01-11 |
SG11202109662YA (en) | 2021-10-28 |
CN115215808A (zh) | 2022-10-21 |
CO2021013496A2 (es) | 2022-01-17 |
JP7474269B2 (ja) | 2024-04-24 |
US20230115366A1 (en) | 2023-04-13 |
US20220064177A1 (en) | 2022-03-03 |
KR20210151820A (ko) | 2021-12-14 |
JP2022526266A (ja) | 2022-05-24 |
AU2020241703A1 (en) | 2021-10-14 |
US11377451B2 (en) | 2022-07-05 |
EP3938354A2 (en) | 2022-01-19 |
BR112021018295A2 (pt) | 2021-11-23 |
CA3133688A1 (en) | 2020-09-24 |
CL2021002409A1 (es) | 2022-06-17 |
IL286350A (en) | 2021-10-31 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
MX2021011272A (es) | Composiciones y metodos para tratar el cancer. | |
AU2018368731A8 (en) | Combination therapies | |
PH12019501116A1 (en) | Compounds with anti-tumor activity against cancer cells bearing egfr or her2 exon 20 | |
MX2023010430A (es) | Inhibidores del homologo del oncogen viral del sarcoma de rata kirsten con mutacion g12d (kras g12d). | |
MX2018013848A (es) | Combinacion de anticuerpos anti-pd-1s y radiacion para tratar cancer. | |
EA200970953A1 (ru) | СПЕЦИФИЧНЫЕ ИНГИБИТОРЫ PDGFRβ | |
EA201290139A1 (ru) | Модуляторы кальциевого канала, активируемого высвобождением кальция, представляющие собой производные пиразола, и способы лечения немелкоклеточного рака легких | |
MX363188B (es) | Identificación de pacientes con necesidad de coterapia del inhibidor de pd-l1. | |
MY152948A (en) | 4-pyrazolyl-n-arylpyrimidin-2-amines and 4-pyrazolyl-n-heteroarylpyrimidin-2-amines as janus kinase inhibitors | |
WO2012016133A3 (en) | Ros1 kinase inhibitors for the treatment of glioblastoma and other p53-deficient cancers | |
TN2010000204A1 (en) | Kinesin inhibitors as cancer therapeutics | |
MX2021014455A (es) | Inhibidores de proteina cinasas dependientes de adn. | |
AU2010266004A8 (en) | Method of treating cancer with Dll4 antagonist and chemotherapeutic agent | |
WO2009137543A3 (en) | Methods for breast cancer screening and treatment | |
MX2018001507A (es) | Composiciones y metodos para tratar cánceres asociados con la activacion del etbr. | |
MX2019012176A (es) | Metodos de combinacion de chk1(sra737)/parpi para inhibir el crecimiento tumoral. | |
MX2021002805A (es) | Terapias de combinacion. | |
JOP20220107A1 (ar) | مثبطات egfr تفارغية وطرق استخدامها | |
MX2023010429A (es) | Inhibidores del homologo del oncogen viral del sarcoma de rata kirsten (kras). | |
AU2018271862A1 (en) | Combination therapy | |
AU2018380132A8 (en) | Tubulin inhibitors | |
PH12020500665A1 (en) | Pladienolide derivatives as spliceosome targeting agents for treating cancer | |
MX2022010860A (es) | Terapia combinada que comprende inhibidores de axl/mer y pd-1/pd-l1. | |
PH12021551276A1 (en) | Combination therapy for the treatment of cancer | |
MX2020006224A (es) | Metodos y terapia combinada para el tratamiento del cancer. |